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Journal Articles

Rac signaling in osteoblastic cells is required for normal bone development but is dispensable for hematopoietic development

Steven W. Lane, Serena De Vita, Kylie A. Alexander, Ruchan Karaman, Michael D. Milsom, Adrienne M. Dorrance, Amy Purdon, Leeann Louis, Mary L. Bouxsein, David A. Williams

Blood (2012) 119 (3): 736–744.

https://doi.org/10.1182/blood-2011-07-368753

Published: 2012

Includes: Supplemental data

Journal Articles

Intact Rac Signaling Is Important for Leukemia Cell Survival

Anja Troeger, MD, Pascal-David Johann, Mumine Senturk, Michael D. Milsom, PhD, David A. Williams, MD

Blood (2010) 116 (21): 2885.

https://doi.org/10.1182/blood.V116.21.2885.2885

Published: 2010

Journal Articles

Rac GTPases play critical roles in early T-cell development

Celine Dumont, Agnieszka Corsoni-Tadrzak, Sandra Ruf, Jasper de Boer, Adam Williams, Martin Turner, Dimitris Kioussis, Victor L. J. Tybulewicz

Blood (2009) 113 (17): 3990–3998.

https://doi.org/10.1182/blood-2008-09-181180

Published: 2009

Journal Articles

Rac GTPases Are Potential Therapeutic Targets in p210-BCR-ABL-Induced Myeloproliferative Disease (MPD).

Emily K. Thomas, PhD, Jose A. Cancelas, MD, PhD, Heedon Chae, PhD, Adrienne D. Cox, PhD, Patricia J. Keller, PhD, Danilo Perrotti, MD, PhD, Paolo Neviani, Brian J. Druker, MD, Yi Zheng, PhD, Chad E. Harris, David A. Williams, MD

Blood (2007) 110 (11): 465.

https://doi.org/10.1182/blood.V110.11.465.465

Published: 2007

Journal Articles

Rac1 and Rac2 GTPases Play Distinct Roles and Are Essential for Full Osteoclast Differentiation.

Matti Korhonen, MD, Haibo Zhao, PhD, Roberta Faccio, PhD, Patric F. Ross, PhD, Tracy M. Hopkins, Jose A. Cancelas, MD, David A. Williams, MD

Blood (2006) 108 (11): 4231.

https://doi.org/10.1182/blood.V108.11.4231.4231

Published: 2006

Journal Articles

Expansion of Normal and Leukemic Human Hematopoietic Stem/Progenitor Cells Requires Rac-Mediated Interaction with Stromal Cells.

Jan Jacob Schuringa, PhD, Marjan Rozenveld-Geugien, BSc, Inge Baas, MD/PhD, Djoke van Gosliga, BSc, Edo Vellenga, MD/PhD

Blood (2005) 106 (11): 1398.

https://doi.org/10.1182/blood.V106.11.1398.1398

Published: 2005

Journal Articles

Rac1 and Rac2 GTPases Play Distinct Roles and Are Essential for Full Osteoclast Differentiation.

Matti Korhonen, MD, Haibo Zhao, MD, PhD, Roberta Faccio, PhD, F. Patrick Ross, PhD, Tracy M. Hopkins, MS, Jose A. Cancelas, MD, Steven L. Teitelbaum, MD, David A. Williams, MD

Blood (2005) 106 (11): 67.

https://doi.org/10.1182/blood.V106.11.67.67

Published: 2005

Journal Articles

Inhibition of the Rho GTPase, Rac, Differentially Inhibits Proliferation of AML Cell Lines and May Serve as a Novel Molecular Target.

Reuven J. Schore, MD, Yi Zheng, PhD, David A. Williams, MD, Yi Gu, PhD

Blood (2005) 106 (11): 1205.

https://doi.org/10.1182/blood.V106.11.1205.1205

Published: 2005

Journal Articles

Rac1 and Rac2 Rho GTPases Distinctly Regulate Stem Cell Engraftment and Mobilization and Are Novel Targets for Pharmacologically-Induced Progenitor Mobilization.

Jose A. Cancelas, MD, PhD, Andrew W. Lee, BS, Rethinasamy Prabhakar, PhD, Michael Jansen, PhD, YI Zheng, PhD, David A. Williams, MD

Blood (2004) 104 (11): 115.

https://doi.org/10.1182/blood.V104.11.115.115

Published: 2004

Journal Articles

RhoH, a Hematopoietic-Specific Rho Gtpase, Regulates Proliferation, Survival, Migration and Engraftment of Hematopoietic Progenitor Cells.

Yi Gu, Ph.D., Aparna C. Jasti, M.S., Michael Jansen, Ph.D., Jamie E. Siefring, B.S., Katherine E. Lee

Blood (2004) 104 (11): 116.

https://doi.org/10.1182/blood.V104.11.116.116

Published: 2004

Journal Articles

Rhogtpase RAC2 Is Required for In Vivo Transformation Activity by P210 Bcr-Abl Fusion Oncogene.

Nithya Krishnan, PhD, Jeff R. Bailey, Victoria Summey-Harner, Claudio Brunstein, PhD, Catherine M. Verfaillie, MD, David A. Williams, MD

Blood (2004) 104 (11): 717.

https://doi.org/10.1182/blood.V104.11.717.717

Published: 2004

Journal Articles

P-21 Activated Kinase 1 (Pak1) Is Critical for Normal Mast Cell Degranulation and Cytokine Production in Response to Antigen Stimulation of the High Affinity IgE Receptor.

Jayme D. Allen, M.D., Clemens Hoffman, Ph.D, Ethel Derr-Yellin, Waylan Bessler, Fen-Chun Yang, M.D., Ph.D., David A. Ingram, M.D., Zahra Jaffer, Ph.D., Amanda Tipton, Johnathan Chernoff, M.D., Ph.D., D. Wade Clapp, M.D.

Blood (2004) 104 (11): 647.

https://doi.org/10.1182/blood.V104.11.647.647

Published: 2004

Journal Articles

The TRQQKRP motif located near the C-terminus of Rac2 is essential for Rac2 biologic functions and intracellular localization

Wen Tao, Marie-Dominique Filippi, Jeffrey R. Bailey, Simon J. Atkinson, Bret Connors, Andrew Evan, David A. Williams

Blood (2002) 100 (5): 1679–1688.

https://doi.org/10.1182/blood.V100.5.1679.h81702001679_1679_1688

Published: 2002

NARROW

Rac signaling in osteoblastic cells is required for normal bone development but is dispensable for hematopoietic development

Intact Rac Signaling Is Important for Leukemia Cell Survival

Rac GTPases play critical roles in early T-cell development

Rac GTPases Are Potential Therapeutic Targets in p210-BCR-ABL-Induced Myeloproliferative Disease (MPD).

Rac1 and Rac2 GTPases Play Distinct Roles and Are Essential for Full Osteoclast Differentiation.

Expansion of Normal and Leukemic Human Hematopoietic Stem/Progenitor Cells Requires Rac-Mediated Interaction with Stromal Cells.

Rac1 and Rac2 GTPases Play Distinct Roles and Are Essential for Full Osteoclast Differentiation.

Inhibition of the Rho GTPase, Rac, Differentially Inhibits Proliferation of AML Cell Lines and May Serve as a Novel Molecular Target.

Rac1 and Rac2 Rho GTPases Distinctly Regulate Stem Cell Engraftment and Mobilization and Are Novel Targets for Pharmacologically-Induced Progenitor Mobilization.

RhoH, a Hematopoietic-Specific Rho Gtpase, Regulates Proliferation, Survival, Migration and Engraftment of Hematopoietic Progenitor Cells.

Rhogtpase RAC2 Is Required for In Vivo Transformation Activity by P210 Bcr-Abl Fusion Oncogene.

P-21 Activated Kinase 1 (Pak1) Is Critical for Normal Mast Cell Degranulation and Cytokine Production in Response to Antigen Stimulation of the High Affinity IgE Receptor.

The TRQQKRP motif located near the C-terminus of Rac2 is essential for Rac2 biologic functions and intracellular localization

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American Society of Hematology

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ASH Publications

American Society of Hematology

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