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Journal Articles

TET Dioxygenase Inhibition As a Therapeutic Strategy in TET2 Mutant Myeloid Neoplasia

Yihong Guan, PhD, Anand D. Tiwari, PhD, James G Phillips, PhD, Metis Hasipek, PhD, Dale Grabowski, BS, Cassandra M Kerr, MS, Vera Adema, PhD, Yasunobu Nagata, MD PhD, Valeria Visconte, PhD, Tomas Radivoyevitch, PhD, Daniel Lindner, MD PhD, Manja Meggendorfer, PhD, Mohamed Abazeed, Mikkael A. Sekeres, MD MS, Torsten Haferlach, MD, Jaroslaw P. Maciejewski, MD PhD, Babal K. Jha, PhD

Blood (2019) 134 (Supplement_1): 880.

https://doi.org/10.1182/blood-2019-131920

Published: 2019

Journal Articles

Exploitation of a Newly Characterized Metabolic-Cytoskeletal Axis for Effective Combination Therapy of Iron Restricted Anemia

Adam N Goldfarb, MD, Katie Freeman, BA, Alejandro Ariel Gru, MD, Zollie White, III, MS, Lorrie L Delehanty, BS

Blood (2019) 134 (Supplement_1): 2233.

https://doi.org/10.1182/blood-2019-129172

Published: 2019

Journal Articles

Mitochondrial Complex II in Intestinal Epithelial Cells Is a Critical Metabolic Checkpoint That Regulates Severity of Gastrointestinal Graft-Versus-Host Disease

Hideaki Fujiwara, Anna V Mathew, Ilya Kovalenko, Pal Anupama, Dan Peltier, Stephanie Kim, Austin Taylor, BA, Katherine Oravecz-Wilson, Yaping Sun, Costas Lyssiotis, Alnawaz Rehemtulla, Subramanian Pennarthur, Pavan Reddy

Blood (2019) 134 (Supplement_1): 584.

https://doi.org/10.1182/blood-2019-126775

Published: 2019

Journal Articles

Inhibition of Anti-Apoptotic Mcl-1 Exerts Anti-Leukemia Activity through Modulation of Leukemia-Stromal Interactions and Metabolic Functions in AML

Bing Z Carter, PhD, Po Yee Mak, Marc Warmoes, Wenjing Tao, Philip Lorenzi, Vivian Ruvolo, MS, Lin Tan, Justin Cidado, PhD, Lisa Drew, PhD, Michael Andreeff, MD PhD

Blood (2019) 134 (Supplement_1): 3727.

https://doi.org/10.1182/blood-2019-124453

Published: 2019

Journal Articles

Identify AMPK-Mediated Autophagy and Oxphos As a Novel Metabolic Vulnerability for Targeted Therapy in Mantle Cell Lymphoma

Yixin Yao, PhD, Yang Liu, MD, Hui Zhang, Angela Leeming, Joseph Mitchell McIntosh, Preetesh Jain, MBBS,MDDM,PhD, Liang Zhang, MD PhD, Krystle Nomie, PhD, Michael L. Wang, MD

Blood (2019) 134 (Supplement_1): 1506.

https://doi.org/10.1182/blood-2019-126738

Published: 2019

Journal Articles

Desideromastica: Tactile Chew Cravings in Iron Deficiency Anemia

Caleb J Scheckel, DO, Didar Yanardag Acik, MD, Aneel A. Ashrani, MD MS, C. Christopher Hook, MD, Lindsey Ann Kluck, APRN, CNP, MSN, Ariela L. Marshall, MD, Rajiv K. Pruthi, MBBS, Aishwarya Ravindran, MBBS, Mithun Vinod Shah, MD PhD, Alexandra Wolanskyj, MD, Ronald S. Go, MD

Blood (2019) 134 (Supplement_1): 4815.

https://doi.org/10.1182/blood-2019-127306

Published: 2019

Journal Articles

DHODH Inhibitors in the Treatment of Acute Myeloid Leukemia: Defining the Mechanism of Action and the Basis of the Metabolic Therapeutic Window

Peggy P. Hsu, MD PhD, Youmna Kfoury, PhD, Najihah Aziz, Jenna Elkhoury, Brittany Hallgren, David T. Scadden, MD, Matthew Vander Heiden, MD PhD, David B Sykes, MD PhD

Blood (2018) 132 (Supplement 1): 2716.

https://doi.org/10.1182/blood-2018-99-113387

Published: 2018

Journal Articles

EVI1 in Acute Myeloid Leukemia Triggers Metabolic Reprograming Associated with Leukemogenesis and Increases Sensitivity to L-Aspalaginase

Yusuke Saito, MD PhD, Daisuke Sawa, MD, Mariko Kinoshita, MD, Ai Yamada, MD, Sachiyo Kamimura, MD, Kazuhiro Morishita, MD PhD, Tomoyoshi Soga, PhD, Hiroshi Moritake, MD PhD

Blood (2018) 132 (Supplement 1): 2601.

https://doi.org/10.1182/blood-2018-99-111581

Published: 2018

Journal Articles

Selective Pharmacologic Inhibition of Paroxysmal Nocturnal Hemoglobinuria Clones

Amy C Graham, BS, MS, Alexey Efanov, PhD, Bartlomiej P. Przychodzen, Cassandra M. Hirsch, Vera Adema, PhD, Valeria Visconte, PhD, Jaroslaw P. Maciejewski

Blood (2018) 132 (Supplement 1): 1303.

https://doi.org/10.1182/blood-2018-99-114973

Published: 2018

Journal Articles

Mll -Partial Tandem Duplication ( Mll -PTD) Causes Pseudohypoxia and Hypermethylation of the Epigenome through Suppression of Mitochondrial Complex II

Asumi Yokota, PhD, Lulu Zhang, PhD, Xiaomei Yan, MD PhD, Xiaomin Feng, MD PhD, Lijun Wen, MS, George Freudiger, Maria Rife, Ally Woeste, Yoshihiro Hayashi, MD PhD, Gang Huang, PhD

Blood (2018) 132 (Supplement 1): 1311.

https://doi.org/10.1182/blood-2018-99-112529

Published: 2018

Journal Articles

SIRT3 Is a Novel Metabolic Driver of and Therapeutic Target for Chemotherapy Resistant Dlbcls

Meng Li, PhD, Ying-Ling Chiang, PhD, Costas Lyssiotis, PhD, Matthew Teater, PhD, Hao Shen, MD, Ling Wang, MS, Jun Young Hong, BS, Hui Jin, PhD, Cihangir Duy, PhD, Sucharita Mistry, PhD, Leandro Cerchietti, MD, Justin Cross, PhD, Lewis Cantley, MD, Hening Lin, PhD, Ari Melnick, MD

Blood (2017) 130 (Supplement 1): 643.

https://doi.org/10.1182/blood.V130.Suppl_1.643.643

Published: 2017

Journal Articles

HEME Degradation Enzyme Biliverdin IXb Reductase Is Required for Stem Cell Glutamine Metabolism

Zongdong Li, PhD, Wadie F. Bahou, MD

Blood (2017) 130 (Supplement 1): 3763.

https://doi.org/10.1182/blood.V130.Suppl_1.3763.3763

Published: 2017

Journal Articles

Succinate Ubiquinone Reductase Activity Predicts Multiple Myeloma Sensitivity to Venetoclax

Richa Bajpai, PhD, Changyong Wei, PhD BS, Shannon Matulis, PhD, Ajay K. Nooka, MDMPH, Samuel McBrayer, PhD, Sagar Lonial, MD, Vikas A. Gupta, MD PhD, Lawrence H. Boise, PhD, Mala Shanmugam, PhD

Blood (2017) 130 (Supplement 1): 4409.

https://doi.org/10.1182/blood.V130.Suppl_1.4409.4409

Published: 2017

Journal Articles

Dimethyl Fumarate Induces Fetal Hemoglobin in Sickle Cell Disease

Sriram Krishnamoorthy, PhD, Dipti Gupta, MS, Sarah Sturtevant, Biaoru Li, PhD, Levi C Makala, DVM, MBA, PhD, William E. Hobbs, MDPhD, David R. Light, PhD, Betty Pace, MD

Blood (2015) 126 (23): 410.

https://doi.org/10.1182/blood.V126.23.410.410

Published: 2015

Journal Articles

Novel Nanomolar Potency Mitochondrial Complex I Inhibitor Iacs-1131 Selectively Kills Oxphos-Dependent AML Cells

Polina Matre, PhD, Marina Protopopova, Ningping Feng, Jason Gay, Jennifer Greer, Juliana Velez, Hong Mu, MD PhD, Alessia Lodi, Surendar Tadi, Shannon Sweeney, Michael Andreeff, MD PhD, Stefano Tiziani, M. Emilia DiFrancesco, Joseph Marszalek, Marina Konopleva, MD PhD

Blood (2014) 124 (21): 622.

https://doi.org/10.1182/blood.V124.21.622.622

Published: 2014

Journal Articles

Efficacy of Novel Glutaminase Inhibitor CB-839 in Acute Myeloid Leukemia

Polina Matre, PhD, Maryam Shariati, Juliana Velez, Yuan Qi, Sergej Konoplev, MD PhD, Xiaoping Su, PhD, Courtney D. DiNardo, MD, Naval Daver, MD, Ravi Majeti, MD PhD, Michael Andreeff, MD PhD, Steven M. Chan, MD PhD, Marina Konopleva, MD PhD

Blood (2014) 124 (21): 3763.

https://doi.org/10.1182/blood.V124.21.3763.3763

Published: 2014

Journal Articles

Dimethyl Fumarate Induces Cytoprotection and Inhibits Inflammation and Vaso-Occlusion in Transgenic Sickle Mice

John D. Belcher, PhD, Julia Nguyen, Chunsheng Chen, Fuad Abdulla, Phong Nguyen, Minh Nguyen, Ping Zhang, PhD, Pauline Xu, Nicholas J. Slipek, Gregory M. Vercellotti, MD

Blood (2014) 124 (21): 219.

https://doi.org/10.1182/blood.V124.21.219.219

Published: 2014

Journal Articles

Initial Experience with Thrombopoetin Receptor Agonists (TRA) in 5 Patients with Refractory HIV-Associated Immune Thrombocytopenic Purpura (ITP)

Mark Kowalczyk, Paul G. Rubinstein, MD, David M Aboulafia, MD

Blood (2014) 124 (21): 5014.

https://doi.org/10.1182/blood.V124.21.5014.5014

Published: 2014

Journal Articles

Biomarkers of Response to the Glutaminase Inhibitor CB-839 in Multiple Myeloma Cells

Andrew Mackinnon, PhD, Mark Bennett, PhD, Mirna Rodriguez, BS, Francesco Parlati, PhD

Blood (2014) 124 (21): 3429.

https://doi.org/10.1182/blood.V124.21.3429.3429

Published: 2014

Journal Articles

The Effects Of Oral Iron Treatment On Reactive Oxygen Radicals, Protective Enzymes and Lipid Peroxidation In Women With Iron Deficiency Anemia

Gurhan Kadikoylu, MD, Arzu Ozkan, MD, Cigdem Yenisey, PhD, Irfan Yavasoglu, Zahit Bolaman, MD

Blood (2013) 122 (21): 4670.

https://doi.org/10.1182/blood.V122.21.4670.4670

Published: 2013

NARROW

TET Dioxygenase Inhibition As a Therapeutic Strategy in TET2 Mutant Myeloid Neoplasia

Exploitation of a Newly Characterized Metabolic-Cytoskeletal Axis for Effective Combination Therapy of Iron Restricted Anemia

Mitochondrial Complex II in Intestinal Epithelial Cells Is a Critical Metabolic Checkpoint That Regulates Severity of Gastrointestinal Graft-Versus-Host Disease

Inhibition of Anti-Apoptotic Mcl-1 Exerts Anti-Leukemia Activity through Modulation of Leukemia-Stromal Interactions and Metabolic Functions in AML

Identify AMPK-Mediated Autophagy and Oxphos As a Novel Metabolic Vulnerability for Targeted Therapy in Mantle Cell Lymphoma

Desideromastica: Tactile Chew Cravings in Iron Deficiency Anemia

DHODH Inhibitors in the Treatment of Acute Myeloid Leukemia: Defining the Mechanism of Action and the Basis of the Metabolic Therapeutic Window

EVI1 in Acute Myeloid Leukemia Triggers Metabolic Reprograming Associated with Leukemogenesis and Increases Sensitivity to L-Aspalaginase

Selective Pharmacologic Inhibition of Paroxysmal Nocturnal Hemoglobinuria Clones

Mll -Partial Tandem Duplication ( Mll -PTD) Causes Pseudohypoxia and Hypermethylation of the Epigenome through Suppression of Mitochondrial Complex II

SIRT3 Is a Novel Metabolic Driver of and Therapeutic Target for Chemotherapy Resistant Dlbcls

HEME Degradation Enzyme Biliverdin IXb Reductase Is Required for Stem Cell Glutamine Metabolism

Succinate Ubiquinone Reductase Activity Predicts Multiple Myeloma Sensitivity to Venetoclax

Dimethyl Fumarate Induces Fetal Hemoglobin in Sickle Cell Disease

Novel Nanomolar Potency Mitochondrial Complex I Inhibitor Iacs-1131 Selectively Kills Oxphos-Dependent AML Cells

Efficacy of Novel Glutaminase Inhibitor CB-839 in Acute Myeloid Leukemia

Dimethyl Fumarate Induces Cytoprotection and Inhibits Inflammation and Vaso-Occlusion in Transgenic Sickle Mice

Initial Experience with Thrombopoetin Receptor Agonists (TRA) in 5 Patients with Refractory HIV-Associated Immune Thrombocytopenic Purpura (ITP)

Biomarkers of Response to the Glutaminase Inhibitor CB-839 in Multiple Myeloma Cells

The Effects Of Oral Iron Treatment On Reactive Oxygen Radicals, Protective Enzymes and Lipid Peroxidation In Women With Iron Deficiency Anemia

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American Society of Hematology

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ASH Publications

American Society of Hematology

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