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Journal Articles

A Novel Role for PLK1 in Leukemia Stem Cell Function in Acute Myeloid Leukemia

Qiang Liu, Alex Murison, Andy G.X. Zeng, Changjiang Xu, Veronique Voisin, Faith Yeung, Amit Subedi, Steven M. Chan, Brian Raught, Gary D Bader, John E. Dick, Jean C.Y. Wang
Journal: Blood
Blood (2022) 140 (Supplement 1): 5920–5921.
https://doi.org/10.1182/blood-2022-169732
Published: 2022
Journal Articles

Thrombopoietin Receptor Signaling Promotes the Competitive Advantage of TET2 -Mutated Hematopoietic Stem and Progenitor Cells in Clonal Hematopoiesis

Yitong Yang, Amit Subedi, Steven M. Chan
Journal: Blood
Blood (2022) 140 (Supplement 1): 981–982.
https://doi.org/10.1182/blood-2022-162554
Published: 2022
Journal Articles

Metformin Treatment Abrogates the Competitive Advantage of Dnmt3a R878H HSPCs By Enhancing DNA Methylation Activity

Mohsen Hosseini, Severine Cathelin, Alex Liu, Yitong Yang, Amit Subedi, Dhanoop Manikoth Ayyathan, Shraddha Pai, Steven M. Chan
Journal: Blood
Blood (2022) 140 (Supplement 1): 977–978.
https://doi.org/10.1182/blood-2022-170366
Published: 2022
Journal Articles

Inhibition of the DOT1L/MPL/JAK2 Signaling Axis Selectively Targets TET2 Mutation-Driven Clonal Hematopoiesis

Yitong Yang, Amit Subedi, Steven M Chan
Journal: Blood
Blood (2021) 138 (Supplement 1): 3281.
https://doi.org/10.1182/blood-2021-153240
Published: 2021
Journal Articles

Nicotinamide Phosphoribosyltransferase Inhibitors Induce Apoptosis of AML Stem Cells through Dysregulation of Lipid Metabolism

Amit Subedi, PhD, Qiang Liu, PhD BSc, David Sharon, PhD, Severine Cathelin, PhD, Gary D Bader, Changjiang Xu, Veronique Voisin, PhD, Angelo D'Alessandro, PhD, Eric R Lechman, PhD, John E. Dick, PhD FRS, Mark D. Minden, Jean C.Y. Wang, MD, Steven M Chan, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 25–26.
https://doi.org/10.1182/blood-2020-142404
Published: 2020
Journal Articles

A Stemness-Based Screen Identifies PLK1 Inhibitors for Targeting Leukemia Stem Cells in AML

Qiang Liu, PhD BSc, Amit Subedi, PhD, Samantha Yao, Changjiang Xu, Veronique Voisin, PhD, Gary D Bader, Steven M Chan, MD PhD, Jean C.Y. Wang, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 34–35.
https://doi.org/10.1182/blood-2020-141740
Published: 2020
Journal Articles

Inhibition of Nicotinamide Phosphoribosyltransferase (NAMPT) Activity Selectively Targets Human Acute Myeloid Leukemia Stem Cells

Amit Subedi, PhD, Qiang Liu, PhD BSc, David Sharon, PhD, Changjiang Xu, Veronique Voisin, PhD, Gary D Bader, Jean Wang, MD, Steven M Chan, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3932.
https://doi.org/10.1182/blood-2018-99-120258
Published: 2018
Journal Articles

Identification of Compounds That Target Acute Myeloid Leukemia Stem Cells Using a Scalable Next-Generation Screening Platform

Qiang Liu, PhD BSc, Amit Subedi, PhD, Changjiang Xu, Veronique Voisin, PhD, Gary D Bader, Steven M Chan, MD PhD, Jean C.Y. Wang, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 259.
https://doi.org/10.1182/blood-2018-99-115323
Published: 2018
Journal Articles

Combination of Enasidenib and Venetoclax Shows Superior Anti-Leukemic Activity Against IDH2 Mutated AML in Patient-Derived Xenograft Models

Severine Cathelin, PhD, David Sharon, PhD, Amit Subedi, PhD, Dan Cojocari, PhD BSc, Darren C. Phillips, PhD, Joel D. Leverson, PhD, Kyle MacBeth, PhD, Brandon Nicolay, Rohini Narayanaswamy, Sebastien Ronseaux, Guowen Liu, PhD, Steven M Chan, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 562.
https://doi.org/10.1182/blood-2018-99-119688
Published: 2018
Journal Articles

Targeting Mitochondrial Translation Overcomes Venetoclax Resistance in Acute Myeloid Leukemia (AML) through Activation of the Integrated Stress Response

David Sharon, PhD, Severine Cathelin, PhD, Amit Subedi, PhD, Ryan Williams, Mariana Benicio, PhD, Troy Ketela, Steven M. Chan, MDPhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 297.
https://doi.org/10.1182/blood.V130.Suppl_1.297.297
Published: 2017