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Journal Articles

Impact and Outcomes of RAS gene Mutations in Core Binding Factor Acute Myeloid Leukemia

Hassan Awada, Ashwin Kishtagari, MBBS, Teodora Kuzmanovic, Jibran Durrani, Cassandra M Kerr, MS, Manja Meggendorfer, PhD, Anjali S. Advani, MD, Aziz Nazha, MD, Hetty E. Carraway, MD MBA, Torsten Haferlach, MD, Mikkael A. Sekeres, MD MS, Valeria Visconte, PhD, Jaroslaw P. Maciejewski, MD PhD

Blood (2019) 134 (Supplement_1): 2720.

https://doi.org/10.1182/blood-2019-131301

Published: 2019

Journal Articles

Rigosertib, a Pan RAS Inhibitor, Decreases Mouse and Human Myeloma Cell Growth in Preclinical Models

Maurizio Zangari, MD, Ikjae Shin, PhD, Antonio Branca, MD, Hanna Yoo, MS, Sophia Fallo, Faith E Davies, MD, Benjamin Hoffman, PhD, Steven M. Fruchtman, MD, Donghoon Yoon, PhD

Blood (2016) 128 (22): 5664.

https://doi.org/10.1182/blood.V128.22.5664.5664

Published: 2016

Journal Articles

Indolent Phenotype of RAS-Associated Autoimmune Leukoproliferative Disorder (RALD) Is Characterized By Single Somatic Mutations in RAS Genes with Absence of Cooperating Mutations

Vollter Anastas, B.S., Weixin Wang, PhD, Susan Price, Zhen Zhao, PhD, V. Koneti Rao, MD, Katherine R. Calvo, MD PhD

Blood (2016) 128 (22): 4268.

https://doi.org/10.1182/blood.V128.22.4268.4268

Published: 2016

Journal Articles

Kras Is Critical for B Cell Lymphopoiesis

Yongwei Zheng, PhD, Yuhong Chen, PhD, Xiaona You, PhD, Mei Yu, PhD, Guoping Fu, PhD, Xinlin Su, Wen Zhu, Zhihong Wu, Jing Zhang, PhD, Renren Wen, PhD, Demin Wang, PhD

Blood (2015) 126 (23): 3588.

https://doi.org/10.1182/blood.V126.23.3588.3588

Published: 2015

Journal Articles

MEK Inhibition Is a Promising Therapeutic Strategy for MLL -Rearranged Infant ALL Patients Carrying RAS Mutations

Mark JB Kerstjens, MSc, Emma MC Driessen, MD, Merel Willekes, BSc, Sandra S Mimoso Pinhancos, MSc, Rob Pieters, MD PhD, Ronald Stam, PhD

Blood (2014) 124 (21): 919.

https://doi.org/10.1182/blood.V124.21.919.919

Published: 2014

Journal Articles

Another path to ERK activation

Paul A. Ney

Blood (2013) 121 (16): 3064–3065.

https://doi.org/10.1182/blood-2013-02-480459

Published: 2013

Journal Articles

Evolution of Sub-Clones with KRAS Mutations In Pediatric Patients with MLL-AF4 Rearrangements

Silvia Bresolin, Emanuela Giarin, Luca Trentin, PhD, Lueder Hinrich Meyer, MD, Giuseppe Basso, MD PhD, Geertruy Kronnie, PhD

Blood (2011) 118 (21): 2454.

https://doi.org/10.1182/blood.V118.21.2454.2454

Published: 2011

Journal Articles

H-ras and N-ras are dispensable for T-cell development and activation but critical for protective Th1 immunity

Salvador Iborra, Manuel Soto, Luiz Stark-Aroeira, Esther Castellano, Balbino Alarcón, Carlos Alonso, Eugenio Santos, Edgar Fernández-Malavé

Blood (2011) 117 (19): 5102–5111.

https://doi.org/10.1182/blood-2010-10-315770

Published: 2011

Journal Articles

Impact of RAS Mutations In Myelodysplastic Syndrome (MDS)

Aref Al-Kali, MD, Rajyalakshmi Luthra, PhD, Carlos E. Bueso-Ramos, MD, Sherry Pierce, RN, BS, Tapan Kadia, MD, Gautam Borthakur, MD, Zeev Estrov, MD, Elias Jabbour, MD, Stefan Faderl, MD, Farhad Ravandi, MD, Jorge Cortes, MD, Hagop M. Kantarjian, MD, Guillermo Garcia-Manero, MD

Blood (2010) 116 (21): 2926.

https://doi.org/10.1182/blood.V116.21.2926.2926

Published: 2010

Journal Articles

Self-association mediated by the Ras association 1 domain of AF6 activates the oncogenic potential of MLL-AF6

Michaela Liedtke, Paul M. Ayton, Tim C. P. Somervaille, Kevin S. Smith, Michael L. Cleary

Blood (2010) 116 (1): 63–70.

https://doi.org/10.1182/blood-2009-09-243386

Published: 2010

Includes: Supplemental data

Journal Articles

Ras-induced reactive oxygen species promote growth factor–independent proliferation in human CD34 + hematopoietic progenitor cells

Paul S. Hole, Lorna Pearn, Amanda J. Tonks, Philip E. James, Alan K. Burnett, Richard L. Darley, Alex Tonks

Blood (2010) 115 (6): 1238–1246.

https://doi.org/10.1182/blood-2009-06-222869

Published: 2010

Includes: Supplemental data

Journal Articles

AML with CBFB-MYH11 Rearrangement Is Characterized by RAS Pathway Alterations in 92% of Cases and Demonstrates a High Frequency of NF1 Deletions.

Claudia Haferlach, MD, Frank Dicker, PhD, Alexander Kohlmann, PhD, Sonja Schindela, Tamara Weiss, Wolfgang Kern, MD, Susanne Schnittger, PhD, Torsten Haferlach, MD

Blood (2009) 114 (22): 272.

https://doi.org/10.1182/blood.V114.22.272.272

Published: 2009

Journal Articles

Absence of Oncogenic Transformation in Long-Term Culture Mesenchymal Cells from Bone Marrow of Children.

Despoina M. Choumerianou, PhD, Helen Dimitriou, PhD, Chrysoula Perdikogianni, MD, PhD, Georgia Martimianaki, BSc, Iordanis Pelagiadis, MD, Maria Kalmanti, MD, PhD

Blood (2007) 110 (11): 4100.

https://doi.org/10.1182/blood.V110.11.4100.4100

Published: 2007

Journal Articles

Characterization of a Novel R-RAS Mutation Cloned from Primary AML Cells.

Christoph W.M. Reuter, MD, PhD, Erdem Aydilek, MD, Fredrick O. Onono, Michael A. Morgan, PhD, Kristine A. Henningfeld, PhD, Arnold Ganser, MD/PhD

Blood (2006) 108 (11): 1439.

https://doi.org/10.1182/blood.V108.11.1439.1439

Published: 2006

Journal Articles

K- Ras Mutations and N- Ras Mutations in Childhood Acute Leukemias with and without MLL Rearrangements.

Der-Cherng Liang, Lee-Yung Shih, Chang-Liang Lai, Tung-Huei Lin, Jen-Fen Fu, Huei-Ying Li, Hsiu-I. Wang, Iou-Jih Hung, Chao-Ping Yang, Tang-Her Jaing, Shu-Huey Chen, Hsi-Che Liu, Lin-Yen Wang

Blood (2005) 106 (11): 2851.

https://doi.org/10.1182/blood.V106.11.2851.2851

Published: 2005

Journal Articles

In Vitro Colony Growth, RAS Genes Sequencing, and Expression of Bcl-2 and Bax Proteins in Chronic Myelomonocytic Leukemia.

Francesco Onida, MD, Clara Ricci, PhD, Federica Servida, PhD, Elisa Fermo, PhD, Mauro Molteni, MD, Clara Cesana, MD, Agostino Cortelezzi, MD, Davide Soligo, MD, PhD, Giorgio Lambertenghi-Deliliers, MD

Blood (2004) 104 (11): 2379.

https://doi.org/10.1182/blood.V104.11.2379.2379

Published: 2004

Journal Articles

Targeted Overexpression of Mutant Activated N- ras Leads to Aberrant Plasma Cell Biology.

Michael A. Linden, PhD, Nicole Kirchhof, DVM, Brian G. Van Ness, PhD

Blood (2004) 104 (11): 1416.

https://doi.org/10.1182/blood.V104.11.1416.1416

Published: 2004

Journal Articles

PTPN11 and RAS Gene Mutation Pattern Identifies an Unique Feature of Upregulated RAS Function in Infant ALL.

Giovanni Cazzaniga, PhD, Simone Martinelli, PhD, Monique L. den Boer, PhD, Lilia Corral, BSc, Monica Spinelli, PhD, Giuseppe Basso, MD, Giulio De Rossi, MD, Rob Pieters, MD, PhD, Marco Tartaglia, MD, PhD, Andrea Biondi, MD

Blood (2004) 104 (11): 996.

https://doi.org/10.1182/blood.V104.11.996.996

Published: 2004

Journal Articles

Constitutive activation of the MEK/ERK pathway mediates all effects of oncogenic H-ras expression in primary erythroid progenitors

Jing Zhang, Harvey F. Lodish

Blood (2004) 104 (6): 1679–1687.

https://doi.org/10.1182/blood-2004-04-1362

Published: 2004

Journal Articles

Role of Ras signaling in erythroid differentiation of mouse fetal liver cells: functional analysis by a flow cytometry–based novel culture system

Jing Zhang, Merav Socolovsky, Alec W. Gross, Harvey F. Lodish

Blood (2003) 102 (12): 3938–3946.

https://doi.org/10.1182/blood-2003-05-1479

Published: 2003

NARROW

Impact and Outcomes of RAS gene Mutations in Core Binding Factor Acute Myeloid Leukemia

Rigosertib, a Pan RAS Inhibitor, Decreases Mouse and Human Myeloma Cell Growth in Preclinical Models

Indolent Phenotype of RAS-Associated Autoimmune Leukoproliferative Disorder (RALD) Is Characterized By Single Somatic Mutations in RAS Genes with Absence of Cooperating Mutations

Kras Is Critical for B Cell Lymphopoiesis

MEK Inhibition Is a Promising Therapeutic Strategy for MLL -Rearranged Infant ALL Patients Carrying RAS Mutations

Another path to ERK activation

Evolution of Sub-Clones with KRAS Mutations In Pediatric Patients with MLL-AF4 Rearrangements

H-ras and N-ras are dispensable for T-cell development and activation but critical for protective Th1 immunity

Impact of RAS Mutations In Myelodysplastic Syndrome (MDS)

Self-association mediated by the Ras association 1 domain of AF6 activates the oncogenic potential of MLL-AF6

Ras-induced reactive oxygen species promote growth factor–independent proliferation in human CD34 + hematopoietic progenitor cells

AML with CBFB-MYH11 Rearrangement Is Characterized by RAS Pathway Alterations in 92% of Cases and Demonstrates a High Frequency of NF1 Deletions.

Absence of Oncogenic Transformation in Long-Term Culture Mesenchymal Cells from Bone Marrow of Children.

Characterization of a Novel R-RAS Mutation Cloned from Primary AML Cells.

K- Ras Mutations and N- Ras Mutations in Childhood Acute Leukemias with and without MLL Rearrangements.

In Vitro Colony Growth, RAS Genes Sequencing, and Expression of Bcl-2 and Bax Proteins in Chronic Myelomonocytic Leukemia.

Targeted Overexpression of Mutant Activated N- ras Leads to Aberrant Plasma Cell Biology.

PTPN11 and RAS Gene Mutation Pattern Identifies an Unique Feature of Upregulated RAS Function in Infant ALL.

Constitutive activation of the MEK/ERK pathway mediates all effects of oncogenic H-ras expression in primary erythroid progenitors

Role of Ras signaling in erythroid differentiation of mouse fetal liver cells: functional analysis by a flow cytometry–based novel culture system

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American Society of Hematology

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ASH Publications

American Society of Hematology

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