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Yasuhiro Kosaka
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Journal Articles

Multiplexed Functional Assessment of Glanzmann Thrombasthenia Variants

Yasuhiro Kosaka, Shancy Jacob, Jorge Di Paola, Justyne Ross, Kristy Lee, Sean Tavtigian, Alun Thomas, Matthew T. Rondina, Paul F. Bray, Jesse W Rowley
Journal: Blood
Blood (2023) 142 (Supplement 1): 1204.
https://doi.org/10.1182/blood-2023-182455
Published: 2023
Journal Articles

Platelet Mitochondria Calcium Uniporter Regulates ITAM-Dependent Platelet Activation and Signaling

Abigail Ajanel Gomez, Frederik Denorme, Irina Portier, Mia Kowalczyk, Sradha Rameshbhatt, Yasuhiro Kosaka, Robert A. Campbell
Journal: Blood
Blood (2023) 142 (Supplement 1): 1187.
https://doi.org/10.1182/blood-2023-189538
Published: 2023
Journal Articles

Mitochondrial Fission Protein Drp1 Regulates Platelet Function

Shancy Jacob, Marina Tistao, Abigail Ajanel Gomez, Frederik Denorme, Yasuhiro Kosaka, Bhanu Kanth Manne, Li Guo, Robert A. Campbell, Matthew T. Rondina, Jesse W Rowley
Journal: Blood
Blood (2023) 142 (Supplement 1): 1201.
https://doi.org/10.1182/blood-2023-187556
Published: 2023
Journal Articles

MAPK-interacting kinase 1 regulates platelet production, activation, and thrombosis

Bhanu Kanth Manne, Robert A. Campbell, Seema Bhatlekar, Abigail Ajanel, Frederik Denorme, Irina Portier, Elizabeth A. Middleton, Neal D. Tolley, Yasuhiro Kosaka, Emilie Montenont, Li Guo, Jesse W. Rowley, Paul F. Bray, Shancy Jacob, Rikiro Fukanaga, Christopher Proud, Andrew S. Weyrich, Matthew T. Rondina
Journal: Blood
Blood (2022) 140 (23): 2477–2489.
https://doi.org/10.1182/blood.2022015568
Published: 2022
Includes: Supplemental data
Journal Articles

Actin Bundling Protein L-Plastin Regulates Megakaryocyte Membrane Rigidity and Platelet Spreading

Li Guo, Seema Bhatlekar, Shancy P Jacob, Bhanu Kanth Manne, Elizabeth Kolawole, Emilia A Tugolukova, Siqi Guo, Yasuhiro Kosaka, Cindy Barba, Brian Evavold, Sharon Celesty Morley, Robert A. Campbell, Paul F. Bray
Journal: Blood
Blood (2022) 140 (Supplement 1): 5510–5511.
https://doi.org/10.1182/blood-2022-169517
Published: 2022
Journal Articles

The mTOR Pathway in Platelets Contributes to the Pathophysiology of Experimental Cerebral Malaria

Irina Portier, Frederik Denorme, Kimberly A Queisser, Yasuhiro Kosaka, Aaron C Petrey, Guy A Zimmerman, Robert A. Campbell, Matthew T. Rondina
Journal: Blood
Blood (2021) 138 (Supplement 1): 580.
https://doi.org/10.1182/blood-2021-152335
Published: 2021
Journal Articles

Mitofusin2 (MFN2) Preserves Mitochondrial Integrity and Function in Megakaryocytes and Platelets

Shancy P Jacob, Yasuhiro Kosaka, Seema Bhatlekar, Alexandra Moody, Victoria Moody, Emilia A Tugolukova, Grayson A Hull, Frederik Denorme, Bhanu Kanth Manne, Li Guo, Rhonda Souvenir, Alicia Eustes, Kelly B Hoerger, Neal D Tolley, Robert A. Campbell, Matthew T. Rondina, E. Dale Abel, Paul F. Bray, Andrew S. Weyrich, Jesse W Rowley
Journal: Blood
Blood (2021) 138 (Supplement 1): 3137.
https://doi.org/10.1182/blood-2021-154329
Published: 2021
Journal Articles

Placental HTRA1 cleaves α 1 -antitrypsin to generate a NET-inhibitory peptide

Robert A. Campbell, Heather D. Campbell, J. Samuel Bircher, Claudia Valeria de Araujo, Frederik Denorme, Jacob L. Crandell, John L. Rustad, Josh Monts, Mark J. Cody, Yasuhiro Kosaka, Christian C. Yost
Journal: Blood
Blood (2021) 138 (11): 977–988.
https://doi.org/10.1182/blood.2020009021
Published: 2021
Includes: Supplemental data
Journal Articles

Platelet MHC class I mediates CD8 + T-cell suppression during sepsis

Li Guo, Sikui Shen, Jesse W. Rowley, Neal D. Tolley, Wenwen Jia, Bhanu Kanth Manne, Kyra N. McComas, Ben Bolingbroke, Yasuhiro Kosaka, Krystin Krauel, Frederik Denorme, Shancy P. Jacob, Alicia S. Eustes, Robert A. Campbell, Elizabeth A. Middleton, Xiao He, Samuel M. Brown, Craig N. Morrell, Andrew S. Weyrich, Matthew T. Rondina
Journal: Blood
Blood (2021) 138 (5): 401–416.
https://doi.org/10.1182/blood.2020008958
Published: 2021
Includes: Multimedia, Supplemental data
Journal Articles

Platelet necrosis mediates ischemic stroke outcome in mice

Frederik Denorme, Bhanu Kanth Manne, Irina Portier, Alicia S. Eustes, Yasuhiro Kosaka, Benjamin T. Kile, Matthew T. Rondina, Robert A. Campbell
Journal: Blood
Blood (2020) 135 (6): 429–440.
https://doi.org/10.1182/blood.2019002124
Published: 2020
Includes: Supplemental data
Journal Articles

Cyclophilin D Mediated Platelet Necrosis Regulates Ischemic Stroke Outcomes in Mice

Frederik Denorme, PhD, Bhanu Kanth Manne, PhD, Yasuhiro Kosaka, PhD, Benjamin Kile, PhD, Matthew T. Rondina, MD, Robert A. Campbell, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3620.
https://doi.org/10.1182/blood-2019-123839
Published: 2019
Journal Articles

Sepsis alters the transcriptional and translational landscape of human and murine platelets

Elizabeth A. Middleton, Jesse W. Rowley, Robert A. Campbell, Colin K. Grissom, Samuel M. Brown, Sarah J. Beesley, Hansjörg Schwertz, Yasuhiro Kosaka, Bhanu K. Manne, Krystin Krauel, Neal D. Tolley, Alicia S. Eustes, Li Guo, Robert Paine, III, Estelle S. Harris, Guy A. Zimmerman, Andrew S. Weyrich, Matthew T. Rondina
Journal: Blood
Blood (2019) 134 (12): 911–923.
https://doi.org/10.1182/blood.2019000067
Published: 2019
Includes: Supplemental data
Journal Articles

Human megakaryocytes possess intrinsic antiviral immunity through regulated induction of IFITM3

Robert A. Campbell, Hansjorg Schwertz, Eugenio D. Hottz, Jesse W. Rowley, Bhanu Kanth Manne, A. Valance Washington, Robert Hunter-Mellado, Neal D. Tolley, Miles Christensen, Alicia S. Eustes, Emilie Montenont, Seema Bhatlekar, Cassandra H. Ventrone, Beth D. Kirkpatrick, Kristen K. Pierce, Stephen S. Whitehead, Sean A. Diehl, Paul F. Bray, Guy A. Zimmerman, Yasuhiro Kosaka, Patricia T. Bozza, Fernando A. Bozza, Andrew S. Weyrich, Matthew T. Rondina
Journal: Blood
Blood (2019) 133 (19): 2013–2026.
https://doi.org/10.1182/blood-2018-09-873984
Published: 2019
Includes: Supplemental data
Journal Articles

Placental HTRA1 Protease Cleaves Alpha-1-Antitrypsin and Generates Neonatal NET-Inhibitory Factor

Robert A. Campbell, PhD, Mark Cody, B.S., Yasuhiro Kosaka, PhD, Heather D Campbell, MD, Christian Yost, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 273.
https://doi.org/10.1182/blood-2018-99-111195
Published: 2018