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Journal Articles

Placental HTRA1 cleaves α 1 -antitrypsin to generate a NET-inhibitory peptide

Robert A. Campbell, Heather D. Campbell, J. Samuel Bircher, Claudia Valeria de Araujo, Frederik Denorme, Jacob L. Crandell, John L. Rustad, Josh Monts, Mark J. Cody, Yasuhiro Kosaka, Christian C. Yost

Blood (2021) 138 (11): 977–988.

https://doi.org/10.1182/blood.2020009021

Published: 2021

Includes: Supplemental data

Journal Articles

Gene Editing ELANE in Human Hematopoietic Stem and Progenitor Cells Reveals Disease Mechanisms and Therapeutic Strategies for Severe Congenital Neutropenia

Shuquan Rao, PhD, Josias Brito-Frazao, Anna V. Serbin, Qiuming Yao, PhD, Kevin Luk, Yuxuan Wu, PhD, Jing Zeng, MD, Chunyan Ren, PhD, Ruth Watkinson, Myriam Armant, PhD, Luca Pinello, PhD, Akiko Shimamura, MD PhD, Benhur Lee, Scot A. Wolfe, PhD, Peter E. Newburger, MD, Daniel E. Bauer, MD PhD

Blood (2019) 134 (Supplement_1): 3.

https://doi.org/10.1182/blood-2019-131073

Published: 2019

Journal Articles

Generation and Characterisation of KY1066, a Fully Human Antibody Targeting the Enzymatic Activity of Matriptase-2 for the Treatment of Iron Overload in Beta Thalassemia

Matthew Wake, PhD, Jonathan Papworth, BSc, Luke Bayliss, BSc, Benjamin Grimshaw, PhD, Natalie Rynkiewicz, PhD, Jemima Paterson, BSc, Alicia Poindron, MSc, Erin Spearing, Emily Carter, Robyne Hudson, BSc, Verena Petzer, MD, Amelie Largounez, BSc, Audrey Belot, BSc, Anais Palin, BSc, Igor Theurl, MD PhD, Volker Germaschewski, Delphine Meynard, PhD

Blood (2019) 134 (Supplement_1): 3532.

https://doi.org/10.1182/blood-2019-124075

Published: 2019

Journal Articles

The Markedly Increased PAI1 in Obesity Induces a Compensatory Increase of Hepatocyte Tpa Expression By Activating a LRP1-CREB1 Pathway

Ze Zheng, MBBS, PhD, Keiko Nakamura, MD, Shana Gershbaum, Ira Tabas, MD PhD

Blood (2019) 134 (Supplement_1): 3625.

https://doi.org/10.1182/blood-2019-129271

Published: 2019

Journal Articles

A Phase 2 Open-Label Study of Danicopan (ACH-0144471) in Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) Who Have an Inadequate Response to Eculizumab Monotherapy

Austin Kulasekararaj, MBBS MDMRCP FRCPath, Antonio M. Risitano, MD PhD, Jaroslaw P. Maciejewski, MD PhD, Rosario Notaro, MD, Peter Browett, BMedSci, MBChB, FRACP, FRCPA, Jong-Wook Lee, MD, Mingjun Huang, PhD, Michael Geffner, MD, Robert A. Brodsky, MD

Blood (2019) 134 (Supplement_1): 3514.

https://doi.org/10.1182/blood-2019-124748

Published: 2019

Journal Articles

Mechanistic Evaluation of Efficacy Using Biomarkers of the Oral, Small Molecule Factor D Inhibitor, Danicopan (ACH-4471), in Untreated Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH)

Antonio M. Risitano, MD PhD, Jong Wook Lee, MD PhD, Rosario Notaro, MD, Robert A. Brodsky, MD, Austin Kulasekararaj, MBBS MDMRCP FRCPath, Jaroslaw P. Maciejewski, MD PhD, Mingjun Huang, PhD, Michael Geffner, MD, Peter Browett, BMedSci, MBChB, FRACP, FRCPA

Blood (2019) 134 (Supplement_1): 2226.

https://doi.org/10.1182/blood-2019-124837

Published: 2019

Journal Articles

CRISPR/Cas9 Mediated ELANE Knock-out Restores Survival and Granulocytic Differentiation of HL60 Cells Expressing Mutant Neutrophil Elastase: Is Neutrophil Elastase a Dispensible Granulocyte Protease?

Vahagn Makaryan, MD, Isabella N. Archibald, Merideth L. Kelley, MS, Breanna Fletcher, BSc, David C. Dale, MD

Blood (2019) 134 (Supplement_1): 435.

https://doi.org/10.1182/blood-2019-124988

Published: 2019

Journal Articles

Cryo-EM Structure of BIVV001 Reveals Coagulation Factor VIII-Von Willebrand Factor D'D3 Interaction Mode

James Fuller, PhD, Joseph Batchelor, PhD, Kevin Knockenhauer, PhD, Hans-Peter Biemann, PhD, Robert Peters

Blood (2019) 134 (Supplement_1): 94.

https://doi.org/10.1182/blood-2019-126645

Published: 2019

Journal Articles

Cofactor and Cofactor Mimetics

Peter J. Lenting, PhD

Blood (2019) 134 (Supplement_1): SCI-17.

https://doi.org/10.1182/blood-2019-121059

Published: 2019

Journal Articles

Evaluation of a Blood Coagulation Factor IX Variant That Functions Independently of Factor VIII As an Alternative Treatment for Hemophilia A

Viola J.F. Strijbis, MSc, Ka Lei Cheung, Pavlina Konstantinova, PhD, Ying Poi Liu, PhD, Sander J van Deventer, MD PhD, Mettine H.A. Bos, PhD

Blood (2019) 134 (Supplement_1): 1110.

https://doi.org/10.1182/blood-2019-124120

Published: 2019

Journal Articles

Bile Acids Induce Platelet Activation Leading to Degranulation and a Prothrombotic Phenotype

Joachim Zobel, Tanja Strini, Martin Tischitz, Sina Pohl, Theresa Greimel, Jörg Jahnel, Axel Schlagenhauf

Blood (2019) 134 (Supplement_1): 4887.

https://doi.org/10.1182/blood-2019-126095

Published: 2019

Journal Articles

Persistence of Exosomes in Patients with Acute Myeloid Leukemia in Complete Remission Suppresses Hematopoiesis

Swathi Namburi, MD, Hal E. Broxmeyer, PhD, Theresa L Whiteside, PhD, Michael Boyiadzis, MD

Blood (2018) 132 (Supplement 1): 3850.

https://doi.org/10.1182/blood-2018-99-115354

Published: 2018

Journal Articles

Novel Insights Into Systemic Iron Regulation

Laura Silvestri, PhD, Alessia Pagani, PhD, Antonella Nai, PhD, Clara Camaschella, MD

Blood (2018) 132 (Supplement 1): SCI-1.

https://doi.org/10.1182/blood-2018-99-109518

Published: 2018

Journal Articles

Mitochondrial Dysfunction in Normal and Malignant Hematopoiesis

Aaron Schimmer, MD PhD

Blood (2018) 132 (Supplement 1): SCI-11.

https://doi.org/10.1182/blood-2018-99-109470

Published: 2018

Journal Articles

Placental HTRA1 Protease Cleaves Alpha-1-Antitrypsin and Generates Neonatal NET-Inhibitory Factor

Robert A. Campbell, PhD, Mark Cody, B.S., Yasuhiro Kosaka, PhD, Heather D Campbell, MD, Christian Yost, MD

Blood (2018) 132 (Supplement 1): 273.

https://doi.org/10.1182/blood-2018-99-111195

Published: 2018

Journal Articles

Contribution of Factor VIII A3 Domain Residues 1793-1795 to a Factor IXa-Interactive Site

Masahiro Takeyama, Keiji Nogami, MDPhD, Kana Sasai, Midori Shima, MD PhD

Blood (2018) 132 (Supplement 1): 1173.

https://doi.org/10.1182/blood-2018-99-113260

Published: 2018

Journal Articles

Lipid-Mediated Relation between Tissue Factor Pathway Inhibitor Activity and Cardiovascular Risk Factors and Diseases in a Large Population Sample

Pauline van Paridon, BSc, Marina Panova-Noeva, Rene van Oerle, Andreas Schulz, Jürgen Prochaska, Natalie Arnold, Irene Schmidtmann, Manfred Beutel, Norbert Pfeiffer, Thomas Münzel, Karl J. Lackner, Tilman M. Hackeng, PhD, Hugo ten Cate, MD PhD, Philipp Wild, Henri M.H. Spronk, PhD

Blood (2018) 132 (Supplement 1): 1169.

https://doi.org/10.1182/blood-2018-99-116932

Published: 2018

Journal Articles

Hepatocyte-Derived Tissue Plasminogen Activator Regulates Systemic Fibrinolysis

Ze Zheng, MDPhD, Lalitha V. Nayak, MD, Mukesh Jain, Ira Tabas, MD PhD

Blood (2018) 132 (Supplement 1): 217.

https://doi.org/10.1182/blood-2018-99-119362

Published: 2018

Journal Articles

Activated Protein C Induces Stabilization of the Outer Retinal Barrier and Inhibits Laser Induced Choroidal Neovascularization in a Murine Model

Tami Livnat, PhD, Yael Nisgav, Msc, Ivan Budnik, MDPhD, Yehonatan Weinberger, MD, Rima Dardik, PhD, Gili Kenet, MD, Dov Weinberger, MD

Blood (2018) 132 (Supplement 1): 73.

https://doi.org/10.1182/blood-2018-99-111375

Published: 2018

Journal Articles

Activated protein C, protease activated receptor 1, and neuroprotection

John H. Griffin, Berislav V. Zlokovic, Laurent O. Mosnier

Blood (2018) 132 (2): 159–169.

https://doi.org/10.1182/blood-2018-02-769026

Published: 2018

NARROW

Placental HTRA1 cleaves α 1 -antitrypsin to generate a NET-inhibitory peptide

Gene Editing ELANE in Human Hematopoietic Stem and Progenitor Cells Reveals Disease Mechanisms and Therapeutic Strategies for Severe Congenital Neutropenia

Generation and Characterisation of KY1066, a Fully Human Antibody Targeting the Enzymatic Activity of Matriptase-2 for the Treatment of Iron Overload in Beta Thalassemia

The Markedly Increased PAI1 in Obesity Induces a Compensatory Increase of Hepatocyte Tpa Expression By Activating a LRP1-CREB1 Pathway

A Phase 2 Open-Label Study of Danicopan (ACH-0144471) in Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) Who Have an Inadequate Response to Eculizumab Monotherapy

Mechanistic Evaluation of Efficacy Using Biomarkers of the Oral, Small Molecule Factor D Inhibitor, Danicopan (ACH-4471), in Untreated Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH)

CRISPR/Cas9 Mediated ELANE Knock-out Restores Survival and Granulocytic Differentiation of HL60 Cells Expressing Mutant Neutrophil Elastase: Is Neutrophil Elastase a Dispensible Granulocyte Protease?

Cryo-EM Structure of BIVV001 Reveals Coagulation Factor VIII-Von Willebrand Factor D'D3 Interaction Mode

Cofactor and Cofactor Mimetics

Evaluation of a Blood Coagulation Factor IX Variant That Functions Independently of Factor VIII As an Alternative Treatment for Hemophilia A

Bile Acids Induce Platelet Activation Leading to Degranulation and a Prothrombotic Phenotype

Persistence of Exosomes in Patients with Acute Myeloid Leukemia in Complete Remission Suppresses Hematopoiesis

Novel Insights Into Systemic Iron Regulation

Mitochondrial Dysfunction in Normal and Malignant Hematopoiesis

Placental HTRA1 Protease Cleaves Alpha-1-Antitrypsin and Generates Neonatal NET-Inhibitory Factor

Contribution of Factor VIII A3 Domain Residues 1793-1795 to a Factor IXa-Interactive Site

Lipid-Mediated Relation between Tissue Factor Pathway Inhibitor Activity and Cardiovascular Risk Factors and Diseases in a Large Population Sample

Hepatocyte-Derived Tissue Plasminogen Activator Regulates Systemic Fibrinolysis

Activated Protein C Induces Stabilization of the Outer Retinal Barrier and Inhibits Laser Induced Choroidal Neovascularization in a Murine Model

Activated protein C, protease activated receptor 1, and neuroprotection

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ASH Publications

American Society of Hematology

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ASH Publications

American Society of Hematology

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