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Journal Articles

ALLCAR19: Updated Data Using AUTO1, a Novel Fast-Off Rate CD19 CAR in Relapsed/Refractory B-Cell Acute Lymphoblastic Leukaemia and Other B-Cell Malignancies

Claire Roddie, PhD MD, Maeve A O'Reilly, MBBCHBAO, Maria A V Marzolini, Leigh Wood, BA, Juliana Dias, Amaia Cadinanos Garai, BSc MSc, Leticia Bosshard, Mahnaz Abbasian, Mark W. Lowdell, BSc, MSc, PhD FRCPath, Graham Wheeler, Joanna Olejnik, Bilyana Popova, MSc, Laura Clifton-Hadley, PhDBSc, Yashma Pathak, Victoria Spanswick, Helen Lowe, John A. Hartley, PhD, Farhatullah Syed, Waseem Qasim, MBBS, PhD, Farzin Farzaneh, PhD, David C. Linch, Martin Pule, MDPhD, Karl S Peggs, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 3–4.
https://doi.org/10.1182/blood-2020-137768
Published: 2020
Journal Articles

Automated Manufacture of Matched Donor-Derived Allogeneic CD19 CAR T-Cells for Relapsed/Refractory B-ALL Following Allogeneic Stem Cell Transplantation: Toxicity, Efficacy and the Important Role of Lymphodepletion

Claire Roddie, PhD MD, Maeve A O'Reilly, MBBCHBAO, Maria A V Marzolini, Leigh Wood, BA, Juliana Dias Alves Pinto, PhD, Mahnaz Abbasian, Ketki Vispute, Leticia Bosshard, Mark W. Lowdell, BSc, MSc, PhD FRCPath, Graham Wheeler, Alex Day, Bilyana Popova, Kim Champion, Yashma Pathak, Alexia Gali, Nasir Mahmoud, Victoria Spanswick, Helen Lowe, John A. Hartley, PhD, Farzin Farzaneh, PhD, Lauren Nickolay, PhD, Fahetullah Syed, Waseem Qasim, MBBS, PhD, David C. Linch, Martin Pule, Karl S Peggs
Journal: Blood
Blood (2019) 134 (Supplement_1): 776.
https://doi.org/10.1182/blood-2019-129640
Published: 2019
Journal Articles

Therapy of Paediatric B-ALL with a Fast Off Rate CD19 CAR Leads to Enhanced Expansion and Prolonged CAR T Cell Persistence in Patients with Low Bone Marrow Tumour Burden, and Is Associated with a Favourable Toxicity Profile

Sara Ghorashian, FRCPath, PhD, Anne Marijn Kramer, MD, Shimobi Onuoha, PhD, Gary Wright, Jack Luke Bartram, MD, Rachel Richardson, MSc, Sarah J Albon, MSc, Joan Casanovas Company, Fernanda Castro, Bilyana Popova, Krystal Villanueva, Jenny Yeung, Aleks Guvenel, PhD, Patrycja Wawrzyniecka, Danielle Pinner, Jan Chu, Giovanna Lucchini, Juliana Silva, MD, Oana Ciocarlie, Arina Lazareva, Sarah Inglott, Kimberly Gilmour, Gulrukh Ahsan, Kim Champion, Andre Lopes, Allan Hackshaw, Farzin Farzaneh, PhD, Robert Chiesa, Kanchan Rao, Denise Bonney, Sujith Samarasinghe, Nicholas John Goulden, MD PhD MRCPath, Ajay Vora, Paul Veys, MD PhD, Rachael E Hough, MD, Robert Wynn, Martin Pule, MD, Persis J Amrolia, FRCP, FRCPath, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 225.
https://doi.org/10.1182/blood-2019-125009
Published: 2019
Journal Articles

AUTO1, a Novel Fast Off CD19CAR Delivers Durable Remissions and Prolonged CAR T Cell Persistence with Low CRS or Neurotoxicity in Adult ALL

Claire Roddie, PhD MD, Maeve A O'Reilly, MBBCHBAO, Maria A V Marzolini, Leigh Wood, BA, Juliana Dias Alves Pinto, PhD, Mahnaz Abbasian, Ketki Vispute, Mark W. Lowdell, BSc, MSc, PhD FRCPath, Graham Wheeler, Joanna Olejnik, Bilyana Popova, Kim Champion, Alexia Gali, Yashma Pathak, Victoria Spanswick, Helen Lowe, John A. Hartley, PhD, Farzin Farzaneh, PhD, David C. Linch, Martin Pule, Karl S Peggs
Journal: Blood
Blood (2019) 134 (Supplement_1): 226.
https://doi.org/10.1182/blood-2019-131086
Published: 2019
Journal Articles

Allogeneic Anti-CD19 CAR T Cells Manufactured from Healthy Donors Provide a Unique Cellular Product with Distinct Phenotypic Characteristics Compared to CAR T Cells Generated from Patients with Mature B Cell Malignancies

Charlotte Graham, MRCP, BSc, MBBS, Agnieszka Jozwik, PhD, Ruby Quartey-Papafio, Nikolaos Ioannou, PhD MSc, BSc, Ana M Metelo, PhD, Carlo Scala, PhD, Glenda Dickson, PhD, Orla Stewart, Maria Almena-Carrasco, Elisa Peranzoni, Alan G. Ramsay, BSc,MSc,PhD, Sandra Dupouy, Pharm.D, PhD, Farzin Farzaneh, PhD, Piers E.M. Patten, BSc, MRCP, MRCPath, PhD, Andrea Pepper, PhD, Reuben Benjamin, FRCPath, MRCP, MBBS, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3228.
https://doi.org/10.1182/blood-2019-123018
Published: 2019
Journal Articles

Preliminary Results of UCART19, an Allogeneic Anti-CD19 CAR T-Cell Product, in a First-in-Human Trial (CALM) in Adult Patients with CD19 + Relapsed/Refractory B-Cell Acute Lymphoblastic Leukemia

Charlotte Graham, MRCP, BSc, MBBS, Deborah Yallop, MBBS FRCP FRCPath PhD, Agnieszka Jozwik, Piers Patten, BSc, MRCP, MRCPath, PhD, Alan Dunlop, Rose Ellard, Orla Stewart, Victoria Potter, Victoria Metaxa, Shireen Kassam, Farzin Farzaneh, PhD, Stephen Devereux, FRCP, FRCPath, PhD, Antonio Pagliuca, MD, Amina Zinai, MD, Florence Binlich, MD, Sandra Dupouy, Pharm.D, PhD, Anne Philippe, Svetlana Balandraud, MD, Frédéric Dubois, Cyril Konto, MD, Premal Patel, MD PhD BSPharm, Ghulam Mufti, DM, FRCP, FRCPath, Reuben Benjamin
Journal: Blood
Blood (2017) 130 (Supplement 1): 887.
https://doi.org/10.1182/blood.V130.Suppl_1.887.887
Published: 2017
Journal Articles

A Novel Low Affinity CD19CAR Results in Durable Disease Remissions and Prolonged CAR T Cell Persistence without Severe CRS or Neurotoxicity in Patients with Paediatric ALL

Sara Ghorashian, FRCPath, PhD, Anne Marijn Kramer, MD, Sarah Jayne Albon, BSc, MSc, Gary Wright, Fernanda Castro, Bilyana Popova, Joan Casanovas Company, Catherine Irving, Winston Vetharoy, Rachel Richardson, Danielle Pinner, Jan Chu, Giovanna Lucchini, MD, Juliana Silva, MD, Oana Ciocarlie, Sarah Inglott, Kim Champion, Allan Hackshaw, Farzin Farzaneh, PhD, Robert Chiesa, Kanchan Rao, Anupama Gopala Rao, MB, MRCP, MRCPath, Philip Ancliffe, MD, Sujith Samarasinghe, Ajay Vora, MD, Paul Veys, MD PhD, Rachael Hough, MD BMBS, FRCP, FRCPath, Robert Wynn, MD, Martin Pule, PhD, Persis J Amrolia
Journal: Blood
Blood (2017) 130 (Supplement 1): 806.
https://doi.org/10.1182/blood.V130.Suppl_1.806.806
Published: 2017
Journal Articles

Functional Characteristics of FAS-L Resistant and IL-2 Deprived Regulatory T Cells (Treg A) in Idiopathic Aplastic Anaemia

Benedetta Costantini, MD, Syed A Mian, PhD, Shok Ping Lim, PhD, Frederic Toulza, PhD, Stephen Orr, PhD, Pilar Perez-Abellan, MSc, Ander Abarrategi, PhD, Farzin Farzaneh, PhD, Dominique Bonnet, PhD, Judith Marsh, MD, Shahram Kordasti, MD PhD, Ghulam Mufti, DM, FRCP, FRCPath
Journal: Blood
Blood (2017) 130 (Supplement 1): 2450.
https://doi.org/10.1182/blood.V130.Suppl_1.2450.2450
Published: 2017
Journal Articles

Automated Manufacture of CAR19 Donor Lymphocytes Incorporated into an Escalated Dose DLI Protocol: Preliminary Results from the CARD Study

Claire Roddie, PhD MD, Lauren Nickolay, PhD, Ulrike Mock, PhD, Praveen Aujla, Gordon W Cheung, Lucas Chan, Alex Day, Graham Wheeler, Bilyana Popova, Kim Champion, Yashma Pathak, Nasir Mahmoud, Helen Lowe, Gulrukh Ahsan, Nourredine Himoudi, Farzin Farzaneh, PhD, David C. Linch, FRCP, Adrian J Thrasher, MD PhD FMedSci, Martin Pule, PhD, Waseem Qasim, MD PhD, Karl Peggs, MBBChir, MRCP, FRCPath
Journal: Blood
Blood (2017) 130 (Supplement 1): 1993.
https://doi.org/10.1182/blood.V130.Suppl_1.1993.1993
Published: 2017
Journal Articles

CD4 + CD25 high Foxp3 + Regulatory T-Cells Are Correlated with Different Risk Factors in Myelodysplastic Syndrome (MDS).

Shahram Y. Kordasti, MD, Wendy Ingram, MD, Janet Hayden, RCN, David Darling, PhD, Linda Barber, PhD, Farzin Farzaneh, PhD, Ghulam Mufti, MD
Journal: Blood
Blood (2007) 110 (11): 2445.
https://doi.org/10.1182/blood.V110.11.2445.2445
Published: 2007
Journal Articles

Hepatocyte Growth Factor Expression in Bone Marrow Microenvironment Is Critical for Progression of MGUS to Myeloma.

Karthik Ramasamy, MD, Stephen Schey, MD, Ghulam J. Mufti, MD, DM, Farzin Farzaneh, PhD, Yolanda Calle, PhD
Journal: Blood
Blood (2007) 110 (11): 4766.
https://doi.org/10.1182/blood.V110.11.4766.4766
Published: 2007
Journal Articles

Expansion of Polyclonal CD4 + CD25 high Foxp3 + Regulatory T-Cells in High Risk Myelodysplastic Syndromes (MDS).

Shahram Y. Kordasti, MD, Wendy Ingram, MD, Janet Hayden, RN, David Darling, PhD, Linda Barber, PhD, Farzin Farzaneh, PhD, Ghulam J. Mufti, MD
Journal: Blood
Blood (2006) 108 (11): 2641.
https://doi.org/10.1182/blood.V108.11.2641.2641
Published: 2006
Journal Articles

TAT-Apoptin Mediated Induction of Apoptosis in Leukaemic Cells.

Joop Gaken, PhD, Louisa Pericleous, PhD, Farzin Farzaneh, PhD, Ghulam J. Mufti, MD, Mahvash Tavassoli, PhD
Journal: Blood
Blood (2006) 108 (11): 1900.
https://doi.org/10.1182/blood.V108.11.1900.1900
Published: 2006