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Eric O’Brien
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Journal Articles

High-Throughput Drug Repurposing Identifies SN-38 As a Potent Inhibitor of AML with Synergistic Effects in Combination with PARP and BCL-2 Inhibitors for Treating KMT2A-Rearranged Leukemias

Mithun Sarangdhar, Eric O'Brien, Brett VanCauwenbergh, Mitali Basu, Jonah Snyder, Grace Leuenberger, John Peter Perentesis
Journal: Blood
Blood (2024) 144 (Supplement 1): 2203.
https://doi.org/10.1182/blood-2024-211351
Published: 2024
Journal Articles

High Throughput Pre-Clinical Models to Determine a Synergistic Molar Ratio of 5-Azacitidine to Venetoclax and Uncover Resistance Mechanisms to 5-Azacitidine and Venetoclax Combination Therapy in Acute Myeloid Leukemia

Mithun Milind Sarangdhar, Eric O'Brien, Brett VanCauwenbergh, Jackson Alexander, Caroline Theile, Mitali Basu, Mayur Sarangdhar, William Seibel, John P Perentesis
Journal: Blood
Blood (2022) 140 (Supplement 1): 10693–10694.
https://doi.org/10.1182/blood-2022-163770
Published: 2022
Journal Articles

Global Gene Expression and Mutation Signatures Are Preserved in PDX Models of Pediatric AML and Aid Discovery of Targeted Therapy for Cases with CBFA2T3/GLIS2 Rearrangement

Mark Wunderlich, MS, Jing Chen, Eric O'Brien, BSc, Nicole Manning, Christina Sexton, Luke Byerly, John P Perentesis, Benjamin Mizukawa, James C Mulloy
Journal: Blood
Blood (2019) 134 (Supplement_1): 3766.
https://doi.org/10.1182/blood-2019-129225
Published: 2019
Journal Articles

Overcoming Adaptive Therapy Resistance in AML By Targeting Immune Response Pathways

Katelyn M. Melgar, PhD, LaQuita M Jones, DO, Mackenzie Walker, Lyndsey C Bolanos, BSc, Kathleen Hueneman, Mark Wunderlich, MS, Jiang-Kang Jiang, Kelli Wilson, Xiaohu Zhang, Patrick Sutter, Xin Xu, Kwangmin Choi, PhD, Gregory Tawa, Donald Lorimer, Jan Abendroth, Eric O'Brien, BSc, Scott Hoyt, Ellin Berman, MD, Christopher Famulare, MS, James C Mulloy, Ross L. Levine, MD, Jan S Rosenbaum, John P Perentesis, Craig J Thomas, PhD, Daniel T. Starczynowski, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3934.
https://doi.org/10.1182/blood-2019-124178
Published: 2019
Journal Articles

Modeling Effective AML Therapies - Comparative Anti-Leukemic Synergy of BCL2 and MCL1 Inhibition Combined and with Chemotherapy

Eric O'Brien, BSc, Brett VanCauwenbergh, BSc, Jackson Alexander, Mitali Basu, MSc, Mark Wunderlich, MS, Mayur Sarangdhar, PhD, Benjamin Mizukawa, John P Perentesis
Journal: Blood
Blood (2019) 134 (Supplement_1): 3370.
https://doi.org/10.1182/blood-2019-131613
Published: 2019
Journal Articles

Therapeutic Targeting of the Ubiquitin Conjugating Enzyme UBE2N in Myeloid Malignancies

Laura Barreyro, PhD, Avery Sampson, BSc, Kathleen Hueneman, BSc, Lyndsey C Bolanos, BSc, Mario Pujato, PhD, Somchai Chutipongtanate, MD PhD, Michael Wyder, MS, Wendy Haffey, PhD, Kwangmin Choi, PhD, Yaseswini Neelamraju, MS, Molly A Smith, BSc, Madeline Niederkorn, BSc, Vighnesh Ramesh, Tomoya Muto, MD PhD, Eric O'Brien, BSc, Cem Meydan, PhD, Susanne Christie, BSc, Xiaona Liu, Francine Garret-Bakelman, MD PhD, Boris Bartholdy, PhD, Britta Will, PhD, Matthew T. Weirauch, PhD, Zartash Gul, MD, Stephen Medlin, MD, John Peter Perentesis, MD, Kenneth D Greis, PhD, William Seibel, PhD, Daniel T. Starczynowski, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4050.
https://doi.org/10.1182/blood-2018-99-115359
Published: 2018
Journal Articles

In Vitro Approach for the Identification of Exceptional Responders in Acute Myeloid Leukemia

Eric O'Brien, BSc, Brett VanCauwenbergh, BSc, Luke Byerly, BSc, Alexander Merk, BSc, Mayur Sarangdhar, PhD, Mark Wunderlich, MS, Mitali Basu, MSc, Benjamin Mizukawa, MD, Erin H. Breese, MD PhD, William Seibel, PhD, John Peter Perentesis, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2212.
https://doi.org/10.1182/blood-2018-99-116650
Published: 2018
Journal Articles

Predicting Drug Response and Novel Therapeutic Candidates Using Signatures of Molecular Alterations in Hematologic Malignancies

Guillaume Labilloy, MS, Eric O'Brien, BSc, Brett VanCauwenbergh, BSc, Luke Byerly, BSc, Mitali Basu, MSc, William Seibel, PhD, Erin H. Breese, MD PhD, John Peter Perentesis, MD, Mayur Sarangdhar, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2219.
https://doi.org/10.1182/blood-2018-99-119933
Published: 2018
Journal Articles

The cell polarity determinant CDC42 controls division symmetry to block leukemia cell differentiation

Benjamin Mizukawa, Eric O’Brien, Daniel C. Moreira, Mark Wunderlich, Cindy L. Hochstetler, Xin Duan, Wei Liu, Emily Orr, H. Leighton Grimes, James C. Mulloy, Yi Zheng
Journal: Blood
Blood (2017) 130 (11): 1336–1346.
https://doi.org/10.1182/blood-2016-12-758458
Published: 2017
Includes: Supplemental data
Journal Articles

Protease-Activated Receptor 1 (PAR-1) Inhibits Proliferation but Enhances Leukemia Stem Cell Activity in Acute Myeloid Leukemia

Susumu Goyama, MD PhD, Mahesh Shrestha, Janet Schibler, Leah Rosenfeldt, Whitney Miller, Eric O'Brien, Benjamin Mizukawa, MD, Toshio Kitamura, MD PhD, Joseph S. Palumbo, MD, James C. Mulloy, PhD
Journal: Blood
Blood (2016) 128 (22): 2730.
https://doi.org/10.1182/blood.V128.22.2730.2730
Published: 2016
Journal Articles

Maintenance Of Bone Marrow Residency and Self-Renewal Of Leukemic Stem Cells By Cdc42 Gtpase

Benjamin Mizukawa, MD, Eric O'Brien, BS, Wei Liu, MD, PhD, Daniel Moriera Ridsdale, MD, Mark Wunderlich, MS, Yi Zheng, PhD, James C. Mulloy, PhD
Journal: Blood
Blood (2013) 122 (21): 2889.
https://doi.org/10.1182/blood.V122.21.2889.2889
Published: 2013