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Journal Articles

In Vitro and In Vivo Potency Differences between AAVRh74var and AAV5 Vectors Encoding the Same High-Activity Human Factor IX Variant, FIX-R338L, Expression Cassette: Implications for Hemophilia B Gene Therapy

Debra D Pittman, Swapnil Rakhe, Lisa J Wilcox, Daniel LeBlanc, Vicente Pagan, Megan L Brophy, Diana Sapashnik, Annette Sievers

Blood (2024) 144 (Supplement 1): 3581.

https://doi.org/10.1182/blood-2024-203983

Published: 2024

Journal Articles

The Effect of Tucaresol on Translational MRI Estimates of Cerebral Physiology in Townes SCD Mice

James A. Goodman, Yi-Fen Yen, Yinching Iris Chen, Suk-Tak Chan, Jonah P. Weigand Wittier, Jay M. Janz, Steven Arkin, Denis Rybin, Kelly Marie Knee, Debra D Pittman, Joseph B. Mandeville

Blood (2023) 142 (Supplement 1): 2491.

https://doi.org/10.1182/blood-2023-189037

Published: 2023

Journal Articles

Evaluation of Longitudinal Pain Study in Sickle Cell Disease (ELIPSIS) by patient-reported outcomes, actigraphy, and biomarkers

Debra D. Pittman, Patrick C. Hines, David Beidler, Denis Rybin, Andrew L. Frelinger, III, Alan D. Michelson, Ke Liu, Xiufeng Gao, Jennell White, Ahmar U. Zaidi, Robert J. Charnigo, Michael U. Callaghan

Blood (2021) 137 (15): 2010–2020.

https://doi.org/10.1182/blood.2020006020

Published: 2021

Includes: Supplemental data

Journal Articles

Validation of Patient-Reported Vaso-Occlusive Crisis Day As a Potential Endpoint in Studies of Sickle Cell Disease

Karin Coyne, PhD, Brooke Currie, Michael U. Callaghan, MD, Kathleen W. Wyrwich, PhD, Sheryl Pease, MBA, Christine L. Baker, JD, MPH, Steven Arkin, MD, Debra D. Pittman, PhD

Blood (2020) 136 (Supplement 1): 17.

https://doi.org/10.1182/blood-2020-137464

Published: 2020

Journal Articles

Antibodies against the erythroferrone N-terminal domain prevent hepcidin suppression and ameliorate murine thalassemia

João Arezes, Niall Foy, Kirsty McHugh, Doris Quinkert, Susan Benard, Anagha Sawant, Joe N. Frost, Andrew E. Armitage, Sant-Rayn Pasricha, Pei Jin Lim, May S. Tam, Edward Lavallie, Debra D. Pittman, Orla Cunningham, Matthew Lambert, John E. Murphy, Simon J. Draper, Reema Jasuja, Hal Drakesmith

Blood (2020) 135 (8): 547–557.

https://doi.org/10.1182/blood.2019003140

Published: 2020

Includes: Supplemental data

Journal Articles

Adeno-Associated Virus Mediated Delivery of a TFPI Antibody Restores Hemostasis in Mouse Model of Hemophilia

Swapnil Rakhe, MS, Reema Jasuja, PhD, Rajani Shelke, Anagha Sawant, Suryanarayan Somanathan, PhD, John E. Murphy, PhD, Debra D Pittman, MS

Blood (2019) 134 (Supplement_1): 3357.

https://doi.org/10.1182/blood-2019-130054

Published: 2019

Journal Articles

Antibodies Against the Erythroferrone N-Terminal Domain Prevent Hepcidin Suppression and Ameliorate Murine Thalassemia

Blood (2019) 134 (Supplement_1): 964.

https://doi.org/10.1182/blood-2019-130246

Published: 2019

Journal Articles

In Vitro and In Vivo Characterization of Marstacimab, an Anti-TFPI Antibody

Chuenlei Parng, PhD, Macy Jin, PhD, Matthew Holsti, PhD, Susan Benard, Swapnil Rakhe, MS, Sunita R. Patel-Hett, PhD, Alison Joyce, Rob Webster, Debra D Pittman, MS

Blood (2019) 134 (Supplement_1): 2391.

https://doi.org/10.1182/blood-2019-130327

Published: 2019

Journal Articles

A Neutralizing Monoclonal Antibody (PF-06741086) Against Tissue Factor Pathway Inhibitor in Combination with Activated Prothrombin Complex Concentrate Increases Hemostasis in Inhibitor Hemophilia Plasmas without Excessive Thrombin Generation

Swapnil Rakhe, MS, Sheryl Bowley, PhD, John E. Murphy, PhD, Debra D Pittman, MS

Blood (2018) 132 (Supplement 1): 3779.

https://doi.org/10.1182/blood-2018-99-119831

Published: 2018

Journal Articles

Efficacy of Anti-TFPI Antibody PF-06741086 Alone and in Combination with Activated Prothrombin Complex Concentrates in Mouse Hemophilia a Bleeding Model

Amey Barakat, Reema Jasuja, PhD, John E. Murphy, PhD, Debra D Pittman, MS

Blood (2018) 132 (Supplement 1): 2460.

https://doi.org/10.1182/blood-2018-99-118431

Published: 2018

Journal Articles

The Tissue Factor Pathway Inhibitor Antibody, PF-06741086, Increases Thrombin Generation in Rare Bleeding Disorder and Von Willebrand Factor Deficient Plasmas

Swapnil Rakhe, MS, Sunita R. Patel-Hett, PhD, Sheryl Bowley, PhD, John E. Murphy, PhD, Debra D Pittman, MS

Blood (2018) 132 (Supplement 1): 2462.

https://doi.org/10.1182/blood-2018-99-119674

Published: 2018

Journal Articles

Transcriptomic Analysis Reveals Erythroferrone Modulates BMP6 Signaling Pathways Involved in Iron Homeostasis and Metabolism

Reema Jasuja, PhD, Anagha Sawant, Debra D Pittman, MS, Jie Quan

Blood (2018) 132 (Supplement 1): 1049.

https://doi.org/10.1182/blood-2018-99-118724

Published: 2018

Journal Articles

Site-Directed Pegylation at Specific Sites Significantly Prolongs the Half-Life of A1A2A3-VWF By Markedly Attenuating LRP1-Mediated Clearance

Jamie M O'Sullivan, Judicael Fazavana, PhD, Alain Chan, PhD, Niamh Cooke, PhD, Virginie Terraube, Justin Cohen, PhD, Debra D Pittman, MS, Orla Cunningham, PhD, Matthew Lambert, James S O'Donnell, MD PhD

Blood (2018) 132 (Supplement 1): 1165.

https://doi.org/10.1182/blood-2018-99-114966

Published: 2018

Journal Articles

Elipsis: A Longitudinal Study of Electronic Patient-Reported Outcomes, Actigraphy and Biomarkers to Identify and Assess at-Home Vaso-Occlusive Crises in Adults and Adolescents with Sickle Cell Disease

Michael U. Callaghan, Patrick C. Hines, MD PhD, Debra D Pittman, MS, David Beidler, PhD, Denis Rybin, PhD, Ahmar Urooj Zaidi, MD BSc, Jennell White, PhD, Ke Liu, PhD, Bryan Hannan, MS, Xiufeng Gao, MD, Andreas M Pleil, PhD, Alexandra Barsdorf, PhD, Martin David, Pharm D, Melanie Simmons, PMP, PSM, Andrew L Frelinger, III, PhD, Alan D Michelson, MD, Nick Clarke, PhD, Robert J Charnigo, MS

Blood (2017) 130 (Supplement 1): 973.

https://doi.org/10.1182/blood.V130.Suppl_1.973.973

Published: 2017

Journal Articles

Safety and Tolerability of PF-04447943 across a Clinical Trial Program Including 277 Patients

Robert J Charnigo, MS, Beesan Tan, PhD, Denis Rybin, PhD, Debra D Pittman, MS, Krupa M. Sivamurthy, MBBS, MD, David Beidler, PhD, Nicholas Clarke, PhD

Blood (2017) 130 (Supplement 1): 3558.

https://doi.org/10.1182/blood.V130.Suppl_1.3558.3558

Published: 2017

Journal Articles

An Antibody to Tissue Factor Pathway Inhibitor (PF-06741086) in Combination with Recombinant Factor VIIa Increases Hemostasis in Hemophilia Plasma without Excessive Thrombin Generation

Swapnil Rakhe, Sunita Patel Hett, John E. Murphy, Debra D Pittman

Blood (2016) 128 (22): 2566.

https://doi.org/10.1182/blood.V128.22.2566.2566

Published: 2016

Journal Articles

Escalating Single Doses of PF-05230907 (Recombinant Factor Xa Variant FXa I16L ) Are Safe and Demonstrate Hemostatic Pharmacology in Healthy Volunteers

Steven Arkin, MD, Fei Hua, PhD, Constantino Kantaridis, MD, Gang Li, PhD, Dana Parsons-Rich, MPH, MPA, Debra D Pittman

Blood (2016) 128 (22): 3781.

https://doi.org/10.1182/blood.V128.22.3781.3781

Published: 2016

Journal Articles

An Antibody to Tissue Factor Pathway Inhibitor (TFPI) Restores Hemostasis after the Onset of Bleeding in Hemophilic a Mouse Injury Models

Reema Jasuja, Amey Barakat, John E. Murphy, Debra D Pittman

Blood (2016) 128 (22): 3761.

https://doi.org/10.1182/blood.V128.22.3761.3761

Published: 2016

Journal Articles

Chronic Administration of the PDE9 Inhibitor PF-04447943 Reduces Leukocyte-Platelet Aggregates and Markers of Endothelial Activation in a Mouse Model of Sickle Cell Disease

Reema Jasuja, Elizabeth Parks, John E. Murphy, Debra D Pittman

Blood (2016) 128 (22): 1293.

https://doi.org/10.1182/blood.V128.22.1293.1293

Published: 2016

Journal Articles

Rivipansel: A Small Pan-Selectin Antagonist Improves Cerebral Perfusion and Inhibits Leukocyte Adhesion and in Murine Sickle Cell Disease Model

Reema Jasuja, Georgette Suidan, Sunita Patel Hett, Kunal Desai, Kevin X Le, Elizabeth Parks, Robert Bell, John E. Murphy, Debra D Pittman

Blood (2016) 128 (22): 270.

https://doi.org/10.1182/blood.V128.22.270.270

Published: 2016

NARROW

In Vitro and In Vivo Potency Differences between AAVRh74var and AAV5 Vectors Encoding the Same High-Activity Human Factor IX Variant, FIX-R338L, Expression Cassette: Implications for Hemophilia B Gene Therapy

The Effect of Tucaresol on Translational MRI Estimates of Cerebral Physiology in Townes SCD Mice

Evaluation of Longitudinal Pain Study in Sickle Cell Disease (ELIPSIS) by patient-reported outcomes, actigraphy, and biomarkers

Validation of Patient-Reported Vaso-Occlusive Crisis Day As a Potential Endpoint in Studies of Sickle Cell Disease

Antibodies against the erythroferrone N-terminal domain prevent hepcidin suppression and ameliorate murine thalassemia

Adeno-Associated Virus Mediated Delivery of a TFPI Antibody Restores Hemostasis in Mouse Model of Hemophilia

Antibodies Against the Erythroferrone N-Terminal Domain Prevent Hepcidin Suppression and Ameliorate Murine Thalassemia

In Vitro and In Vivo Characterization of Marstacimab, an Anti-TFPI Antibody

A Neutralizing Monoclonal Antibody (PF-06741086) Against Tissue Factor Pathway Inhibitor in Combination with Activated Prothrombin Complex Concentrate Increases Hemostasis in Inhibitor Hemophilia Plasmas without Excessive Thrombin Generation

Efficacy of Anti-TFPI Antibody PF-06741086 Alone and in Combination with Activated Prothrombin Complex Concentrates in Mouse Hemophilia a Bleeding Model

The Tissue Factor Pathway Inhibitor Antibody, PF-06741086, Increases Thrombin Generation in Rare Bleeding Disorder and Von Willebrand Factor Deficient Plasmas

Transcriptomic Analysis Reveals Erythroferrone Modulates BMP6 Signaling Pathways Involved in Iron Homeostasis and Metabolism

Site-Directed Pegylation at Specific Sites Significantly Prolongs the Half-Life of A1A2A3-VWF By Markedly Attenuating LRP1-Mediated Clearance

Elipsis: A Longitudinal Study of Electronic Patient-Reported Outcomes, Actigraphy and Biomarkers to Identify and Assess at-Home Vaso-Occlusive Crises in Adults and Adolescents with Sickle Cell Disease

Safety and Tolerability of PF-04447943 across a Clinical Trial Program Including 277 Patients

An Antibody to Tissue Factor Pathway Inhibitor (PF-06741086) in Combination with Recombinant Factor VIIa Increases Hemostasis in Hemophilia Plasma without Excessive Thrombin Generation

Escalating Single Doses of PF-05230907 (Recombinant Factor Xa Variant FXa I16L ) Are Safe and Demonstrate Hemostatic Pharmacology in Healthy Volunteers

An Antibody to Tissue Factor Pathway Inhibitor (TFPI) Restores Hemostasis after the Onset of Bleeding in Hemophilic a Mouse Injury Models

Chronic Administration of the PDE9 Inhibitor PF-04447943 Reduces Leukocyte-Platelet Aggregates and Markers of Endothelial Activation in a Mouse Model of Sickle Cell Disease

Rivipansel: A Small Pan-Selectin Antagonist Improves Cerebral Perfusion and Inhibits Leukocyte Adhesion and in Murine Sickle Cell Disease Model

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American Society of Hematology

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American Society of Hematology

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