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Journal Articles

Loss of Phospholipase C Gamma 1 (PLCG1) Impairs AML1-ETO Induced Leukemia Stem Cell Self-Renewal

Blood (2019) 134 (Supplement_1): 531.

https://doi.org/10.1182/blood-2019-121996

Published: 2019

Journal Articles

Ongoing Results of a Phase 1B/2 Dose-Escalation and Cohort-Expansion Study of the Selective, Noncovalent, Reversible Bruton'S Tyrosine Kinase Inhibitor, Vecabrutinib, in B-Cell Malignancies

John N. Allan, MD, Krish Patel, MD, Anthony R. Mato, MDMSCE, William G. Wierda, MD PhD, Javier Pinilla Ibarz, MD PhD, Michael Y. Choi, MD, Susan M. O'Brien, MD, Jeff P. Sharman, MD, Mazyar Shadman, MD, Douglas E Gladstone, MD, Matthew S. Davids, MD, John M. Pagel, MD PhD DSc, Renee Ward, MD PhD, Gary Acton, MD, Pietro Taverna, PhD, Judith A. Fox, PhD, Richard R. Furman, MD, Jennifer R. Brown, MD PhD

Blood (2019) 134 (Supplement_1): 3041.

https://doi.org/10.1182/blood-2019-126286

Published: 2019

Journal Articles

Ibrutinib Selects for Cells with Elevated Reactive Oxygen Species and Downregulated Phosphatases

Nathan Camp, PhD, Meghan Garrett, Ajay K. Gopal, MD, Richard James, PhD

Blood (2019) 134 (Supplement_1): 3795.

https://doi.org/10.1182/blood-2019-124454

Published: 2019

Journal Articles

Dual Inhibition of PI3K-δ and PI3K-γ By Duvelisib Eliminates CLL B Cells, Impairs CLL-Supporting Cells, and Overcomes Ibrutinib Resistance in a Patient-Derived Xenograft Model

Shih-Shih Chen, PhD, Jeffery Lorne Kutok, MD PhD, Gerardo Ferrer, PhD, Priyadarshini Ravichandran, Michael Ibrahim, Yasmine Kieso, MSCR, Jacqueline C Barrientos, MD MS, David T. Weaver, PhD, Jonathan A Pachter, PhD, Kanti R Rai, MD, Nicholas Chiorazzi, MD

Blood (2018) 132 (Supplement 1): 4420.

https://doi.org/10.1182/blood-2018-99-109853

Published: 2018

Journal Articles

Halofuginone Exerts Antileukemic Effects in TP53 Mutated Cell Lines

Larissa Cândido, Carol Hassibe Thomé, Cleide Lucia de Araújo Silva, Daniel Antunes Moreno, Isabel Weinhäuser, Luciana Yamamoto de Almeida, Camila Bonaldo, Eduardo Magalhães Rego, MDPhD, Arnon Nagler, MD, Diego Antonio Pereira-Martins

Blood (2017) 130 (Supplement 1): 5572.

https://doi.org/10.1182/blood.V130.Suppl_1.5572.5572

Published: 2017

Journal Articles

Essential Role for Phospholipase C Gamma 1 (PLC-γ1) in the Survival of t(8;21) Acute Myeloid Leukemia

Hasan Mahmud, PhD, Frank JG Scherpen, Tiny Meeuwsen-de Boer, Harm-Jan Lourens, Eveline S. de Bont

Blood (2016) 128 (22): 1699.

https://doi.org/10.1182/blood.V128.22.1699.1699

Published: 2016

Journal Articles

Myeloid Leukemia Stem Cells Depend on Phospholipase C Gamma 1 (Plcg1) Signaling

Tina M. Schnoeder, PhD, Patricia Arreba-Tutusaus, MSc, BS, Juliane Mohr, PhD, Soenke Weinert, PhD, Stephanie Frey, Anja Sammt, Lars Bullinger, MD, Florian H. Heidel, MD

Blood (2016) 128 (22): 1202.

https://doi.org/10.1182/blood.V128.22.1202.1202

Published: 2016

Journal Articles

High Sensitivity Testing Shows Multiclonal Mutations in Patients with CLL Treated with BTK Inhibitor and Lack of Mutations in Ibrutinib-Naive Patients

Adam Albitar, Wanlong Ma, BS, Ivan De Dios, Jeffrey Estrella, Mohammed Farooqui, DO, Adrian Wiestner, MD PhD, Maher Albitar

Blood (2015) 126 (23): 716.

https://doi.org/10.1182/blood.V126.23.716.716

Published: 2015

Journal Articles

Kinome Profiling Identifies Phospholipase C Gamma 1 (PLCγ1) As a Potential Target for t(8;21) AML

Hasan Mahmud, PhD, Frank JG Scherpen, Tiny Meeuwsen-de Boer, Harm Jan Lourens, Eveline S. de Bont

Blood (2015) 126 (23): 1384.

https://doi.org/10.1182/blood.V126.23.1384.1384

Published: 2015

Journal Articles

A Novel Inhibitor of BET Family Bromodomains Demonstrates In Vivo and I n Vi tro Potency in B-Cell Malignancies

Dalia El-Gamal, PhD, Zachary A. Hing, BS, Shaneice Mitchell, BS, Taylor D. LaFollette, Paul J. Brennan, Joseph M. Flynn, DO, MPH, Jeffrey A. Jones, MD MPH, Farrukh Awan, MD MS, Leslie A. Andritsos, MD, James S. Blachly, MD, Katie Williams, MS, Bonnie K. Harrington, DVM, Virginia M. Goettl, DVM, PhD, Jennifer A. Woyach, MD, Amy M. Lehman, MAS, Lianbo Yu, PhD, John C. Byrd, MD, Rosa Lapalombella, PhD

Blood (2015) 126 (23): 318.

https://doi.org/10.1182/blood.V126.23.318.318

Published: 2015

Journal Articles

Smoothened (SMO) Is an Adaptor Protein That Recruits TRAF6 and Phospholipase C Gamma 2 (PLCg2) to Enhance the Activation of NF-Kb Signaling Pathway

Nitin Agarwal, PhD, Chae Hwa Kim, MD, Kranthi Kunkalla, MS, Gloria Yang, Youley Tjendra, MD, Yadong Liu, MD, Changju Qu, MDPhD, Francisco Vega, MD PhD

Blood (2015) 126 (23): 3907.

https://doi.org/10.1182/blood.V126.23.3907.3907

Published: 2015

Journal Articles

Bruton's Tyrosine Kinase Inhibition Is Associated with Manageable Cardiac Toxicity

Alison Romisher, Joseph Carver, MD, Stephen J. Schuster, MD, Jakub Svoboda, MD, Alexandra Vandegrift, BA, Allison Rago, BSN, Rupal O'Quinn, MD, Bonnie Ky, MD, Anthony R. Mato, MD

Blood (2015) 126 (23): 4529.

https://doi.org/10.1182/blood.V126.23.4529.4529

Published: 2015

Journal Articles

Combination of Ibrutinib and BCL-2 or SYK Inhibitors in Ibrutinib Resistant ABC-Subtype of Diffuse Large B-Cell Lymphoma

Hsu-Ping Kuo, Richard Crowley, Ling Xue, Karl J. Schweighofer, Leo WK. Cheung, Sidney Hsieh, Karl Eckert, BA, Matthias Versele, Betty Y. Chang

Blood (2014) 124 (21): 505.

https://doi.org/10.1182/blood.V124.21.505.505

Published: 2014

Journal Articles

Epo-Induced Erythroid Maturation Is Dependent On Plcγ1 Signalling

Tina M Schnoeder, PhD, Patricia Arreba-Tutusaus, MSc, Inga Griehl, cand. med., Lars Bullinger, MD, PhD, Konstanze Doehner, MD, Christoph Plass, PhD, Daniel B Lipka, MD, Florian H Heidel, MD, Thomas Fischer, M.D. Ph.D.

Blood (2013) 122 (21): 1182.

https://doi.org/10.1182/blood.V122.21.1182.1182

Published: 2013

Journal Articles

Identification of Phospholipase C Gamma 1 As a Key Regulator of Erythropoiesis

Tina M Schnoeder, PhD, Patricia Arreba-Tutusaus, MSc, Inga Griehl, cand. med., Daniel B Lipka, MD, Florian H Heidel, MD, Thomas Fischer, MD

Blood (2012) 120 (21): 4744.

https://doi.org/10.1182/blood.V120.21.4744.4744

Published: 2012

Journal Articles

In Vivo Screening for Tumor Suppressors In Hematological Malignancies Using Barcode RNAi

Roland Jäger, Markus Muellner, Florian Grebien, Thorsten Klampfl, Ashot Harutyunyan, Damla Olcaydu, Tiina Berg, Sebastian Nijman, Robert Kralovics

Blood (2010) 116 (21): 998.

https://doi.org/10.1182/blood.V116.21.998.998

Published: 2010

Journal Articles

PTEN Regulates SYK-Directed AKT Activation in MCL.

Martina Rudelius, MD, Stefania Pittaluga, MD, PhD, Denise Sebasigari, Theresa Davies-Hill, Margit Klier, Leticia Quintanilla-Martinez, MD, Falko Fend, Prof, Yoko Tabe, Mark Raffeld, MD

Blood (2009) 114 (22): 2941.

https://doi.org/10.1182/blood.V114.22.2941.2941

Published: 2009

Journal Articles

Targeting Btk in Lymphoma: PCI-32765 Inhibits Tumor Growth in Mouse Lymphoma Models and a Fluorescent Analog of PCI-32765 Is an Active-Site Probe That Enables Assessment of Btk Inhibition In Vivo .

Lee A. Honigberg, PhD, Ashley M. Smith, B.S., Jun Chen, Ph.D., Patti Thiemann, B.S., Erik Verner, Ph.D.

Blood (2007) 110 (11): 1592.

https://doi.org/10.1182/blood.V110.11.1592.1592

Published: 2007

Journal Articles

ZAP-70 Enhances IgM Signaling in Chronic Lymphocytic Leukemia Cells Independent of Its Tyrosine Kinase Activity.

Liguang Chen, PhD, MD, Lang Huynh, Arthur Weiss, PhD,MD, Thomas J. Kipps, PhD,MD

Blood (2006) 108 (11): 585.

https://doi.org/10.1182/blood.V108.11.585.585

Published: 2006

Journal Articles

Identification of a Novel Pathway in BCR/ABL Signal Transduction Involving Akt-Independent Activation of PLC-gamma/mTOR/p70-S6K.

Boyka Markova, Christoph Huber, Thomas Fischer

Blood (2006) 108 (11): 2120.

https://doi.org/10.1182/blood.V108.11.2120.2120

Published: 2006

NARROW

Loss of Phospholipase C Gamma 1 (PLCG1) Impairs AML1-ETO Induced Leukemia Stem Cell Self-Renewal

Ongoing Results of a Phase 1B/2 Dose-Escalation and Cohort-Expansion Study of the Selective, Noncovalent, Reversible Bruton'S Tyrosine Kinase Inhibitor, Vecabrutinib, in B-Cell Malignancies

Ibrutinib Selects for Cells with Elevated Reactive Oxygen Species and Downregulated Phosphatases

Dual Inhibition of PI3K-δ and PI3K-γ By Duvelisib Eliminates CLL B Cells, Impairs CLL-Supporting Cells, and Overcomes Ibrutinib Resistance in a Patient-Derived Xenograft Model

Halofuginone Exerts Antileukemic Effects in TP53 Mutated Cell Lines

Essential Role for Phospholipase C Gamma 1 (PLC-γ1) in the Survival of t(8;21) Acute Myeloid Leukemia

Myeloid Leukemia Stem Cells Depend on Phospholipase C Gamma 1 (Plcg1) Signaling

High Sensitivity Testing Shows Multiclonal Mutations in Patients with CLL Treated with BTK Inhibitor and Lack of Mutations in Ibrutinib-Naive Patients

Kinome Profiling Identifies Phospholipase C Gamma 1 (PLCγ1) As a Potential Target for t(8;21) AML

A Novel Inhibitor of BET Family Bromodomains Demonstrates In Vivo and I n Vi tro Potency in B-Cell Malignancies

Smoothened (SMO) Is an Adaptor Protein That Recruits TRAF6 and Phospholipase C Gamma 2 (PLCg2) to Enhance the Activation of NF-Kb Signaling Pathway

Bruton's Tyrosine Kinase Inhibition Is Associated with Manageable Cardiac Toxicity

Combination of Ibrutinib and BCL-2 or SYK Inhibitors in Ibrutinib Resistant ABC-Subtype of Diffuse Large B-Cell Lymphoma

Epo-Induced Erythroid Maturation Is Dependent On Plcγ1 Signalling

Identification of Phospholipase C Gamma 1 As a Key Regulator of Erythropoiesis

In Vivo Screening for Tumor Suppressors In Hematological Malignancies Using Barcode RNAi

PTEN Regulates SYK-Directed AKT Activation in MCL.

Targeting Btk in Lymphoma: PCI-32765 Inhibits Tumor Growth in Mouse Lymphoma Models and a Fluorescent Analog of PCI-32765 Is an Active-Site Probe That Enables Assessment of Btk Inhibition In Vivo .

ZAP-70 Enhances IgM Signaling in Chronic Lymphocytic Leukemia Cells Independent of Its Tyrosine Kinase Activity.

Identification of a Novel Pathway in BCR/ABL Signal Transduction Involving Akt-Independent Activation of PLC-gamma/mTOR/p70-S6K.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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