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Journal Articles

Blocking Lysosomal Two-Pore Channel 2 Function Inhibits Proliferation of Multidrug Resistant Leukemia Cells and Sensitizes Them to Vincristine Treatment

Martin Müller, MSc, Franz Geisslinger, Susanne Gerndt, Ramona Schütz, Yu-Kai Chao, Franz Bracher, Christian Grimm, Angelika Vollmar, Karin Bartel
Journal: Blood
Blood (2019) 134 (Supplement_1): 2081.
https://doi.org/10.1182/blood-2019-128195
Published: 2019
Journal Articles

Proteomic Profiling and Mechanistic Investigating of a Novel Anti-Cancer Small Molecule Inhibitor of Sec61

Yu Qian, PhD, Henry W.B. Johnson, PhD, Christopher J. Kirk, PhD, Eric Lowe, BS, Dustin McMinn, PhD, Beatriz Millare, BS, Tony Muchamuel, MS, Jinhai Wang, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2076.
https://doi.org/10.1182/blood-2019-125988
Published: 2019
Journal Articles

The Role of SOD2 in Maintaining Endothelial Cell Function in SCD

Atinuke Dosunmu-Ogunbi, Yingze Zhang, PhD, Seyed Mehdi Nouraie, PhD MD, Adam Straub, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3563.
https://doi.org/10.1182/blood-2019-131238
Published: 2019
Journal Articles

This Is a Title in Title Case: Prediction of CML Evolution By Telomere Length Analysis at the Single-Chromosome Level

Jingyuan Lu, Yingxing Zhou, Xiaomei Yan, Quanyi Lu
Journal: Blood
Blood (2019) 134 (Supplement_1): 2937.
https://doi.org/10.1182/blood-2019-126895
Published: 2019
Journal Articles

Targeting the Plasma Cell Specific Purine Metabolic Enzyme, AMPD1, Induces Multiple Myeloma Cell Death Accompanying NAD Depletion

Yawara Kawano, MD PhD, Takayuki Sasano, Saki Kushima, Yuki Inada, Nao Nishimura, MD, Hiroyuki Hata, MD PhD, Masao Matsuoka, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3097.
https://doi.org/10.1182/blood-2019-125756
Published: 2019
Journal Articles

Characterization of Pathogenic Variants Associated with Hereditary Thrombocytopenias in Families from the Czech Republic

Zuzana Vrzalova, PhD, Katerina Stano Kozubik, PhD, Lenka Radova, PhD, Jakub Trizuljak, MD, Sarka Pospisilova, Prof PhD, Michael Doubek, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2343.
https://doi.org/10.1182/blood-2019-122696
Published: 2019
Journal Articles

Direct Visualization of Platelet Integrins Using ANTI-Transmembrane Domain Peptides Containing a BLUE Fluorescent Amino Acid

Karen Pei Yi Fong, PhD BS, Ismail A. Ahmed, PhD, Marco Mravic, B.S., M.S., Hyunil Jo, PhD, William F. DeGrado, PhD, Feng Gai, PhD, Joel S. Bennett, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2344.
https://doi.org/10.1182/blood-2019-128363
Published: 2019
Journal Articles

Over-Expression of Transferrin Receptor (TFRC/CD71) and Low Expression of Innate and Adaptive Immune Cell Subsets in HIV-Associated, GCB-DLBCL By Digital Gene Expression Profiling

Alanna Maguire, PhDMSc, Xianfeng Chen, BSc, Lee Wisner, A.A., Colleen Ramsower, B.S. M.B., Betty Glinsmann-Gibson, MS, Lisa M. Rimsza, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2783.
https://doi.org/10.1182/blood-2019-129346
Published: 2019
Journal Articles

Pharmacologic Normalization of Altered Transcriptome of SF3B1 Mutant Myeloid Neoplasia

Valeria Visconte, PhD, Vera Adema, PhD, Anand D. Tiwari, PhD, Cassandra M Kerr, MS, Hassan Awada, Bartlomiej Przychodzen, Allison Noe, Rachel Toth, Christina Snider, Yvonne Parker, Yuriy Fedorov, Drew Adams, Hetty E. Carraway, MD MBA, Anjali S. Advani, MD, Kevin R Kelly, MD PhD, Steffan T. Nawrocki, PhD, Jennifer S. Carew, PhD, Heesun J. Rogers, MD PhD, Daniel J. Lindner, Mikkael A. Sekeres, MD MS, James G Phillips, PhD, Jaroslaw P. Maciejewski, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 564.
https://doi.org/10.1182/blood-2019-129189
Published: 2019
Journal Articles

Pharmacological Inhibition of the RNA m 6 a Writer METTL3 As a Novel Therapeutic Strategy for Acute Myeloid Leukemia

Konstantinos Tzelepis, Etienne De Braekeleer, PhD MSc, Eliza Yankova, PhD, Justyna Rak, PhD, Demetrios Aspris, MSc, Ana Filipa Domingues, PhD, Richard Fosbeary, Alan Hendrick, PhD, Dan Leggate, PhD, Yaara Ofir-Rosenfeld, PhD, Alexandra Sapetschnig, PhD, Cristina Pina, MDDPhil, Mark Albertella, PhD, Wesley Blackaby, PhD, Oliver Rausch, PhD, George S. Vassiliou, FRCPath, MRCP, PhD, Tony Kouzarides, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 403.
https://doi.org/10.1182/blood-2019-127962
Published: 2019
Journal Articles

Effective Novel Fto Inhibitors Show Potent Anti-Cancer Efficacy and Suppress Drug Resistance

Rui Su, PhD, Lei Dong, PhD, Yangchan Li, Li Han, Min Gao, Mark Wunderlich, MS, Xiaolan Deng, Hongzhi Li, PhD, Lei Gao, Chenying Li, MD, Sean Robison, Brandon Tan, Ying Qing, Xi Qin, Emily Prince, Jun Xie, Hanjun Qin, Yue Huang, Wei Li, Chao Shen, PhD, Jie Sun, PhD, Kulkarni Prakash, Hengyou Weng, PhD, Huilin Huang, PhD, Zhenhua Chen, PhD, Bin Zhang, PhD, Xiwei Wu, PhD, Mark J Olsen, Markus Müschen, MD PhD, Guido Marcucci, MD, Salgia Ravi, Ling Li, PhD, Caiguang Yang, Zejuan Li, MD, James C Mulloy, Minjie Wei, David A Horne, PhD, Jianjun Chen, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 233.
https://doi.org/10.1182/blood-2019-124535
Published: 2019
Journal Articles

Development of Novel Second Generation DC/Tumor Fusion Vaccine in Lymphoma

Shira Orr, PhD, Marzia Capelletti, PhD MBBS, Haider Ghiasuddin, Dina Stroopinsky, PhD, Jessica Liegel, MD, Myrna Nahas, MD, Matthew Weinstock, MD, Adam Morin, Robin M. Joyce, MD, Salvia Jain, MD, Jon E. Arnason, MD, Maryam Rahimian, MD, Lina Bisharat, Shufen Meng, MD, Donald Kufe, MD, Jacalyn Rosenblatt, MD, David E. Avigan, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 392.
https://doi.org/10.1182/blood-2019-124768
Published: 2019
Journal Articles

Downregulation of Sprr1a Contributes to the Pathobiology of Sickle Cell Disease

Donovan A Argueta, BSc, Anupam Aich, PhD, Jianxun Lei, PhD, Sergei Nekhai, PhD, Tatiana Ammosova, PhD, Xionghao Lin, PhD, Anindya Bagchi, PhD, Kalpna Gupta, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 75.
https://doi.org/10.1182/blood-2019-129004
Published: 2019
Journal Articles

The Risk of Bleeding in Patients Receiving Ibrutinib Combined with Novel Direct Oral Anticoagulants

Michal Ariela Raz, MD, Jon E. Arnason, MD, Osnat Bairey, MD PhD, Lev Shvidel, MD, Ariel Aviv, MD, Sharon Ben Baruch, MD, Chava Perry, MD PhD, Nadav Sarid, MD, David Varon, MD, Ilya Kirgner, MD, Yair Herishanu, MD, Irit Avivi
Journal: Blood
Blood (2019) 134 (Supplement_1): 4314.
https://doi.org/10.1182/blood-2019-125356
Published: 2019
Journal Articles

Ironomycin Induces Diffuse Large B-Cell Lymphoma Cell Death By Targeting Iron Metabolism Addiction

Julie Devin, PharmD, Tatiana Cañeque, Yea-Lih Lin, PhD, Guillaume Cartron, Philippe Pasero, PhD, Caroline Bret, PhD PharmD, Raphael Rodriguez, Jerome Moreaux, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3960.
https://doi.org/10.1182/blood-2019-129954
Published: 2019
Journal Articles

Meds433, a New Dihydroorotate Dehydrogenase Inhibitor, Induces Apoptosis and Differentiation in Acute Myeloid Leukemia

Valentina Gaidano, MD, Paola Circosta, PhD, Alessandro Cignetti, MD PhD, Mohammad Houshmand, Nicoletta Vitale, PhD, Stefano Sainas, PhD, Agnese Pippione, PhD, Manuela Marraudino, PhD, Brigitta Bonaldo, MD, Marta Giorgis, PhD, Donatella Boschi, PhD, Marco Lucio Lolli, PhD, Giuseppe Saglio, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3942.
https://doi.org/10.1182/blood-2019-128085
Published: 2019
Journal Articles

PTPN11 Mutated Acute Myeloid Leukemia (AML) Features an Abundant Epichaperome Network and Is Sensitive to the Epichaperome Inhibitor PU-H71

Justin D. Kaner, MD, Montreh Tavakkoli, MA,MD, Lisa Toudic, Brett M. Stevens, PhD, Craig T Jordan, PhD, Tony Taldone, PhD, Gabriela Chiosis, PhD, Ellen K. Ritchie, MD, Pinkal Desai, MDMPH, Michael B. Samuel, MD, Sangmin Lee, MD, Gail J. Roboz, MD, Monica L. Guzman, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3935.
https://doi.org/10.1182/blood-2019-128276
Published: 2019
Journal Articles

Targeting Misfolded p53 and p53 Aggregation to Overcome Resistance to Apoptosis in Acute Myeloid Leukemia

Michael Andreeff, MD PhD, Jianfang Zeng, MD, Alice Soragni, PhD, Vivian Ruvolo, Bing Z Carter, PhD, Jo Ishizawa, MD PhD, Jared K. Burks, PhD, David Eisenberg, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3786.
https://doi.org/10.1182/blood-2019-130900
Published: 2019
Journal Articles

Prognostic Implications of Serum Monoclonal Protein Positivity By Mass-Fix in Bone Marrow Minimal Residual Disease Negative (MRD-) Patients with Multiple Myeloma

Jithma P. Abeykoon, MD, David L Murray, MD PhD, Isaiah Murray, Dragan Jevremovic, MD PhD, Angela Dispenzieri, MD, Bonnie Kaye Arendt, Surendra Dasari, PhD, Morie A Gertz, MD, Wilson I Gonsalves, MD, Taxiarchis Kourelis, MD, Eli Muchtar, MD, David Dingli, MD PhD, Rahma M Warsame, MD, Ronald S. Go, MD, Martha Q. Lacy, MD, Nelson Leung, MD, Francis K. Buadi, MB, CHB, Yi Lin, MD PhD, Robert A. Kyle, MD, S. Vincent Rajkumar, MD, Shaji K. Kumar, MD, Prashant Kapoor, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4386.
https://doi.org/10.1182/blood-2019-130771
Published: 2019
Journal Articles

Epichaperome Abundance Predicts Response to the Epichaperome Inhibitor, Puh-71, in Acute Myeloid Leukemia

Montreh Tavakkoli, MA,MD, Justin D. Kaner, MD, Sharma Sahil, PhD, Tony Taldone, PhD, Swathi Merugu, PhD, Gabriela Chiosis, PhD, Gail J. Roboz, MD, Monica L. Guzman, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5145.
https://doi.org/10.1182/blood-2019-125175
Published: 2019