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Journal Articles

Targeting Glycolysis in Multiple Myeloma: Novel Strategies in the Treatment of Proteasome Inhibitor Resistant in Hypoxic Conditions

Seiichi Okabe, MD PhD, Yuko Tanaka, MD PhD, Mitsuru Moriyama, Akihiko Gotoh, MD PhD

Blood (2019) 134 (Supplement_1): 4344.

https://doi.org/10.1182/blood-2019-129818

Published: 2019

Journal Articles

Targeting Metabolic Enzyme Pyruvate Kinase M2: A Novel Strategy to Inhibit Platelet Function and Arterial Thrombosis

Manasa K Nayak, PhD, Madankumar Ghatge, PhD, Nirav Dhanesha, PhD, Gagan D Flora, PhD, Manish Jain, PhD, Omar Rodriguez, MD BS, Kathleen Markan, PhD, Mathhhew Potthoff, PhD, Steven R. Lentz, MD PhD, Anil K Chauhan, PhD

Blood (2019) 134 (Supplement_1): 1056.

https://doi.org/10.1182/blood-2019-129027

Published: 2019

Journal Articles

Activated Pentose Phosphate Pathway Mediated By Fbp-1 Upregulation Supports Progression of Acute Myeloid Leukemia with High EVI-1 Expression

Hideaki Mizuno, MD, Yuki Kagoya, MD PhD, Junji Koya, MD PhD, Yosuke Masamoto, MD PhD, Mineo Kurokawa, MD PhD

Blood (2018) 132 (Supplement 1): 757.

https://doi.org/10.1182/blood-2018-99-118922

Published: 2018

Journal Articles

SLC2A5 Overexpression in Childhood Philadelphia Chromosome Positive Acute Lymphoblastic Leukaemia

Pan Zhao, MD, Yuhuan Zheng, PhD, Ting Niu, MD PhD

Blood (2018) 132 (Supplement 1): 5286.

https://doi.org/10.1182/blood-2018-99-118875

Published: 2018

Journal Articles

EVI1 in Acute Myeloid Leukemia Triggers Metabolic Reprograming Associated with Leukemogenesis and Increases Sensitivity to L-Aspalaginase

Yusuke Saito, MD PhD, Daisuke Sawa, MD, Mariko Kinoshita, MD, Ai Yamada, MD, Sachiyo Kamimura, MD, Kazuhiro Morishita, MD PhD, Tomoyoshi Soga, PhD, Hiroshi Moritake, MD PhD

Blood (2018) 132 (Supplement 1): 2601.

https://doi.org/10.1182/blood-2018-99-111581

Published: 2018

Journal Articles

Antagonizing PPARγ Expands Human Hematopoietic Stem and Progenitor Cells By Switching on FBP1-Repressed Glycolysis and Preventing Differentiation

Bin Guo, PhD, Xinxin Huang, PhD, Hal E. Broxmeyer, PhD

Blood (2017) 130 (Supplement 1): 709.

https://doi.org/10.1182/blood.V130.Suppl_1.709.709

Published: 2017

Journal Articles

PFKFB3 Is a Crucial Target in the Treatment of Tyrosine Kinase Inhibitor Resistant Chronic Myelogenous Leukemia

Yu Zhu, Jianyong Li, Chun Qiao, Yi Shan, MD, Sixuan Qian, Yaoyu Chen, Ming Hong, Huihui Zhao, Huapeng LI, Xuejun Zhu, Yang Zhongfa

Blood (2016) 128 (22): 3936.

https://doi.org/10.1182/blood.V128.22.3936.3936

Published: 2016

Journal Articles

Cap Analysis of Gene Expression (CAGE) Sequencing Reveals Alterations of the Transcript Signatures in Acute Monocytic Leukemia Cells By Fatty Acid Oxidation Inhibition

Yoko Tabe, MD PhD, Marina Konopleva, MD PhD, Norikazu Monma, PhD, Kazuho Ikeo, PhD, Kaoru Mogushi, PhD, Yasunari Yamanaka, MD PhD, Hiromichi Matsushita, MD PhD, Takashi Miida, MD PhD, Yoshihide Hayashizaki, MD PhD, Michael Andreeff, MD PhD

Blood (2015) 126 (23): 3631.

https://doi.org/10.1182/blood.V126.23.3631.3631

Published: 2015

Journal Articles

Novel FAO Inhibitor Avocatin B Induces Apoptosis of Acute Monocytic Leukemia Cells in Adipocyte Co-Culture System Via ER Stress and ATF4 Activation

Yoko Tabe, MD PhD, Shinichi Yamamoto, PhD, Mika Kikkawa, PhD, Hikari Taka, PhD, Kaoru Mogushi, PhD, Hiromichi Mastushita, MD PhD, Takashi Miida, MDPhD, Michael Andreeff, MD PhD, Paul A Spagnuolo, PhD, Marina Konopleva, MD PhD

Blood (2015) 126 (23): 3692.

https://doi.org/10.1182/blood.V126.23.3692.3692

Published: 2015

Journal Articles

L-Asparaginase More Effectively Targets Leukemic Cells with Low Glycolytic Activity

Simcikova Marketa, Alena Pecinova, Ivana Hermanova, David Pajuelo Reguera, Katerina Rejlova, Marketa Zaliova, Jan Stuchly, Tomas Mracek, Jan Trka, Julia Starkova

Blood (2015) 126 (23): 1285.

https://doi.org/10.1182/blood.V126.23.1285.1285

Published: 2015

Journal Articles

MUC1 As a Potential Therapeutic Target in Cutaneous T-Cell Lymphoma

Salvia Jain, MD, Maroof Alam, PhD, Hasan Rajabi, PhD, Dina Stroopinsky, PhD, Li Yin, PhD, Jacalyn Rosenblatt, MD, Kristen A Palmer, Maxwell Douglas Coll, Athalia Rachel Pyzer, MD, Katarina Luptakova, MD, Jon Arnason, MD, Robin Joyce, MD, Michal Bar-Natan, MD, Poorvi Somaiya, MSc, Rachael A Clark, MDPhD, Thomas S. Kupper, MD, Donald Kufe, MD, David Avigan, MD

Blood (2014) 124 (21): 808.

https://doi.org/10.1182/blood.V124.21.808.808

Published: 2014

Journal Articles

Epigenetic Regulation of Hematopoietic Stem and Progenitor Cells By the Eset Histone Methyltranferas

Shuhei Koide, Keiyo Takubo, MD PhD, Motohiko Oshima, PhD, Satoru Miyagi, PhD, Hirotaka Matsui, MD PhD, Hiroshi Kimura, PhD, Changshan Wang, PhD, George R Wendt, Shogo Yabata, Yoichi Shinkai, MD PhD, Toshio Suda, MD PhD, Atsushi Iwama, MD PhD

Blood (2014) 124 (21): 765.

https://doi.org/10.1182/blood.V124.21.765.765

Published: 2014

Journal Articles

Metabolic Re-Programming in Notch-Activated T-ALL By mTOR Inhibitor AZD2014 Combined with L-Asparaginase

Yoko Tabe, MD PhD, Masako Harada, PhD, Yuka Miyamae, Tsutomu Fujimura, Saiko Kazuno, Takashi Ueno, Takashi Miida, MD PhD, Michael Andreeff, MD PhD, Marina Konopleva, MD PhD

Blood (2014) 124 (21): 3626.

https://doi.org/10.1182/blood.V124.21.3626.3626

Published: 2014

Journal Articles

Small Molecule Activation Of Pyruvate Kinase Normalizes Metabolic Activity In Red Cells From Patients With Pyruvate Kinase Deficiency-Associated Hemolytic Anemia

Charles Kung, Ph.D., Jeff Hixon, Penelope Kosinski, Gavin Histen, Collin Hill, Yaguang Si, Andrew Kernytsky, Yue Chen, Ph.D., Byron DeLaBarre, Michelle Clasquin, Helen Ho, Furha I. Cossor, MD MS, Ellis J. Neufeld, MD, PhD, Frank Salituro, Janeta Popovici-Muller, Samuel Agresta, MD, Lee Silverman, Lenny Dang

Blood (2013) 122 (21): 2180.

https://doi.org/10.1182/blood.V122.21.2180.2180

Published: 2013

Journal Articles

Metabolomic Profiling Identifies Mechanisms Regulating Hypoxia-Induced Drug Resistance In Multiple Myeloma

Patricia Maiso, PhD, Daisy Huynh, MPS, Yosra Aljawai, MS, John M. Asara, PhD, Antonio Sacco, BS, Michele Moschetta, MD, Yuji Mishima, PhD, Aldo M Roccaro, MD, PhD, Alec Kimmelman, MD, PhD, Irene M. Ghobrial, MD

Blood (2013) 122 (21): 121.

https://doi.org/10.1182/blood.V122.21.121.121

Published: 2013

Journal Articles

Glucose Phosphate Isomerase Deficiency In 2 Patients With Novel Mutations Presenting As Severe Neurologic Abnormalities and Transfusion Dependent Hemolytic Anemia

Mammen Puliyel, M.B., B.S., Patrick G. Gallagher, MD, Vasilios Berdoukas, MBBS, Bertil Glader, MD, PhD, Thomas Coates, MD

Blood (2013) 122 (21): 947.

https://doi.org/10.1182/blood.V122.21.947.947

Published: 2013

Journal Articles

Small Molecule Activators Of AMPK Block The Glycogen Production Required For Transformation Of Myeloid Leukemia Cells

Haymanti Bhanot, PhD, Mamatha M. Reddy, PhD, Atsushi Nonami, MD, PhD, Ellen L. Weisberg, PhD, Kelly Xing, Sabrina K. Salgia, John M. Asara, PhD, Richard M. Stone, MD, James D. Griffin, MD, Martin Sattler, PhD

Blood (2013) 122 (21): 1479.

https://doi.org/10.1182/blood.V122.21.1479.1479

Published: 2013

Journal Articles

Distinct Metabolic Dependency of Normal and Leukemic Cells in a Mouse Model

Blood (2011) 118 (21): 759.

https://doi.org/10.1182/blood.V118.21.759.759

Published: 2011

Journal Articles

The Hexosamine Biosyntheic Pathway and Platinum-Ethylenedicysteine-Glucosamine (Pt-ECG) for Targeted Therapy in Diffuse Large B-Cell Lymphoma

Lan V Pham, PhD, Jerry Bryant, M.S., Archito T. Tamayo, MS, Richard Mendez, M.S., Edna Chum, David J Yang, Ph.D, David Rollo, MD, Ph.D, Richard J. Ford, MD, PhD

Blood (2011) 118 (21): 587.

https://doi.org/10.1182/blood.V118.21.587.587

Published: 2011

Journal Articles

Molecular Characterization of Hemoglobinopathies and Red Cell Enzymopathies in the Czech and Slovak Populations: An Update

Martina Divoka, Renata Mojzikova, Lucie Piterkova, Pavla Pospisilova, Martina Partschova, Monika Horvathova, Dagmar Pospisilova, Zuzana Laluhova Striezencova, Jaroslav Cermak, MD, PhD, Karel Indrak, Vladimir Divoky

Blood (2011) 118 (21): 5307.

https://doi.org/10.1182/blood.V118.21.5307.5307

Published: 2011

NARROW

Targeting Glycolysis in Multiple Myeloma: Novel Strategies in the Treatment of Proteasome Inhibitor Resistant in Hypoxic Conditions

Targeting Metabolic Enzyme Pyruvate Kinase M2: A Novel Strategy to Inhibit Platelet Function and Arterial Thrombosis

Activated Pentose Phosphate Pathway Mediated By Fbp-1 Upregulation Supports Progression of Acute Myeloid Leukemia with High EVI-1 Expression

SLC2A5 Overexpression in Childhood Philadelphia Chromosome Positive Acute Lymphoblastic Leukaemia

EVI1 in Acute Myeloid Leukemia Triggers Metabolic Reprograming Associated with Leukemogenesis and Increases Sensitivity to L-Aspalaginase

Antagonizing PPARγ Expands Human Hematopoietic Stem and Progenitor Cells By Switching on FBP1-Repressed Glycolysis and Preventing Differentiation

PFKFB3 Is a Crucial Target in the Treatment of Tyrosine Kinase Inhibitor Resistant Chronic Myelogenous Leukemia

Cap Analysis of Gene Expression (CAGE) Sequencing Reveals Alterations of the Transcript Signatures in Acute Monocytic Leukemia Cells By Fatty Acid Oxidation Inhibition

Novel FAO Inhibitor Avocatin B Induces Apoptosis of Acute Monocytic Leukemia Cells in Adipocyte Co-Culture System Via ER Stress and ATF4 Activation

L-Asparaginase More Effectively Targets Leukemic Cells with Low Glycolytic Activity

MUC1 As a Potential Therapeutic Target in Cutaneous T-Cell Lymphoma

Epigenetic Regulation of Hematopoietic Stem and Progenitor Cells By the Eset Histone Methyltranferas

Metabolic Re-Programming in Notch-Activated T-ALL By mTOR Inhibitor AZD2014 Combined with L-Asparaginase

Small Molecule Activation Of Pyruvate Kinase Normalizes Metabolic Activity In Red Cells From Patients With Pyruvate Kinase Deficiency-Associated Hemolytic Anemia

Metabolomic Profiling Identifies Mechanisms Regulating Hypoxia-Induced Drug Resistance In Multiple Myeloma

Glucose Phosphate Isomerase Deficiency In 2 Patients With Novel Mutations Presenting As Severe Neurologic Abnormalities and Transfusion Dependent Hemolytic Anemia

Small Molecule Activators Of AMPK Block The Glycogen Production Required For Transformation Of Myeloid Leukemia Cells

Distinct Metabolic Dependency of Normal and Leukemic Cells in a Mouse Model

The Hexosamine Biosyntheic Pathway and Platinum-Ethylenedicysteine-Glucosamine (Pt-ECG) for Targeted Therapy in Diffuse Large B-Cell Lymphoma

Molecular Characterization of Hemoglobinopathies and Red Cell Enzymopathies in the Czech and Slovak Populations: An Update

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American Society of Hematology

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American Society of Hematology

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