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Journal Articles

MDH1-mediated malate-aspartate NADH shuttle maintains the activity levels of fetal liver hematopoietic stem cells

Free
Hao Gu, Chiqi Chen, Xiaoxin Hao, Ni Su, Dan Huang, Yejun Zou, Shu-Hai Lin, Xianjun Chen, Denghao Zheng, Ligen Liu, Zhuo Yu, Li Xie, Yaping Zhang, Xiaoxiao He, Xiaoyun Lai, Xiaocui Zhang, Guo-Qiang Chen, Yuzheng Zhao, Yi Yang, Joseph Loscalzo, Junke Zheng
Journal: Blood
Blood (2020) 136 (5): 553–571.
https://doi.org/10.1182/blood.2019003940
Published: 2020
Includes: Multimedia, Supplemental data
Journal Articles

iPLA2β Contributes to Activation of Human and Mouse Platelets Via ITAM Receptors Fcγ RIIA and GPVI

Free
Shaji Abraham, PhD, Pravin Patel, BA, Ulhas P. Naik, PhD, Steven Edward McKenzie, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2339.
https://doi.org/10.1182/blood-2019-128426
Published: 2019
Journal Articles

O-Glcnacylation Is Essential for Erythropoiesis

Free
Matthew P Parker, BS, Halyna Fedosyuk, MS, Lesya V Novikova, PhD, Zhen Zhang, PhD, Chad Slawson, PhD, Kenneth R Peterson, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2218.
https://doi.org/10.1182/blood-2019-129468
Published: 2019
Journal Articles

CD4 + T Cells Sustain Aggressive Chronic Lymphocytic Leukemia through a CD40L-Independent Mechanism

Free
Matteo Bellone, MD, Paolo Dellabona, MD PhD, Arianna Calcinotto, BS, Giulia Casorati, PhD, Alessandra Rovida, PhD, Maria Teresa Sabrina Bertilaccio, PhD, Elena Cattaneo, Matteo Grioni, Federico caligaris-Cappio, Paolo Ghia, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 683.
https://doi.org/10.1182/blood-2019-128246
Published: 2019
Journal Articles

Anti-FVIII Antibody and Inhibitor Development Patterns in Hemophilia A Mouse Models: A Systematic Review

Free
Sajjad Afraz, MD MSc, George Zhao, Davide Matino, MD MSc, Anthony K.C. Chan, MBBS, FRCPC
Journal: Blood
Blood (2019) 134 (Supplement_1): 2402.
https://doi.org/10.1182/blood-2019-131441
Published: 2019
Journal Articles

Protein Arginine Methyltransferase 1 (PRMT1) Dampens Self-Renewal and Promotes Differentiation of Hematopoietic Stem Cells in Mouse Models

Free
Hairui Su, PhD, Szu-Mam Liu, PhD, Chiao-Wang Sun, PhD, Mark T. Bedford, PhD, Xinyang Zhao, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2460.
https://doi.org/10.1182/blood-2019-127226
Published: 2019
Journal Articles

Megakaryocyte Ablation Ameliorates Bone Marrow Fibrosis By Reducing Myofibroblast Differentiation in a Mouse Model of Primary Myelofibrosis

Free
Yutein Chung, PhD, Huiyan Jin, PhD, Claire Trasorras, Francina Gonzalez, Sang Hee Min, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2493.
https://doi.org/10.1182/blood-2019-132186
Published: 2019
Journal Articles

A FULLY Human Bispecific Antibody Functionally Rescues Factor VIII Deficiency EX VIVO

Free
Wei Wang, PhD, John Blackwood, PhD, Roberto Magliozzi, PhD, Leonardo Moraes, PhD, Jeffrey Hollins, PhD, Alessandro Sinopoli, PhD, Bertie Chi, PhD, Laura Mitchell, PhD, Chris Sellick, PhD, Claire Pearce, PhD, Igor Theurl, MD PhD, Volker Germaschewski, Jacob Galson, PhD, Luca Badiali, PhD, Karen Dickson, PhD, Allan Bradley, PhD, E-Chiang Lee, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2410.
https://doi.org/10.1182/blood-2019-123359
Published: 2019
Journal Articles

Epigallocatechin-3-Gallate Induces Cellular Differentiation and Reduces Leukemia Burden in PML/Rarα Mice By Increasing Reactive Oxygen Species and Reducing PIN1 Expression

Free
Fernanda I Della Via, MSc, Rodrigo Naoto Shiraishi, PhDstudent, Santos Irene, PhD, Karla P Ferro, PhD, Myriam Salazar-Terreros, PhDMSc, Gilberto C Franchi Junior, Eduardo M Rego, MD PhD, Sara T Olalla Saad, PhD, Cristiane Okuda Torello, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5765.
https://doi.org/10.1182/blood-2019-130542
Published: 2019
Journal Articles

Targeted Therapy of Acute Chest Syndrome with Recombinant Heme Oxygenase-1 Revealed By the Resistance of Young Transgenic Sickle Cell Mice to Heme-Induced Acute Lung Injury

Free
Rimi Hazra, Samit Ghosh, Bethany Flage, Matthew Crouthamel, Clark Pan, Xiuxia Sun, Bohong Zhang, Joseph Sypek, Solomon Fiifi Ofori-Acquah
Journal: Blood
Blood (2019) 134 (Supplement_1): 74.
https://doi.org/10.1182/blood-2019-127198
Published: 2019
Journal Articles

CD47 Regulates Red Blood Cell Alloimmunization in Mice

Free
Ryan Jajosky, MD, Connie Arthur, PhD, Jerry Allen, BS, Megan Fuller, BS, Patricia E Zerra, MD, Cheryl Maier, MD PhD, Sean R. Stowell, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 100.
https://doi.org/10.1182/blood-2019-131598
Published: 2019
Journal Articles

An Authentic Murine Model of Fetal/Neonatal Alloimmune Thrombocytopenia

Free
Huiying Zhi, PhD, Maria Therese Ahlen, PhD, Trude Rasmussen, Bjørn Skogen, MD, Peter J. Newman, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 97.
https://doi.org/10.1182/blood-2019-130573
Published: 2019
Journal Articles

A CXCL10/CXCR3 Driven Thymic Epithelium-Leukemia Cell Crosstalk Augments T Cell Acute Lymphoblastic Leukemia Notch1 Signalling

Free
Ashwini M Patil, MSc, Stefanie Kesper, Vishal Khairnar, PhD, Marco Luciani, Michael Möllmann, Ulrich Dührsen, Prof, MD PhD, Joachim R Göthert, PD, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2537.
https://doi.org/10.1182/blood-2019-125331
Published: 2019
Journal Articles

LIM Domain Protein 1 (Ldb1) Is Required for Lmo2 Oncogene-Induced Thymocyte Self-Renewal and T-Cell Leukemia in a Mouse Model of Human T-ALL

Free
Liqi Li, PhD, Apratim Mitra, Bin Zhao, Seeyoung Choi, Jan Lee, Daniel Stamos, Claude Warzecha, Karl Pfeifer, Joyce Hardwick, Bryan Venters, Paul Love, Utpal Dave, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2538.
https://doi.org/10.1182/blood-2019-127534
Published: 2019
Journal Articles

Clinical ALK5 Inhibitor, Vactosertib, Reverses TGFβ-1 Stimulated Smad-2 Driven Ineffective Hematopoiesis in MDS

Free
Srinivas Aluri, Kimo Bachiashvili, MD, Anjali Budhathoki, MD, Tushar D Bhagat, PhD, Gaurav S Choudhary, PhD, Shanisha Gordon, Nandini Ramachandra, Kith Pradhan, PhD, Shahina Maqbool, Aditi Shastri, MD, Jung Im Huh, Sunjin Hwang, Kim Seong-Jin, PhD, Hui Zhang, Britta Will, PhD, Amittha Wickrema, PhD, Ulrich G. Steidl, MD PhD, Amit Verma, MBBS
Journal: Blood
Blood (2019) 134 (Supplement_1): 2990.
https://doi.org/10.1182/blood-2019-127561
Published: 2019
Journal Articles

Inhibition of PIM Kinases Targets Synthetic Vulnerabilities and Enhances Antigen Presentation in B-Cell Lymphoma

Free
Patrizia Mondello, MD PhD MSc, Chiara Tarantelli, PhD, Luciano Cascione, PhD, Alberto Arribas, PhD, Andrea Rinaldi, Anas Younes, MD, Francesco Bertoni, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2858.
https://doi.org/10.1182/blood-2019-125123
Published: 2019
Journal Articles

Arsenic Trioxide Abrogate MN1 Mediated RA-Resistance in Acute Promyelocytic Leukemia

Free
Diego A Pereira-Martins, MSc, Juan L Coelho-Silva, BSc, MSc, Isabel Weinhäuser, MSc, Luisa C A Koury, MD, Raul Antônio Morais Melo, MD PhD, Rosane Bittencourt, Katia B Pagnano, MD PhD, Ricardo Pasquini, MD, Elenaide C. Nunes, MD, Evandro Maranhão Fagundes, MD, Ana Beatriz F. Gloria, MD, Fabio R. Kerbauy, MD, Armand Keating, MD, Martin S. Tallman, MD, Raul Ribeiro, MD, Richard Dillon, MA, PhD MRCP, FRCPath, Arnold Ganser, MD, Michael Heuser, MD, Bob Löwenberg, MD PhD, Peter Valk, PhD, Miguel A. Sanz, Nancy Berliner, MD, Antonio R. Lucena-Araujo, PhD, Eduardo M Rego, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5166.
https://doi.org/10.1182/blood-2019-131595
Published: 2019
Journal Articles

A Novel Chemical Compound Inhibiting Hematopoietic Cell Kinase (iHCK) Has a Synergic Effect with Azacytidine (Aza) or Cytarabine (Ara-C) for Acute Myeloid Leukemia Treatment

Free
Fernanda Marconi Roversi, Maura Lima Pereira Bueno, undergraduate, Cristiane Okuda Torello, PhD, Fernanda I Della Via, MSc, Renata Giardini Rosa, PhD, Juares Ednaldo Romero Bianco, PhD, Adriana Silva Santos Duarte, PhD, Eduardo M Rego, MD PhD, Alessio Molinari, Maurizio Botta, Sara T Olalla Saad, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4650.
https://doi.org/10.1182/blood-2019-128959
Published: 2019
Journal Articles

MYC Oncogene Abrogates Natural Killer (NK) Cell-Mediated Immune Surveillance of B- and T- Lymphoid Malignancies By Suppressing STAT1/2-Type I IFN Signaling

Free
Srividya Swaminathan, PhD, Line Dam Heftdal, MD, Daniel Liefwalker, PhD, Renumathy Dhanasekaran, MD, Anja Deutzmann, PhD, Crista Horton, BS, Adriane Mosley, BS, Mariola Liebersbach, BS, Andrew Gentles, PhD, Holden T. Maecker, PhD, Dean Felsher, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 730.
https://doi.org/10.1182/blood-2019-122607
Published: 2019
Journal Articles

Mutant ASXL1 Promotes Expansion of the Phenotypic Hematopoietic Stem Cell Compartment

Free
Takeshi Fujino, MD, Susumu Goyama, MD PhD, Yuki Sugiura, PhD, Daichi Inoue, MD PhD, Satoshi Yamasaki, PhD, Akiko Matsumoto, Naru Sato, MD, Hironobu Morinaga, PhD, Shiori Shikata, Tomofusa Fukuyama, MD PhD, Yosuke Tanaka, PhD, Shuhei Asada, MD PhD, Tsuyoshi Fukushima, MD PhD, Hiroaki Honda, MD PhD, Emi K Nishimura, MD PhD, Tatsuhiro Shibata, MD PhD, Makoto Suematsu, MD PhD, Toshio Kitamura, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 821.
https://doi.org/10.1182/blood-2019-127904
Published: 2019