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Bilineal evolution of a U2AF1-mutated clone associated with acquisition of distinct secondary mutations
GATA2 deficiency phenotype associated with tandem duplication of GATA2 and overexpression of GATA2-AS1
A prognostic model (BATAP) with external validation for patients with transplant-associated thrombotic microangiopathy
Detection of clonotypic DNA in the cerebrospinal fluid as a marker of central nervous system invasion in lymphoma
Adding venetoclax to fludarabine/busulfan RIC transplant for high-risk MDS and AML is feasible, safe, and active
Venetoclax and azacitidine compared with induction chemotherapy for newly diagnosed patients with acute myeloid leukemia
An MRD-stratified pediatric protocol is as deliverable in adolescents and young adults as in children with ALL
Do age, fitness, and concomitant medications influence management and outcomes of patients with CLL treated with ibrutinib?
Evans syndrome in adults: an observational multicenter study
Anticoagulation in cancer-associated thromboembolism with thrombocytopenia: a prospective, multicenter cohort study
The diagnostic red blood cell distribution width as a prognostic factor in acute myeloid leukemia
Issue Archive
Table of Contents
EXCEPTIONAL CASE REPORT
Bilineal evolution of a U2AF1-mutated clone associated with acquisition of distinct secondary mutations
Clinical Trials & Observations
Nathan D. Montgomery,Jonathan Galeotti,Steven M. Johnson,Leah Commander,Eric T. Weimer,Pranil K. Chandra,Tariq Nazir,Thomas B. Alexander,Joshua F. Zeidner,Matthew C. Foster
GATA2 deficiency phenotype associated with tandem duplication of GATA2 and overexpression of GATA2-AS1
Clinical Trials & Observations
Preeti Singh,Maninder Heer,Anastasia Resteu,Aneta Mikulasova,Mojgan Reza,Laëtitia Largeaud,Stéphanie Dufrechou,Naïs Prade,Rachel E. Dickinson,Jacinta Bustamante,Bénédicte Neven,Venetia Bigley,Eric Delabesse,Daniel Rico,Marlène Pasquet,Matthew Collin
STIMULUS REPORT
Randomized evaluation of quizartinib and low-dose ara-C vs low-dose ara-C in older acute myeloid leukemia patients
Mike Dennis,on behalf of the UK NCRI AML Working Group,Ian F. Thomas,on behalf of the UK NCRI AML Working Group,Cono Ariti,on behalf of the UK NCRI AML Working Group,Laura Upton,on behalf of the UK NCRI AML Working Group,Alan K. Burnett,on behalf of the UK NCRI AML Working Group,Amanda Gilkes,on behalf of the UK NCRI AML Working Group,Rohini Radia,on behalf of the UK NCRI AML Working Group,Claire Hemmaway,on behalf of the UK NCRI AML Working Group,Priyanka Mehta,on behalf of the UK NCRI AML Working Group,Steven Knapper,on behalf of the UK NCRI AML Working Group,Richard E. Clark,on behalf of the UK NCRI AML Working Group,Mhairi Copland,on behalf of the UK NCRI AML Working Group,Nigel Russell,on behalf of the UK NCRI AML Working Group,Robert K. Hills,on behalf of the UK NCRI AML Working Group
CLINICAL TRIALS AND OBSERVATIONS
A prognostic model (BATAP) with external validation for patients with transplant-associated thrombotic microangiopathy
Clinical Trials & Observations
Peng Zhao,Ye-jun Wu,Yun He,Shan Chong,Qing-yuan Qu,Rui-xin Deng,Xiao-wan Sun,Qiu-sha Huang,Xiao Liu,Xiao-lu Zhu,Feng-rong Wang,Yuan-yuan Zhang,Xiao-dong Mo,Wei Han,Jing-zhi Wang,Yu Wang,Huan Chen,Yu-hong Chen,Xiang-yu Zhao,Ying-jun Chang,Lan-ping Xu,Kai-yan Liu,Xiao-jun Huang,Xiao-hui Zhang
Detection of clonotypic DNA in the cerebrospinal fluid as a marker of central nervous system invasion in lymphoma
Clinical Trials & Observations
Adam J. Olszewski,Anna D. Chorzalska,Max Petersen,Thomas A. Ollila,Adam Zayac,Habibe Kurt,Diana O. Treaba,John L. Reagan,Andrew Hsu,Pamela C. Egan,James Butera,Rabin Niroula,John Vatkevich,Jordan Robison,Ilyas Sahin,Allison P. Jacob,Chelsea D. Mullins,Patrycja M. Dubielecka
Adding venetoclax to fludarabine/busulfan RIC transplant for high-risk MDS and AML is feasible, safe, and active
Clinical Trials & Observations
Jacqueline S. Garcia,Haesook T. Kim,H. Moses Murdock,Corey S. Cutler,Jennifer Brock,Mahasweta Gooptu,Vincent T. Ho,John Koreth,Sarah Nikiforow,Rizwan Romee,Roman Shapiro,Fiona Loschi,Jeremy Ryan,Geoffrey Fell,Hannah Q. Karp,Fabienne Lucas,Annette S. Kim,Danielle Potter,Thelma Mashaka,Richard M. Stone,Daniel J. DeAngelo,Anthony Letai,R. Coleman Lindsley,Robert J. Soiffer,Joseph H. Antin
Venetoclax and azacitidine compared with induction chemotherapy for newly diagnosed patients with acute myeloid leukemia
Clinical Trials & Observations
Evan M. Cherry,Diana Abbott,Maria Amaya,Christine McMahon,Marc Schwartz,Julie Rosser,Audrey Sato,Jeffrey Schowinsky,Anagha Inguva,Mohd Minhajuddin,Shanshan Pei,Brett Stevens,Amanda Winters,Craig T. Jordan,Clayton Smith,Jonathan A. Gutman,Daniel A. Pollyea
An MRD-stratified pediatric protocol is as deliverable in adolescents and young adults as in children with ALL
Clinical Trials & Observations
Matthew Greenwood,Toby Trahair,Rosemary Sutton,Michael Osborn,John Kwan,Sally Mapp,Rebecca Howman,Antoinette Anazodo,Brenton Wylie,James D’Rozario,Mark Hertzberg,Ian Irving,David Yeung,Luke Coyle,Amanda Jager,Dan Engeler,Nicola Venn,Chris Frampton,Andrew H. Wei,Kenneth Bradstock,Luciano Dalla-Pozza
HEALTH SERVICES AND OUTCOMES
LYMPHOID NEOPLASIA
Do age, fitness, and concomitant medications influence management and outcomes of patients with CLL treated with ibrutinib?
Clinical Trials & Observations
Alessandra Tedeschi,Anna Maria Frustaci,Francesca Romana Mauro,Annalisa Chiarenza,Marta Coscia,Stefania Ciolli,Gianluigi Reda,Luca Laurenti,Marzia Varettoni,Roberta Murru,Claudia Baratè,Paolo Sportoletti,Antonino Greco,Chiara Borella,Valentina Rossi,Marina Deodato,Annalisa Biagi,Giulia Zamprogna,Angelo Curto Pelle,Gianfranco Lapietra,Candida Vitale,Francesca Morelli,Ramona Cassin,Alberto Fresa,Chiara Cavalloni,Massimiliano Postorino,Claudia Ielo,Roberto Cairoli,Francesco Di Raimondo,Marco Montillo,Giovanni Del Poeta
Peripheral T-cell lymphoma: molecular profiling recognizes subclasses and identifies prognostic markers
Marta Rodríguez,Ruth Alonso-Alonso,Laura Tomás-Roca,Socorro M. Rodríguez-Pinilla,Rebeca Manso-Alonso,Laura Cereceda,Jennifer Borregón,Teresa Villaescusa,Raúl Córdoba,Margarita Sánchez-Beato,Ismael Fernández-Miranda,Isabel Betancor,Carmen Bárcena,Juan F. García,Manuela Mollejo,Mónica García-Cosio,Paloma Martin-Acosta,Fina Climent,Dolores Caballero,Lorena de la Fuente,Pablo Mínguez,Linda Kessler,Catherine Scholz,Antonio Gualberto,Rufino Mondéjar,Miguel A. Piris
MYELOID NEOPLASIA
Simple and robust methylation test for risk stratification of patients with juvenile myelomonocytic leukemia
Hironobu Kitazawa,Yusuke Okuno,Hideki Muramatsu,Kosuke Aoki,Norihiro Murakami,Manabu Wakamatsu,Kyogo Suzuki,Kotaro Narita,Shinsuke Kataoka,Daisuke Ichikawa,Motoharu Hamada,Rieko Taniguchi,Nozomu Kawashima,Eri Nishikawa,Atsushi Narita,Nobuhiro Nishio,Asahito Hama,Mignon L. Loh,Elliot Stieglitz,Seiji Kojima,Yoshiyuki Takahashi
PLATELETS AND THROMBOPOIESIS
Expanding the genetic spectrum of TUBB1-related thrombocytopenia
Verónica Palma-Barqueros,Loredana Bury,Shinji Kunishima,María Luisa Lozano,Augustín Rodríguez-Alen,Nuria Revilla,Natalia Bohdan,José Padilla,María P. Fernández-Pérez,María Eugenia de la Morena-Barrio,Ana Marín-Quiles,Rocío Benito,María F. López-Fernández,Shally Marcellini,Ana Zamora-Cánovas,Vicente Vicente,Constantino Martínez,Paolo Gresele,José M. Bastida,José Rivera,on behalf of the Inherited Platelet Disorders Project, Grupo Español de Alteraciones Plaquetarias Congénitas (GEAPC), Spanish Society of Thrombosis and Haemostasis (SETH)
Evans syndrome in adults: an observational multicenter study
Clinical Trials & Observations
Bruno Fattizzo,Marc Michel,Juri Alessandro Giannotta,Dennis Lund Hansen,Maria Arguello,Emanuele Sutto,Nicola Bianchetti,Andrea Patriarca,Silvia Cantoni,María Eva Mingot-Castellano,Vickie McDonald,Marco Capecchi,Anna Zaninoni,Dario Consonni,Josephine Mathilde Vos,Nicola Vianelli,Frederick Chen,Andreas Glenthøj,Henrik Frederiksen,Tomás José González-López,Wilma Barcellini
THROMBOSIS AND HEMOSTASIS
Anticoagulation in cancer-associated thromboembolism with thrombocytopenia: a prospective, multicenter cohort study
Clinical Trials & Observations
Brian J. Carney,Tzu-Fei Wang,Siyang Ren,Gemlyn George,Amer Al Homssi,Manila Gaddh,Gregory C. Connolly,Vinay I. Shah,Thomas Bogue,Abigail Bartosic,Donna Neuberg,Lisa Baumann Kreuziger,Jeffrey I. Zwicker,on behalf of the VENUS Network Investigators
TRANSPLANTATION
RESEARCH LETTER
Inhibiting casein kinase 2 sensitizes acute lymphoblastic leukemia cells to venetoclax via MCL1 degradation
Juan Lázaro-Navarro,Helia Judith Pimentel-Gutiérrez,Anton Gauert,Anja I. H. Hagemann,Jassi Eisenschmid,Nicola Gökbuget,Binje Vick,Irmela Jeremias,Felix Seyfried,Lüder Hinrich Meyer,Klaus-Michael Debatin,Kathrin Richer,Miriam Bultman,Martin Neumann,Sonja Hänzelmann,Hubert Serve,Kathy Astrahantseff,Michael A. Rieger,Cornelia Eckert,Claudia D. Baldus,Lorenz Bastian
The diagnostic red blood cell distribution width as a prognostic factor in acute myeloid leukemia
Clinical Trials & Observations
Vladan Vucinic,Leo Ruhnke,Katja Sockel,Maximilian Alexander Röhnert,Donata Backhaus,Dominic Brauer,Georg-Nikolaus Franke,Dietger Niederwieser,Martin Bornhäuser,Christoph Röllig,Uwe Platzbecker,Sebastian Schwind,Madlen Jentzsch
KMT2A-CBL rearrangements in acute leukemias: clinical characteristics and genetic breakpoints
Alex Bataller,Francesca Guijarro,Aurélie Caye-Eude,Marion Strullu,Arthur Sterin,Oscar Molina,Patrice Chevallier,Marketa Zaliova,Jan Zuna,Pablo Mozas,Laura Magnano,Nathalie Grardel,Pascale Cornillet-Lefebvre,Jen-Fen Fu,Lee-Yung Shih,Temenuzhka Boneva,Elisabeth Nacheva,Silvia Beà,Mònica López-Guerra,Clara Bueno,Pablo Menéndez,Jordi Esteve,Patrizia Larghero,Claus Meyer,Rolf Marschalek
COMMENTARY
Consensus statement for the perinatal management of patients with α thalassemia major
Tippi C. MacKenzie,Ali Amid,Michael Angastiniotis,Craig Butler,Sandra Gilbert,Juan Gonzalez,Roberta L. Keller,Sandhya Kharbanda,Melanie Kirby-Allen,Barbara A. Koenig,Wade Kyono,Ashutosh Lal,Billie R. Lianoglou,Mary E. Norton,Keith K. Ogasawara,Tachjaree Panchalee,Mara Rosner,Marisa Schwab,Alexis Thompson,John S. Waye,Elliott Vichinsky
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Cover Image
Cover Image
Coimmunostaining of β1-tubulin p.ArgR359Trp mutant (green) and α-tubulin (red) in transfected CHO cells.
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