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Issue Archive

Volume 5, Issue 24
December 28 2021
Issue Cover

Table of Contents

EXCEPTIONAL CASE REPORT

Bilineal evolution of a U2AF1-mutated clone associated with acquisition of distinct secondary mutations
Clinical Trials & Observations
Nathan D. Montgomery,Jonathan Galeotti,Steven M. Johnson,Leah Commander,Eric T. Weimer,Pranil K. Chandra,Tariq Nazir,Thomas B. Alexander,Joshua F. Zeidner,Matthew C. Foster
View Articletitled, Bilineal evolution of a <em>U2AF1</em>-mutated clone associated with acquisition of distinct secondary mutations
GATA2 deficiency phenotype associated with tandem duplication of GATA2 and overexpression of GATA2-AS1
Clinical Trials & Observations
Preeti Singh,Maninder Heer,Anastasia Resteu,Aneta Mikulasova,Mojgan Reza,Laëtitia Largeaud,Stéphanie Dufrechou,Naïs Prade,Rachel E. Dickinson,Jacinta Bustamante,Bénédicte Neven,Venetia Bigley,Eric Delabesse,Daniel Rico,Marlène Pasquet,Matthew Collin
View Articletitled, GATA2 deficiency phenotype associated with tandem duplication of <em>GATA2</em> and overexpression of <em>GATA2-AS1</em>
Supplemental data

STIMULUS REPORT

Randomized evaluation of quizartinib and low-dose ara-C vs low-dose ara-C in older acute myeloid leukemia patients
Mike Dennis,Ian F. Thomas,Cono Ariti,Laura Upton,Alan K. Burnett,Amanda Gilkes,Rohini Radia,Claire Hemmaway,Priyanka Mehta,Steven Knapper,Richard E. Clark,Mhairi Copland,Nigel Russell,Robert K. Hills,on behalf of the UK NCRI AML Working Group
View Articletitled, Randomized evaluation of quizartinib and low-dose ara-C vs low-dose ara-C in older acute myeloid leukemia patients
Supplemental data
CAR T-cell therapy for secondary CNS DLBCL
Gulrayz Ahmed,Mehdi Hamadani,Nirav N. Shah
View Articletitled, CAR T-cell therapy for secondary CNS DLBCL
Supplemental data

CLINICAL TRIALS AND OBSERVATIONS

A prognostic model (BATAP) with external validation for patients with transplant-associated thrombotic microangiopathy
Clinical Trials & Observations
Peng Zhao,Ye-jun Wu,Yun He,Shan Chong,Qing-yuan Qu,Rui-xin Deng,Xiao-wan Sun,Qiu-sha Huang,Xiao Liu,Xiao-lu Zhu,Feng-rong Wang,Yuan-yuan Zhang,Xiao-dong Mo,Wei Han,Jing-zhi Wang,Yu Wang,Huan Chen,Yu-hong Chen,Xiang-yu Zhao,Ying-jun Chang,Lan-ping Xu,Kai-yan Liu,Xiao-jun Huang,Xiao-hui Zhang
View Articletitled, A prognostic model (BATAP) with external validation for patients with transplant-associated thrombotic microangiopathy
Supplemental data
Detection of clonotypic DNA in the cerebrospinal fluid as a marker of central nervous system invasion in lymphoma
Clinical Trials & Observations
Adam J. Olszewski,Anna D. Chorzalska,Max Petersen,Thomas A. Ollila,Adam Zayac,Habibe Kurt,Diana O. Treaba,John L. Reagan,Andrew Hsu,Pamela C. Egan,James Butera,Rabin Niroula,John Vatkevich,Jordan Robison,Ilyas Sahin,Allison P. Jacob,Chelsea D. Mullins,Patrycja M. Dubielecka
View Articletitled, Detection of clonotypic DNA in the cerebrospinal fluid as a marker of central nervous system invasion in lymphoma
Supplemental data
Adding venetoclax to fludarabine/busulfan RIC transplant for high-risk MDS and AML is feasible, safe, and active
Clinical Trials & Observations
Jacqueline S. Garcia,Haesook T. Kim,H. Moses Murdock,Corey S. Cutler,Jennifer Brock,Mahasweta Gooptu,Vincent T. Ho,John Koreth,Sarah Nikiforow,Rizwan Romee,Roman Shapiro,Fiona Loschi,Jeremy Ryan,Geoffrey Fell,Hannah Q. Karp,Fabienne Lucas,Annette S. Kim,Danielle Potter,Thelma Mashaka,Richard M. Stone,Daniel J. DeAngelo,Anthony Letai,R. Coleman Lindsley,Robert J. Soiffer,Joseph H. Antin
View Articletitled, Adding venetoclax to fludarabine/busulfan RIC transplant for high-risk MDS and AML is feasible, safe, and active
Supplemental data
Venetoclax and azacitidine compared with induction chemotherapy for newly diagnosed patients with acute myeloid leukemia
Clinical Trials & Observations
Evan M. Cherry,Diana Abbott,Maria Amaya,Christine McMahon,Marc Schwartz,Julie Rosser,Audrey Sato,Jeffrey Schowinsky,Anagha Inguva,Mohd Minhajuddin,Shanshan Pei,Brett Stevens,Amanda Winters,Craig T. Jordan,Clayton Smith,Jonathan A. Gutman,Daniel A. Pollyea
View Articletitled, Venetoclax and azacitidine compared with induction chemotherapy for newly diagnosed patients with acute myeloid leukemia
Supplemental data
An MRD-stratified pediatric protocol is as deliverable in adolescents and young adults as in children with ALL
Clinical Trials & Observations
Matthew Greenwood,Toby Trahair,Rosemary Sutton,Michael Osborn,John Kwan,Sally Mapp,Rebecca Howman,Antoinette Anazodo,Brenton Wylie,James D’Rozario,Mark Hertzberg,Ian Irving,David Yeung,Luke Coyle,Amanda Jager,Dan Engeler,Nicola Venn,Chris Frampton,Andrew H. Wei,Kenneth Bradstock,Luciano Dalla-Pozza
View Articletitled, An MRD-stratified pediatric protocol is as deliverable in adolescents and young adults as in children with ALL
Supplemental data

HEALTH SERVICES AND OUTCOMES

Portable medical orders and end-of-life measures in acute myeloid leukemia and myelodysplastic syndromes
Marissa LoCastro,Andrea M. Baran,Jane L. Liesveld,Eric Huselton,Michael W. Becker,Kristen Marie O’Dwyer,Omar S. Aljitawi,Megan Baumgart,Eric Snyder,Benzi Kluger,Kah Poh Loh,Jason H. Mendler
View Articletitled, Portable medical orders and end-of-life measures in acute myeloid leukemia and myelodysplastic syndromes

LYMPHOID NEOPLASIA

Do age, fitness, and concomitant medications influence management and outcomes of patients with CLL treated with ibrutinib?
Clinical Trials & Observations
Alessandra Tedeschi,Anna Maria Frustaci,Francesca Romana Mauro,Annalisa Chiarenza,Marta Coscia,Stefania Ciolli,Gianluigi Reda,Luca Laurenti,Marzia Varettoni,Roberta Murru,Claudia Baratè,Paolo Sportoletti,Antonino Greco,Chiara Borella,Valentina Rossi,Marina Deodato,Annalisa Biagi,Giulia Zamprogna,Angelo Curto Pelle,Gianfranco Lapietra,Candida Vitale,Francesca Morelli,Ramona Cassin,Alberto Fresa,Chiara Cavalloni,Massimiliano Postorino,Claudia Ielo,Roberto Cairoli,Francesco Di Raimondo,Marco Montillo,Giovanni Del Poeta
View Articletitled, Do age, fitness, and concomitant medications influence management and outcomes of patients with CLL treated with ibrutinib?
Supplemental data
Combination brentuximab vedotin and bendamustine for pediatric patients with relapsed/refractory Hodgkin lymphoma
Clinical Trials & Observations
Christopher J. Forlenza,Nitya Gulati,Audrey Mauguen,Michael J. Absalon,Sharon M. Castellino,Anna Franklin,Frank G. Keller,Neerav Shukla
View Articletitled, Combination brentuximab vedotin and bendamustine for pediatric patients with relapsed/refractory Hodgkin lymphoma
Peripheral T-cell lymphoma: molecular profiling recognizes subclasses and identifies prognostic markers
Marta Rodríguez,Ruth Alonso-Alonso,Laura Tomás-Roca,Socorro M. Rodríguez-Pinilla,Rebeca Manso-Alonso,Laura Cereceda,Jennifer Borregón,Teresa Villaescusa,Raúl Córdoba,Margarita Sánchez-Beato,Ismael Fernández-Miranda,Isabel Betancor,Carmen Bárcena,Juan F. García,Manuela Mollejo,Mónica García-Cosio,Paloma Martin-Acosta,Fina Climent,Dolores Caballero,Lorena de la Fuente,Pablo Mínguez,Linda Kessler,Catherine Scholz,Antonio Gualberto,Rufino Mondéjar,Miguel A. Piris
View Articletitled, Peripheral T-cell lymphoma: molecular profiling recognizes subclasses and identifies prognostic markers
Supplemental data

MYELOID NEOPLASIA

Simple and robust methylation test for risk stratification of patients with juvenile myelomonocytic leukemia
Hironobu Kitazawa,Yusuke Okuno,Hideki Muramatsu,Kosuke Aoki,Norihiro Murakami,Manabu Wakamatsu,Kyogo Suzuki,Kotaro Narita,Shinsuke Kataoka,Daisuke Ichikawa,Motoharu Hamada,Rieko Taniguchi,Nozomu Kawashima,Eri Nishikawa,Atsushi Narita,Nobuhiro Nishio,Asahito Hama,Mignon L. Loh,Elliot Stieglitz,Seiji Kojima,Yoshiyuki Takahashi
View Articletitled, Simple and robust methylation test for risk stratification of patients with juvenile myelomonocytic leukemia
Supplemental data

PLATELETS AND THROMBOPOIESIS

Expanding the genetic spectrum of TUBB1-related thrombocytopenia
Verónica Palma-Barqueros,Loredana Bury,Shinji Kunishima,María Luisa Lozano,Augustín Rodríguez-Alen,Nuria Revilla,Natalia Bohdan,José Padilla,María P. Fernández-Pérez,María Eugenia de la Morena-Barrio,Ana Marín-Quiles,Rocío Benito,María F. López-Fernández,Shally Marcellini,Ana Zamora-Cánovas,Vicente Vicente,Constantino Martínez,Paolo Gresele,José M. Bastida,José Rivera,on behalf of the Inherited Platelet Disorders Project, Grupo Español de Alteraciones Plaquetarias Congénitas (GEAPC), Spanish Society of Thrombosis and Haemostasis (SETH)
View Articletitled, Expanding the genetic spectrum of <em>TUBB1</em>-related thrombocytopenia
Supplemental data
Evans syndrome in adults: an observational multicenter study
Clinical Trials & Observations
Bruno Fattizzo,Marc Michel,Juri Alessandro Giannotta,Dennis Lund Hansen,Maria Arguello,Emanuele Sutto,Nicola Bianchetti,Andrea Patriarca,Silvia Cantoni,María Eva Mingot-Castellano,Vickie McDonald,Marco Capecchi,Anna Zaninoni,Dario Consonni,Josephine Mathilde Vos,Nicola Vianelli,Frederick Chen,Andreas Glenthøj,Henrik Frederiksen,Tomás José González-López,Wilma Barcellini
View Articletitled, Evans syndrome in adults: an observational multicenter study
Supplemental data

THROMBOSIS AND HEMOSTASIS

Anticoagulation in cancer-associated thromboembolism with thrombocytopenia: a prospective, multicenter cohort study
Clinical Trials & Observations
Brian J. Carney,Tzu-Fei Wang,Siyang Ren,Gemlyn George,Amer Al Homssi,Manila Gaddh,Gregory C. Connolly,Vinay I. Shah,Thomas Bogue,Abigail Bartosic,Donna Neuberg,Lisa Baumann Kreuziger,Jeffrey I. Zwicker,on behalf of the VENUS Network Investigators
View Articletitled, Anticoagulation in cancer-associated thromboembolism with thrombocytopenia: a prospective, multicenter cohort study

TRANSPLANTATION

Cardiac toxicity after matched allogeneic hematopoietic cell transplant in the posttransplant cyclophosphamide era
Clinical Trials & Observations
Jason Yeh,Laura Whited,Rima M. Saliba,Gabriela Rondon,Jose Banchs,Elizabeth Shpall,Richard Champlin,Uday Popat
View Articletitled, Cardiac toxicity after matched allogeneic hematopoietic cell transplant in the posttransplant cyclophosphamide era

RESEARCH LETTER

Inhibiting casein kinase 2 sensitizes acute lymphoblastic leukemia cells to venetoclax via MCL1 degradation
Juan Lázaro-Navarro,Helia Judith Pimentel-Gutiérrez,Anton Gauert,Anja I. H. Hagemann,Jassi Eisenschmid,Nicola Gökbuget,Binje Vick,Irmela Jeremias,Felix Seyfried,Lüder Hinrich Meyer,Klaus-Michael Debatin,Kathrin Richer,Miriam Bultman,Martin Neumann,Sonja Hänzelmann,Hubert Serve,Kathy Astrahantseff,Michael A. Rieger,Cornelia Eckert,Claudia D. Baldus,Lorenz Bastian
View Articletitled, Inhibiting casein kinase 2 sensitizes acute lymphoblastic leukemia cells to venetoclax via MCL1 degradation
Supplemental data
The diagnostic red blood cell distribution width as a prognostic factor in acute myeloid leukemia
Clinical Trials & Observations
Vladan Vucinic,Leo Ruhnke,Katja Sockel,Maximilian Alexander Röhnert,Donata Backhaus,Dominic Brauer,Georg-Nikolaus Franke,Dietger Niederwieser,Martin Bornhäuser,Christoph Röllig,Uwe Platzbecker,Sebastian Schwind,Madlen Jentzsch
View Articletitled, The diagnostic red blood cell distribution width as a prognostic factor in acute myeloid leukemia
Supplemental data
Blastic plasmocitoid dendritic cell neoplasm with leukemic spread: a GIMEMA survey
Caterina Giovanna Valentini,Alfonso Piciocchi,Fabio Facchetti,Fabio Guolo,Alessandro Pulsoni,Marco Vignetti,Livio Pagano
View Articletitled, Blastic plasmocitoid dendritic cell neoplasm with leukemic spread: a GIMEMA survey
KMT2A-CBL rearrangements in acute leukemias: clinical characteristics and genetic breakpoints
Alex Bataller,Francesca Guijarro,Aurélie Caye-Eude,Marion Strullu,Arthur Sterin,Oscar Molina,Patrice Chevallier,Marketa Zaliova,Jan Zuna,Pablo Mozas,Laura Magnano,Nathalie Grardel,Pascale Cornillet-Lefebvre,Jen-Fen Fu,Lee-Yung Shih,Temenuzhka Boneva,Elisabeth Nacheva,Silvia Beà,Mònica López-Guerra,Clara Bueno,Pablo Menéndez,Jordi Esteve,Patrizia Larghero,Claus Meyer,Rolf Marschalek
View Articletitled, <em>KMT2A-CBL</em> rearrangements in acute leukemias: clinical characteristics and genetic breakpoints

COMMENTARY

Consensus statement for the perinatal management of patients with α thalassemia major
Tippi C. MacKenzie,Ali Amid,Michael Angastiniotis,Craig Butler,Sandra Gilbert,Juan Gonzalez,Roberta L. Keller,Sandhya Kharbanda,Melanie Kirby-Allen,Barbara A. Koenig,Wade Kyono,Ashutosh Lal,Billie R. Lianoglou,Mary E. Norton,Keith K. Ogasawara,Tachjaree Panchalee,Mara Rosner,Marisa Schwab,Alexis Thompson,John S. Waye,Elliott Vichinsky
View Articletitled, Consensus statement for the perinatal management of patients with α thalassemia major
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Phillips NS, Mulrooney DA, Williams AM, et al. Neurocognitive impairment associated with chronic morbidity in long-term survivors of Hodgkin Lymphoma. Blood Adv. 2023;7(23):7270-7278.
Amino acid supplementation confers protection to red blood cells before Plasmodium falciparum bystander stress
A multicenter study of venetoclax-based treatment for patients with Richter transformation of chronic lymphocytic leukemia
Race and ethnicity reporting and representation in hemophilia clinical trials
Immune status and selection of patients for immunotherapy in myeloma: a proposal

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