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Journal Articles

DKK1 activates noncanonical NF-κB signaling via IL-6–induced CKAP4 receptor in multiple myeloma

Xin Li, Jingjing Wang, Shuai Zhu, Jinxin Zheng, Ying Xie, Hongmei Jiang, Jing Guo, Yixuan Wang, Ziyi Peng, Mengqi Wang, Jingya Wang, Sheng Wang, Yuping Zhong, Zhiqiang Liu
Journal: Blood Advances
Blood Adv (2021) 5 (18): 3656–3667.
https://doi.org/10.1182/bloodadvances.2021004315
Published: 2021
Includes: Supplemental data
Journal Articles

Lymphoid blast transformation in an MPN with BCR-JAK2 treated with ruxolitinib: putative mechanisms of resistance

Clinical Trials & Observations
Justin Anthony Chen, Yanli Hou, Krishna M. Roskin, Daniel A. Arber, Charles D. Bangs, Linda B. Baughn, Athena M. Cherry, Mark D. Ewalt, Andrew Z. Fire, Laure Fresard, Hutton M. Kearney, Stephen B. Montgomery, Robert S. Ohgami, Kathryn E. Pearce, Beth A. Pitel, Jason D. Merker, Jason Gotlib
Journal: Blood Advances
Blood Adv (2021) 5 (17): 3492–3496.
https://doi.org/10.1182/bloodadvances.2020004174
Published: 2021
Includes: Supplemental data
Journal Articles

Discovery and validation of a novel subgroup and therapeutic target in idiopathic multicentric Castleman disease

Sheila K. Pierson, Sushila Shenoy, Ana B. Oromendia, Alexander M. Gorzewski, Ruth-Anne Langan Pai, Christopher Shield Nabel, Jason R. Ruth, Sophia A. T. Parente, Daniel J. Arenas, Mary Guilfoyle, Manjula Reddy, Michael Weinblatt, Nancy Shadick, Mark Bower, Alessia Dalla Pria, Yasufumi Masaki, Laura Katz, Jason Mezey, Philip Beineke, David Lee, Craig Tendler, Taku Kambayashi, Alexander Fosså, Frits van Rhee, David C. Fajgenbaum
Journal: Blood Advances
Blood Adv (2021) 5 (17): 3445–3456.
https://doi.org/10.1182/bloodadvances.2020004016
Published: 2021
Includes: Supplemental data
Journal Articles

Development of immunosuppressive myeloid cells to induce tolerance in solid organ and hematopoietic cell transplant recipients

Clinical Trials & Observations
Kent P. Jensen, David A. Hongo, XuHuai Ji, PingPing Zheng, Rahul D. Pawar, Thomas Hsin-Hsu Wu, Stephan Busque, John D. Scandling, Judith A. Shizuru, Robert Lowsky, Asha Shori, Suparna Dutt, Jeffrey Waters, Anirudh Saraswathula, Jeanette Baker, John S. Tamaresis, Philip Lavori, Robert Negrin, Holden Maecker, Edgar G. Engleman, Everett Meyer, Samuel Strober
Journal: Blood Advances
Blood Adv (2021) 5 (17): 3290–3302.
https://doi.org/10.1182/bloodadvances.2020003669
Published: 2021
Includes: Supplemental data
Journal Articles

Lentiviral correction of enzymatic activity restrains macrophage inflammation in adenosine deaminase 2 deficiency

Matteo Zoccolillo, Immacolata Brigida, Federica Barzaghi, Serena Scala, Raisa Jofra Hernández, Luca Basso-Ricci, Mariasilvia Colantuoni, Emanuela Pettinato, Lucia Sergi Sergi, Giulia Milardi, Paola Capasso, Angelo Lombardo, Silvia Gregori, Francesca Sanvito, Francesca Schena, Simone Cesaro, Francesca Conti, Andrea Pession, Fabio Benedetti, Marco Gattorno, Pui Y. Lee, Luigi Naldini, Maria Pia Cicalese, Alessandro Aiuti, Alessandra Mortellaro
Journal: Blood Advances
Blood Adv (2021) 5 (16): 3174–3187.
https://doi.org/10.1182/bloodadvances.2020003811
Published: 2021
Includes: Supplemental data
Journal Articles

Final results of a phase 2 clinical trial of LCL161, an oral SMAC mimetic for patients with myelofibrosis

Clinical Trials & Observations
Naveen Pemmaraju, Bing Z. Carter, Prithviraj Bose, Nitin Jain, Tapan M. Kadia, Guillermo Garcia-Manero, Carlos E. Bueso-Ramos, Courtney D. DiNardo, Sharon Bledsoe, Naval G. Daver, Uday Popat, Marina Y. Konopleva, Lingsha Zhou, Sherry Pierce, Zeev E. Estrov, Gautam M. Borthakur, Maro Ohanian, Wei Qiao, Lucia Masarova, Xuemei Wang, Po Yee Mak, Jorge Cortes, Elias Jabbour, Srdan Verstovsek
Journal: Blood Advances
Blood Adv (2021) 5 (16): 3163–3173.
https://doi.org/10.1182/bloodadvances.2020003829
Published: 2021
Journal Articles

Preclinical activity and determinants of response of the GPRC5DxCD3 bispecific antibody talquetamab in multiple myeloma

Christie P. M. Verkleij, Marloes E. C. Broekmans, Mark van Duin, Kristine A. Frerichs, Rowan Kuiper, A. Vera de Jonge, Martin Kaiser, Gareth Morgan, Amy Axel, Rengasamy Boominathan, Jocelyn Sendecki, Amy Wong, Raluca I. Verona, Pieter Sonneveld, Sonja Zweegman, Homer C. Adams, III, Tuna Mutis, Niels W. C. J. van de Donk
Journal: Blood Advances
Blood Adv (2021) 5 (8): 2196–2215.
https://doi.org/10.1182/bloodadvances.2020003805
Published: 2021
Includes: Supplemental data
Journal Articles

Antineoplastic and anti-inflammatory effects of bortezomib on systemic chronic active EBV infection

Mayumi Yoshimori, Haruna Shibayama, Ken-Ichi Imadome, Fuyuko Kawano, Ayaka Ohashi, Miwako Nishio, Norio Shimizu, Morito Kurata, Shigeyoshi Fujiwara, Ayako Arai
Journal: Blood Advances
Blood Adv (2021) 5 (7): 1805–1815.
https://doi.org/10.1182/bloodadvances.2020002417
Published: 2021
Includes: Supplemental data
Journal Articles

Precocious clonal hematopoiesis in Down syndrome is accompanied by immune dysregulation

Clinical Trials & Observations
L. Alexander Liggett, Matthew D. Galbraith, Keith P. Smith, Kelly D. Sullivan, Ross E. Granrath, Belinda Enriquez-Estrada, Kohl T. Kinning, Jessica R. Shaw, Angela L. Rachubinski, Joaquin M. Espinosa, James DeGregori
Journal: Blood Advances
Blood Adv (2021) 5 (7): 1791–1796.
https://doi.org/10.1182/bloodadvances.2020003858
Published: 2021
Includes: Supplemental data
Journal Articles

Characteristics and outcomes of KSHV-associated multicentric Castleman disease with or without other KSHV diseases

Clinical Trials & Observations
Ramya Ramaswami, Kathryn Lurain, Mark N. Polizzotto, Irene Ekwede, Kirsta Waldon, Seth M. Steinberg, Ralph Mangusan, Anaida Widell, Adam Rupert, Jomy George, Priscila H. Gonçalves, Vickie A. Marshall, Denise Whitby, Hao-Wei Wang, Stefania Pittaluga, Elaine S. Jaffe, Richard F. Little, Thomas S. Uldrick, Robert Yarchoan
Journal: Blood Advances
Blood Adv (2021) 5 (6): 1660–1670.
https://doi.org/10.1182/bloodadvances.2020004058
Published: 2021
Includes: Supplemental data
Journal Articles

A BCMAxCD3 bispecific T cell–engaging antibody demonstrates robust antitumor efficacy similar to that of anti-BCMA CAR T cells

David J. DiLillo, Kara Olson, Katja Mohrs, Thomas Craig Meagher, Kevin Bray, Olga Sineshchekova, Thomas Startz, Jessica Kuhnert, Marc W. Retter, Stephen Godin, Prachi Sharma, Frank Delfino, John Lin, Eric Smith, Gavin Thurston, Jessica R. Kirshner
Journal: Blood Advances
Blood Adv (2021) 5 (5): 1291–1304.
https://doi.org/10.1182/bloodadvances.2020002736
Published: 2021
Includes: Supplemental data
Journal Articles

Low-dose decitabine for refractory prolonged isolated thrombocytopenia after HCT: a randomized multicenter trial

Clinical Trials & Observations
Yaqiong Tang, Jia Chen, Qifa Liu, Tiantian Chu, Tingting Pan, Jianying Liang, Xue Feng He, Feng Chen, Ting Yang, Xiao Ma, Xiaojin Wu, Shaoyan Hu, Xingyu Cao, Xiaohui Hu, Jiong Hu, Yuejun Liu, Jiaqian Qi, Yueping Shen, Changgeng Ruan, Yue Han, Depei Wu
Journal: Blood Advances
Blood Adv (2021) 5 (5): 1250–1258.
https://doi.org/10.1182/bloodadvances.2020002790
Published: 2021
Includes: Supplemental data
Journal Articles

Low-density PD-1 expression on resting human natural killer cells is functional and upregulated after transplantation

Zachary Davis, Martin Felices, Todd Lenvik, Sujan Badal, Joshua T. Walker, Peter Hinderlie, James L. Riley, Daniel A. Vallera, Bruce R. Blazar, Jeffrey S. Miller
Journal: Blood Advances
Blood Adv (2021) 5 (4): 1069–1080.
https://doi.org/10.1182/bloodadvances.2019001110
Published: 2021
Includes: Supplemental data
Journal Articles

Kinase inhibitors developed for treatment of hematologic malignancies: implications for immune modulation in COVID-19

Chaja F. Jacobs, Eric Eldering, Arnon P. Kater
Journal: Blood Advances
Blood Adv (2021) 5 (3): 913–925.
https://doi.org/10.1182/bloodadvances.2020003768
Published: 2021
Includes: Supplemental data
Journal Articles

Teclistamab is an active T cell–redirecting bispecific antibody against B-cell maturation antigen for multiple myeloma

Kodandaram Pillarisetti, Gordon Powers, Leopoldo Luistro, Alexander Babich, Eric Baldwin, Yingzhe Li, Xiaochun Zhang, Mark Mendonça, Nate Majewski, Rupesh Nanjunda, Diana Chin, Kathryn Packman, Yusri Elsayed, Ricardo Attar, François Gaudet
Journal: Blood Advances
Blood Adv (2020) 4 (18): 4538–4549.
https://doi.org/10.1182/bloodadvances.2020002393
Published: 2020
Includes: Supplemental data
Journal Articles

AMG 701 induces cytotoxicity of multiple myeloma cells and depletes plasma cells in cynomolgus monkeys

Rebecca L. Goldstein, Ana Goyos, Chi-Ming Li, Petra Deegen, Pamela Bogner, Alexander Sternjak, Oliver Thomas, Matthias Klinger, Joachim Wahl, Matthias Friedrich, Benno Rattel, Edwin Lamas, Xiaoshan Min, Athena Sudom, Mozhgan Farshbaf, Angela Coxon, Mercedesz Balazs, Tara Arvedson
Journal: Blood Advances
Blood Adv (2020) 4 (17): 4180–4194.
https://doi.org/10.1182/bloodadvances.2020002565
Published: 2020
Includes: Supplemental data
Journal Articles

Hematopoietic recovery in patients receiving chimeric antigen receptor T-cell therapy for hematologic malignancies

Clinical Trials & Observations
Tania Jain, Andrea Knezevic, Martina Pennisi, Yunxin Chen, Josel D. Ruiz, Terence J. Purdon, Sean M. Devlin, Melody Smith, Gunjan L. Shah, Elizabeth Halton, Claudia Diamonte, Michael Scordo, Craig S. Sauter, Elena Mead, Bianca D. Santomasso, M. Lia Palomba, Connie W. Batlevi, Molly A. Maloy, Sergio Giralt, Eric Smith, Renier Brentjens, Jae H. Park, Miguel-Angel Perales, Sham Mailankody
Journal: Blood Advances
Blood Adv (2020) 4 (15): 3776–3787.
https://doi.org/10.1182/bloodadvances.2020002509
Published: 2020
Includes: Supplemental data
Journal Articles

Immunomodulatory drugs suppress Th1-inducing ability of dendritic cells but enhance Th2-mediated allergic responses

Vien Phan, Tomoki Ito, Muneo Inaba, Yoshiko Azuma, Kayoko Kibata, Noriko Inagaki-Katashiba, Akihiro Tanaka, Atsushi Satake, Shosaku Nomura
Journal: Blood Advances
Blood Adv (2020) 4 (15): 3572–3585.
https://doi.org/10.1182/bloodadvances.2019001410
Published: 2020
Includes: Supplemental data
Journal Articles

Inflammation-driven activation of JAK/STAT signaling reversibly accelerates acute myeloid leukemia in vitro

Jan Habbel, Lucas Arnold, Yiyang Chen, Michael Möllmann, Kirsten Bruderek, Sven Brandau, Ulrich Dührsen, Maher Hanoun
Journal: Blood Advances
Blood Adv (2020) 4 (13): 3000–3010.
https://doi.org/10.1182/bloodadvances.2019001292
Published: 2020
Includes: Supplemental data
Journal Articles

Gut dysbiosis modulates the immune response to factor VIII in murine hemophilia A

Julie Tarrant, Matthew Cormier, Kate Nesbitt, Courtney Dwyer, Christine Hough, David Lillicrap
Journal: Blood Advances
Blood Adv (2020) 4 (12): 2644–2655.
https://doi.org/10.1182/bloodadvances.2019001144
Published: 2020
Includes: Supplemental data