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Journal Articles

PIM447, a Pan-PIM Kinase Inhibitor, in Combination with Venetoclax Exerts a Potent Anti-Tumor Activity in the Bone Marrow Niche

Fernanda Marconi Roversi, Maura Lima Pereira Bueno, Samara de Sousa Mariano, Fernanda Soares Niemann, Adriana da Silva Santos Duarte, Audrey Bastos, Nádia Ghinelli Amôr, Irene Santos, Jose Andres Yunes, Sandra Pinho, Sara Teresinha Olalla Saad

Blood (2024) 144 (Supplement 1): 3589.

https://doi.org/10.1182/blood-2024-201572

Published: 2024

Journal Articles

Novel MET Inhibitors Provide a Therapeutic Opportunity for AML By Overcoming the Protective Action of the Bone Marrow Niche

Maura Lima Pereira Bueno, Charles Ayemoba, Anna M Di Staulo, Sen Zhang, Fernanda Soares Niemann, Nádia Ghinelli Amôr, Irene Santos, Adriana da Silva Santos Duarte, Audrey Bastos, Sara Teresinha Olalla Saad, Sandra Pinho, Fernanda Marconi Roversi

Blood (2024) 144 (Supplement 1): 4968.

https://doi.org/10.1182/blood-2024-201077

Published: 2024

Journal Articles

Inhibition of MET Tyrosine Kinase Provides a Strategy for Targeting the Inflammatory Tumor Microenvironment

Maura Lima Pereira Bueno, Irene Santos, Nádia Ghinelli Amôr, Adriana Duarte da Silva Santos, Audrey Bastos, Karla Priscila Ferro, Sara Teresinha Olalla Saad, Fernanda Marconi Roversi

Blood (2023) 142 (Supplement 1): 2264.

https://doi.org/10.1182/blood-2023-185204

Published: 2023

Journal Articles

HGF Regulation in the Tumor-Supportive Microenvironment Combined with Pan-PIM Kinases Inhibition in Malignant Cells As a Multi-Target Approach for Acute Myeloid Leukemia

Fernanda Marconi Roversi, Maura Lima Pereira Bueno, Fernanda Soares Niemann, Irene Santos, Nádia Ghinelli Amôr, Adriana Duarte da Silva Santos, Audrey Bastos, Sara Teresinha Olalla Saad

Blood (2023) 142 (Supplement 1): 3641.

https://doi.org/10.1182/blood-2023-185179

Published: 2023

Journal Articles

Combined Inhibition of MCL1 By AZD5991 and BCL2/Bclxl By AZD4320 As Promising Strategies to Overcome Acute Leukemia Tumor Burden and Niche Chemoresistance

Maura Lima Pereira Bueno, Leonardo Artico, Adriana Silva Santos Duarte, Audrey Basso, Jose Andres Yunes, Sara T. Olalla Saad, Fernanda Marconi Roversi

Blood (2022) 140 (Supplement 1): 4943–4944.

https://doi.org/10.1182/blood-2022-158620

Published: 2022

Journal Articles

HCK Inhibition Displays Antineoplastic Activity on Acute Leukemia and Promotes Immune Regulation of the Bone Marrow Tumor Microenvironment

Fernanda Marconi Roversi, Maura Lima Pereira Bueno, Audrey Basso, Adriana Silva Santos Duarte, Juliete A.F. Silva, Sara T Olalla Saad

Blood (2022) 140 (Supplement 1): 7806–7807.

https://doi.org/10.1182/blood-2022-158579

Published: 2022

Journal Articles

A Novel WNT5A-Mimicking Peptide Affects Leukemia Cell Survival in the Bone Marrow Microenvironment

Fernanda Marconi Roversi, Maura Lima Pereira Bueno, Rafael Gonçalves Barbosa Gomes, Guilherme Rossi Assis-Mendonça, Paulo Latuf Filho, Adriana Silva Santos Duarte, Sara T Olalla Saad

Blood (2021) 138 (Supplement 1): 2949.

https://doi.org/10.1182/blood-2021-148744

Published: 2021

Journal Articles

A Novel Chemical Compound Inhibiting Hematopoietic Cell Kinase (iHCK) Has a Synergic Effect with Azacytidine (Aza) or Cytarabine (Ara-C) for Acute Myeloid Leukemia Treatment

Fernanda Marconi Roversi, Maura Lima Pereira Bueno, undergraduate, Cristiane Okuda Torello, PhD, Fernanda I Della Via, MSc, Renata Giardini Rosa, PhD, Juares Ednaldo Romero Bianco, PhD, Adriana Silva Santos Duarte, PhD, Eduardo M Rego, MD PhD, Alessio Molinari, Maurizio Botta, Sara T Olalla Saad, PhD

Blood (2019) 134 (Supplement_1): 4650.

https://doi.org/10.1182/blood-2019-128959

Published: 2019

Journal Articles

A Novel Antisense Long Noncoding RNA Modulates NR4A1 Protein Level in Myeloid Malignancies

Flávia Adolfo Corrocher, MSc, Ada Congrains, PhD, Fernanda Soares Niemann, MSc, Bruna Palodetto, MSc, Fernanda Marconi Roversi, PhD, Mariana Ozello Baratti, PhD, Paula de Melo Campos, PhD, Sara Teresinha Olalla Saad, PhD MD

Blood (2015) 126 (23): 2442.

https://doi.org/10.1182/blood.V126.23.2442.2442

Published: 2015

Journal Articles

Knockdown of HCK Reduces Cell Death and Erythroid Differentiation in Human CD34 + Hematopoietic Progenitor Cells

Fernanda Marconi Roversi, PhD, Fernando Vieira Pericole, MD, Adriana da Silva Santos Duarte, PhD, Karla Priscila Ferro, PhD, Flávia Adolfo Corrocher, MSc, Bruna Palodetto, MSc, Ana Leda Longhini, PhD, Maurizio Botta, PhD, Sara T. Olalla Saad, MD, PhD

Blood (2015) 126 (23): 2860.

https://doi.org/10.1182/blood.V126.23.2860.2860

Published: 2015

Journal Articles

Methylation of HAI-2/SPINT2 in Bone Marrow Mesenchymal Stromal Cells of MDS and AML Patients Affects Hematopoietic Stem Cell Survival and Adhesion

Fernanda Marconi Roversi, PhD, Nathalia Moreno Cury, MSc, Matheus Rodrigues Lopes, MSc, Fernando Vieira Pericole, MD, Marisa Claudia Alvarez Prax, PhD, Karla Priscila Ferro, PhD, Patricia Favaro, PhD, José Andres Yunes, PhD, Sara T. Olalla Saad, MD, PhD

Blood (2015) 126 (23): 2847.

https://doi.org/10.1182/blood.V126.23.2847.2847

Published: 2015

Journal Articles

Hematopoietic Cell Kinase (HCK) Is Involved in Myelodysplastic Syndromes and Acute Leukemia Pathophysiology By Modulating PI3K Pathway and Enhancing Erythroid Differentiation

Fernanda Marconi Roversi, PhD, Fernando V Pericole, MD, João Agostinho Machado-Neto, MSc, Ana Leda Longhini, PhD, Adriana Silva Santos Duarte, PhD, Bruna Palodetto, MSc, Flavia Adolfo Corrocher, MSc, Fabiola Traina, MD PhD, Sara T Olalla Saad, MD PhD

Blood (2014) 124 (21): 1891.

https://doi.org/10.1182/blood.V124.21.1891.1891

Published: 2014

Journal Articles

BRD4 Short Isoform Is a Myelodysplasia Prognostic Marker Involved in Inappropriate DNA Damage Response

Fernando V Pericole, MD, Fernanda Marconi Roversi, PhD, Adriana Silva Santos Duarte, PhD, Bruna Palodetto, MSc, Flavia Adolfo Corrocher, MSc, Fabiola Traina, MD PhD, Mariana Lazarini, PhD, Sara T Olalla Saad, MD PhD

Blood (2014) 124 (21): 3234.

https://doi.org/10.1182/blood.V124.21.3234.3234

Published: 2014

Journal Articles

Downregulation Of SPINT2 Expression In Stromal Cells From Myelodysplastic Syndrome Patients Increases HGF and SDF-1 Secretion and Promotes Cell-Cell Adhesion By Alteration In Integrin Expression

Fernanda Marconi Roversi, PhD, Matheus Rodrigues Lopes, MSc, João Agostinho Machado-Neto, MSc, Ana Leda Longhini, PhD, Adriana da Silva Santos Duarte, PhD, Bruna Palodetto, MSc, Flavia Adolfo Corrocher, MSc, Paula de Melo Campos, MD, Mariana Ozello Baratti, PhD, Fernando V Pericole, MD, Patricia Favaro, PhD, Fabiola Traina, M.D., Ph.D., Sara Teresinha Saad, MD, PhD

Blood (2013) 122 (21): 2763.

https://doi.org/10.1182/blood.V122.21.2763.2763

Published: 2013

Journal Articles

Hematopoietic Cell Kinase (HCK) Is Highly Expressed in Myelodysplastic Syndrome (MDS) and Regulates Proliferation, Cell Cycle Progression and Hematopoietic Differentiation

Fernanda Marconi Roversi, PhD, João Machado-Neto, MSc, Bruna Palodetto, MSc, Flávia Adolfo Corrocher, MSc, Mariana Ozello Baratti, PhD, Paula de Melo Campos, MD, Fabiola Traina, MD, PhD, Sara T Olalla Saad, MD, PhD

Blood (2012) 120 (21): 3813.

https://doi.org/10.1182/blood.V120.21.3813.3813

Published: 2012

Journal Articles

Transcription Factors and MicroRNAs Expression Profiles in Reticulocytes From Beta Thalassemia Intermedia and Sickle Cell Anemia Patients,

Regiane Ferreira, M.Sc., Marcos André Cavalcanti Bezerra, Ph.D., Fernanda Marconi Roversi, M.Sc., Dulcinéia Martins Albuquerque, BSc, MSc, PhD, Aderson S Araujo, MD, PhD, Fernando Ferreira Costa, MD, PhD

Blood (2011) 118 (21): 3201.

https://doi.org/10.1182/blood.V118.21.3201.3201

Published: 2011

Journal Articles

Expressions of KLF1, FOXO3a, HOOK3 and MIER1 genes Are Associated with Fetal Hemoglobin Levels in Hereditary Persistence of Fetal Hemoglobin,

Fernanda Marconi Roversi, M.Sc., Anderson Ferreira Cunha, Ph.D., Ana Flavia Brugnerotto, M.Sc., Regiane Ferreira, M.Sc., Dulcinéia Martins Albuquerque, BSc, MSc, PhD, Carolina Lanaro, B.Sc., Ph, D, Joao Machado-Neto, MSc, Sara T. Olalla-Saad, M.D., Ph.D., Fernando Ferreira Costa, MD, PhD

Blood (2011) 118 (21): 3195.

https://doi.org/10.1182/blood.V118.21.3195.3195

Published: 2011

Journal Articles

The -195C→G Substitution In Brazilian Hereditary Persistence of Fetal Hemoglobin Decreases NF-E1/YY1 Binding and Increases PAX1 Binding to the A Gamma Globin Promoter Region

Fernanda Marconi Roversi, M.Sc., Anderson Ferreira Cunha, Ph.D., Carolina Lanaro, Ph.D., Ana Flavia Brugnerotto, Maria Emília Favero, M.Sc., Dulcinéia Martins Albuquerque, Ph.D., Fernando Ferreira Costa, Ph.D., M.D.

Blood (2010) 116 (21): 2066.

https://doi.org/10.1182/blood.V116.21.2066.2066

Published: 2010

NARROW

PIM447, a Pan-PIM Kinase Inhibitor, in Combination with Venetoclax Exerts a Potent Anti-Tumor Activity in the Bone Marrow Niche

Novel MET Inhibitors Provide a Therapeutic Opportunity for AML By Overcoming the Protective Action of the Bone Marrow Niche

Inhibition of MET Tyrosine Kinase Provides a Strategy for Targeting the Inflammatory Tumor Microenvironment

HGF Regulation in the Tumor-Supportive Microenvironment Combined with Pan-PIM Kinases Inhibition in Malignant Cells As a Multi-Target Approach for Acute Myeloid Leukemia

Combined Inhibition of MCL1 By AZD5991 and BCL2/Bclxl By AZD4320 As Promising Strategies to Overcome Acute Leukemia Tumor Burden and Niche Chemoresistance

HCK Inhibition Displays Antineoplastic Activity on Acute Leukemia and Promotes Immune Regulation of the Bone Marrow Tumor Microenvironment

A Novel WNT5A-Mimicking Peptide Affects Leukemia Cell Survival in the Bone Marrow Microenvironment

A Novel Chemical Compound Inhibiting Hematopoietic Cell Kinase (iHCK) Has a Synergic Effect with Azacytidine (Aza) or Cytarabine (Ara-C) for Acute Myeloid Leukemia Treatment

A Novel Antisense Long Noncoding RNA Modulates NR4A1 Protein Level in Myeloid Malignancies

Knockdown of HCK Reduces Cell Death and Erythroid Differentiation in Human CD34 + Hematopoietic Progenitor Cells

Methylation of HAI-2/SPINT2 in Bone Marrow Mesenchymal Stromal Cells of MDS and AML Patients Affects Hematopoietic Stem Cell Survival and Adhesion

Hematopoietic Cell Kinase (HCK) Is Involved in Myelodysplastic Syndromes and Acute Leukemia Pathophysiology By Modulating PI3K Pathway and Enhancing Erythroid Differentiation

BRD4 Short Isoform Is a Myelodysplasia Prognostic Marker Involved in Inappropriate DNA Damage Response

Downregulation Of SPINT2 Expression In Stromal Cells From Myelodysplastic Syndrome Patients Increases HGF and SDF-1 Secretion and Promotes Cell-Cell Adhesion By Alteration In Integrin Expression

Hematopoietic Cell Kinase (HCK) Is Highly Expressed in Myelodysplastic Syndrome (MDS) and Regulates Proliferation, Cell Cycle Progression and Hematopoietic Differentiation

Transcription Factors and MicroRNAs Expression Profiles in Reticulocytes From Beta Thalassemia Intermedia and Sickle Cell Anemia Patients,

Expressions of KLF1, FOXO3a, HOOK3 and MIER1 genes Are Associated with Fetal Hemoglobin Levels in Hereditary Persistence of Fetal Hemoglobin,

The -195C→G Substitution In Brazilian Hereditary Persistence of Fetal Hemoglobin Decreases NF-E1/YY1 Binding and Increases PAX1 Binding to the A Gamma Globin Promoter Region

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American Society of Hematology

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American Society of Hematology

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