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Prediction of Patients at Risk of CD19 Neg Relapse Following CD19-Directed CAR T Cell Therapy in B Cell Precursor Acute Lymphoblastic Leukemia

Pablo Domizi, PhD, Astraea Jager, BS, Jolanda Sarno, PhD, Charles G. Mullighan, MBBS, MD, Stephan Grupp, MD PhD, Elena Sotillo, PhD, David M. Barrett, Kara L. Davis, DO
Journal: Blood
Blood (2019) 134 (Supplement_1): 749.
https://doi.org/10.1182/blood-2019-128883
Published: 2019
Journal Articles

Next Generation CRISPR Gene-Edited and Off-the-Shelf Virus-Specific T-Cells for the Immunocompromised Patient

Rafet Basar, MD, May Daher, MD, Nadima Uprety, MS, Elif Gokdemir, BS, Abdullah Saleh Alsuliman, PhD, Mayela Carolina Mendt, PhD, Lucila Kerbauy, MD, Mayra Shanley, PhD, Gonca Ozcan, MD, Emily Ensley, BS, Ana Karen Nunez Cortes, MD, Li Li, MD, Junjun Lu, Mecit Kaplan, MS, Vandana Nandivada, BS, MS, Mustafa Bdaiwi, MD, Ye Li, Luciana Melo Garcia, MD, Enli Liu, MD, Sonny Ang, PhD, Pinaki P Banerjee, PhD, Richard E. Champlin, MD, Elizabeth J. Shpall, MD, Katayoun Rezvani, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1944.
https://doi.org/10.1182/blood-2019-125276
Published: 2019
Journal Articles

The Combination of Dexamethasone and Ruxolitinib Synergistically Attenuates Disease Manifestations in a Preclinical Model of Hemophagocytic Lymphohistiocytosis

Lauren K. Meyer, Katherine Verbist, PhD, Sabrin Albeituni, PhD, Rachel Bassett, Michelle L. Hermiston, MD PhD, Kim E. Nichols, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 81.
https://doi.org/10.1182/blood-2019-129112
Published: 2019
Journal Articles

Whole-Genome CRISPR Screen Reveals the Mechanism of Relapse in Patient-Derived Cells Representing High-Risk Paediatric ALL

Katarzyna Szoltysek, PhD, Helen Blair, Sirintra Nakjang, Ricky Tirtakusuma, Mankaran Singh, Ryan Nelson, Hesta McNeill, Catherine Dodd, Melanie Beckett, Lynsey McKenzie, Edward Law, Josef Vormoor, MD PhD, Deepali Pal, Olaf Heidenreich
Journal: Blood
Blood (2019) 134 (Supplement_1): 3952.
https://doi.org/10.1182/blood-2019-124818
Published: 2019
Journal Articles

Identification of Genetic Vulnerabilities and Synthetic-Lethal Targets in NSD2-High Multiple Myeloma

Amin Sobh, PhD, Charlotte Kaestner, Alberto Riva, PhD, Jonathan D. Licht, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3757.
https://doi.org/10.1182/blood-2019-125951
Published: 2019
Journal Articles

Elevated ANXA1 Expression Causes Glucocorticoid Resistance in Acute Lymphoblastic Leukemia Via Activating the Wnt/β-Catenin Signaling Pathway

Ping Liu, Dan Ma, MD, Jishi Wang, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5198.
https://doi.org/10.1182/blood-2019-130322
Published: 2019
Journal Articles

MAPK-ERK Pathway Activation: The Achilles' Heel of IL-7R‒Induced Steroid Resistance

Jordy C.G. Van Der Zwet, MD, Jessica G.C.A.M. Buijs-Gladdines, Willem K. Smits, Zhongli Chen, MSc, Jules P.P. Meijerink, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1292.
https://doi.org/10.1182/blood-2019-124721
Published: 2019
Journal Articles

Peri-Transplant Steroids Enhance GVL and Attenuate GVHD By Redistributing Alloreactive Donor T Cells from the Gut into the Bone Marrow

Takayuki Inouye, MD PhD, Motoko Koyama, MD PhD, Ensbey Kathleen, Nicholas Greene, Luke Samson, Hiroyasu Ogawa, MD PhD, Geoffrey R. Hill, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3210.
https://doi.org/10.1182/blood-2019-129341
Published: 2019
Journal Articles

Dexamethasone Accelerates the Transition of Human BFU-E to CFU-E and Enhances CFU-E Proliferation through Cell Cycle Regulation

Ryan Ashley, BS, MS, Hongxia Yan, MS, Brian Dulmovits, BA, MS, Nan Wang, PhD, Julien Papoin, MS, Jeffrey M Lipton, MD PhD, Mohandas Narla, DSc, Anupama Narla, MD, Lionel Blanc, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3620.
https://doi.org/10.1182/blood-2018-99-116596
Published: 2018
Journal Articles

A Gain of Function Mutation in the NSD2 Histone Methyltransferase Drives Glucocorticoid Resistance of Acute Lymphoblastic Leukemia

Jianping Li, MD, Catalina Troche, PhD, Alok Swaroop, PhD, Marta Kulis, PhD, Jon Oyer, PhD, Christine Will, MS, Daphne Dupere-Richer, PhD, Alberto Riva, PhD, Crissandra Pipe, LATG, Sharon Norton, MS, Richard Lynn Bennett, PhD, Jonathan D. Licht, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 653.
https://doi.org/10.1182/blood-2018-99-116309
Published: 2018
Journal Articles

Mutational Landscape and Temporal Evolution during Treatment of Relapsed Acute Lymphoblastic Leukemia

Benshang Li, Yongjin Li, PhD, Shuhong Shen, MD PhD, Yingchi Zhang, Samuel Brady, PhD, Xiaotu Ma, Yu Liu, PhD, Ningling Wang, Diane Flasch, Matthew Myers, Heather Mulder, BS, Yanling Liu, Liqing Tian, Kohei Hagiwara, MD, Hui Zhang, Ying Shao, Hongye Sun, Lele Sun, Ting-Nien Lin, Lijuan Du, Fan Yang, Michael Rusch, BS, Michael Edmonson, John Easton, PhD, Xiaofan Zhu, PhD, Jingliao Zhang, MD, Cheng Cheng, PhD, Benjamin Raphael, Jing-Yan Tang, James R. Downing, MD, Bin-Bing Zhou, Ching-Hon Pui, MD, Jun J. Yang, PhD, Jinghui Zhang
Journal: Blood
Blood (2018) 132 (Supplement 1): 917.
https://doi.org/10.1182/blood-2018-99-119144
Published: 2018
Journal Articles

Coordination of Pro- and Anti-Inflammatory Signals Determine Human Hematopoietic Stem and Progenitor Cell Expansion

Jalila Chagraoui, PhD, Elisa Tomellini, PhD, Leo Aubert, Iman Fares, PhD, Jean-Francois Spinella, PhD, Simon Girard, Nadine Mayotte, Philippe P Roux, PhD, Guy Sauvageau, MD, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2555.
https://doi.org/10.1182/blood-2018-99-111917
Published: 2018
Journal Articles

CD166 Engagement Augments Mouse and Human Hematopoietic Stem and Progenitor Function Via Activation of Stem Cell-Associated and Cell Cycle Pathways

Joydeep Ghosh, PhD, Jing Zhang, PhD, Chi Zhang, PhD, Xinxin Huang, PhD, Safa F. Mohamad, MS, Maegan L. Capitano, PhD, Andrea M. Gunawan, Scott Cooper, MS, Bin Guo, PhD, Qingchun Cai, PhD, Hal E. Broxmeyer, PhD, Edward F. Srour, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1282.
https://doi.org/10.1182/blood-2018-99-119251
Published: 2018
Journal Articles

Haploinsufficiency for NR3C1 Drives Glucocorticoid Resistance By Inactivation the PI3K/AKT/GSK3β/Bim Pathway in Adult Acute Lymphoblastic Leukemia

Xiao Haowen, MD PhD, Yingying Ding, Yang Gao, Limengmeng Wang, PhD, Huafang Wang, Xiaohong Yu, He Huang, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1328.
https://doi.org/10.1182/blood-2018-99-120089
Published: 2018
Journal Articles

Stimulation of the Proliferation of Mouse and Human Definitive Erythroid Progenitors By Activation of the Vitamin D Receptor Transcription Factor

Margaret H. Baron, MD, Jeffrey H. Barminko, PhD, Brad M. Reinholt, PhD, Mohandas Narla, DSc
Journal: Blood
Blood (2018) 132 (Supplement 1): 1029.
https://doi.org/10.1182/blood-2018-99-113846
Published: 2018
Journal Articles

Chemogenomic Approach Unveils the Increased Susceptibility of RUNX1 -Mutated AML to Glucocorticoids

Laura Simon, BSc, MSc, Vincent-Philippe Lavallee, MD, Marie-Eve Bordeleau, PhD, Bernhard Lehnertz, PhD, Tara MacRae, Jalila Chagraoui, PhD, Jean-Francois Spinella, PhD, Geneviève Boucher, Thierry Bertomeu, PhD, Jasmin Coulombe-Huntington, PhD, Mike Tyers, PhD, Sébastien Lemieux, PhD, Anne Marinier, PhD, Josée Hébert, MD, Guy Sauvageau, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4675.
https://doi.org/10.1182/blood-2018-99-111030
Published: 2018
Journal Articles

Glucocorticoid Resistance in IKZF1-Deleted BCP-ALL: It Is PTEN Again

Laurens Van Der Meer, PhD, Rene Marke, MSc, Miriam Butler, MSc, Dorette van Ingen Schenau, MSc, Blanca Scheijen, PhD, Frank van Leeuwen, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4088.
https://doi.org/10.1182/blood-2018-99-112888
Published: 2018
Journal Articles

Aberrant Level of Estrogen Correlates with Defective Thrombopoiesis during Pregnancy in Patients with Immune Thrombocytopenia

Qi Chen, Xiao Liu, Jing-Zhong Zhao, Chen-Cong Wang, Ya-Nan Wang, Jing Xue, Jia-Min Zhang, MD, Xiao-Lu Zhu, Yun He, Qian-Ming Wang, Hai-Xia Fu, Lan-Ping Xu, Kai-Yan Liu, Xiao-Jun Huang, MD, Xiaohui Zhang, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1047.
https://doi.org/10.1182/blood.V130.Suppl_1.1047.1047
Published: 2017
Journal Articles

A Pharmacologic Approach Using Pomalidomide and Dexamethasone to Study Stage-Specific Regulation of Erythroid Progenitors

Brian M Dulmovits, MS, Nan Wang, PhD, Hongxia Yan, MS, Julien Papoin, MS, Ryan Ashley, BS, MS, John Hale, Jeffrey M Lipton, MDPhD, Mohandas Narla, DSc, Anupama Narla, MD, Lionel Blanc, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 12.
https://doi.org/10.1182/blood.V130.Suppl_1.12.12
Published: 2017
Journal Articles

CREBBP Histone Acetyltransferase Domain Mutations Result in Dexamethasone Resistance in B-Progenitor Acute Lymphoblastic Leukemia

Yunchao Chang, PhD, David W. Woessner, PhD MS, Wenwei Lin, PhD, Taosheng Chen, PhD, Beisi Xu, PhD, Yiping Fan, PhD, Haiyan Tan, PhD, Junmin Peng, PhD, Lawryn Kasper, PhD, Michelle L. Churchman, PhD, Mignon L. Loh, MD, Stephen P. Hunger, MD, Aman Seth, PhD, Karen Gascoigne, PhD, Paul K Brindle, PhD, Charles G. Mullighan, MBBS, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 560.
https://doi.org/10.1182/blood.V130.Suppl_1.560.560
Published: 2017