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Journal Articles

CRISPR-Cas9 Genome Editing of γ-Globin Promoters in Human Hematopoietic Stem Cells to Induce Erythrocyte Fetal Hemoglobin for Treatment of β-Hemoglobinopathies

Blood (2019) 134 (Supplement_1): 2066.

https://doi.org/10.1182/blood-2019-131318

Published: 2019

Journal Articles

Mutant ASXL1 Disrupts Paraspeckle Formation through Aberrant Interaction with Nono in Hematopoietic Cells

Yamamoto Keita, MD, Susumu Goyama, MD PhD, Shuhei Asada, MD PhD, Takeshi Fujino, MD, Tomofusa Fukuyama, MD PhD, Yosuke Tanaka, MD, Ayana Kon, MD PhD, Yasuhito Nannya, MD PhD, Seishi Ogawa, MD PhD, Reina Onoguchi, PhD, Nobuyoshi Akimitsu, PhD, Toshio Kitamura, MD PhD

Blood (2019) 134 (Supplement_1): 2514.

https://doi.org/10.1182/blood-2019-125472

Published: 2019

Journal Articles

Distinct Implications of TP53 Hits for Patients with Treatment-Related MDS and AML

Teodora Kuzmanovic, Bhumika J. Patel, MD, Yasunobu Nagata, Hassan Awada, MD, Cassandra M. Hirsch, Bartlomiej P. Przychodzen, Srinivasa Reddy Sanikommu, MD, Louis Williams, MD MBA, Sudipto Mukherjee, MD PhD MPH, Anjali S. Advani, MD, Aziz Nazha, Aaron T. Gerds, MD MS, Tomas Radivoyevitch, PhD, Hetty E. Carraway, MD MBA, Mikkael A. Sekeres, MD MS, Jaroslaw P. Maciejewski

Blood (2018) 132 (Supplement 1): 4353.

https://doi.org/10.1182/blood-2018-99-120059

Published: 2018

Journal Articles

NPM1c Alters FLT3-D835Y Localization and Signaling Thereby Inducing a Fulminant Myeloproliferative Disorder in Mice

Alina Rudorf, MSc, Tony Andreas Müller, PhD, Cathrin Klingeberg, PhD, George S. Vassiliou, MD PhD, Allan Bradley, PhD, Robert Zeiser, MD, Justus Duyster, Anna Lena Illert, MD

Blood (2017) 130 (Supplement 1): 303.

https://doi.org/10.1182/blood.V130.Suppl_1.303.303

Published: 2017

Journal Articles

DNA Damaging Agents Cause a Sub-Cellular Re-Localisation of Nucleophosmin in an npm1 Mutated Acute Myeloid Leukemia (AML) Cell Line and in Primary AML Cells Carrying an npm1 Mutation

Graham D. Bailey, PhD, Asma Akhtar, BSc, Nigel H. Russell, Claire Seedhouse, PhD

Blood (2017) 130 (Supplement 1): 1251.

https://doi.org/10.1182/blood.V130.Suppl_1.1251.1251

Published: 2017

Journal Articles

Expanded Phenotypic and Genetic Heterogeneity in the Clinical Spectrum of FPD-AML: Lymphoid Malignancies and Skin Disorders Are Common Features in Carriers of Germline RUNX1 Mutations

Anna L Brown, PhD, Christopher N Hahn, PhD, Catherine Carmichael, Ella Wilkins, Milena Babic, BMPharBio (Hons), Chan-Eng Chong, PhD, Xiao-Chun Li, Joelle Michaud, Ping Cannon, Nicola Poplawski, MBChB, DipPaed, FRACP, MD, Meryl Altree, Kerry Phillips, Louise Jaensch, Miriam Fine, Andreas W Schreiber, PhD, Jinghua Feng, PhD, Lesley Rawlings, PhD, Cassandra Vakulin, Carolyn Butcher, Richard D'Andrea, PhD, Ian D Lewis, MBBS, PhD FRACP, FRCPA, Nigel Patton, Cecily Forsyth, MBBS, FRACP, FRCPA, Sally Mapp, PhD MD, Helen Mar Fan, Rachel Susman, Sue Morgan, FRACP, FRCPA, MBBS, Julian Cooney, MD, Mark S Currie, MD, Uday R. Popat, MD, Kenneth Bradstock, MBBS, PhD, April D. Sorrell, MD, Carolyn J. Owen, MD MDes(UK), FRCPC, Marshall S Horwitz, MD PhD, Devendra Hiwase, MBBS, FRACP, FRCPA, MD PhD, Alwin Krämer, MD, Stefan Fröhling, MD, Lucy A Godley, MD PhD, Jane E Churpek, MD, Hamish S Scott, BSc, PhD FFSc (RCPA), FAHMS

Blood (2016) 128 (22): 1212.

https://doi.org/10.1182/blood.V128.22.1212.1212

Published: 2016

Journal Articles

Nuclear Import of Janus Kinase 1 Is Mediated By Multiple Alpha Importins and Is Required for the Survival of Diffuse Large B-Cell Lymphoma

Lixin Rui, PhD

Blood (2016) 128 (22): 780.

https://doi.org/10.1182/blood.V128.22.780.780

Published: 2016

Journal Articles

A Peptide Nucleic Acid Targeting Nuclear Rad51 Sensitizes Myeloma Cells to Melphalan Chemotoxicity Both in Vitro and in Vivo

David Alagpulinsa, BPham, Srinivas Ayyadevara, PhD, Shmuel Yaccoby, PhD, Robert shmookler Reis, DPhil

Blood (2014) 124 (21): 3529.

https://doi.org/10.1182/blood.V124.21.3529.3529

Published: 2014

Journal Articles

Expression of the ETS Transcription Factor GABPα Is Correlated to BCR-ABL/ABL ratio in Human CML and Mediates Imatinib Sensitivity

Georgi Manukjan, MSc, Tim Ripperger, MDPhD, Laura Santer, BSc, Nils von Neuhoff, PhD, Arnold Ganser, MD, Axel Schambach, MDPhD, Brigitte Schlegelberger, MD, Doris Steinemann, PhD

Blood (2014) 124 (21): 1787.

https://doi.org/10.1182/blood.V124.21.1787.1787

Published: 2014

Journal Articles

Thymocyte Selection-Associated High-Mobility Group Box Protein (TOX) Induces Genomic Instability in T-Cell Acute Lymphoblastic Leukemia

Riadh Lobbardi, PhD, Jordan Pinder, PhD, Barbara Martinez-Pastor, PhD, Jessica S Blackburn, PhD, Nouran Abdelfattah, Deborah Toiber, PhD, Manon De Waard, John M. Asara, PhD, Raul Mostoslavsky, MDPhD, Graham Dellaire, PhD, David M. Langenau, PhD

Blood (2014) 124 (21): 475.

https://doi.org/10.1182/blood.V124.21.475.475

Published: 2014

Journal Articles

Somatic Mutations and Loss-Of-Heterozygosity Impair The DNA Repair Functions Of CUX1 in Myelodysplastic Syndromes (MDS)

Naoko Hosono, MD, PhD, Zubaidah M Ramdzan, PhD, Ranjana Pal, PhD, Hideki Makishima, MD, PhD, Bartlomiej P Przychodzen, PhD, Mikkael A. Sekeres, MD, MS, Kenichi Yoshida, MD, Yuichi Shiraishi, PhD, Satoru Miyano, PhD, Seishi Ogawa, MD, PhD, Alain Nepveu, PhD, Jaroslaw P. Maciejewski, MD, PhD

Blood (2013) 122 (21): 1246.

https://doi.org/10.1182/blood.V122.21.1246.1246

Published: 2013

Journal Articles

Prevention Of Relapse In Acute Myeloid Leukemia By Dendritic Cell Vaccination: Report on a Phase II Study With 29 Patients

Zwi N. Berneman, MD, PhD, FRCP, Ann Van de Velde, MD, Sébastien Anguille, MD, Yannick Willemen, MD, Wilfried A. Schroyens, MD, PhD, Alain P. Gadisseur, MD, PhD, Inge Vrelust, MD, Griet Nijs, MT, Barbara Stein, MSc, Nathalie Cools, PhD, Ronald Malfait, MD, Marie-Berthe Maes, PharmD, PhD, Katrien Vermeulen, PhD, Viggo F. Van Tendeloo, PhD, Evelien L. Smits, PhD

Blood (2013) 122 (21): 236.

https://doi.org/10.1182/blood.V122.21.236.236

Published: 2013

Journal Articles

OSU-2S, A Novel FTY720 derivative, Mediates Cytotoxicity In Chronic Lymphocytic Leukemia Through PKC Dependent Modulation of SHP1 Tyrosine Phosphatase

Rajeswaran Mani, DVM, Frank W Frissora, M.S., Ching-Shih Chen, Ph.D, John C. Byrd, MD, Natarajan Muthusamy, DVM, Ph.D

Blood (2011) 118 (21): 2499.

https://doi.org/10.1182/blood.V118.21.2499.2499

Published: 2011

Journal Articles

Patient-derived C-terminal mutation of FANCI causes protein mislocalization and reveals putative EDGE motif function in DNA repair

Luca Colnaghi, Mathew J. K. Jones, Xiomaris M. Cotto-Rios, Detlev Schindler, Helmut Hanenberg, Tony T. Huang

Blood (2011) 117 (7): 2247–2256.

https://doi.org/10.1182/blood-2010-07-295758

Published: 2011

Journal Articles

MicroSPECT/CT Imaging of Human Leukemia Engraftment In NOD-Scid Mice Using [111In]-Labeled 7G3 Anti-CD123 Antibodies

Jeffrey V. Leyton, PhD, Catherine Gao, BSc, Meiduo Hu, PhD, John E. Dick, PhD, Mark D. Minden, MD, PhD, Raymond Reilly, PhD

Blood (2010) 116 (21): 968.

https://doi.org/10.1182/blood.V116.21.968.968

Published: 2010

Journal Articles

Importin-β1 and Nucleus Transporter Chromosome Region Maintenance 1 (CRM1) Constitute the Nucleocytoplasmic Transport System of STAT3 in Blood-Derived CLL Cells.

Inbal Hazan-Halevy, PhD., David Harris, Zhiming Liu, Alessandra Ferrajoli, MD., Michael J Keating, M.D., Zeev Estrov, MD

Blood (2008) 112 (11): 1059.

https://doi.org/10.1182/blood.V112.11.1059.1059

Published: 2008

Journal Articles

Early Target Genes of CALM/AF10 as Revealed by Gene Expression Profiling.

Medhanie Assmelash Mulaw, Alexandre Krause, Alexander Riedel, Belay Tizazu, Hendrik Reuter, Stefan K. Bohlander

Blood (2008) 112 (11): 2260.

https://doi.org/10.1182/blood.V112.11.2260.2260

Published: 2008

Journal Articles

Mutations of the SBDS Gene Result in Nuclear Mislocalization.

Masafumi Yamaguchi, PhD, Kingo Fujimura, MD, PhD, Hanae Toga-Yamaguchi, Valentina Svetic, PhD, Naoki Okamura, PhD, Rajesh Chopra, PhD

Blood (2008) 112 (11): 2034.

https://doi.org/10.1182/blood.V112.11.2034.2034

Published: 2008

Journal Articles

PHF23: A Novel Erythropoietin-Induced Gene Associated with AML and MDS.

Vivien M. Hodges, PhD, Susan Rainey, PhD, Victoria Smyth, PhD, Ken Mills, PhD, Terence R.J. Lappin, PhD, A. Peter Maxwell, MD PhD

Blood (2007) 110 (11): 3178.

https://doi.org/10.1182/blood.V110.11.3178.3178

Published: 2007

Journal Articles

An Intron-Derived Insertion/Truncation Mutation in the BCR-ABL Kinase Domain in Three CML Patients Undergoing Kinase Inhibitor Therapy.

Jennifer Laudadio, MD, Michael W.N. Deininger, MD, Michael J. Mauro, MD, Brian J. Druker, MD, Richard D. Press, MD, PhD

Blood (2007) 110 (11): 1953.

https://doi.org/10.1182/blood.V110.11.1953.1953

Published: 2007

NARROW

CRISPR-Cas9 Genome Editing of γ-Globin Promoters in Human Hematopoietic Stem Cells to Induce Erythrocyte Fetal Hemoglobin for Treatment of β-Hemoglobinopathies

Mutant ASXL1 Disrupts Paraspeckle Formation through Aberrant Interaction with Nono in Hematopoietic Cells

Distinct Implications of TP53 Hits for Patients with Treatment-Related MDS and AML

NPM1c Alters FLT3-D835Y Localization and Signaling Thereby Inducing a Fulminant Myeloproliferative Disorder in Mice

DNA Damaging Agents Cause a Sub-Cellular Re-Localisation of Nucleophosmin in an npm1 Mutated Acute Myeloid Leukemia (AML) Cell Line and in Primary AML Cells Carrying an npm1 Mutation

Expanded Phenotypic and Genetic Heterogeneity in the Clinical Spectrum of FPD-AML: Lymphoid Malignancies and Skin Disorders Are Common Features in Carriers of Germline RUNX1 Mutations

Nuclear Import of Janus Kinase 1 Is Mediated By Multiple Alpha Importins and Is Required for the Survival of Diffuse Large B-Cell Lymphoma

A Peptide Nucleic Acid Targeting Nuclear Rad51 Sensitizes Myeloma Cells to Melphalan Chemotoxicity Both in Vitro and in Vivo

Expression of the ETS Transcription Factor GABPα Is Correlated to BCR-ABL/ABL ratio in Human CML and Mediates Imatinib Sensitivity

Thymocyte Selection-Associated High-Mobility Group Box Protein (TOX) Induces Genomic Instability in T-Cell Acute Lymphoblastic Leukemia

Somatic Mutations and Loss-Of-Heterozygosity Impair The DNA Repair Functions Of CUX1 in Myelodysplastic Syndromes (MDS)

Prevention Of Relapse In Acute Myeloid Leukemia By Dendritic Cell Vaccination: Report on a Phase II Study With 29 Patients

OSU-2S, A Novel FTY720 derivative, Mediates Cytotoxicity In Chronic Lymphocytic Leukemia Through PKC Dependent Modulation of SHP1 Tyrosine Phosphatase

Patient-derived C-terminal mutation of FANCI causes protein mislocalization and reveals putative EDGE motif function in DNA repair

MicroSPECT/CT Imaging of Human Leukemia Engraftment In NOD-Scid Mice Using [111In]-Labeled 7G3 Anti-CD123 Antibodies

Importin-β1 and Nucleus Transporter Chromosome Region Maintenance 1 (CRM1) Constitute the Nucleocytoplasmic Transport System of STAT3 in Blood-Derived CLL Cells.

Early Target Genes of CALM/AF10 as Revealed by Gene Expression Profiling.

Mutations of the SBDS Gene Result in Nuclear Mislocalization.

PHF23: A Novel Erythropoietin-Induced Gene Associated with AML and MDS.

An Intron-Derived Insertion/Truncation Mutation in the BCR-ABL Kinase Domain in Three CML Patients Undergoing Kinase Inhibitor Therapy.

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American Society of Hematology

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American Society of Hematology

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