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Issue Archive

Volume 5, Issue 18
September 28 2021
Issue Cover

Table of Contents

BLOOD ADVANCES TALK

Thrombosis and novel hemophilia therapies: the fine line between clotting and bleeding
Maureane Hoffman
View Articletitled, Thrombosis and novel hemophilia therapies: the fine line between clotting and bleeding
Supplemental data

CLINICAL GUIDELINES

American Society of Hematology 2021 guidelines for sickle cell disease: stem cell transplantation
Julie Kanter,Robert I. Liem,Françoise Bernaudin,Javier Bolaños-Meade,Courtney D. Fitzhugh,Jane S. Hankins,M. Hassan Murad,Julie A. Panepinto,Damiano Rondelli,Shalini Shenoy,John Wagner,Mark C. Walters,Teonna Woolford,Joerg J. Meerpohl,John Tisdale
View Articletitled, American Society of Hematology 2021 guidelines for sickle cell disease: stem cell transplantation
Supplemental data

STIMULUS REPORT

Lack of differential impact of del17p on survival in African Americans compared with White patients with multiple myeloma: a VA study
Clinical Trials & Observations
Nathanael R. Fillmore,Diana Cirstea,Anusha Munjuluri,Hassan Yameen,Sarvari V. Yellapragada,Nhan V. Do,Mary T. Brophy,Raphael E. Szalat,Nikhil C. Munshi
View Articletitled, Lack of differential impact of del17p on survival in African Americans compared with White patients with multiple myeloma: a VA study
A novel activating JAK1 mutation in chronic eosinophilic leukemia
William Shomali,Alisa Damnernsawad,Talent Theparee,David Sampson,Quinlan Morrow,Fei Yang,Sebastian Fernandez-Pol,Richard Press,James Zehnder,Jeffrey W. Tyner,Jason Gotlib
View Articletitled, A novel activating <em>JAK1</em> mutation in chronic eosinophilic leukemia
Supplemental data
Nf1 and Sh2b3 mutations cooperate in vivo in a mouse model of juvenile myelomonocytic leukemia
Carolina E. Morales,Elliot Stieglitz,Scott C. Kogan,Mignon L. Loh,Benjamin S. Braun
View Articletitled, <em>Nf1</em> and <em>Sh2b3</em> mutations cooperate in vivo in a mouse model of juvenile myelomonocytic leukemia
Supplemental data
Impact of sickle cell trait on morbidity and mortality from SARS-CoV-2 infection
Clinical Trials & Observations
Lauren E. Merz,Kavita Mistry,Donna Neuberg,Revital Freedman,Gerda Menard,David M. Dorfman,Hae Soo Park,Katherine Jolley,Maureen O. Achebe
View Articletitled, Impact of sickle cell trait on morbidity and mortality from SARS-CoV-2 infection

REVIEW ARTICLE

The promise and perils of immunotherapy
Stefanie Lesch,Saar Gill
View Articletitled, The promise and perils of immunotherapy
Canonical Wnt: a safeguard and threat for erythropoiesis
Rosa A. Krimpenfort,Micha Nethe
View Articletitled, Canonical Wnt: a safeguard and threat for erythropoiesis

LYMPHOID NEOPLASIA

Tissue-resident macrophages promote early dissemination of multiple myeloma via IL-6 and TNFα
Ilseyar Akhmetzyanova,Tonya Aaron,Phillip Galbo,Anastasia Tikhonova,Igor Dolgalev,Masato Tanaka,Iannis Aifantis,Deyou Zheng,Xingxing Zang,David Fooksman
View Articletitled, Tissue-resident macrophages promote early dissemination of multiple myeloma via IL-6 and TNFα
Supplemental data
Multicenter analysis of geriatric fitness and real-world outcomes in older patients with classical Hodgkin lymphoma
Clinical Trials & Observations
Victor M. Orellana-Noia,Krista Isaac,Mary-Kate Malecek,Nancy L. Bartlett,Timothy J. Voorhees,Natalie S. Grover,Steven R. Hwang,N. Nora Bennani,Rachel Hu,Brian T. Hill,Eric Mou,Ranjana H. Advani,Jordan Carter,Kevin A. David,Hatcher J. Ballard,Jakub Svoboda,Michael C. Churnetski,Gabriela Magarelli,Tatyana A. Feldman,Jonathon B. Cohen,Andrew M. Evens,Craig A. Portell
View Articletitled, Multicenter analysis of geriatric fitness and real-world outcomes in older patients with classical Hodgkin lymphoma
Supplemental data
Physiologic IGFBP7 levels prolong IGF1R activation in acute lymphoblastic leukemia
Leonardo Luís Artico,Angelo Brunelli Albertoni Laranjeira,Livia Weijenborg Campos,Juliana Ronchi Corrêa,Priscila Pini Zenatti,José Barreto Campello Carvalheira,Sandra Regina Brambilla,Alexandre Eduardo Nowill,Silvia Regina Brandalise,José Andrés Yunes
View Articletitled, Physiologic IGFBP7 levels prolong IGF1R activation in acute lymphoblastic leukemia
Supplemental data
Outcome of limited-stage nodular lymphocyte-predominant Hodgkin lymphoma and the impact of a PET-adapted approach
Clinical Trials & Observations
Phoebe T. M. Cheng,Diego Villa,R. Petter Tonseth,David W. Scott,Alina S. Gerrie,Ciara L. Freeman,Tom Pickles,Andrea C. Lo,Pedro Farinha,Jeffrey W. Craig,Graham W. Slack,Randy D. Gascoyne,François Bénard,Don Wilson,Brian Skinnider,Joseph M. Connors,Laurie H. Sehn,Kerry J. Savage
View Articletitled, Outcome of limited-stage nodular lymphocyte-predominant Hodgkin lymphoma and the impact of a PET-adapted approach
DKK1 activates noncanonical NF-κB signaling via IL-6–induced CKAP4 receptor in multiple myeloma
Xin Li,Jingjing Wang,Shuai Zhu,Jinxin Zheng,Ying Xie,Hongmei Jiang,Jing Guo,Yixuan Wang,Ziyi Peng,Mengqi Wang,Jingya Wang,Sheng Wang,Yuping Zhong,Zhiqiang Liu
View Articletitled, DKK1 activates noncanonical NF-κB signaling via IL-6–induced CKAP4 receptor in multiple myeloma
Supplemental data
Targeting pediatric leukemia-propagating cells with anti-CD200 antibody therapy
Paraskevi Diamanti,Charlotte V. Cox,Benjamin C. Ede,Robert A. Uger,John P. Moppett,Allison Blair
View Articletitled, Targeting pediatric leukemia-propagating cells with anti-CD200 antibody therapy
Supplemental data

MYELOID NEOPLASIA

Increased levels of NETosis in myeloproliferative neoplasms are not linked to thrombotic events
Clinical Trials & Observations
Stefan Schmidt,Dimitri Daniliants,Elisabeth Hiller,Eberhard Gunsilius,Dominik Wolf,Clemens Feistritzer
View Articletitled, Increased levels of NETosis in myeloproliferative neoplasms are not linked to thrombotic events
Supplemental data

PLATELETS AND THROMBOPOIESIS

The brain-derived neurotrophic factor prompts platelet aggregation and secretion
Imane Boukhatem,Samuel Fleury,Melanie Welman,Jessica Le Blanc,Chantal Thys,Kathleen Freson,Myron G. Best,Thomas Würdinger,Bruce G. Allen,Marie Lordkipanidzé
View Articletitled, The brain-derived neurotrophic factor prompts platelet aggregation and secretion
Supplemental data

THROMBOSIS AND HEMOSTASIS

Polyphosphate-induced thrombosis in mice is factor XII dependent and is attenuated by histidine-rich glycoprotein
Rida A. Malik,Ji Zhou,James C. Fredenburgh,Tammy K. Truong,Jeff R. Crosby,Alexey S. Revenko,Jeffrey I. Weitz
View Articletitled, Polyphosphate-induced thrombosis in mice is factor XII dependent and is attenuated by histidine-rich glycoprotein
Supplemental data

TRANSFUSION MEDICINE

Preclinical evaluation of immunotherapeutic regimens for fetal/neonatal alloimmune thrombocytopenia
Huiying Zhi,Maria T. Ahlen,Björn Skogen,Debra K. Newman,Peter J. Newman
View Articletitled, Preclinical evaluation of immunotherapeutic regimens for fetal/neonatal alloimmune thrombocytopenia
Supplemental data

TRANSPLANTATION

Autologous and allogeneic hematopoietic cell transplantation for diffuse large B-cell lymphoma–type Richter syndrome
Clinical Trials & Observations
Alex F. Herrera,Kwang Woo Ahn,Carlos Litovich,Yue Chen,Amer Assal,Qaiser Bashir,Ruthee-Lu Bayer,Melanie Coleman,Zachariah DeFilipp,Nosha Farhadfar,Matthew Greenwood,Theresa Hahn,Mitchell Horwitz,Caron Jacobson,Samantha Jaglowski,Sylvie Lachance,Amelia Langston,Bassam Mattar,Richard T. Maziarz,Joseph McGuirk,Mohammad A. H. Mian,Sunita Nathan,Adrienne Phillips,Kevin Rakszawski,Henrik Sengeloev,Shalini Shenoy,Robert Stuart,Craig S. Sauter,Mohamed A. Kharfan-Dabaja,Mehdi Hamadani
View Articletitled, Autologous and allogeneic hematopoietic cell transplantation for diffuse large B-cell lymphoma–type Richter syndrome
Supplemental data

VASCULAR BIOLOGY

An irradiated marrow niche reveals a small noncollagenous protein mediator of homing, dermatopontin
Ashley C. Kramer,Yuliana Astuti,Alexis Elfstrum,Michael J. Lehrke,Jakub Tolar,Bruce R. Blazar,Amanda L. Blake,Mandy E. Taisto,Justin W. Furcich,Erin E. Nolan,Wilaiwan W. Durose,Beau R. Webber,Athena Geisness,David K. Wood,Troy C. Lund
View Articletitled, An irradiated marrow niche reveals a small noncollagenous protein mediator of homing, dermatopontin
Supplemental data

RESEARCH LETTER

Real-world outcomes of axicabtagene ciloleucel in adult patients with primary mediastinal B-cell lymphoma
Clinical Trials & Observations
Jennifer L. Crombie,Loretta J. Nastoupil,Robert Redd,Kevin Tang,Geoffrey Shouse,Alex F. Herrera,Victor A. Chow,Mazyar Shadman,Omar Castaneda Puglianini,Anna Saucier,Caron A. Jacobson,Philippe Armand,Gary Simmons
View Articletitled, Real-world outcomes of axicabtagene ciloleucel in adult patients with primary mediastinal B-cell lymphoma
  • Cover Image

    Cover Image

    issue cover

    Representative fluorescence imaging of neutrophil extracellular traps (NETs) confirming NETosis in primary human neutrophils after exposition to 4 µM ionomycin for 4 hours. Antibody staining labeled citrullinated histone H3 red (Cy5, red) and human myeloperoxidase green (Cy3, yellow), while DNA was counterstained with DAPI (4′,6-diamidino-2-phenylindole; blue). See the article by Schmidt et al.

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