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Journal Articles

Oxidized Mitochondrial DNA Engages TLR9 to Activate the NLRP3 Inflammasome in Myelodysplastic Syndromes

Grace A Ward, BS, Kathy McGraw, PhD, Amy F McLemore, M.S., Nghi B Lam, M.S., Hsin-An Hou, Benjamin S. Meyer, Alan F. List, MD

Blood (2019) 134 (Supplement_1): 774.

https://doi.org/10.1182/blood-2019-122358

Published: 2019

Journal Articles

Soluble Guanylate Cyclase Modulators Effect Fetal Hemoglobin Levels through a Non-cGMP-Protein Kinase G Signaling Pathway

Bin Sun, PhD, Valerie Miller, MS, Karin P Potoka, MD, Yukio Nakamura, MD PhD, Mark T Gladwin, MD, Grant C. Bullock, MD PhD

Blood (2018) 132 (Supplement 1): 1060.

https://doi.org/10.1182/blood-2018-99-120306

Published: 2018

Journal Articles

Results of a Phase 1, Dose-Escalation Study of FF-10501-01 in Patients with Relapsed/Refractory Acute Myeloid Leukemia (AML) or Hypomethylating Agent (HMA)-Resistant Myelodysplastic Syndrome (MDS)

Guillermo Garcia-Manero, MD, Michael R. Kurman, MD, Courtney D. DiNardo, MD MSc, Naveen Pemmaraju, MD, Yesid Alvarado, MD, Kiran Naqvi, MD MPH, Farhad Ravandi, MD, Elias J. Jabbour, MD, Ricardo Delumpa, BSN, Timothy Madden, PhD, Gary Maier, PhD, Hiroyuki Iwamura, PhD, Hagop M. Kantarjian, MD

Blood (2018) 132 (Supplement 1): 1438.

https://doi.org/10.1182/blood-2018-99-116613

Published: 2018

Journal Articles

Oxidized Mitochondrial DNA Is a Catalyst and Biomarker of Pyroptotic Cell Death in Myelodysplastic Syndromes

Grace A Ward, BS, Kathy L McGraw, PhD, Amy F McLemore, M.S., Farnoosh Abbas-Aghababazadeh, PhD, Hsin-An Hou, MD PhD, Thu Le Trinh, PhD, Nicole D. Vincelette, PhD, Benjamin S. Meyer, Alexis H Onimus, BS, Alexandra Calescibetta, Erika A Eksioglu, PhD MS, Sheng Wei, MD, Alan F. List, MD

Blood (2018) 132 (Supplement 1): 3076.

https://doi.org/10.1182/blood-2018-99-118493

Published: 2018

Journal Articles

Intravascular Hemolysis Leads to Increased Esophagus Smooth Muscle Contractions in Mice: Implication for Dysphagia and Odynophagia

Fabio H Silva, PhD, Eduardo C Alexandre, PhD, Fabiano B Calmasini, PhD, Carla Fernanda Franco-Penteado, BSc, PhD, Edson Antunes, PhD, Kleber Yotsumoto Fertrin, MD PhD, Fernando Ferreira Costa, MD PhD

Blood (2017) 130 (Supplement 1): 3470.

https://doi.org/10.1182/blood.V130.Suppl_1.3470.3470

Published: 2017

Journal Articles

Safety and Tolerability of PF-04447943 across a Clinical Trial Program Including 277 Patients

Robert J Charnigo, MS, Beesan Tan, PhD, Denis Rybin, PhD, Debra D Pittman, MS, Krupa M. Sivamurthy, MBBS, MD, David Beidler, PhD, Nicholas Clarke, PhD

Blood (2017) 130 (Supplement 1): 3558.

https://doi.org/10.1182/blood.V130.Suppl_1.3558.3558

Published: 2017

Journal Articles

Clonal Evolution Mechanisms and Collateral Sensitivity to Impdh Inhibitor Therapy in Relapsed Lymphoblastic Leukemia

Chelsea Dieck, Gannie Tzoneva, PhD, Koichi Oshima, MD PhD, Alberto Ambesi-Impiombato, Marta Sanchez-Martin, PhD, Maria Luisa Sulis, MD, Motohiro Kato, MD PhD, Katsuyoshi Koh, MD, Maddalena Paganin, PhD, Giuseppe Basso, MD, Julie M. Gastier-Foster, PhD, Mignon L. Loh, MD, Renate Kirschner-Schwabe, PhD, Chioma Madubata, Raul Rabadan, Adolfo A. Ferrando, MD PhD

Blood (2017) 130 (Supplement 1): 2602.

https://doi.org/10.1182/blood.V130.Suppl_1.2602.2602

Published: 2017

Journal Articles

Severe Trauma Leads to a Fall in Intracellular Triphosphates and a Rise in cAMP in Platelets

Daniel N Darlington, PhD, Xiaowu Wu, MD MSc, Andrew P. Cap, MD PhD

Blood (2017) 130 (Supplement 1): 2318.

https://doi.org/10.1182/blood.V130.Suppl_1.2318.2318

Published: 2017

Journal Articles

The Clinical-Stage sGC Stimulator IW-1701 Prevents Increase of Plasma Biomarkers of Intravascular Inflammation and Suppresses Leukocyte-Endothelial Interactions in Tnfα-Treated Mice

Boris Tchernychev, Susanne Feil, Peter Germano, William Warren, Elisabeth Lonie, Robert Feil, Todd G Milne, John Hadcock, Yueh-Tyng Chien, Mark G Currie, Regina Margaret Graul

Blood (2017) 130 (Supplement 1): 447.

https://doi.org/10.1182/blood.V130.Suppl_1.447.447

Published: 2017

Journal Articles

Anti-Leukemia Effect of FF-10501-01, a Novel Inosine 5'-Monophosphate Dehydrogenase Inhibitor, in Acute Myeloid Leukemia

Hui Yang, MD PhD, Zachary S. Bohannan, MA, Zhihong Fang, Irene Gañán-Gómez, PhD, Yue Wei, PhD, Linda J. Paradiso, DVM, MBA, Hiroyuki Iwamura, Dphil, Guillermo Garcia-Manero, MD

Blood (2016) 128 (22): 2756.

https://doi.org/10.1182/blood.V128.22.2756.2756

Published: 2016

Journal Articles

Cellular Metabolomic Profiling in AML Cell Lines Is Linked to Differences in in Vitro Cytarabine Chemosensitivity

Bradley Stockard, Pharm.D, Joy D Guingab, Neha Sanjeev Bhise, BPharm, Timothy Garrett, Jatinder K Lamba, PhD

Blood (2016) 128 (22): 3954.

https://doi.org/10.1182/blood.V128.22.3954.3954

Published: 2016

Journal Articles

Comparison of Laboratory Data of Patients with Tafro Syndrome and Idiopathic Multicentric Castleman Disease: A Japanese Retrospective Study

Shino Fujimoto, MD, Hiroshi Kawabata, MD PhD, Nozomu Kurose, MD PhD, Kazue Takai, MD PhD, Masaru Kojima, MD PhD, Norifumi Tsukamoto, MD PhD, Tomohiro Kinoshita, MD PhD, Shigeo Nakamura, MD PhD, Sadao Aoki, MD PhD, Yasufumi Masaki, MD PhD

Blood (2016) 128 (22): 4893.

https://doi.org/10.1182/blood.V128.22.4893.4893

Published: 2016

Journal Articles

Decoding the RNA Editome of Normal Versus Malignant Progenitor Cell Aging Short Title: RNA Editing in Normal Aging and MDS/AML Stem Cells

Leslie A Crews, PhD, Qingfei Jiang, PhD, Larisa Balaian, PhD, Heather Leu, BS, Nathan Delos Santos, Angela C Court, Anil Sadarangani, PhD, Sheldon Morris, MD, Rainer F. Storb, MD, Anna Kulidjian, MD, Edward D. Ball, MD, Catriona Jamieson, MD PhD

Blood (2016) 128 (22): 1519.

https://doi.org/10.1182/blood.V128.22.1519.1519

Published: 2016

Journal Articles

Chronic Administration of the PDE9 Inhibitor PF-04447943 Reduces Leukocyte-Platelet Aggregates and Markers of Endothelial Activation in a Mouse Model of Sickle Cell Disease

Reema Jasuja, Elizabeth Parks, John E. Murphy, Debra D Pittman

Blood (2016) 128 (22): 1293.

https://doi.org/10.1182/blood.V128.22.1293.1293

Published: 2016

Journal Articles

Aberrant a-to-I RNA Editing and Prognostic Impact of Adar in Multiple Myeloma Patients with 1q Amplification

Alessandro Lagana, PhD, Deepak Perumal, PhD, Violetta V Leshchenko, PhD, Pei-Yu Kuo, MS, Brian Kidd, PhD, Jonathan J Keats, PhD, Mary Derome, MS, Jennifer Yesil, MS, Daniel Auclair, PhD, Deepu Madduri, Ajai Chari, MD, Hearn Jay Cho, MD PhD, Bart Barlogie, MD PhD, Sundar Jagannath, MD, Joel Dudley, PhD, Samir Parekh, MD

Blood (2016) 128 (22): 357.

https://doi.org/10.1182/blood.V128.22.357.357

Published: 2016

Journal Articles

Inhibition of Impdh As an Effective Treatment for MLL-Fusion Leukemia

Susumu Goyama, MD PhD, Shiori Shikata, Yasutaka Hayashi, Yuto Izawa, Janet Schibler, Hiroyuki Iwamura, Dphil, Motoki Saito, PhD, Satoshi Kofuji, Kazutaka Sumita, Atsuo T Sasaki, James C. Mulloy, PhD, Toshio Kitamura, MD PhD

Blood (2016) 128 (22): 750.

https://doi.org/10.1182/blood.V128.22.750.750

Published: 2016

Journal Articles

p38α Activates Purine Metabolism to Initiate Hematopoietic Stem Cell Cycling

Daiki Karigane, MD, Shinichiro Okamoto, Toshio Suda, MD PhD, Keiyo Takubo, MD PhD

Blood (2015) 126 (23): 776.

https://doi.org/10.1182/blood.V126.23.776.776

Published: 2015

Journal Articles

Elevated Plasma Thrombospondin-1 (TSP1) Levels Are Correlated with Oxidative Stress and Worse Cognitive Function in Sickle Cell Disease

Enrico M Novelli, MD MS, Lynda Little-Ihrig, BS, Dana Rae Jorgensen, MPH, C Elizabeth Shaaban, PhD, Jeffrey S Isenberg, MD MPH, Meryl A Butters, PhD, Caterina Rosano, MD MPH

Blood (2015) 126 (23): 2184.

https://doi.org/10.1182/blood.V126.23.2184.2184

Published: 2015

Journal Articles

Upregulation of Vav3 Is Required for Leukemogenesis By BCR-ABL through Polycomb Repression Complex Dependent De-Repression of the Cdkn2a Locus

Megha Desai, PhD, Kyung-Hee Chang, PhD, E. David Muench, BS, Anjelika Gasilina, Ashley Wellendorf, Xose R Bustelo, H. Leighton Grimes, PhD, Nicolas Nassar, PhD, Jose A Cancelas, MD PhD

Blood (2015) 126 (23): 3661.

https://doi.org/10.1182/blood.V126.23.3661.3661

Published: 2015

Journal Articles

Anti-Leukemia Effect of FF-10501-01, a Novel Inosine 5'-Monophosphate Dehydrogenase Inhibitor, in Advanced Acute Myeloid Leukemia (AML) and Myelodysplastic Syndromes (MDS), Including Hypomethylating Agent (HMA) Failures

Guillermo Garcia-Manero, MD, Hui Yang, MD PhD, Zhihong Fang, Courtney DiNardo, MD, Elias Jabbour, MD, Naveen Pemmaraju, MD, Ricardo Delumpa, RN, Christopher Loiselle, RN, Susan Denton, RN, Whitney Smith, Hiroyuki Iwamura, PhD, Teletha Gipson, PhD, Michele Rosner, MS, Timothy Madden, PharmD, Thomas J. Myers, MD, Linda J. Paradiso, DVM, MBA

Blood (2015) 126 (23): 3800.

https://doi.org/10.1182/blood.V126.23.3800.3800

Published: 2015

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Oxidized Mitochondrial DNA Engages TLR9 to Activate the NLRP3 Inflammasome in Myelodysplastic Syndromes

Soluble Guanylate Cyclase Modulators Effect Fetal Hemoglobin Levels through a Non-cGMP-Protein Kinase G Signaling Pathway

Results of a Phase 1, Dose-Escalation Study of FF-10501-01 in Patients with Relapsed/Refractory Acute Myeloid Leukemia (AML) or Hypomethylating Agent (HMA)-Resistant Myelodysplastic Syndrome (MDS)

Oxidized Mitochondrial DNA Is a Catalyst and Biomarker of Pyroptotic Cell Death in Myelodysplastic Syndromes

Intravascular Hemolysis Leads to Increased Esophagus Smooth Muscle Contractions in Mice: Implication for Dysphagia and Odynophagia

Safety and Tolerability of PF-04447943 across a Clinical Trial Program Including 277 Patients

Clonal Evolution Mechanisms and Collateral Sensitivity to Impdh Inhibitor Therapy in Relapsed Lymphoblastic Leukemia

Severe Trauma Leads to a Fall in Intracellular Triphosphates and a Rise in cAMP in Platelets

The Clinical-Stage sGC Stimulator IW-1701 Prevents Increase of Plasma Biomarkers of Intravascular Inflammation and Suppresses Leukocyte-Endothelial Interactions in Tnfα-Treated Mice

Anti-Leukemia Effect of FF-10501-01, a Novel Inosine 5'-Monophosphate Dehydrogenase Inhibitor, in Acute Myeloid Leukemia

Cellular Metabolomic Profiling in AML Cell Lines Is Linked to Differences in in Vitro Cytarabine Chemosensitivity

Comparison of Laboratory Data of Patients with Tafro Syndrome and Idiopathic Multicentric Castleman Disease: A Japanese Retrospective Study

Decoding the RNA Editome of Normal Versus Malignant Progenitor Cell Aging Short Title: RNA Editing in Normal Aging and MDS/AML Stem Cells

Chronic Administration of the PDE9 Inhibitor PF-04447943 Reduces Leukocyte-Platelet Aggregates and Markers of Endothelial Activation in a Mouse Model of Sickle Cell Disease

Aberrant a-to-I RNA Editing and Prognostic Impact of Adar in Multiple Myeloma Patients with 1q Amplification

Inhibition of Impdh As an Effective Treatment for MLL-Fusion Leukemia

p38α Activates Purine Metabolism to Initiate Hematopoietic Stem Cell Cycling

Elevated Plasma Thrombospondin-1 (TSP1) Levels Are Correlated with Oxidative Stress and Worse Cognitive Function in Sickle Cell Disease

Upregulation of Vav3 Is Required for Leukemogenesis By BCR-ABL through Polycomb Repression Complex Dependent De-Repression of the Cdkn2a Locus

Anti-Leukemia Effect of FF-10501-01, a Novel Inosine 5'-Monophosphate Dehydrogenase Inhibitor, in Advanced Acute Myeloid Leukemia (AML) and Myelodysplastic Syndromes (MDS), Including Hypomethylating Agent (HMA) Failures

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