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Journal Articles

Quantitative Immunoprecipitation Free Light Chain Mass Spectrometry (QIP-FLC-MS) Simplifies Monoclonal Protein Assessment and Provides Added Clinical Value in Systemic AL Amyloidosis

Faye Amelia Sharpley, BA MA MSc MBBChir FRCPath, Hannah Victoria Giles, FRCPath, MRCP, Richa Manwani, MBBS, FRCPath, BSc, Shameem Mahmood, Sajitha Sachchithanantham, Helen J Lachmann, MA MB BChir MDFRCP, Julian D Gillmore, MBBS, MD PhD FRCP, Carol J Whelan, Philip N Hawkins, Ashutosh D Wechalekar, MB BS, MD FRCP, FRCPath, DM

Blood (2019) 134 (Supplement_1): 4375.

https://doi.org/10.1182/blood-2019-128175

Published: 2019

Journal Articles

Bovine Heparin Demonstrates the Same Interaction with HIT Antibodies As Porcine Heparin

Jeanine Walenga, PhD, Walter Jeske, PhD, Sabrina Bertini, Giulia Risi, Michelle Sung, BS, Ambar Farooqui, Cassie Bacher, Debra Hoppensteadt, PhD, Omer Iqbal, MD, Bruce Lewis, Mamdouh Bakhos, MD

Blood (2019) 134 (Supplement_1): 2351.

https://doi.org/10.1182/blood-2019-127304

Published: 2019

Journal Articles

Pozelimab, a Human Antibody Against Complement Factor C5, Demonstrates Robust Inhibition of Alternative Complement Activity Both in Normal Human Serum and in Phase I Normal Healthy Volunteers

Kishor Devalaraja-Narashimha, PhD DVM, Yan G Ni, PhD, Cong Huang, Ming-Dauh Wang, PhD, Umesh Chaudhari, MD, Srinivasa Prasad, PhD, Olivier Harari, MD PhD, Andrew J Rankin, PhD, Lori Morton, PhD, Jonathan Weyne, MD

Blood (2019) 134 (Supplement_1): 2278.

https://doi.org/10.1182/blood-2019-129865

Published: 2019

Journal Articles

B Cell Restricted Expression of Mutated IKZF3 modulates BCR Signaling and Homing Pathways in a Mouse Model of CLL

Gregory Lazarian, PharmD, Shanye Yin, PhD, Elisa Ten Hacken, PhD, Tomasz Sewastianik, MSc,PhD, Alba Font-tello, PhD, Heather Joyal, Elizabeth Witten, Mei Zheng, Christopher J. Ott, PhD, Donna S Neuberg, ScD, Lili Wang, MD PhD, Ruben D. Carrasco, MD PhD, Catherine J. Wu, MD

Blood (2019) 134 (Supplement_1): 848.

https://doi.org/10.1182/blood-2019-123963

Published: 2019

Journal Articles

Rash in Patients after T-Cell-Depleted Peripheral Blood Stem Cell Transplantation: Eosinophilia and Pruritus Do Not Distinguish Acute Graft-Versus-Host Disease from Drug Rash

Skylar A Klager, MS, Sean M Devlin, PhD, Margaret Hannum, MS, Ann A. Jakubowski, MD PhD, Alina Markova, MD

Blood (2018) 132 (Supplement 1): 4570.

https://doi.org/10.1182/blood-2018-99-110307

Published: 2018

Journal Articles

A Novel Mass Spectrometry Method to Identify the Serum Monoclonal Light Chain Component and Infer Organ Involvement in Systemic Light Chain Amyloidosis

Faye Sharpley, Richa Manwani, MBBS, FRCPath, BSc, Shameem Mahmood, Sajitha Sachchithanantham, Helen Lachmann, Julian Gillmore, Carol Whelan, Philip Hawkins, Ashutosh D. Wechalekar

Blood (2018) 132 (Supplement 1): 4445.

https://doi.org/10.1182/blood-2018-99-114028

Published: 2018

Journal Articles

A Randomized, Double-Blind, Placebo-Controlled Phase 1 Study of the Pharmacokinetics and Pharmacodynamics of REGN3918, a Human Antibody Against Complement Factor C5, in Healthy Volunteers

Jonathan Weyne, MD, Yan Ni, PhD, Richard DelGizzi, PA, MS, Stephen Godin, PhD, Lori Morton, PhD, Srinivasa Prasad, PhD, Andrew J Rankin, PhD, Melissa Simek-Lemos, MPH, ming-Dauh Wang, PhD, Ronda Rippley, PhD, Olivier Harari, MD PhD

Blood (2018) 132 (Supplement 1): 1039.

https://doi.org/10.1182/blood-2018-99-112262

Published: 2018

Journal Articles

Altering Glycosphingolipid Composition to Improve Multiple Myeloma Bone Complication

Houfu Leng, MSc, DPhil, MBBS, BSc, Adel Ersek, PhD, Emma Morris, DPhil, Beatriz Gamez Molina, PhD, Claire M. Edwards, PhD, Nicole Horwood, PhD

Blood (2018) 132 (Supplement 1): 1942.

https://doi.org/10.1182/blood-2018-99-112237

Published: 2018

Journal Articles

Prenatal Transplantation of Placental Cells Engineered to Express FVIII Leads to Corrective Plasma Levels of FVIII after Birth

M. Graca Almeida-Porada, MD PhD, Sunil George, PhD, Alshaima Morsi, MD, Nadia El-Akabawy, MD, Jorge Figueroa, Jordan E Shields, MS, Diane Meares, Andrew M. Farland, MD, Anthony Atala, MD, Christopher B Doering, PhD, H. Trent Spencer, PhD, Christopher D Porada, PhD

Blood (2017) 130 (Supplement 1): 361.

https://doi.org/10.1182/blood.V130.Suppl_1.361.361

Published: 2017

Journal Articles

Coversin, a Novel C5 Complement Inhibitor, Is Safe and Effective in the Treatment of PNH: Results of a Phase II Clinical Trial

Anita Hill, MBChB (Hons), PhD, Wynne Weston-Davies, MB FRCS, Miles Nunn, PhD, Tadeusz Robak, MD PhD, Jerzy Windyga, MD, Andrzej Hellmann, MD PhD DSc, Austin G. Kulasekararaj, MBBS, MD MRCP, FRCPath, Agniezka Piekarska, Anna Szmigielska-Kaplon, Morag Griffin, Talha Munir

Blood (2017) 130 (Supplement 1): 4747.

https://doi.org/10.1182/blood.V130.Suppl_1.4747.4747

Published: 2017

Journal Articles

A Preliminary Analysis of the Incidence of Transfusion-Related Acute Lung Injury (TRALI) in a Sheep Model Following Transfusion with the Supernatant from Leukodepleted Red Cell Units

John-Paul Tung, Gabriela Simonova, Sara Diab, Kimble Dunster, Margaret Passmore, Elise Roche, Wesley Bierman, Denisa Meka, Melinda M Dean, John F Fraser

Blood (2016) 128 (22): 1462.

https://doi.org/10.1182/blood.V128.22.1462.1462

Published: 2016

Journal Articles

Pirfenidone Reverses Murine Chronic Graft Versus Host Disease

Jing Du, Ryan P Flynn, PhD, Katelyn Paz, Ante Vulic, MD, Tara M. Robinson, MD PhD, Katie E Lineburg, BSc, Kelli P A Macdonald, PhD, Geoffrey R Hill, Jonathan S Serody, MD, Ivan Maillard, MD PhD, Angela Panoskaltsis-Mortari, PhD, Timothy Schacker, MD, Leo Luznik, MD, Bruce R. Blazar, MD

Blood (2016) 128 (22): 1158.

https://doi.org/10.1182/blood.V128.22.1158.1158

Published: 2016

Journal Articles

Outcomes of Pharmacokinetically Targeted Busulfan-Based Conditioning Regimen for Patients with Myelodysplastic Syndrome and Acute Myelogenous Leukemia Undergoing CD34 Selected Allogeneic Hematopoietic Stem Cell Transplantation

Kristen Beyer, PharmD, Anthony Proli, PharmD, Junting Zheng, Sean Devlin, PhD, Valkal Bhatt, PharmD, Andrew Lin, PharmD, Esperanza B. Papadopoulos, MD, Ann A. Jakubowski, MD PhD, Miguel Perales, MD, Sergio Giralt, MD, Hugo Castro-Malaspina, MD, Roni Tamari, MD

Blood (2016) 128 (22): 3392.

https://doi.org/10.1182/blood.V128.22.3392.3392

Published: 2016

Journal Articles

BAFF and CD4 T-Cells Are Major Survival Factors for Splenic Plasma Cells in B Cell Depletion Context: Implications for Autoimmune Diseases

Lan-Huong Thai, MD PhDstudent, Ailsa Robbins, Simon Le Gallou, PhD, Nicolas Cagnard, Jean-Claude Weill, Professor, Claude-Agnès Reynaud, PhD, Matthieu Mahevas, MD PhD

Blood (2016) 128 (22): 129.

https://doi.org/10.1182/blood.V128.22.129.129

Published: 2016

Journal Articles

Phylogenetic Analysis Identifies a Subset of ADAMTS13 Domains That Are Highly Conserved and Essential for Allosteric Regulation

Joshua Muia, PhD, Jian Zhu, PhD, Suellen Greco, DVM, Karen Vanhoorelbeke, PhD, Louis Deforche, PhD, Lisa Westfield, Garima Tyagi, PhD, J. Evan Sadler, MD PhD

Blood (2016) 128 (22): 1385.

https://doi.org/10.1182/blood.V128.22.1385.1385

Published: 2016

Journal Articles

ANX005, an Inhibitory Antibody Against C1q, Blocks Complement Activation Triggered By Cold Agglutinins in Human Disease

Morie A. Gertz, MD MACP, Haiyan Qiu, PhD, Laura Kendall, Mario Saltarelli, MDPhD, Ted Yednock, PhD, Sethu Sankaranarayanan, PhD

Blood (2016) 128 (22): 1265.

https://doi.org/10.1182/blood.V128.22.1265.1265

Published: 2016

Journal Articles

A Subcutaneously Administered Investigational RNAi Therapeutic (ALN-CC5) Targeting Complement C5 for Treatment of PNH and Complement-Mediated Diseases: Preliminary Phase 1/2 Study Results in Patients with PNH

Anita Hill, Anna Gaya Valls, Morag Griffin, Talha Munir, Anna Borodovsky, Nori Kawahata, Helen Mclean, Kelvin Shi, Angela M. Partisano, Jae Kim, Nader Najafian, Alvaro Urbano

Blood (2016) 128 (22): 3891.

https://doi.org/10.1182/blood.V128.22.3891.3891

Published: 2016

Journal Articles

Comparison of Ufh and Enoxaparin Originated from Bovine, Ovine and Porcine Mucosa with Functional Coagulation Assays

Grigorios T. Gerotziafas, MD PhD, Patrick Van Dreden, PhD, Walter Jeske, PhD, Jeanine M. Walenga, PhD, Debra Hoppensteadt, PhD, Annette Larsen, Ismail Elalamy, MD PhD, Yiming Yao, Jawed Fareed, PhD

Blood (2016) 128 (22): 5020.

https://doi.org/10.1182/blood.V128.22.5020.5020

Published: 2016

Journal Articles

Targeted Inhibition of Activated Protein C Anticoagulant Activity By Monoclonal Antibody HAPC1573 for Treatment of Hemophilia

Xiao-Yan Zhao, PhD, Subramanian Yegneswaran, PhD, Maxine Bauzon, Derek Sim, Chandra Patel, PhD, Doug Schneider, Kirk McLean, Ying Zhu, MD, Xiaoqiao Jiang, Vince Evans, Jian-Ming Gu, PhD, Inge Ivens, PhD, Jun Xu, PhD, Peter Wolfgang Bringmann, PhD, Katalin Kauser, Charles Esmon, PhD

Blood (2016) 128 (22): 80.

https://doi.org/10.1182/blood.V128.22.80.80

Published: 2016

Journal Articles

Porcine and Ovine Mucosal Heparins and Their Depolymerized Derivatives Are Comparable in Contrast to Their Bovine Equivalents

Olivia Bouchard, Debra Hoppensteadt, PhD, Paula Maia, Alice Silva de Castro, Emmanuele Kumar, Nil Guler, MD, Walter Jeske, PhD, Daniel Kahn, BS, Jeanine M. Walenga, PhD, Erwin Coyne, Yimng Yao, Jawed Fareed, PhD

Blood (2016) 128 (22): 5027.

https://doi.org/10.1182/blood.V128.22.5027.5027

Published: 2016

NARROW

Quantitative Immunoprecipitation Free Light Chain Mass Spectrometry (QIP-FLC-MS) Simplifies Monoclonal Protein Assessment and Provides Added Clinical Value in Systemic AL Amyloidosis

Bovine Heparin Demonstrates the Same Interaction with HIT Antibodies As Porcine Heparin

Pozelimab, a Human Antibody Against Complement Factor C5, Demonstrates Robust Inhibition of Alternative Complement Activity Both in Normal Human Serum and in Phase I Normal Healthy Volunteers

B Cell Restricted Expression of Mutated IKZF3 modulates BCR Signaling and Homing Pathways in a Mouse Model of CLL

Rash in Patients after T-Cell-Depleted Peripheral Blood Stem Cell Transplantation: Eosinophilia and Pruritus Do Not Distinguish Acute Graft-Versus-Host Disease from Drug Rash

A Novel Mass Spectrometry Method to Identify the Serum Monoclonal Light Chain Component and Infer Organ Involvement in Systemic Light Chain Amyloidosis

A Randomized, Double-Blind, Placebo-Controlled Phase 1 Study of the Pharmacokinetics and Pharmacodynamics of REGN3918, a Human Antibody Against Complement Factor C5, in Healthy Volunteers

Altering Glycosphingolipid Composition to Improve Multiple Myeloma Bone Complication

Prenatal Transplantation of Placental Cells Engineered to Express FVIII Leads to Corrective Plasma Levels of FVIII after Birth

Coversin, a Novel C5 Complement Inhibitor, Is Safe and Effective in the Treatment of PNH: Results of a Phase II Clinical Trial

A Preliminary Analysis of the Incidence of Transfusion-Related Acute Lung Injury (TRALI) in a Sheep Model Following Transfusion with the Supernatant from Leukodepleted Red Cell Units

Pirfenidone Reverses Murine Chronic Graft Versus Host Disease

Outcomes of Pharmacokinetically Targeted Busulfan-Based Conditioning Regimen for Patients with Myelodysplastic Syndrome and Acute Myelogenous Leukemia Undergoing CD34 Selected Allogeneic Hematopoietic Stem Cell Transplantation

BAFF and CD4 T-Cells Are Major Survival Factors for Splenic Plasma Cells in B Cell Depletion Context: Implications for Autoimmune Diseases

Phylogenetic Analysis Identifies a Subset of ADAMTS13 Domains That Are Highly Conserved and Essential for Allosteric Regulation

ANX005, an Inhibitory Antibody Against C1q, Blocks Complement Activation Triggered By Cold Agglutinins in Human Disease

A Subcutaneously Administered Investigational RNAi Therapeutic (ALN-CC5) Targeting Complement C5 for Treatment of PNH and Complement-Mediated Diseases: Preliminary Phase 1/2 Study Results in Patients with PNH

Comparison of Ufh and Enoxaparin Originated from Bovine, Ovine and Porcine Mucosa with Functional Coagulation Assays

Targeted Inhibition of Activated Protein C Anticoagulant Activity By Monoclonal Antibody HAPC1573 for Treatment of Hemophilia

Porcine and Ovine Mucosal Heparins and Their Depolymerized Derivatives Are Comparable in Contrast to Their Bovine Equivalents

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American Society of Hematology

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American Society of Hematology

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