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Cirino Botta, MD
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Journal Articles

Global Rnaseq/Proteomic-Phoshoproteomic Analysis Unveil Mir-21 As a Central Player in Driving Th17 Mediated Bone Disease in MM

Marco Rossi, MD, Emanuela Altomare, PhD, Cirino Botta, MD, Maria Eugenia Gallo Cantafio, Marco Gaspari, Domenico Taverna, Sarvide Sarai, Daniele Caracciolo, MD, Paola Critelli, MD, Francesco Conforti, Maria Teresa Di Martino, PhD, Bruno Paiva, PhD, Pierosandro Tagliaferri, MD, Pierfrancesco Tassone, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 505.
https://doi.org/10.1182/blood-2019-122429
Published: 2019
Journal Articles

Single-Cell Characterization of the Multiple Myeloma (MM) Immune Microenvironment Identifies CD27-Negative T Cells As Potential Source of Tumor-Reactive Lymphocytes

Cirino Botta, MD, Cristina Pérez Ruiz, Ibai Goicoechea, PhD, Noemi Puig, MD PhD, María Teresa Cedena, Lourdes Cordon, Aintzane Zabaleta, PhD, Leire Burgos, Catarina Maia, Sara Rodríguez, PhD, Idoia Rodriguez, Sarai Sarvide, Diego Alignani, PhD, Amaia Vilas-Zornoza, PhD, Erika Lorenzo-Vivas, PhD, Laura Rosinol Dachs, Albert Oriol, MD, María Jesús Blanchard, Rafael Rios, MD PhD, Anna Sureda, MD PhD, Rafael Martínez, Jesús Martín, Joan Bargay, MD PhD, Javier De La Rubia, Marco Rossi, MD, Pierosandro Tagliaferri, MD, Pierfrancesco Tassone, MD, Massimo Gentile, Juana Merino, Felipe Prosper, MD PhD, Alberto Orfao, MD PhD, Maria-Victoria Mateos, Juan-José Lahuerta, MD PhD, Joan Bladé, MD PhD, Jesús San-Miguel, Bruno Paiva, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 506.
https://doi.org/10.1182/blood-2019-123974
Published: 2019
Journal Articles

The Pathogenesis of Multiple Myeloma (MM) Is Preceded By Mutated Lymphopoiesis and B Cell Oligoclonality That Persist in Patients with Negative Minimal Residual Disease (MRD)

Sara Rodríguez, PhD, Noemi Puig, MD PhD, Katerina Gemenetzi, Ibai Goicoechea, PhD, Cirino Botta, MD, Andreas Agathangelidis, PhD, Rafael Valdés-Mas, Juan José Garcés, María Teresa Cedena, José J Pérez, Leire Burgos, Maria Jose Calasanz, PhD BSc, Diego Alignani, PhD, Amaia Vilas-Zornoza, PhD, Erika Lorenzo-Vivas, PhD, Irene Aires, Idoia Rodriguez, Sarvide Sarai, Felipe Prosper, MD PhD, Jose Angel Martinez-Climent, MD PhD, Alberto Orfao, MD PhD, Ramón García-Sanz, MD PhD, Joaquin Martinez-Lopez, MD PhD, Juan-José Lahuerta, MD PhD, Laura Rosinol Dachs, Joan Bladé, MD, Maria-Victoria Mateos, Anastasia Hadzidimitriou, PhD, Jesús San-Miguel, Bruno Paiva, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 509.
https://doi.org/10.1182/blood-2019-128049
Published: 2019
Journal Articles

Waldenström's Macroglobulinemia (WM) Is Preceded By Clonal Lymphopoiesis Including MYD88 L265P in Progenitor B Cells

Sara Rodríguez, PhD, Cirino Botta, MD, Jon Celay, PhD, Ibai Goicoechea, PhD, Maria J Garcia-Barchino, PhD, Rafael Valdés-Mas, Yolanda Carrasco, Daniel Alameda, PhD, Juan José Garcés, Marta Larrayoz, PhD, Susana Santos, Diego Alignani, PhD, Amaia Vilas-Zornoza, PhD, Erika Lorenzo-Vivas, PhD, Cristina Pérez Ruiz, Sonia Garate, Sarvide Sarai, Amaia Gascue, Christian Reinhardt, MD, Isidro Sanchez-Garcia, PhD, Maria Jose Larrayoz, PhD, Maria Jose Calasanz, PhD BSc, Felipe Prosper, MD PhD, Marina Motta, Antonella Anastasia, Antonio Sacco, RN, Massimo Gentile, Sara Duarte, Helena Vitoria, Catarina Geraldes, MD PhD, Artur Paiva, Aldo M. Roccaro, MD PhD, Jesús San-Miguel, Jose Angel Martinez-Climent, MD PhD, Bruno Paiva, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1527.
https://doi.org/10.1182/blood-2019-126889
Published: 2019
Journal Articles

Flowct: A Semi-Automated Workflow for Deconvolution of Immunophenotypic Data and Objective Reporting on Large Datasets

Cirino Botta, MD, Catarina Maia, Cristina Pérez Ruiz, Irene Manrique, Juan José Garcés, Sara Rodríguez, PhD, Leire Burgos, Juana Merino, Aitziber Lopez Lopez, Noemi Puig, MD PhD, María Teresa Cedena, Artur Paiva, Marco Rossi, Pierosandro Tagliaferri, MD, Piefrancesco Tassone, MD, Massimo Gentile, MD, Ivan M. Borrello, MD, Laura Rosinol Dachs, Maria-Victoria Mateos, MD PhD, Juan-José Lahuerta, MD PhD, Joan Bladé, MD, Jesús San-Miguel, Bruno Paiva, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4355.
https://doi.org/10.1182/blood-2019-122088
Published: 2019
Journal Articles

Evaluation of the International Prognostic Index for Chronic Lymphocytic Leukemia (CLL-IPI) and Validation of a Proposed Novel Risk Model (BALL Score) in Real-World Relapsed/Refractory (R/R) CLL Patients Receiving Idelalisib and Rituximab

Massimo Gentile, Gianluigi Reda, MD, Francesca Romana Mauro, MD, Paolo Sportoletti, Luca Laurenti, MD, Marta Coscia, MD PhD, Anna G Recchia, PhD BS, PharmD, Marzia Varettoni, Roberta Murru, MD, Annalisa Chiarenza, MD PhD, Adalgisa Condoluci, MD, Riccardo Moia, MD, Daniela Pietrasanta, MD, Giacomo Loseto, MD, Ugo Consoli, MD, Ilaria Scortechini, Ernesto Vigna, MD, Cirino Botta, MD, Vincenzo Ludovico Fraticelli, MD, Alessio Di Prima, MD, Giovanni Tripepi, Davide Rossi, MD PhD, Gianluca Gaidano, MD PhD, Valter Gattei, MD, Fortunato Morabito, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5485.
https://doi.org/10.1182/blood-2019-126717
Published: 2019
Journal Articles

Transcriptomic Profiling of Circulating Tumor Cells (CTCs) in Multiple Myeloma (MM): A New Model to Understand Disease Dissemination

Juan José Garcés, Michal Šimíček, Marco Vicari, Lucie Brozova, MSc, Leire Burgos, Renata Bezděková, MSc., Diego Alignani, PhD, Maria Jose Calasanz, BSc, PhD, Katerina Growkova, Ludek Pour, MD, Rafael Rios, MD PhD, Joaquin Martinez-Lopez, MD PhD, Pamela Millacoy, Luis Palomera, MD PhD, Rafael Del Orbe, Sonia Garate, Laura Blanco, Patricia Maiso, PhD, Zuzana Chyra, Alexander Vdovin, Tomas Jelinek, Cirino Botta, MD, Halima El Omri, Xabier Agirre, PhD, Felipe Prosper, MD PhD, Roman Hajek, MD PhD, Jesus F San-Miguel, MD PhD, Bruno Paiva, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 245.
https://doi.org/10.1182/blood-2018-99-113331
Published: 2018
Journal Articles

Detailed Phenotypic, Molecular and Functional Profiling of Myeloid Derived Suppressor Cells (MDSCs) in the Tumor Immune Microenvironment (TIME) of Multiple Myeloma (MM)

Cristina Pérez Ruiz, Aintzane Zabaleta, PhD, Noemi Puig, MD PhD, María Teresa Cedena, Juana Merino, Diego Alignani, PhD, Sonia Garate, Ibai Goicoechea, PhD, David Lara-Astiaso, PhD, Sarai Sarvide, Cirino Botta, MD, Joaquin Martinez Lopez, MD PhD, Albert Oriol, MD, Rafael Rios, MD PhD, Laura Rosinol, MD PhD, Maria-Victoria Mateos, MD PhD, Juan-José Lahuerta, MD PhD, Joan Bladé, MD, Jesus F San-Miguel, MD PhD, Bruno Paiva, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4436.
https://doi.org/10.1182/blood-2018-99-111102
Published: 2018
Journal Articles

Targeting a Specific Glycosylated Epitope of CD43 with a New Humanized Monoclonal Antibody for the Treatment of Pediatric and Adult T-Cell Acute Lymphoblastic Leukemia (T-ALL)

Cirino Botta, MD, Giuseppe Gaipa, PhD, Maria Eugenia Gallo Cantafio, PhD, Chiara Buracchi, PhD, Maria Anna Siciliano, MD, Caterina Riillo, MD, Katia Grillone, PhD, Alessandro Gulino, Maria Cucè, Nicoletta Staropoli, Andrea Ghelli Luserna Di Rora, Franca Maria Tuccillo, Maria Teresa Di Martino, Claudio Tripodo, MD, Marco Rossi, MD, Giovanni Martinelli, Andrea Biondi, MD, Pierosandro Tagliaferri, Pierfrancesco Tassone, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1418.
https://doi.org/10.1182/blood-2018-99-118572
Published: 2018
Journal Articles

Synthetic MiR-29b Mimics Potentiate Dendritic-Cell Based Immunotherapy Against Multiple Myeloma In Vitro and In Vivo

Cirino Botta, MD, Marco Rossi, MD, Maria Rita Pitari, PhD, Annamaria Gullà, MD, Teresa Del Giudice, MD, Eugenio Morelli, MD, Eleonora Iuliano, MD, Emanuela Altomare, PhD, Nicola Amodio, PhD, Maria Teresa Di Martino, PhD, Pierpaolo Correale, MD, Pierosandro Tagliaferri, MD, Pierfrancesco Tassone, MD
Journal: Blood
Blood (2013) 122 (21): 4489.
https://doi.org/10.1182/blood.V122.21.4489.4489
Published: 2013
Journal Articles

In Vitro and Vivo Activity Against Multiple Myeloma Cells Of a Novel Locked Nucleic Acid (LNA)-Mir-221 Inhibitor

Maria Teresa Di Martino, PhD, Annamaria Gullà, MD, Maria Eugenia Gallo Cantafio, Emanuela Altomare, PhD, Nicola Amodio, PhD, Emanuela Leone, PhD, Santo Giovanni Lio, Eugenio Morelli, MD, Daniele Caracciolo, MD, Cirino Botta, MD, Antonino Neri, MD, Niels M Frandsen, PhD, Pierosandro Tagliaferri, MD, Pierfrancesco Tassone, MD
Journal: Blood
Blood (2013) 122 (21): 3166.
https://doi.org/10.1182/blood.V122.21.3166.3166
Published: 2013
Journal Articles

Inhibition Of Mir-21 In HS-5 Bone Marrow Stromal Cells In The Presence Of Multiple Myeloma cells Restores RANKL/OPG Ratio: A Potential Therapeutic Approach For Myeloma-Related Bone Disease

Maria Rita Pitari, PhD, Marco Rossi, MD, Cirino Botta, MD, Eugenio Morelli, MD, Annamaria Gullà, MD, Eleonora Iuliano, MD, Teresa Del Giudice, MD, Nicola Amodio, PhD, Maria Teresa Di Martino, PhD, Fortunato Morabito, MD, Pierosandro Tagliaferri, MD, Pierfrancesco Tassone, MD
Journal: Blood
Blood (2013) 122 (21): 683.
https://doi.org/10.1182/blood.V122.21.683.683
Published: 2013
Journal Articles

Mir-29b Negatively Regulates Osteoclastic Cell Differentiation and Function: Implications for the Treatment of Multiple Myeloma-Related Bone Disease

Marco Rossi, MD, Maria Rita Pitari, PhD student, Nicola Amodio, PhD, Maria Teresa Di Martino, PhD, Emanuela Leone, PhD, Francesco Conforti, MD, Francesco Maria Paolino, PhD student, Cirino Botta, MD, Teresa Del Giudice, MD, Eleonora Iuliano, MD, Manlio Ferrarini, MD, Pierosandro Tagliaferri, MD, Pierfrancesco Tassone, MD
Journal: Blood
Blood (2012) 120 (21): 3960.
https://doi.org/10.1182/blood.V120.21.3960.3960
Published: 2012