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Journal Articles

Increased oxygen affinity: to have and to hold

Charles T. Quinn, Russell E. Ware

Blood (2021) 138 (13): 1094–1095.

https://doi.org/10.1182/blood.2021013243

Published: 2021

Journal Articles

Treatment of sickle cell disease by increasing oxygen affinity of hemoglobin

Eric R. Henry, Belhu Metaferia, Quan Li, Julia Harper, Robert B. Best, Kristen E. Glass, Troy Cellmer, Emily B. Dunkelberger, Anna Conrey, Swee Lay Thein, H. Franklin Bunn, William A. Eaton

Blood (2021) 138 (13): 1172–1181.

https://doi.org/10.1182/blood.2021012070

Published: 2021

Includes: Supplemental data

Journal Articles

PP-14, a Novel Structurally-Enhanced Antisickling Allosteric Hemoglobin Effector, Increases Oxygen Affinity and Disrupts Hemoglobin S Polymer Formation

Martin K. Safo, PhD, Piyusha P Pagare, PhD, Mohini Ghatge, PhD, Carla Casu, PhD, Valentina Ghiaccio, PhD, Nancy Anabaraonye, Xiaomeng Xu, MS, Stefano Rivella, PhD, Patrick C. Hines, MD PhD, Ke Liu, PhD, Yan Zhang, PhD, Jürgen Venitz, MD PhD, Osheiza Abdulmalik, DVM

Blood (2019) 134 (Supplement_1): 73.

https://doi.org/10.1182/blood-2019-128646

Published: 2019

Journal Articles

Results from Part A of the Hemoglobin Oxygen Affinity Modulation to Inhibit HbS Polymerization (HOPE) Trial (GBT440-031), a Placebo-Controlled Randomized Study Evaluating Voxelotor (GBT440) in Adults and Adolescents with Sickle Cell Disease

Blood (2018) 132 (Supplement 1): 505.

https://doi.org/10.1182/blood-2018-99-118508

Published: 2018

Journal Articles

Thromboembolic and Vascular Complications in Patients with Secondary Erythrocytosis Caused By High Oxygen Affinity Variant Hb Coimbra

Bruna Cunha Santos, Susan Elisabeth Jorge, BS, PhD, Dulcinéia Martins de Albuquerque, Simone Cristina Olenscki Gilli, MD PhD, Maria de Fátima Sonati, Kleber Yotsumoto Fertrin, MD PhD, Fernando Ferreira Costa, MD PhD

Blood (2017) 130 (Supplement 1): 3526.

https://doi.org/10.1182/blood.V130.Suppl_1.3526.3526

Published: 2017

Journal Articles

GTx011, a Potent Allosteric Modifier of Hemoglobin Oxygen Affinity, Prevents RBC Sickling in Whole Blood and Prolongs RBC Half-Life in Vivo in a Murine Model of Sickle Cell Disease

Kobina Dufu, PhD, Donna Oksenberg, PhD, Chengjing Zhou, Athiwat Hutchaleelaha, PhD, David R. Archer, PhD

Blood (2014) 124 (21): 217.

https://doi.org/10.1182/blood.V124.21.217.217

Published: 2014

Journal Articles

GTx011, a Novel Agent That Improves Rheological Properties Of Sickle Cell Blood By Increasing Oxygen Affinity For Hemoglobin

Mira Patel, PhD, Donna Oksenberg, PhD, Abel Silva, BS, Andreas Betz, PhD, Brian Metcalf, PhD, Uma Sinha, PhD

Blood (2013) 122 (21): 2207.

https://doi.org/10.1182/blood.V122.21.2207.2207

Published: 2013

Journal Articles

Thiocarbmoylation Chemistry Based Pegylation Of αα Fumaryl-Hb Is Unique As It Does Not Induce An Increase In Oxygen Affinity: High Oxygen Affinity Pegylated Crosslinked Hbs Are Better As Oxygen Therapeutics

Fantao Meng, PhD, Amy Tsai, PhD, Marcos Intaglietta, PhD, Seetharama A. Acharya, PhD

Blood (2013) 122 (21): 1164.

https://doi.org/10.1182/blood.V122.21.1164.1164

Published: 2013

Journal Articles

GTx011, a Potent Allosteric Modifier Of Hemoglobin Oxygen Affinity, Delays Polymerization and Prevents Sickling

Kobina Dufu, PhD, Donna Oksenberg, PhD, Brian Metcalf, PhD, Uma Sinha, PhD

Blood (2013) 122 (21): 316.

https://doi.org/10.1182/blood.V122.21.316.316

Published: 2013

Journal Articles

A Phase 1, First-in-Man, Dose-Response Study of Aes-103 (5-HMF), an Anti-Sickling, Allosteric Modifier of Hemoglobin Oxygen Affinity in Healthy Norman Volunteers

Warren Stern, Ph.D., David Mathews, M.D., John McKew, Ph.D., Xiqgiang Shen, Ph.D., Gregory J. Kato, M.D.

Blood (2012) 120 (21): 3210.

https://doi.org/10.1182/blood.V120.21.3210.3210

Published: 2012

Journal Articles

Effect of Aes-103 Anti-Sickling Agent On Oxygen Affinity and Stability of Red Blood Cells From Patients with Sickle Cell Anemia

Laurel G. Mendelsohn, M.S., Leah Pedoeim, BS, Eduard J. van Beers, MD, PhD, Rehan Saiyed, BS, James S Nichols, RN, Xunde Wang, Ph.D., Gregory J. Kato, M.D.

Blood (2012) 120 (21): 85.

https://doi.org/10.1182/blood.V120.21.85.85

Published: 2012

Journal Articles

Investigation of the Molecular Basis of High Oxygen Affinity Hemoglobin Brigham (α 2 A β 2 100 Pro→Leu ) In a Subject with Familial Erythrocytosis

Bindu Abraham, Yiping Jia, Francine Wood, Chad Reiter, Jay Nelson Lozier, Jeffery L. Miller, Abdu Alayash

Blood (2010) 116 (21): 4806.

https://doi.org/10.1182/blood.V116.21.4806.4806

Published: 2010

Journal Articles

Hydroxyurea Induces Expression of HbF and Increase of P50 in High Oxygen Affinity Hemoglobinopathy.

Ghislain Cournoyer, MD, Harry Bard, MD, Xiaoduan Weng, MD, PhD, Louise Robin, TM, Carmen Gagnon, BSc, Denis Soulieres, MD, MSc

Blood (2004) 104 (11): 3730.

https://doi.org/10.1182/blood.V104.11.3730.3730

Published: 2004

Journal Articles

Sickle Cell Patietns with a High Percentage of HBF-Containing RBC (F Cells) Have Shorter Survival of RBC that Lack HBF.

Robert Suez Franco, Ph.D., Peter Ciraolo, M.S., Mary B. Palascak, B.S., Clinton H. Joiner, M.D., Ph.D., Zahida Yasin, M.D., Donald L. Rucknagel, M.D., Ph.D.

Blood (2004) 104 (11): 3588.

https://doi.org/10.1182/blood.V104.11.3588.3588

Published: 2004

Journal Articles

Finding of 8 New Therapeutic Agents by the Use of New High-Throughput Drug Screening Methods Established by the Nhlbi Sicke Cell Disease Reference Laboratory.

Toshio Asakura, MD, PhD, Osheiza Abdulmalik, DVM, Efe Iyamu, PhD, Qiukan Chen, MD, Jisheng Yang, Carlo Brugnara, MD, Greg Evans, PhD

Blood (2004) 104 (11): 3751.

https://doi.org/10.1182/blood.V104.11.3751.3751

Published: 2004

Journal Articles

Amino Acids Responsible for Decreased 2, 3-Biphosphosphoglycerate Binding to Fetal Hemoglobin

Kazuhiko Adachi, Patrick Konitzer, Jian Pang, Konda S. Reddy, Saul Surrey

Blood (1997) 90 (8): 2916–2920.

https://doi.org/10.1182/blood.V90.8.2916

Published: 1997

Journal Articles

A Transgenic Mouse Model of Hemoglobin S Antilles Disease

R.A. Popp, D.M. Popp, S.G. Shinpock, M.Y. Yang, J.G. Mural, M.d.P. Aguinaga, P. Kopsombut, P.D. Roa, E.A. Turner, E.M. Rubin

Blood (1997) 89 (11): 4204–4212.

https://doi.org/10.1182/blood.V89.11.4204

Published: 1997

Journal Articles

Hemoglobin Ohio (beta 142 Ala replaced by): a new abnormal hemoglobin with high oxygen affinity and erythrocytosis

WF Moo-Penn, RG Schneider, T Shih, RT Jones, S Govindarajan, PG Govindarajan, LC Patchen

Blood (1980) 56 (2): 246–250.

https://doi.org/10.1182/blood.V56.2.246.246

Published: 1980

Journal Articles

Methemoglobin reduction in red cells: effect of a high oxygen affinity hemoglobin

F Taketa, KJ Matteson, JY Chen, JA Libnoch

Blood (1980) 55 (1): 116–118.

https://doi.org/10.1182/blood.V55.1.116.116

Published: 1980

NARROW

Increased oxygen affinity: to have and to hold

Treatment of sickle cell disease by increasing oxygen affinity of hemoglobin

PP-14, a Novel Structurally-Enhanced Antisickling Allosteric Hemoglobin Effector, Increases Oxygen Affinity and Disrupts Hemoglobin S Polymer Formation

Results from Part A of the Hemoglobin Oxygen Affinity Modulation to Inhibit HbS Polymerization (HOPE) Trial (GBT440-031), a Placebo-Controlled Randomized Study Evaluating Voxelotor (GBT440) in Adults and Adolescents with Sickle Cell Disease

Thromboembolic and Vascular Complications in Patients with Secondary Erythrocytosis Caused By High Oxygen Affinity Variant Hb Coimbra

GTx011, a Potent Allosteric Modifier of Hemoglobin Oxygen Affinity, Prevents RBC Sickling in Whole Blood and Prolongs RBC Half-Life in Vivo in a Murine Model of Sickle Cell Disease

GTx011, a Novel Agent That Improves Rheological Properties Of Sickle Cell Blood By Increasing Oxygen Affinity For Hemoglobin

Thiocarbmoylation Chemistry Based Pegylation Of αα Fumaryl-Hb Is Unique As It Does Not Induce An Increase In Oxygen Affinity: High Oxygen Affinity Pegylated Crosslinked Hbs Are Better As Oxygen Therapeutics

GTx011, a Potent Allosteric Modifier Of Hemoglobin Oxygen Affinity, Delays Polymerization and Prevents Sickling

A Phase 1, First-in-Man, Dose-Response Study of Aes-103 (5-HMF), an Anti-Sickling, Allosteric Modifier of Hemoglobin Oxygen Affinity in Healthy Norman Volunteers

Effect of Aes-103 Anti-Sickling Agent On Oxygen Affinity and Stability of Red Blood Cells From Patients with Sickle Cell Anemia

Investigation of the Molecular Basis of High Oxygen Affinity Hemoglobin Brigham (α 2 A β 2 100 Pro→Leu ) In a Subject with Familial Erythrocytosis

Hydroxyurea Induces Expression of HbF and Increase of P50 in High Oxygen Affinity Hemoglobinopathy.

Sickle Cell Patietns with a High Percentage of HBF-Containing RBC (F Cells) Have Shorter Survival of RBC that Lack HBF.

Finding of 8 New Therapeutic Agents by the Use of New High-Throughput Drug Screening Methods Established by the Nhlbi Sicke Cell Disease Reference Laboratory.

Amino Acids Responsible for Decreased 2, 3-Biphosphosphoglycerate Binding to Fetal Hemoglobin

A Transgenic Mouse Model of Hemoglobin S Antilles Disease

Hemoglobin Ohio (beta 142 Ala replaced by): a new abnormal hemoglobin with high oxygen affinity and erythrocytosis

Methemoglobin reduction in red cells: effect of a high oxygen affinity hemoglobin

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American Society of Hematology

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American Society of Hematology

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