Homoharringtonine inhibits the NOTCH/MYC pathway and exhibits antitumor effects in T-cell acute lymphoblastic leukemia

2.

Lonetti

A

,

Cappellini

A

,

Bertaina

A

, et al.

Improving nelarabine efficacy in T cell acute lymphoblastic leukemia by targeting aberrant PI3K/AKT/mTOR signaling pathway

.

J Hematol Oncol

.

2016

;

9

(

1

):

114

.

3.

Lu

S

,

Wang

J

.

Homoharringtonine and omacetaxine for myeloid hematological malignancies

.

J Hematol Oncol

.

2014

;

7

:

2

.

4.

Nazha

A

,

Kantarjian

H

,

Cortes

J

,

Quintas-Cardama

A

.

Omacetaxine mepesuccinate (synribo) - newly launched in chronic myeloid leukemia

.

Expert Opin Pharmacother

.

2013

;

14

(

14

):

1977

-

1986

.

5.

Li

C

,

Dong

L

,

Su

R

, et al.

Homoharringtonine exhibits potent anti-tumor effect and modulates DNA epigenome in acute myeloid leukemia by targeting SP1/TET1/5hmC

.

Haematologica

.

2020

;

105

(

1

):

148

-

160

.

6.

Chen

R

,

Guo

L

,

Chen

Y

,

Jiang

Y

,

Wierda

WG

,

Plunkett

W

.

Homoharringtonine reduced Mcl-1 expression and induced apoptosis in chronic lymphocytic leukemia

.

Blood

.

2011

;

117

(

1

):

156

-

164

.

7.

Kantarjian

HM

,

Talpaz

M

,

Smith

TL

, et al.

Homoharringtonine and low-dose cytarabine in the management of late chronic-phase chronic myelogenous leukemia

.

J Clin Oncol

.

2000

;

18

(

20

):

3513

-

3521

.

8.

Gurel

G

,

Blaha

G

,

Moore

PB

,

Steitz

TA

.

U2504 determines the species specificity of the A-site cleft antibiotics: the structures of tiamulin, homoharringtonine, and bruceantin bound to the ribosome

.

J Mol Biol

.

2009

;

389

(

1

):

146

-

156

.

9.

Chen

XJ

,

Zhang

WN

,

Chen

B

, et al.

Homoharringtonine deregulates MYC transcriptional expression by directly binding NF-kappaB repressing factor

.

Proc Natl Acad Sci U S A

.

2019

;

116

(

6

):

2220

-

2225

.

10.

Langenau

DM

,

Traver

D

,

Ferrando

AA

, et al.

Myc-induced T cell leukemia in transgenic zebrafish

.

Science

.

2003

;

299

(

5608

):

887

-

890

.

11.

Smith

DP

,

Bath

ML

,

Metcalf

D

,

Harris

AW

,

Cory

S

.

MYC levels govern hematopoietic tumor type and latency in transgenic mice

.

Blood

.

2006

;

108

(

2

):

653

-

661

.

12.

Roderick

JE

,

Tesell

J

,

Shultz

LD

, et al.

c-Myc inhibition prevents leukemia initiation in mice and impairs the growth of relapsed and induction failure pediatric T-ALL cells

.

Blood

.

2014

;

123

(

7

):

1040

-

1050

.

13.

King

B

,

Trimarchi

T

,

Reavie

L

, et al.

The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability

.

Cell

.

2013

;

153

(

7

):

1552

-

1566

.

14.

Herranz

D

,

Ambesi-Impiombato

A

,

Palomero

T

, et al.

A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia

.

Nat Med

.

2014

;

20

(

10

):

1130

-

1137

.

15.

DeAngelo

DJ

,

Yu

D

,

Johnson

JL

, et al.

Nelarabine induces complete remissions in adults with relapsed or refractory T-lineage acute lymphoblastic leukemia or lymphoblastic lymphoma: Cancer and Leukemia Group B study 19801

.

Blood

.

2007

;

109

(

12

):

5136

-

5142

.

16.

Teachey

DT

,

Devidas

M

,

Wood

BL

, et al.

Children's Oncology Group trial AALL1231: a phase III clinical trial testing bortezomib in newly diagnosed T-cell acute lymphoblastic leukemia and lymphoma

.

J Clin Oncol

.

2022

;

40

(

19

):

2106

-

2118

.

17.

Bride

KL

,

Vincent

TL

,

Im

SY

, et al.

Preclinical efficacy of daratumumab in T-cell acute lymphoblastic leukemia

.

Blood

.

2018

;

131

(

9

):

995

-

999

.

18.

Chonghaile

TN

,

Roderick

JE

,

Glenfield

C

, et al.

Maturation stage of T-cell acute lymphoblastic leukemia determines BCL-2 versus BCL-XL dependence and sensitivity to ABT-199

.

Cancer Discov

.

2014

;

4

(

9

):

1074

-

1087

.

19.

Ferrando

AA

.

The role of NOTCH1 signaling in T-ALL

.

Hematology Am Soc Hematol Educ Program

.

2009

;

2009

(

1

):

353

-

361

.

20.

Liu

Y

,

Easton

J

,

Shao

Y

, et al.

The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia

.

Nat Genet

.

2017

;

49

(

8

):

1211

-

1218

.

21.

Sanchez-Martin

M

,

Ferrando

A

.

The NOTCH1-MYC highway toward T-cell acute lymphoblastic leukemia

.

Blood

.

2017

;

129

(

9

):

1124

-

1133

.

22.

Rodriguez

S

,

Abundis

C

,

Boccalatte

F

, et al.

Therapeutic targeting of the E3 ubiquitin ligase SKP2 in T-ALL

.

Leukemia

.

2020

;

34

(

5

):

1241

-

1252

.

23.

Carlesso

N

,

Aster

JC

,

Sklar

J

,

Scadden

DT

.

Notch1-induced delay of human hematopoietic progenitor cell differentiation is associated with altered cell cycle kinetics

.

Blood

.

1999

;

93

(

3

):

838

-

848

.