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Journal Articles

Analysis of Metformin Effects on Bone Marrow Fibrosis and Disease Progression in Primary Myelofibrosis Patients: Preliminary Results of an Open Label Phase II Trial (FIBROMET)

Paula De Melo Campos, MD, Katia B Pagnano, MD PhD, Rubia Mancuso, Francisco Breno S. Teófilo, Juan L Coelho-Silva, BSc, MSc, Fernanda I Della Via, MSc, Leandro Luiz Lopes Freitas, MD PhD, Hernandes F. Carvalho, PhD, Fernando Ferreira Costa, MD PhD, Fabiola Traina, MD PhD, Sara T Olalla Saad, PhD

Blood (2019) 134 (Supplement_1): 554.

https://doi.org/10.1182/blood-2019-130648

Published: 2019

Journal Articles

IGF1R-IRS1/2 Signaling Pathway Is a Potential Target for FLT3-Mutated Acute Myeloid Leukemia

Juan L Coelho-Silva, BSc, MSc, Diego A Pereira-Martins, MSc, Virginia Campos Silvestrini, BSc, MSc, Eduardo M Rego, MD PhD, Vitor Marcel Faca, PhD, João Agostinho Machado-Neto, PhD, Fabiola Traina, MD PhD

Blood (2019) 134 (Supplement_1): 2689.

https://doi.org/10.1182/blood-2019-132129

Published: 2019

Journal Articles

Predictive Simulation Modeling in JAK2-Mutant MPNs Identified Ruxolitinib and Sorafenib As a Synergistic Drug Combination for Disease Modifying Therapy

Peter P. Sayeski, PhD, Leylah M. Drusbosky, PhD, Neeraj Kumar Singh, B.Tech, Anusha Pampana, Shahabuddin Usmani, MS, Mohammed Sauban, BE, Abha Kushwaha, Anu Ramakrishnan, Taher Abbasi, MS, MBA, Shireen Vali, PhD, Christopher R. Cogle, MD

Blood (2017) 130 (Supplement 1): 5287.

https://doi.org/10.1182/blood.V130.Suppl_1.5287.5287

Published: 2017

Journal Articles

The Pharmacological IGF1R-IRS1/2 Inhibitor NT157 Presents Multiple Anti-Neoplastic Effects in Myeloproliferative Neoplasms

Bruna Alves Fenerich, BSc, João Agostinho Machado-Neto, BSc, Ana Paula Nunes Rodrigues Alves, MSc, Paula De Melo Campos, MD PhD, Jaqueline Cristina Fernandes, BSc, MSc, Juan Luiz Coelho-Silva, BSc, MSc, Renata Scopim Ribeiro, BSc, MSc, Fernanda B da Silva, BSc and MSc, Priscila Santos Scheucher, PhD, Lorena Lobo Figueiredo-Pontes, MD PhD, Eduardo Magalhães Rego, MDPhD, Fabiola Traina, MD PhD

Blood (2017) 130 (Supplement 1): 1253.

https://doi.org/10.1182/blood.V130.Suppl_1.1253.1253

Published: 2017

Journal Articles

Pharmacological IGF1R/IRS Inhibitor, NT157, Effectively Induces Apoptosis and CDKN1A Expression in Acute Lymphoblastic Leukemia Cells

Ana Paula Nunes Rodrigues Alves, M.Sc., João Agostinho Machado-Neto, PhD, Jaqueline Cristina Fernandes, B.Sc., Bruna Alves Fenerich, B.Sc., Fernanda Borges da Silva, B.Sc., Priscila Santos Scheucher, PhD, Belinda Pinto Simões, MD, PhD, Eduardo Magalhães Rego, MD, PhD, Fabiola Traina, MD, PhD

Blood (2016) 128 (22): 3971.

https://doi.org/10.1182/blood.V128.22.3971.3971

Published: 2016

Journal Articles

Pharmacological IRS1/2 Inhibition Reduces Cell Viability in BCR-ABL1 Positive Cells

Renata Scopim-Ribeiro, M.Sc., João Agostinho Machado-Neto, PhD, Paula de Melo Campos, PhD, Adriana da Silva Santos Duarte, PhD, Priscila Santos Scheucher, PhD, Amélia Góes, PhD, Sara Teresinha Olalla Saad, MD, PhD, Belinda Pinto Simoes, MD, PhD, Eduardo Magalhães Rego, MD, PhD, Fabiola Traina, MD, PhD

Blood (2015) 126 (23): 2772.

https://doi.org/10.1182/blood.V126.23.2772.2772

Published: 2015

Journal Articles

High-Depth, Targeted, Next Generation Sequencing Identifies Novel Genetic Alterations in Cutaneous T-Cell Lymphoma

Kimon V. Argyropoulos, MD, Steven M Horwitz, MD, Franck Rapaport, PhD, Enrico Velardi, PhD, Patricia Myskowski, MD, Christiane Querfeld, Melissa Pulitzer, MD, Ahmet Dogan, MD PhD, Meighan Gallagher, MA, Nicholas D. Socci, PhD, Ross L. Levine, MD, Minal Patel, BA, Natasha Galasso, Marcel van den Brink, MD PhD, Lia Palomba, MD

Blood (2015) 126 (23): 1485.

https://doi.org/10.1182/blood.V126.23.1485.1485

Published: 2015

Journal Articles

Activating Mutations of Insulin Receptor Substrate 2 (IRS2) in Patients with Tyrosine Kinase Inhibitor-Refractory Chronic Myeloid Leukemia

Samantha L Savage, Christopher A. Eide, Kyle F Concannon, Daniel Bottomly, MS, Beth Wilmot, PhD, Shannon K. McWeeney, PhD, Julia Elizabeth Maxson, PhD, Jeffrey W. Tyner, PhD, Cristina E. Tognon, PhD, Brian J. Druker, MD

Blood (2015) 126 (23): 2461.

https://doi.org/10.1182/blood.V126.23.2461.2461

Published: 2015

Journal Articles

IRS2 Inhibition Reduces Cell Proliferation and Has Cumulative Effects with Ruxolitinib in JAK2 V617F Cells

Paula De Melo Campos, MD, João Agostinho Machado-Neto, MSc, Patricia Favaro, PhD, Fernando Ferreira Costa, MD PhD, Sara Teresinha Olalla Saad, MD PhD, Fabiola Traina, MD PhD

Blood (2014) 124 (21): 3219.

https://doi.org/10.1182/blood.V124.21.3219.3219

Published: 2014

Journal Articles

Discovery of Novel EPO/EPOR/JAK2 Targets and Signal Transduction Factors Via Proteomic-Based Interrogations of Post-Translational Motif Modifications

Don M Wojchowski, PhD, Su Su, PhD, Ashley Johnson, BA, Edward Jachimowicz, MS, Matthew P Stokes, PhD, Jennifer M Green, PhD, Jeffrey C Silva, PhD

Blood (2014) 124 (21): 1335.

https://doi.org/10.1182/blood.V124.21.1335.1335

Published: 2014

Journal Articles

Genomic Characterization Of Newly Established Two Distinct Patient-Driven Multiple Myeloma Cell Lines (SNU_MM1393_BM and SNU_MM1393_SC) From a Single Patient

Youngil Koh, MD, Kwang-Sung Ahn, Ph.D., Chansu Lee, MS, Woo June Jung, BS, Hyun Jung Lee, MD, Dong Soon Lee, MD, PhD, Hyo Jung Kim, M.D., Ph.D., Hwi-Joong Yoon, MD, Ph.D., Sung-Soo Yoon, MD, PhD

Blood (2013) 122 (21): 5361.

https://doi.org/10.1182/blood.V122.21.5361.5361

Published: 2013

Journal Articles

Loss Of IKZF1 Function Mediates Resistance Towards Glucocorticoid-Induced Apoptosis

Jorn Havinga, MSc, Laurensia Yuniati, MSc, Marc Demkes, BSc, Dorette van Ingen Schenau, Msc, Roland P. Kuiper, PhD, Peter M. Hoogerbrugge, Frank N. van Leeuwen, PhD, Blanca Scheijen, PhD

Blood (2013) 122 (21): 3865.

https://doi.org/10.1182/blood.V122.21.3865.3865

Published: 2013

Journal Articles

IRS2 Associates With JAK2 and May Be Involved In Cell Proliferation Pathways In Chronic Myeloproliferative Neoplasms

Paula de Melo Campos, MD, Joao Machado-Neto, MSc, Adriana Silva Santos Duarte, PhD, Rafaela Mendonça, Irene Lorand-Metze, MD, PhD, Fernando F. Costa, M.D., Ph.D., Sara T O Saad, MD, PhD, Fabiola Traina, M.D., Ph.D.

Blood (2013) 122 (21): 1598.

https://doi.org/10.1182/blood.V122.21.1598.1598

Published: 2013

Journal Articles

Insulin/IGF1 Pathway Inhibition in Combination with All-Trans Retinoic Acid in Acute Promyelocytic Leukemia

Tiphanie Durfort, Luca Mazzarella, Pier Giuseppe Pelicci

Blood (2012) 120 (21): 1347.

https://doi.org/10.1182/blood.V120.21.1347.1347

Published: 2012

Journal Articles

Identification of Candidate Transcriptional Biomarkers Associated with Chronic Graft-Versus-Host Disease Following Allogeneic Hematopoietic Cell Transplantation

Holbrook E Kohrt, MD, PhD, Lu Tian, PhD, Li Li, PhD, Ash A. Alizadeh, MD, PhD, Sue Hsieh, PhD, Samuel Strober, MD, Minnie Sarwal, MD PhD, Robert Lowsky, MD

Blood (2012) 120 (21): 4190.

https://doi.org/10.1182/blood.V120.21.4190.4190

Published: 2012

Journal Articles

Downregulation of IRS2 in Myelodysplastic Syndrome (MDS) May Be Related to Impaired Cell Differentiation,

Joao Machado-Neto, MSc, Patricia Favaro, PhD, Mariana Lazarini, PhD, Adriana S S Duarte, PhD, Leticia Fröhlich Archangelo, PhD, Irene Lorand-Metze, MD, PhD, Fernando Ferreira Costa, MD, PhD, Sara T Olalla Saad, MD, PhD, Fabiola Traina, MD, PhD

Blood (2011) 118 (21): 3814.

https://doi.org/10.1182/blood.V118.21.3814.3814

Published: 2011

Journal Articles

IRS2 Is Dowregulated In Primary MDS Cells and During MDS Erythroid Differentiation

Joao Machado-Neto, BSci, Patricia Favaro, Ph.D., Mariana Lazarini, PhD, Adriana S S Duarte, PhD, Letícia Fröhlich-Archangelo, Fernando Ferreira Costa, Ph.D., M.D., Sara T. Olalla-Saad, M.D., Ph.D., Fabiola Traina, MD, PhD

Blood (2010) 116 (21): 1886.

https://doi.org/10.1182/blood.V116.21.1886.1886

Published: 2010

Journal Articles

Aberrant Expression of Regulatory miRNAs and Transcripts for IRS-PI3K Growth and Survival Signaling In Waldenstrom's Macroglobulinemia

Zachary Hunter, Yang Cao, MD, Megan Lewicki, Jenny Sun, MD, Hsiuyi Tseng, Christina Hanzis, Philip Brodsky, Robert Manning, Lian Xu, Guang Yang, MD, Yangsheng Zhou, MD, Xia Liu, MD, Jingrui Jiang, Christopher Patterson, Steven P. Treon, MD, PhD

Blood (2010) 116 (21): 1912.

https://doi.org/10.1182/blood.V116.21.1912.1912

Published: 2010

Journal Articles

Mutations of the Wilms tumor 1 gene ( WT1 ) in older patients with primary cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study

Blood (2010) 116 (5): 788–792.

https://doi.org/10.1182/blood-2010-01-262543

Published: 2010

Includes: Supplemental data

Journal Articles

Comparison of Clinical and Biologic Significance of WT1 Mutations in Populations of Older (≥60 years[y]) and Younger (<60 y) Adult Patients (Pts) with Cytogenetically Normal (CN) De Novo Acute Myeloid Leukemia (AML): a Cancer and Leukemia Group B (CALGB) Study.

Heiko Becker, MD, Guido Marcucci, MD, Kati Maharry, MAS, Michael D. Radmacher, PhD, Krzysztof Mrózek, MD, PhD, Susan P. Whitman, PhD, Peter Paschka, MD, Dean Margeson, MAS, Yue-Zhong Wu, MS, Sebastian Schwind, MD, Christian Langer, MD, Maria R. Baer, MD, Andrew J. Carroll, PhD, Michael A. Caligiuri, MD, Jonathan E. Kolitz, MD, Richard A. Larson, MD, Clara D. Bloomfield, MD

Blood (2009) 114 (22): 326.

https://doi.org/10.1182/blood.V114.22.326.326

Published: 2009

NARROW

Analysis of Metformin Effects on Bone Marrow Fibrosis and Disease Progression in Primary Myelofibrosis Patients: Preliminary Results of an Open Label Phase II Trial (FIBROMET)

IGF1R-IRS1/2 Signaling Pathway Is a Potential Target for FLT3-Mutated Acute Myeloid Leukemia

Predictive Simulation Modeling in JAK2-Mutant MPNs Identified Ruxolitinib and Sorafenib As a Synergistic Drug Combination for Disease Modifying Therapy

The Pharmacological IGF1R-IRS1/2 Inhibitor NT157 Presents Multiple Anti-Neoplastic Effects in Myeloproliferative Neoplasms

Pharmacological IGF1R/IRS Inhibitor, NT157, Effectively Induces Apoptosis and CDKN1A Expression in Acute Lymphoblastic Leukemia Cells

Pharmacological IRS1/2 Inhibition Reduces Cell Viability in BCR-ABL1 Positive Cells

High-Depth, Targeted, Next Generation Sequencing Identifies Novel Genetic Alterations in Cutaneous T-Cell Lymphoma

Activating Mutations of Insulin Receptor Substrate 2 (IRS2) in Patients with Tyrosine Kinase Inhibitor-Refractory Chronic Myeloid Leukemia

IRS2 Inhibition Reduces Cell Proliferation and Has Cumulative Effects with Ruxolitinib in JAK2 V617F Cells

Discovery of Novel EPO/EPOR/JAK2 Targets and Signal Transduction Factors Via Proteomic-Based Interrogations of Post-Translational Motif Modifications

Genomic Characterization Of Newly Established Two Distinct Patient-Driven Multiple Myeloma Cell Lines (SNU_MM1393_BM and SNU_MM1393_SC) From a Single Patient

Loss Of IKZF1 Function Mediates Resistance Towards Glucocorticoid-Induced Apoptosis

IRS2 Associates With JAK2 and May Be Involved In Cell Proliferation Pathways In Chronic Myeloproliferative Neoplasms

Insulin/IGF1 Pathway Inhibition in Combination with All-Trans Retinoic Acid in Acute Promyelocytic Leukemia

Identification of Candidate Transcriptional Biomarkers Associated with Chronic Graft-Versus-Host Disease Following Allogeneic Hematopoietic Cell Transplantation

Downregulation of IRS2 in Myelodysplastic Syndrome (MDS) May Be Related to Impaired Cell Differentiation,

IRS2 Is Dowregulated In Primary MDS Cells and During MDS Erythroid Differentiation

Aberrant Expression of Regulatory miRNAs and Transcripts for IRS-PI3K Growth and Survival Signaling In Waldenstrom's Macroglobulinemia

Mutations of the Wilms tumor 1 gene ( WT1 ) in older patients with primary cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study

Comparison of Clinical and Biologic Significance of WT1 Mutations in Populations of Older (≥60 years[y]) and Younger (<60 y) Adult Patients (Pts) with Cytogenetically Normal (CN) De Novo Acute Myeloid Leukemia (AML): a Cancer and Leukemia Group B (CALGB) Study.

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American Society of Hematology

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American Society of Hematology

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