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Issue Archive

Volume 3, Issue 12
June 25 2019
Issue Cover

Table of Contents

BLOOD ADVANCES TALK

Managing patients who are receiving warfarin or a direct oral anticoagulant and need an elective surgery or procedure
James Douketis,Andrea Cervi
View Articletitled, Managing patients who are receiving warfarin or a direct oral anticoagulant and need an elective surgery or procedure
Supplemental data

DRUG ADVANCES

Romiplostim for the management of pediatric immune thrombocytopenia: drug development and current practice
Clinical Trials & Observations
Cindy E. Neunert,Melissa J. Rose
View Articletitled, Romiplostim for the management of pediatric immune thrombocytopenia: drug development and current practice

EXCEPTIONAL CASE REPORTS

B-cell acute lymphoblastic leukemia with high mutation burden presenting in a child with constitutional mismatch repair deficiency
Clinical Trials & Observations
Benjamin Oshrine,Nanette Grana,Colin Moore,Johnny Nguyen,Melissa Crenshaw,Melissa Edwards,Sumedha Sudhaman,Victoria J. Forster,Uri Tabori
View Articletitled, B-cell acute lymphoblastic leukemia with high mutation burden presenting in a child with constitutional mismatch repair deficiency
BRAF-V600E–mutated Rosai-Dorfman-Destombes disease and Langerhans cell histiocytosis with response to BRAF inhibitor
Clinical Trials & Observations
Rosemarie Mastropolo,Allison Close,Steven W. Allen,Kenneth L. McClain,Scott Maurer,Jennifer Picarsic
View Articletitled, <em>BRAF</em>-V600E–mutated Rosai-Dorfman-Destombes disease and Langerhans cell histiocytosis with response to BRAF inhibitor
Supplemental data
Myoclonic jerks complicating treatment of acute promyelocytic leukemia: case report and literature review
Clinical Trials & Observations
John Y. Rhee,Douglas Tremblay,Amy M. Chan,Martin S. Tallman,John Mascarenhas
View Articletitled, Myoclonic jerks complicating treatment of acute promyelocytic leukemia: case report and literature review

STIMULUS REPORTS

CRISPR genome editing of murine hematopoietic stem cells to create Npm1-Alk causes ALK+ lymphoma after transplantation
Soumya Sundara Rajan,Lingxiao Li,Mercedes F. Kweh,Kranthi Kunkalla,Amit Dipak Amin,Nitin K. Agarwal,Francisco Vega,Jonathan H. Schatz
View Articletitled, CRISPR genome editing of murine hematopoietic stem cells to create <em>Npm1-Alk</em> causes ALK<sup>+</sup> lymphoma after transplantation
Supplemental data
Inhibition of EZH2 and immune signaling exerts synergistic antitumor effects in chronic lymphocytic leukemia
Elisavet Chartomatsidou,Stavroula Ntoufa,Konstantia Kotta,Alessandra Rovida,Maria Anna Akritidou,Daniela Belloni,Elisabetta Ferrero,Theoni Trangas,Niki Stavroyianni,Achilles Anagnostopoulos,Richard Rosenquist,Paolo Ghia,Nikos Papakonstantinou,Kostas Stamatopoulos
View Articletitled, Inhibition of EZH2 and immune signaling exerts synergistic antitumor effects in chronic lymphocytic leukemia
Supplemental data

REVIEW ARTICLE

In vivo dynamics of human hematopoietic stem cells: novel concepts and future directions
Serena Scala,Alessandro Aiuti
View Articletitled, In vivo dynamics of human hematopoietic stem cells: novel concepts and future directions

CLINICAL TRIALS AND OBSERVATIONS

Long-term safety of single-agent ibrutinib in patients with chronic lymphocytic leukemia in 3 pivotal studies
Clinical Trials & Observations
Steven E. Coutre,John C. Byrd,Peter Hillmen,Jacqueline C. Barrientos,Paul M. Barr,Stephen Devereux,Tadeusz Robak,Thomas J. Kipps,Anna Schuh,Carol Moreno,Richard R. Furman,Jan A. Burger,Michael O’Dwyer,Paolo Ghia,Rudolph Valentino,Stephen Chang,James P. Dean,Danelle F. James,Susan M. O’Brien
View Articletitled, Long-term safety of single-agent ibrutinib in patients with chronic lymphocytic leukemia in 3 pivotal studies
Supplemental data
CyBorD-DARA is potent initial induction for MM and enhances ADCP: initial results of the 16-BCNI-001/CTRIAL-IE 16-02 study
Clinical Trials & Observations
M. O’Dwyer,R. Henderson,S. D. Naicker,M. R. Cahill,P. Murphy,V. Mykytiv,J. Quinn,C. McEllistrim,J. Krawczyk,J. Walsh,E. Lenihan,T. Kenny,A. Hernando,G. Hirakata,I. Parker,E. Kinsella,G. Gannon,A. Natoni,K. Lynch,A. E. Ryan
View Articletitled, CyBorD-DARA is potent initial induction for MM and enhances ADCP: initial results of the 16-BCNI-001/CTRIAL-IE 16-02 study
Supplemental data

IMMUNOBIOLOGY AND IMMUNOTHERAPY

Absence of complement component 3 does not prevent classical pathway–mediated hemolysis
Lingjun Zhang,Yang Dai,Ping Huang,Thomas L. Saunders,David A. Fox,Jijun Xu,Feng Lin
View Articletitled, Absence of complement component 3 does not prevent classical pathway–mediated hemolysis

MYELOID NEOPLASIA

A genomics-informed computational biology platform prospectively predicts treatment responses in AML and MDS patients
Clinical Trials & Observations
Leylah M. Drusbosky,Neeraj Kumar Singh,Kimberly E. Hawkins,Cesia Salan,Madeleine Turcotte,Elizabeth A. Wise,Amy Meacham,Vindhya Vijay,Glenda G. Anderson,Charlie C. Kim,Saumya Radhakrishnan,Yashaswini Ullal,Anay Talawdekar,Huzaifa Sikora,Prashant Nair,Arati Khanna-Gupta,Taher Abbasi,Shireen Vali,Subharup Guha,Nosha Farhadfar,Hemant S. Murthy,Biljana N. Horn,Helen L. Leather,Paul Castillo,Caitlin Tucker,Christina Cline,Leslie Pettiford,Jatinder K. Lamba,Jan S. Moreb,Randy A. Brown,Maxim Norkin,John W. Hiemenz,Jack W. Hsu,William B. Slayton,John R. Wingard,Christopher R. Cogle
View Articletitled, A genomics-informed computational biology platform prospectively predicts treatment responses in AML and MDS patients
Supplemental data

SYSTEMATIC REVIEW

Defining autoimmune hemolytic anemia: a systematic review of the terminology used for diagnosis and treatment
Quentin A. Hill,Anita Hill,Sigbjørn Berentsen
View Articletitled, Defining autoimmune hemolytic anemia: a systematic review of the terminology used for diagnosis and treatment
Supplemental data

THROMBOSIS AND HEMOSTASIS

Tumor microenvironment and clonal monocytes from chronic myelomonocytic leukemia induce a procoagulant climate
Johanna Zannoni,Natacha Mauz,Landry Seyve,Mathieu Meunier,Karin Pernet-Gallay,Julie Brault,Claire Jouzier,David Laurin,Mylène Pezet,Martine Pernollet,Jean-Yves Cahn,Fabrice Cognasse,Benoît Polack,Sophie Park
View Articletitled, Tumor microenvironment and clonal monocytes from chronic myelomonocytic leukemia induce a procoagulant climate
Supplemental data

TRANSPLANTATION

Outcomes of haploidentical vs matched sibling transplantation for acute myeloid leukemia in first complete remission
Clinical Trials & Observations
Armin Rashidi,Mehdi Hamadani,Mei-Jie Zhang,Hai-Lin Wang,Hisham Abdel-Azim,Mahmoud Aljurf,Amer Assal,Ashish Bajel,Asad Bashey,Minoo Battiwalla,Amer M. Beitinjaneh,Nelli Bejanyan,Vijaya Raj Bhatt,Javier Bolaños-Meade,Michael Byrne,Jean-Yves Cahn,Mitchell Cairo,Stefan Ciurea,Edward Copelan,Corey Cutler,Andrew Daly,Miguel-Angel Diaz,Nosha Farhadfar,Robert P. Gale,Siddhartha Ganguly,Michael R. Grunwald,Theresa Hahn,Shahrukh Hashmi,Gerhard C. Hildebrandt,H. Kent Holland,Nasheed Hossain,Christopher G. Kanakry,Mohamed A. Kharfan-Dabaja,Nandita Khera,Yener Koc,Hillard M. Lazarus,Jong-Wook Lee,Johan Maertens,Rodrigo Martino,Joseph McGuirk,Reinhold Munker,Hemant S. Murthy,Ryotaro Nakamura,Sunita Nathan,Taiga Nishihori,Neil Palmisiano,Sagar Patel,Joseph Pidala,Rebecca Olin,Richard F. Olsson,Betul Oran,Olov Ringden,David Rizzieri,Jacob Rowe,Mary Lynn Savoie,Kirk R. Schultz,Sachiko Seo,Brian C. Shaffer,Anurag Singh,Melhem Solh,Keith Stockerl-Goldstein,Leo F. Verdonck,John Wagner,Edmund K. Waller,Marcos De Lima,Brenda M. Sandmaier,Mark Litzow,Dan Weisdorf,Rizwan Romee,Wael Saber
View Articletitled, Outcomes of haploidentical vs matched sibling transplantation for acute myeloid leukemia in first complete remission
Supplemental data
Haploidentical vs haplo-cord transplant in adults under 60 years receiving fludarabine and melphalan conditioning
Clinical Trials & Observations
Koen van Besien,Andrew Artz,Richard E. Champlin,Danielle Guarneri,Michael R. Bishop,Julianne Chen,Usama Gergis,Tsiporah Shore,Hongtao Liu,Gabriela Rondon,Sebastian A. Mayer,Samer A. Srour,Wendy Stock,Stefan O. Ciurea
View Articletitled, Haploidentical vs haplo-cord transplant in adults under 60 years receiving fludarabine and melphalan conditioning
External validation and comparison of multiple prognostic scores in allogeneic hematopoietic stem cell transplantation
Clinical Trials & Observations
Roni Shouval,Joshua A. Fein,Aniela Shouval,Ivetta Danylesko,Noga Shem-Tov,Maya Zlotnik,Ronit Yerushalmi,Avichai Shimoni,Arnon Nagler
View Articletitled, External validation and comparison of multiple prognostic scores in allogeneic hematopoietic stem cell transplantation
Supplemental data
  • Cover Image

    Cover Image

    issue cover

    COVER FIGURE
    Immunohistochemistry staining of a spleen in a mouse with T-cell lymphoma for CD30 after transplantation with CRISPR-modified hematopoietic stem cells. The image was taken at 600× magnification. See the article by Rajan et al.

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