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Journal Articles

A factor VIIIa–mimetic bispecific antibody, Mim8, ameliorates bleeding upon severe vascular challenge in hemophilia A mice

Henrik Østergaard, Jacob Lund, Per J. Greisen, Stine Kjellev, Anette Henriksen, Nikolai Lorenzen, Eva Johansson, Gustav Røder, Morten G. Rasch, Laust B. Johnsen, Thomas Egebjerg, Søren Lund, Henrik Rahbek-Nielsen, Prafull S. Gandhi, Kasper Lamberth, Mette Loftager, Lisbeth M. Andersen, Amalie C. Bonde, Fabian Stavenuiter, Daniel E. Madsen, Xun Li, Thomas L. Holm, Carsten D. Ley, Peter Thygesen, Haisun Zhu, Rong Zhou, Karina Thorn, Zhiru Yang, Mette B. Hermit, Jais R. Bjelke, Bjarne G. Hansen, Ida Hilden
Journal: Blood
Blood (2021) 138 (14): 1258–1268.
https://doi.org/10.1182/blood.2020010331
Published: 2021
Includes: Supplemental data
Journal Articles

High Avidity IgM-Based CD20xCD3 Bispecific Antibody (IGM-2323) for Enhanced T-Cell Dependent Killing with Minimal Cytokine Release

Ramesh Baliga, PhD, Keyu Li, PhD, Marigold Manlusoc, Paul Hinton, Dean Ng, PhD, Madeline Tran, Bing Shan, PhD, Hai Lu, Avneesh Saini, PhD, Sachi Rahman, Yuan Cao, PhD, Chitra Saraiya, Marvin Peterson, PhD, Steve Carroll, PhD, Daniel Chen, MD PhD, Bruce Keyt, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1574.
https://doi.org/10.1182/blood-2019-131650
Published: 2019
Journal Articles

TNB-486, a Novel Fully Human Bispecific CD19 x CD3 Antibody That Kills CD19-Positive Tumor Cells with Minimal Cytokine Secretion

Harbani Malik, PhD, Ben Buelow, MD PhD, Udaya Rangaswamy, PhD, Aarti Balasubramani, Andrew Boudreau, Kevin Dang, Laura Davison, PhD, Shelley Force Aldred, Katherine Marie Harris, MD, Suhasini Iyer, PhD, Brett Jorgensen, PhD, Duy Pham, MBA, Kirthana Prabhakar, Ute Schellenberger, PhD, Harshad Ugamraj, Nathan Trinklein, PhD, Wim Van Schooten, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4070.
https://doi.org/10.1182/blood-2019-123226
Published: 2019
Journal Articles

TJC4, a Differentiated Anti-CD47 Antibody with Novel Epitope and RBC Sparing Properties

Zhen Meng, PhD, Zhengyi Wang, PhD, Bingshi Guo, PhD, Wei Cao, PhD, Huaqiong Shen, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4063.
https://doi.org/10.1182/blood-2019-122793
Published: 2019
Journal Articles

Mim8 - a Next-Generation FVIII Mimetic Bi-Specific Antibody - Potently Restores the Hemostatic Capacity in Hemophilia a Settings in Vitro and In Vivo

Stine L Kjellev, PhDDVM, Henrik Østergaard, PhD, Per Jr Greisen, PhD, Mette B Hermit, PhD, Karina Thorn, PhD, Bjarne G Hansen, PhD, Rong Zhou, PhD, Jais Rose Bjelke, PhD, Marianne Kjalke, PhD, Jacob Lund, PhD, Thomas L Holm, PhD, Carsten Dan Ley, PhD, Daniel Elenius, PhD, Peter Thygesen, PhD, Mette Loftager, PhD, Morten G Rasch, PhD, Nikolai Lorenzen, PhD, Prafull S Gandhi, PhD, Kasper Lamberth, PhD, Thomas Egebjerg, Søren Lund, PhD, Anette Henriksen, PhD, Henrik Rahbek-Nielsen, PhD, Zhiru Yang, Ida Hilden
Journal: Blood
Blood (2019) 134 (Supplement_1): 96.
https://doi.org/10.1182/blood-2019-122817
Published: 2019
Journal Articles

Efficacy of OR21, a Novel Oral Demethylating Agent in Chronic Myeloid Leukemia

Kazuharu Kamachi, MD, Hiroshi Ureshino, MD, Nao Yoshida, MD, Yuki Kurahashi, Tatsuro Watanabe, PhD, Seiji Okada, MD PhD, Shinya Kimura, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5365.
https://doi.org/10.1182/blood-2019-125460
Published: 2019
Journal Articles

CTX-8573, an Innate-Cell Engager Targeting BCMA, is a Highly Potent Multispecific Antibody for the Treatment of Multiple Myeloma

Jennifer Watkins-Yoon, Wilson Guzman, Amanda Oliphant, Sara Haserlat, Alan Leung, Claire Chottin, Michael Ophir, Jai Vekeria, Allison P Nelson, Zach Frye, Jason Lajoie, Puru Nanjappa, Sujan Lama, Dalton Markrush, William McConaughy, Xianzhe Wang, Neal Schilling, Doyeob Kim, Paul Wu, Lucy Liu, Kenneth Rogers, Francois Villinger, Bing Gong, Stephen Hamilton, Piotr Bobrowicz, Thomas Schuetz, Michael Schmidt, Monia Draghi
Journal: Blood
Blood (2019) 134 (Supplement_1): 3182.
https://doi.org/10.1182/blood-2019-128749
Published: 2019
Journal Articles

First-in-Human, Phase 1/2 Trial to Assess the Safety and Clinical Activity of Subcutaneous GEN3013 (DuoBody ® -CD3×CD20) in B-Cell Non-Hodgkin Lymphomas

Pieternella Lugtenburg, MD PhD, Rogier Mous, MD PhD, Michael Roost Clausen, Martine E.D. Chamuleau, Peter Johnson, MDFRCP, Kim Linton, PhD, Simon Rule, Roberto S Oliveri, MD PhD, Dena DeMarco, Ida H Hiemstra, PhD, Guang Chen, Ada Azaryan, Manish Gupta, Tahamtan Ahmadi, Martin Hutchings, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 758.
https://doi.org/10.1182/blood-2019-121460
Published: 2019
Journal Articles

MAA868, a novel FXI antibody with a unique binding mode, shows durable effects on markers of anticoagulation in humans

Alexander W. Koch, Nikolaus Schiering, Samu Melkko, Stefan Ewert, Janeen Salter, Yiming Zhang, Peter McCormack, Jianying Yu, Xueming Huang, Yu-Hsin Chiu, Zhiping Chen, Simone Schleeger, Geraldine Horny, Keith DiPetrillo, Lionel Muller, Andreas Hein, Frederic Villard, Meike Scharenberg, Paul Ramage, Ulrich Hassiepen, Serge Côté, Julie DeGagne, Carsten Krantz, Jörg Eder, Brian Stoll, Kenneth Kulmatycki, David L. Feldman, Peter Hoffmann, Craig T. Basson, Robert J. A. Frost, Yasser Khder
Journal: Blood
Blood (2019) 133 (13): 1507–1516.
https://doi.org/10.1182/blood-2018-10-880849
Published: 2019
Includes: Supplemental data
Journal Articles

SKY59: A Long-Lasting Engineered Anti-C5 Antibody for Subcutaneously Injectable Anti-Complement Therapy

Kenta Haraya, PhD, Zenjiro Sampei, PhD, Tatsuhiko Tachibana, PhD, Taku Fukuzawa, PhD, Siok Wan Gan, PhD, Meiri Shida-Kawazoe, PhD, Yuichiro Shimizu, PhD, Masaru Muraoka, PhD, Tomoyuki Igawa, PhD, Takehisa Kitazawa, DVM, Junichi Nezu, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3611.
https://doi.org/10.1182/blood-2018-99-110145
Published: 2018
Journal Articles

CD117-Amanitin Antibody Drug Conjugates Effectively Deplete Human and Non-Human Primate HSCs: Proof of Concept As a Targeted Strategy for Conditioning Patients for Bone Marrow Transplant

Bradley R Pearse, PhD, Sean M McDonough, MS, Jennifer L Proctor, BS, Rajiv Panwar, PhD, Ganapathy Sarma, PhD, Molly A McShea, MS, Lena Kien, BS, Junia Dushime, BS, Hillary L Adams, MS, Sharon L. Hyzy, MS, Melissa L. Brooks, BS, Rahul Palchaudhuri, PhD, Qing Li, PhD, Nathan M Kallen, BA, Pranoti Sawant, MS, Charlotte F McDonagh, PhD, Anthony E. Boitano, PhD, Michael P. Cooke, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3314.
https://doi.org/10.1182/blood-2018-99-114881
Published: 2018
Journal Articles

Targeting CD45 with an Amanitin Antibody-Drug Conjugate Effectively Depletes Human HSCs and Immune Cells for Transplant Conditioning

Rahul Palchaudhuri, PhD, Bradley R Pearse, PhD, Jennifer L Proctor, BS, Sharon L. Hyzy, MS, Sharon Aslanian, MS, Sean M McDonough, MS, Ganapathy Sarma, PhD, Melissa L. Brooks, BS, Anjali Bhat, MS, Danielle Ladwig, MS, Molly A McShea, MS, Nathan M Kallen, BA, Qing Li, PhD, Rajiv Panwar, PhD, Junia Dushime, BS, Pranoti Sawant, MS, Hillary L Adams, MS, Patrick C. Falahee, PhD, Tahirih L Lamothe, Andrew D Gabros, Lena Kien, BS, Geoff Gillard, PhD, Charlotte F McDonagh, PhD, Anthony E. Boitano, PhD, Michael P. Cooke, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4526.
https://doi.org/10.1182/blood-2018-99-117167
Published: 2018
Journal Articles

A Next-Generation Fc-Bearing CD3-Engaging Bispecific DART ® Platform with Extended Pharmacokinetic and Expanded Pharmacologic Window: Characterization As CD123 x CD3 and CD19 x CD3 DART Molecules

Ezio Bonvini, MD, Ross La Motte-Mohs, PhD, Ling Huang, Chia-Ying Kao Lam, PhD, Thomas Kaufman, Liqin Liu, PhD, Ralph F. Alderson, PhD, Kurt Stahl, Jennifer G. Brown, PhD, Hua Li, Sharad Sharma, PhD, James Tamura, PhD, Syd Johnson, PhD, Paul Moore, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 5230.
https://doi.org/10.1182/blood-2018-99-116264
Published: 2018
Journal Articles

Therapeutic Potential of AO-176, a Next Generation Humanized CD47 Antibody, for Hematologic Malignancies

W. Casey Wilson, PhD, Myriam N Bouchlaka, BS, PhD, Ben J Capoccia, PhD, Ronald R Hiebsch, BS, Michael J Donio, BS, Robyn J Puro, PhD, Alun J Carter, PhD, Prabir Chakraborty, PhD, Pamela T Manning, PhD, Robert W Karr, MD, Vicki Sung, PhD, Daniel S Pereira, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4180.
https://doi.org/10.1182/blood-2018-99-118456
Published: 2018
Journal Articles

Targeting a Specific Glycosylated Epitope of CD43 with a New Humanized Monoclonal Antibody for the Treatment of Pediatric and Adult T-Cell Acute Lymphoblastic Leukemia (T-ALL)

Cirino Botta, MD, Giuseppe Gaipa, PhD, Maria Eugenia Gallo Cantafio, PhD, Chiara Buracchi, PhD, Maria Anna Siciliano, MD, Caterina Riillo, MD, Katia Grillone, PhD, Alessandro Gulino, Maria Cucè, Nicoletta Staropoli, Andrea Ghelli Luserna Di Rora, Franca Maria Tuccillo, Maria Teresa Di Martino, Claudio Tripodo, MD, Marco Rossi, MD, Giovanni Martinelli, Andrea Biondi, MD, Pierosandro Tagliaferri, Pierfrancesco Tassone, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1418.
https://doi.org/10.1182/blood-2018-99-118572
Published: 2018
Journal Articles

A Novel Full Length Anti-FLT3 CD3 Bispecific Antibody for the Treatment of Acute Myeloid Leukemia

Ivana Djuretic, PhD, Veena Krishnamoorthy, PhD, Cesar Sommer, PhD, Danielle E. Dettling, Kris Poulsen, Wei Chen, PhD, Wenyue Hu, PhD, Allison Given Chunyk, Kevin Lindquist, Shobha Potluri, PhD, Robert C Rickert, PhD, Barbra Sasu, PhD, Javier Chaparro-Riggers, PhD, Yik Andy Yeung, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1445.
https://doi.org/10.1182/blood-2018-99-119915
Published: 2018
Journal Articles

OR21, a New Oral DNA Methyltransferase Inhibitor for Treatment of MDS and AML

Hiroshi Ureshino, MD, Tatsuro Watanabe, PhD, Yuki Kurahashi, Yuki Fukuda Kurahashi, Kaoru Tohyama, MD, Seiji Okada, MD PhD, Toshikazu Ushijima, MD PhD, Hiroshi Ureshino, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 5499.
https://doi.org/10.1182/blood-2018-99-112362
Published: 2018
Journal Articles

REGN5458, a Bispecific BCMAxCD3 T Cell Engaging Antibody, Demonstrates Robust In Vitro and In Vivo Anti-Tumor Efficacy in Multiple Myeloma Models, Comparable to That of BCMA CAR T Cells

David J Dilillo, PhD, Kara Olson, MS, Katja Mohrs, T. Craig Meagher, PhD, Kevin Bray, PhD, Olga Sineshchekova, Thomas Startz, Marc Retter, PhD, Stephen Godin, PhD, Frank Delfino, PhD, John Lin, PhD, Eric Smith, PhD, Olin Gavin Thurston, PhD, Jessica R. Kirshner, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1944.
https://doi.org/10.1182/blood-2018-99-112500
Published: 2018
Journal Articles

Development of a Pegylated Dimeric Recombinant Factor VIII-Fc Fusion Protein for the Treatment for Hemophilia a Patients

Bin Liu, PhD, Xiaoshan Wang, Master, Xueqin Li, Master, Haixia Yan, PhD, Shuya Wang, Master, Xi Zhu, Pengju Wang, Jie Gao, Master, Yali Wang, PhD, Hongsheng Su, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3783.
https://doi.org/10.1182/blood-2018-99-112030
Published: 2018
Journal Articles

Absence of Plasma Gastric Biomarker Elevations with Chronic Dosing of Avatrombopag, a Novel Oral Thrombopoietin Receptor Agonist, in Patients with Chronic Immune Thrombocytopenia in Phase 3 Trials

James B. Bussel, MD, Lee F. Allen, MD PhD, Wei Tian, PhD, David J. Kuter, MD DPhil
Journal: Blood
Blood (2018) 132 (Supplement 1): 3740.
https://doi.org/10.1182/blood-2018-99-116873
Published: 2018