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Journal Articles

Ibrutinib Therapy Downregulates Toso, the Fcr for IgM, Expression in CLL Patients

Mariela Sivina, Gordon Duncan, MSc, Takashi Sakamoto, MD PhD, Ekaterina Kim, MS, Alicia Vaca, PhD, Elena Maria Hartmann, MD, Michael J Keating, MBBS, Alessandra Ferrajoli, MD, William G. Wierda, MD PhD, Tak Mak, PhD DSc, Andreas Rosenwald, MD, Jan A. Burger, MD PhD

Blood (2019) 134 (Supplement_1): 5448.

https://doi.org/10.1182/blood-2019-125716

Published: 2019

Journal Articles

The Paracaspase MALT1 Acts Independently of Pre-B-Cell Receptor Signaling As a Key Factor in Leukemic Cell Survival in Precursor B-Cell Acute Lymphoblastic Leukemia

Nakhle S. Saba, MD, Jade Meyers, Lorena Fontan, PhD, Ari Melnick, MD, Adrian Wiestner, MD PhD, Patricia Lobelle-Rich, Ekaterina Kim, MS, Jan A. Burger, MD PhD, Yara Mouawad, MD, Prescott L. Deininger, PhD, Francisco Socola, MD, Hana Safah, MD, Erik K Flemington, PhD

Blood (2019) 134 (Supplement_1): 1288.

https://doi.org/10.1182/blood-2019-131376

Published: 2019

Journal Articles

CG-806, a First-in-Class Pan-FLT3/Pan-BTK Inhibitor, Exhibits Broad Signaling Inhibition in Chronic Lymphocytic Leukemia Cells

Ekaterina Kim, MS, Hongying Zhang, MD PhD, Mariela Sivina, Alicia Vaca, PhD, Philip A. Thompson, MBBS, Nitin Jain, MD, Alessandra Ferrajoli, MD, Zeev E. Estrov, MD, Michael J Keating, MBBS, William G. Wierda, MD PhD, William G Rice, PhD, Michael Andreeff, MD PhD, Jan A. Burger, MD PhD

Blood (2019) 134 (Supplement_1): 3051.

https://doi.org/10.1182/blood-2019-124473

Published: 2019

Journal Articles

Expansion of T Helper Cell Subsets in Chronic Lymphocytic Leukemia Cell Co-Cultures with Nurselike Cells

Alicia Vaca, PhD, Mariela Sivina, Karen Clise-Dwyer, PhD, Ekaterina Kim, MS, Michael J Keating, MBBS, Alessandra Ferrajoli, MD, William G. Wierda, MD PhD, Dan Li, PhD, Qing Ma, PhD, Jan A. Burger, MD PhD

Blood (2019) 134 (Supplement_1): 1746.

https://doi.org/10.1182/blood-2019-125827

Published: 2019

Journal Articles

IKZF3 p.L162R Is a Recurrent Hotspot Mutation in Chronic Lymphocytic Leukemia (CLL)

Koichi Takahashi, MD, Candida Vitale, MD, Carlos Bueso-Ramos, Feng Wang, PhD, Ekaterina Kim, MS, Jianhua Zhang, Curtis Gumbs, Mark Routbort, MD PhD, Zeev Estrov, MD, Nitin Jain, MD, Guillermo Garcia-Manero, MD, Hagop M. Kantarjian, MD, Jan A. Burger, MD PhD, Alessandra Ferrajoli, MD, Michael Keating, MBBS, Andrew Futreal, PhD, William Wierda, MD PhD

Blood (2015) 126 (23): 4136.

https://doi.org/10.1182/blood.V126.23.4136.4136

Published: 2015

Journal Articles

Immunoglobulin Heavy Chain (IgH) Knockout Inhibits Proliferation of Pre-BCR + B-Cell Acute Lymphoblastic Leukemia (B-ALL) Via a FOXO1 and MYC Dependent Mechanism

Stefan Koehrer, MD, Ondrej Havranek, MDPhD, R Eric Davis, MD, Felix Seyfried, MD, Greg Coffey, PhD, Ekaterina Kim, MS, Nathalie Y. Rosin, PhD, Elisa ten Hacken, PhD, Ulrich Jäger, MD, Katrina Vanura, PhD, Susan O'Brien, MD, Deborah A. Thomas, MD, Hagop M. Kantarjian, MD, Dipanjan Ghosh, PhD, Zhiqiang Wang, Lüder Hinrich Meyer, MD, Hassan Jumaa, PhD, Jan A. Burger, MDPhD

Blood (2014) 124 (21): 287.

https://doi.org/10.1182/blood.V124.21.287.287

Published: 2014

Journal Articles

Addition of Rituximab Abrogates Ibrutinib-Induced Lymphocytosis and Promotes More Rapid Decrease in Absolute Lymphocyte Counts in Patients with Relapsed Chronic Lymphocytic Leukemia

Ekaterina Kim, MS, Lillian Werner, Michael J Keating, MBBS, William G. Wierda, MD PhD, Alessandra Ferrajoli, MD, Zeev Estrov, MD, Gracy Zacharian, Thomas J. Kipps, MD, Hagop M. Kantarjian, MD, Donna Neuberg, ScD, Susan O'Brien, MD, Jan A. Burger, MD PhD

Blood (2014) 124 (21): 1998.

https://doi.org/10.1182/blood.V124.21.1998.1998

Published: 2014

Journal Articles

Bruton′s Tyrosine Kinase Inhibitor Ibrutinib Interferes With Constitutive and Induced Pre-B Cell Receptor Signaling In B-Cell Acute Lymphoblastic Leukemia

Ekaterina Kim, MS, Stefan Koehrer, MD, Nathalie Y. Rosin, PhD, Zhiqiang Wang, Ph.D., Deborah A. Thomas, MD, Farhad Ravandi, MD, Steven M. Kornblau, MD, Hagop M. Kantarjian, MD, Susan O'Brien, MD, Zeev Estrov, MD, Joseph J. Buggy, PhD, Markus Muschen, MD, PhD, Richard E. Davis, MD, Jan A. Burger, MD, PhD

Blood (2013) 122 (21): 1399.

https://doi.org/10.1182/blood.V122.21.1399.1399

Published: 2013

Journal Articles

The PI3K Delta Inhibitor Idelalisib Interferes With Pre-B Cell Receptor Signaling In Acute Lymphoblastic Leukemia (ALL): A New Therapeutic Concept

Nathalie Y. Rosin, PhD, Ekaterina Kim, MS, Stefan Koehrer, MD, Zhiqiang Wang, Ph.D., Susan O'Brien, MD, William G. Wierda, MD, Deborah A. Thomas, MD, Zeev Estrov, MD, Hagop M. Kantarjian, MD, Brian Lannutti, PhD, Richard E. Davis, PhD, Jan A. Burger, MD, PhD

Blood (2013) 122 (21): 2632.

https://doi.org/10.1182/blood.V122.21.2632.2632

Published: 2013

Journal Articles

Pre-BCR Signaling Activity Predicts Sensitivity To Syk Kinase Inhibition In B Cell Acute Lymphoblastic Leukemia (B-ALL)

Stefan Koehrer, MD, Richard E. Davis, M.D., Greg Coffey, PhD, Ekaterina Kim, MS, Nathalie Y. Rosin, PhD, Elisa ten Hacken, Susan O'Brien, MD, William G. Wierda, MD, PhD, Zeev Estrov, MD, Deborah A. Thomas, MD, Hagop M. Kantarjian, MD, Zhiqiang Wang, Ph.D., Hassan Jumaa, PhD, Jan A. Burger, MD, PhD

Blood (2013) 122 (21): 614.

https://doi.org/10.1182/blood.V122.21.614.614

Published: 2013

Journal Articles

Activity of Bruton's Tyrosine Kinase (BTK) Inhibitor Ibrutinib (PCI-32765) in B-Cell Acute Lymphoblastic Leukemia (B-ALL).

Ekaterina Kim, MS, Stefan Koehrer, MD, Nathalie Y Rosin, PhD, Deborah A. Thomas, MD, Farhad Ravandi, MD, Steven M. Kornblau, MD, PhD, Hagop M. Kantarjian, MD, Susan O'Brien, MD, Zeev Estrov, MD, PhD, Joseph J. Buggy, PhD, Jan A. Burger, MD, PhD

Blood (2012) 120 (21): 2569.

https://doi.org/10.1182/blood.V120.21.2569.2569

Published: 2012

Journal Articles

Efficacy of PRT060318, a Novel Highly Specific SYK Inhibitor, in Acute Lymphoblastic Leukemia (ALL)

Stefan KÖhrer, MD, Greg Coffey, PhD, Ekaterina Kim, MS, Nathalie Y Rosin, PhD, Uma Sinha, PhD, Anjali Pandey, PhD, Medhat Shehata, Ulrich Jäger, Susan M. O'Brien, MD, William G. Wierda, MD, Ph.D., Zeev Estrov, MD, PhD, Deborah Thomas, MD, Hagop M Kantarjian, Jan A. Burger, MD, PhD

Blood (2012) 120 (21): 3532.

https://doi.org/10.1182/blood.V120.21.3532.3532

Published: 2012

Journal Articles

In Vitro Effects of PI3Kδ Inhibitor GS-1101 (Cal-101) in Acute Lymphoblastic Leukemia (ALL)

Nathalie Y Rosin, PhD, Stefan Koehrer, MD, Ekaterina Kim, MS, Susan O'Brien, M.D., William G. Wierda, MD, Ph.D., Deborah A. Thomas, MD, Zeev Estrov, MD, PhD, Hagop M. Kantarjian, MD, Brian J. Lannutti, PhD, Jan A. Burger, MD, PhD

Blood (2012) 120 (21): 3534.

https://doi.org/10.1182/blood.V120.21.3534.3534

Published: 2012

NARROW

Ibrutinib Therapy Downregulates Toso, the Fcr for IgM, Expression in CLL Patients

The Paracaspase MALT1 Acts Independently of Pre-B-Cell Receptor Signaling As a Key Factor in Leukemic Cell Survival in Precursor B-Cell Acute Lymphoblastic Leukemia

CG-806, a First-in-Class Pan-FLT3/Pan-BTK Inhibitor, Exhibits Broad Signaling Inhibition in Chronic Lymphocytic Leukemia Cells

Expansion of T Helper Cell Subsets in Chronic Lymphocytic Leukemia Cell Co-Cultures with Nurselike Cells

IKZF3 p.L162R Is a Recurrent Hotspot Mutation in Chronic Lymphocytic Leukemia (CLL)

Immunoglobulin Heavy Chain (IgH) Knockout Inhibits Proliferation of Pre-BCR + B-Cell Acute Lymphoblastic Leukemia (B-ALL) Via a FOXO1 and MYC Dependent Mechanism

Addition of Rituximab Abrogates Ibrutinib-Induced Lymphocytosis and Promotes More Rapid Decrease in Absolute Lymphocyte Counts in Patients with Relapsed Chronic Lymphocytic Leukemia

Bruton′s Tyrosine Kinase Inhibitor Ibrutinib Interferes With Constitutive and Induced Pre-B Cell Receptor Signaling In B-Cell Acute Lymphoblastic Leukemia

The PI3K Delta Inhibitor Idelalisib Interferes With Pre-B Cell Receptor Signaling In Acute Lymphoblastic Leukemia (ALL): A New Therapeutic Concept

Pre-BCR Signaling Activity Predicts Sensitivity To Syk Kinase Inhibition In B Cell Acute Lymphoblastic Leukemia (B-ALL)

Activity of Bruton's Tyrosine Kinase (BTK) Inhibitor Ibrutinib (PCI-32765) in B-Cell Acute Lymphoblastic Leukemia (B-ALL).

Efficacy of PRT060318, a Novel Highly Specific SYK Inhibitor, in Acute Lymphoblastic Leukemia (ALL)

In Vitro Effects of PI3Kδ Inhibitor GS-1101 (Cal-101) in Acute Lymphoblastic Leukemia (ALL)

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American Society of Hematology

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American Society of Hematology

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