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Journal Articles

The Alpha Emitter Astatine-211 Targeted to CD38 Can Eradicate Multiple Myeloma in Minimal Residual Disease Models

Shyril O'Steen, PhD, Melissa C. Comstock, BS, Johnnie J. Orozco, MD PhD, Donald K. Hamlin, BS, D. Scott Wilbur, PhD, Jon Jones, BS, Aimee Kenoyer, BS, Margaret E. Nartea, BS, Yukang Lin, PhD, Brian W. Miller, PhD, Sherilyn A. Tuazon, MD, Brian G. Till, MD, Ajay K. Gopal, MD, Brenda M. Sandmaier, MD, Oliver W. Press, MD PhD, Damian J. Green, MD

Blood (2018) 132 (Supplement 1): 1941.

https://doi.org/10.1182/blood-2018-99-119555

Published: 2018

Journal Articles

Novel Bispecific Antibody Targeting CD45 and 90 Y-DOTA Is Effective Therapy for Acute Myeloid Leukemia in Preclinical Murine Models

Johnnie J. Orozco, MD PhD, Aimee Kenoyer, BS, Yukang Lin, PhD, Darrell R. Fisher, PhD, Donald K. Hamlin, BS, D. Scott Wilbur, PhD, Alexandra Hernandez, BS, Rosario Guel, Margaret E. Nartea, Shyril O'Steen, PhD, Mark D Hylarides, PhD, Brian G Till, MD, Damian J. Green, MD, Ajay K. Gopal, MD, Kelly D Orcutt, PhD, Karl Dane Wittrup, PhD, Brenda M. Sandmaier, MD, John M. Pagel, MD PhD, Oliver W. Press, MD PhD

Blood (2017) 130 (Supplement 1): 1355.

https://doi.org/10.1182/blood.V130.Suppl_1.1355.1355

Published: 2017

Journal Articles

Addition of Astatine-211-Labeled Anti-CD45 Antibody to Total Body Irradiation (TBI) As Conditioning for DLA-Identical Marrow Transplantation: A Novel Strategy to Overcome Graft Rejection in a Canine Presensitization Model

Huiying Qiu, MD, Erlinda B Santos, Rainer F. Storb, MD, Donald K Hamlin, D Scott Wilbur, PhD, Brenda M Sandmaier, MD

Blood (2016) 128 (22): 2152.

https://doi.org/10.1182/blood.V128.22.2152.2152

Published: 2016

Journal Articles

211 At-Anti-CD45 Radioimmunotherapy Can Replace TBI Prior to Haploidentical Bone Marrow Transplantation and Yield Long-Term Hematopoietic Engraftment

Johnnie J. Orozco, MD PhD, Aimee L. Kenoyer, BS, Ethan R. Balkin, PhD, Donald K. Hamlin, BS, D Scott Wilbur, PhD, Sofia H.L. Frost, PhD, Mark D. Hylarides, PhD, Damian J. Green, MD, Ajay K. Gopal, MD, Brenda M. Sandmaier, MD, Oliver W. Press, MD PhD, Paul V. O'Donnell, MD PhD, John M. Pagel, MD PhD

Blood (2014) 124 (21): 2417.

https://doi.org/10.1182/blood.V124.21.2417.2417

Published: 2014

Journal Articles

Pre-Targeted Radioimmunotherapy Employing a Recombinant Bispecific Antibody Using a Murine Xenograft Model of Human Leukemia

Aimee L. Kenoyer, BS, Yukang Lin, PhD, Johnnie J. Orozco, MD PhD, Ethan Balkin, Don Hamlin, BS, Alexandra H. Hernandez, BS, Chen Fang, PhD, Kelly Laird, Sofia H.L. Frost, PhD, Mark Hylarides, PhD, Kelly D. Orcutt, PhD, D Scott Wilbur, PhD, K. Dane Wittrup, PhD, Oliver W. Press, MD PhD, John Pagel, MD PhD

Blood (2014) 124 (21): 3749.

https://doi.org/10.1182/blood.V124.21.3749.3749

Published: 2014

Journal Articles

Astatine-211 Conjugated To Anti-CD20 Monoclonal Antibody Eliminates B-Cell Lymphoma In a Mouse Model

Damian J. Green, MD, Mazyar Shadman, MD, MPH, Shani L. Frayo, BS, Jon C. Jones, Mark D. Hylarides, PhD, Aimee L. Kenoyer, BS, D. Scott Wilbur, PhD, Donald K. Hamlin, BS, Yukang Lin, PhD, Ajay K. Gopal, MD, Sofia H.L. Frost, PhD, Johnnie J. Orozco, MD, PhD, John M. Pagel, MD, PhD, Oliver W. Press, MD, PhD

Blood (2013) 122 (21): 4415.

https://doi.org/10.1182/blood.V122.21.4415.4415

Published: 2013

Journal Articles

Anti-CD45 Monoclonal Antibody (MAb) Dose Optimization For Astatine-211 ( 211 At)-Radioimmunotherapy (RIT) Of Relapsed Non-Hodgkin Lymphoma (NHL) In a Canine Model

Sofia H.L. Frost, PhD, Erlinda B. Santos, BS, Brian W. Miller, PhD, Tom A. Bäck, PhD, Donald K. Hamlin, BS, D. Scott Wilbur, PhD, Aimee L. Kenoyer, BS, Shani L. Frayo, BS, Oliver W. Press, MD, PhD, Rainer Storb, MD, Brenda M. Sandmaier, MD, John M. Pagel, MD, PhD

Blood (2013) 122 (21): 5139.

https://doi.org/10.1182/blood.V122.21.5139.5139

Published: 2013

Journal Articles

Anti-CD38 Pretargeted Radioimmunotherapy Eradicates Multiple Myeloma Xenografts In a Murine Model

Damian J. Green, MD, Jon C. Jones, Mark D. Hylarides, PhD, Donald K. Hamlin, BS, D Scott Wilbur, PhD, Yukang Lin, PhD, Aimee L. Kenoyer, BS, Shani L. Frayo, BS, William I. Bensinger, MD, Ajay K. Gopal, MD, Johnnie J. Orozco, MD, PhD, Theodore A. Gooley, PhD, Brent L. Wood, MD, PhD, John M. Pagel, MD, PhD, Oliver W. Press, MD, PhD

Blood (2013) 122 (21): 882.

https://doi.org/10.1182/blood.V122.21.882.882

Published: 2013

Journal Articles

Anti-CD45 Radioimmunotherapy Using the Alpha-Emitting Radionuclide 211 At Combined with Bone Marrow Transplantation Prolongs Survival in a Disseminated Murine Leukemia Model

Johnnie J. Orozco, MD, PhD, Aimee Kenoyer, BS, Tom Bäck, PhD, Ethan R. Balkin, PhD, Donald K. Hamlin, BS, D Scott Wilbur, PhD, Darrell R. Fisher, PhD, Shani L. Frayo, BS, Mark D. Hylarides, PhD, Damian J. Green, MD, Ajay K. Gopal, MD, Oliver W. Press, MD, PhD, John M. Pagel, MD, PhD

Blood (2012) 120 (21): 4096.

https://doi.org/10.1182/blood.V120.21.4096.4096

Published: 2012

Journal Articles

Anti-CD45 Radioimmunotherapy Facilitates Donor Engraftment and Prolongs Survival in the Absence of TBI Prior to Haploidentical Bone Marrow Transplantation in a Disseminated Murine Leukemia Model

Johnnie J. Orozco, MD, PhD, Aimee Kenoyer, BS, Ethan R. Balkin, PhD, Donald K. Hamlin, BS, D Scott Wilbur, PhD, Darrell R. Fisher, PhD, Shani L. Frayo, BS, Mark D. Hylarides, PhD, Damian J. Green, MD, Ajay K. Gopal, MD, Paul O'Donnell, MD, PhD, Oliver W. Press, MD, PhD, John M. Pagel, MD, PhD

Blood (2012) 120 (21): 4101.

https://doi.org/10.1182/blood.V120.21.4101.4101

Published: 2012

Journal Articles

Anti-CD38 Pretargeted Radioimmunotherapy Demonstrates Therapeutic Efficacy In a Human Multiple Myeloma Mouse Xenograft Model

Damian J. Green, MD, Nural N. Orgun, Mark D. Hylarides, PhD, John M. Pagel, MD, PhD, Donald K. Hamlin, D. Scott Wilbur, PhD, Yukang Lin, PhD, Amiee L. Kenoyer, Shani L. Frayo, BS, William I. Bensinger, MD, Ajay K. Gopal, MD, Johnnie J. Orozco, MD, PhD, Theodore A. Gooley, PhD, Brent L. Wood, MD, PhD, Oliver W. Press, MD, PhD

Blood (2011) 118 (21): 1842.

https://doi.org/10.1182/blood.V118.21.1842.1842

Published: 2011

Journal Articles

Conventional Anti-CD45 Radioimmunotherapy Comparing 90 Y or 177 Lu for Treatment of AML in a Syngeneic Disseminated Murine Leukemia Model,

Johnnie J. Orozco, MD, PhD, Aimee Kenoyer, Amanda Axtman, Shani L. Frayo, BS, Paul J. Morris, Donald K. Hamlin, D. Scott Wilbur, PhD, Darrell R. Fisher, PhD, Mark D. Hylarides, PhD, Damian J. Green, MD, Ajay K. Gopal, MD, Ted Gooley, Oliver W. Press, MD, PhD, John M. Pagel, MD, PhD

Blood (2011) 118 (21): 3636.

https://doi.org/10.1182/blood.V118.21.3636.3636

Published: 2011

Journal Articles

Anti-CD45 Ab Pretargeted Radioimmunotherapy Using An Alpha Emitting Radionuclide (213Bi) Delivers Selective Radiation to Human Myeloid Leukemias in a Mouse Xenograft Model and Results in High Rates of Complete Remission and Long Term Survival.

Aimee L. Kenoyer, BS, Oliver W. Press, MD, PhD, Steven I. Park, MD, Tom Back, Donald K. Hamlin, BS, D. Scott Wilbur, PhD, Darrell R. Fisher, PhD, Shani M. Wilbur, BS, Amanda Axtman, BS, Nural Orgun, Yukang Lin, PhD, Ajay K. Gopal, MD, Jaideep Shenoi, MD, Damian J. Green, MD, Frederick R Appelbaum, John M. Pagel, MD, PhD

Blood (2009) 114 (22): 1035.

https://doi.org/10.1182/blood.V114.22.1035.1035

Published: 2009

Journal Articles

Conventional and Pretargeted Radioimmunotherapy with Bismuth-213 to Target and Treat CD20-Expressing Non-Hodgkin Lymphoma: A Preclinical Model for Consolidation Therapy to Eradicate Minimal Residual Disease.

Steven I. Park, MD, Jaideep Shenoi, MD, John M. Pagel, MD, PhD, Donald K. Hamlin, Nural Orgun, Aimee L. Kenoyer, Shani M. Wilbur, BS, Amanda Axtman, D. Scott Wilbur, PhD, Yukang Lin, PhD, Darrell R. Fisher, PhD, Ajay K. Gopal, MD, Damian J. Green, MD, Oliver W. Press, MD, PhD

Blood (2009) 114 (22): 2705.

https://doi.org/10.1182/blood.V114.22.2705.2705

Published: 2009

Journal Articles

Evaluation of Toxicity and Tissue Radiation Doses Obtained in Mice with An Anti-CD45 Monoclonal Antibody (mAb) Labeled with the Alpha-Emitting Radionuclides, Astatine-211 or Bismuth-213.

Hirohisa Nakamae, MD, PhD, D. Scott Wilbur, PhD, Donald K Hamlin, Monica S Thakar, MD, Erlinda B Santos, Darrell R Fisher, PhD, Amiee L Kenoyer, John M. Pagel, MD, PhD, Oliver W. Press, MD, PhD, Rainer F. Storb, MD, Brenda M. Sandmaier, MD

Blood (2008) 112 (11): 3270.

https://doi.org/10.1182/blood.V112.11.3270.3270

Published: 2008

Journal Articles

Extracorporeal Adsorption Following Infusion of Radiolabeled Anti-CD20 Antibody Clears Unbound Radioimmunoconjugate from the Circulation and Reduces Radiation Exposure of Normal Organs in the Nonhuman Primate.

Damian J. Green, MD, Eneida R. Nemecek, MD, Nathan Hedin, BS, Anastasia Pantelias, MA, Yukang Lin, PhD, John M. Pagel, MD,PhD, Darrell R. Fisher, PhD, Don K. Hamlin, BS, D. Scott Wilbur, PhD, Ajay Gopal, MD, Rune Nilsson, PhD, Bengt E.B. Sandberg, PhD, Oliver W. Press, MD,PhD

Blood (2006) 108 (11): 2500.

https://doi.org/10.1182/blood.V108.11.2500.2500

Published: 2006

NARROW

The Alpha Emitter Astatine-211 Targeted to CD38 Can Eradicate Multiple Myeloma in Minimal Residual Disease Models

Novel Bispecific Antibody Targeting CD45 and 90 Y-DOTA Is Effective Therapy for Acute Myeloid Leukemia in Preclinical Murine Models

Addition of Astatine-211-Labeled Anti-CD45 Antibody to Total Body Irradiation (TBI) As Conditioning for DLA-Identical Marrow Transplantation: A Novel Strategy to Overcome Graft Rejection in a Canine Presensitization Model

211 At-Anti-CD45 Radioimmunotherapy Can Replace TBI Prior to Haploidentical Bone Marrow Transplantation and Yield Long-Term Hematopoietic Engraftment

Pre-Targeted Radioimmunotherapy Employing a Recombinant Bispecific Antibody Using a Murine Xenograft Model of Human Leukemia

Astatine-211 Conjugated To Anti-CD20 Monoclonal Antibody Eliminates B-Cell Lymphoma In a Mouse Model

Anti-CD45 Monoclonal Antibody (MAb) Dose Optimization For Astatine-211 ( 211 At)-Radioimmunotherapy (RIT) Of Relapsed Non-Hodgkin Lymphoma (NHL) In a Canine Model

Anti-CD38 Pretargeted Radioimmunotherapy Eradicates Multiple Myeloma Xenografts In a Murine Model

Anti-CD45 Radioimmunotherapy Using the Alpha-Emitting Radionuclide 211 At Combined with Bone Marrow Transplantation Prolongs Survival in a Disseminated Murine Leukemia Model

Anti-CD45 Radioimmunotherapy Facilitates Donor Engraftment and Prolongs Survival in the Absence of TBI Prior to Haploidentical Bone Marrow Transplantation in a Disseminated Murine Leukemia Model

Anti-CD38 Pretargeted Radioimmunotherapy Demonstrates Therapeutic Efficacy In a Human Multiple Myeloma Mouse Xenograft Model

Conventional Anti-CD45 Radioimmunotherapy Comparing 90 Y or 177 Lu for Treatment of AML in a Syngeneic Disseminated Murine Leukemia Model,

Anti-CD45 Ab Pretargeted Radioimmunotherapy Using An Alpha Emitting Radionuclide (213Bi) Delivers Selective Radiation to Human Myeloid Leukemias in a Mouse Xenograft Model and Results in High Rates of Complete Remission and Long Term Survival.

Conventional and Pretargeted Radioimmunotherapy with Bismuth-213 to Target and Treat CD20-Expressing Non-Hodgkin Lymphoma: A Preclinical Model for Consolidation Therapy to Eradicate Minimal Residual Disease.

Evaluation of Toxicity and Tissue Radiation Doses Obtained in Mice with An Anti-CD45 Monoclonal Antibody (mAb) Labeled with the Alpha-Emitting Radionuclides, Astatine-211 or Bismuth-213.

Extracorporeal Adsorption Following Infusion of Radiolabeled Anti-CD20 Antibody Clears Unbound Radioimmunoconjugate from the Circulation and Reduces Radiation Exposure of Normal Organs in the Nonhuman Primate.

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American Society of Hematology

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American Society of Hematology

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