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Journal Articles

Pharmacological Inhibition of the RNA m 6 a Writer METTL3 As a Novel Therapeutic Strategy for Acute Myeloid Leukemia

Konstantinos Tzelepis, Etienne De Braekeleer, PhD MSc, Eliza Yankova, PhD, Justyna Rak, PhD, Demetrios Aspris, MSc, Ana Filipa Domingues, PhD, Richard Fosbeary, Alan Hendrick, PhD, Dan Leggate, PhD, Yaara Ofir-Rosenfeld, PhD, Alexandra Sapetschnig, PhD, Cristina Pina, MDDPhil, Mark Albertella, PhD, Wesley Blackaby, PhD, Oliver Rausch, PhD, George S. Vassiliou, FRCPath, MRCP, PhD, Tony Kouzarides, PhD

Blood (2019) 134 (Supplement_1): 403.

https://doi.org/10.1182/blood-2019-127962

Published: 2019

Journal Articles

Selective Targeting of Histone Deacetylase 11 Disables Metabolism of Myeloproliferative Neoplasms

Blood (2019) 134 (Supplement_1): 474.

https://doi.org/10.1182/blood-2019-127235

Published: 2019

Journal Articles

Molecular Mechanisms Mediating Relapse Following Ivosidenib Monotherapy in Patients with IDH1 -Mutant Relapsed or Refractory Acute Myeloid Leukemia

Sung Choe, PhD, Hongfang Wang, PhD, Courtney D. DiNardo, MD MSc, Eytan M. Stein, MD, Stephane De Botton, Amir T. Fathi, MD, Martin S. Tallman, MD, Hagop M. Kantarjian, MD, Richard M. Stone, MD, Lynn Quek, MD PhD, Zenon Konteatis, PhD, Lenny Dang, PhD, Vickie Zhang, PhD, Hua Liu, PhD, Eyal C. Attar, MD, Bin Wu, PhD

Blood (2019) 134 (Supplement_1): 545.

https://doi.org/10.1182/blood-2019-122671

Published: 2019

Journal Articles

Phenotypic Corrections of Ex Vivo Erythrocytes Derived from Chronic Hemolytic Anemia Patients Due to Krϋppel-like Factor 1 ( KLF-1 ) Mutations By AG-348: A Novel Synthetic Pyruvate Kinase Activator

Thidarat Suksangpleng, PhD, Kalaya Tachavanich, M.Sc., Suchada Riolueang, MSc, Supachai Ekwattanakit, PhDMD, Vip Viprakasit, MD DPhil

Blood (2019) 134 (Supplement_1): 2220.

https://doi.org/10.1182/blood-2019-131720

Published: 2019

Journal Articles

Identification of FASN-Dependent Onco-Metabolic Regulation of the Pentose Phosphate Pathway (PPP) and Nucleotide Metabolism in Non-Hodgkin Lymphoma (NHL)

Ravi Dashnamoorthy, PhD, Afshin Beheshti, PhD, Xiaoyang Su, PhD, Ying Chen, PhD, Maisarah Mokhtar, B.S, Gregory Dolnikowski, Frederick Lansigan, MD, William B Kinlaw, III, MD, Sandeep Dave, MD, Andrew M. Evens, DO, MSc

Blood (2019) 134 (Supplement_1): 1573.

https://doi.org/10.1182/blood-2019-126382

Published: 2019

Journal Articles

Spectrum of Genetic Defects and Phenotype-Genotype Correlation in Dyserythropoietic Anemias: Bench to Bedside Approach in the Indian Scenario

Reena Das, MD, Manu Jamwal, PhD, Anu Aggarwal, PhD, Prashant Sharma, DM, Man Updesh Singh Sachdeva, MD, Deepak Bansal, MD, Sreejesh Sreedharanunni, DM, Narender Kumar, MD, Shano Naseem, MD, Jasmina Ahluwalia, MD, Neelam Varma, MD, Pankaj Malhotra, MD, Arindam Maitra, PhD

Blood (2019) 134 (Supplement_1): 950.

https://doi.org/10.1182/blood-2019-126453

Published: 2019

Journal Articles

Management Algorithms for Gaucher Disease Type 1 in Saudi Arabia: A Consensus Result from a National Meeting

Ayman Alhejazi, MD, Abdul Kareem Almomen, MD, Ahmad M Tarawah, Ahmed M AlSuliman, Hussain H. Al Saeed, MBBS, MD, Mahsen AlSaleh, MD, Ohoud F Kashari, Marwan Elbagoury, MSc, Omar Hussein

Blood (2019) 134 (Supplement_1): 4864.

https://doi.org/10.1182/blood-2019-122822

Published: 2019

Journal Articles

Preclinical Evaluation of MAX-40279, a FLT3/FGFR Dual Kinase Inhibitor for Treatment of Acute Myeloid Leukemia

Yuguang Wang, PhD, Hanying Bao, MD PhD, Nong Zhang, PhD, Feilan Wang, PhD, Yunsong He, MD, Tianzhi Wu, PhD

Blood (2018) 132 (Supplement 1): 3997.

https://doi.org/10.1182/blood-2018-99-110414

Published: 2018

Journal Articles

Monitoring Asparaginase Activity in 21 Patients with Extranodal NK/T-Cell Lymphoma Shows a Very High Proportion of Asparaginase Inactivation

Arnaud Jaccard, MD PhD, Sammara Chaubard, MD, Jean-François Benoist, MD, Lucile Couronne, Laure Philippe, MD, Emmanuel Gyan, MD PhD, Ronan Le Calloch, MD, Aline Moignet Autrel, MD, Rémy Gressin, MD, Jacques Vargaftig, MD PhD, Aline Clavert, MD, Emmanuel Bachy, MD PhD, Olivier Hermine, MD PhD

Blood (2018) 132 (Supplement 1): 5351.

https://doi.org/10.1182/blood-2018-99-118439

Published: 2018

Journal Articles

Isoprenoid Amide Bisphosphonates As a Novel Class of Geranylgeranyl Diphosphate Synthase Inhibitors

Michelle L. Varney, MS, Daniel B. Goetz, BA, David F. Wiemer, PhD, Sarah A. Holstein, MD PhD

Blood (2018) 132 (Supplement 1): 4679.

https://doi.org/10.1182/blood-2018-99-112965

Published: 2018

Journal Articles

Structure-Function Relationships of Novel Benzimidazole-Based Inhibitors of the Isoprenoid Biosynthetic Pathway in Myeloma Cells

Michelle L. Varney, MS, Nazmul H. Bhuiyan, B.S., David F. Wiemer, PhD, Sarah A. Holstein, MD PhD

Blood (2017) 130 (Supplement 1): 3345.

https://doi.org/10.1182/blood.V130.Suppl_1.3345.3345

Published: 2017

Journal Articles

The Role of TCA Cycle Compounds in Erythroid Heme Synthesis and Its Regulation During an Inflammatory Response

Jason R. Marcero, BS, Joseph S. Burch, PhD, John D. Phillips, PhD, James E. Cox, PhD, Laurie K. Jackson, PhD, Harry A. Dailey, PhD

Blood (2017) 130 (Supplement 1): 3473.

https://doi.org/10.1182/blood.V130.Suppl_1.3473.3473

Published: 2017

Journal Articles

β1,4-Galactosyltransferase 1 Is a Key Regulator of Thrombopoiesis

Silvia Giannini, PhD, Melissa M. Lee-Sundlov, PhD, Max Adelman, Antonija Jurak Begonja, PhD, Joseph T. Lau, PhD, Herve Falet, PhD, Karin M. Hoffmeister, MD

Blood (2017) 130 (Supplement 1): 1018.

https://doi.org/10.1182/blood.V130.Suppl_1.1018.1018

Published: 2017

Journal Articles

Glucose-6-Phosphate Dehydrogenase Deficiency in Blood Donors Is Associated with Decreased Post-Transfusion Red Cell Recovery

Richard O Francis, MD PhD, Danamarie Belpulsi, MD, Mark Soffing, PharmD, Randy Yeh, MD, Esther E Coronel, MD, Arif Sheikh, MD, Steven Spitalnik, MD, Eldad A. Hod, MD

Blood (2017) 130 (Supplement 1): 706.

https://doi.org/10.1182/blood.V130.Suppl_1.706.706

Published: 2017

Journal Articles

Development and Characterization of the Novel Orally Bioavailable EZH1/2 Dual Inhibitor DS-3201

Daisuke Honma, PhD, Nobuaki Adachi, PhD, Osamu Kanno, PhD, Jun Watanabe, Makoto Hirasawa, Emi Nosaka, Machiko Shiroishi, Takeshi Takizawa, Isao Yasumatsu, Takao Horiuchi, PhD, Akira Nakao, PhD, Keisuke Suzuki, Tomonori Yamasaki, Katsuyoshi Nakajima, Miho Hayakawa, Takanori Yamazaki, Kazushi Araki, D.V.M., PhD, Kosaku Fujiwara, PhD

Blood (2017) 130 (Supplement 1): 2073.

https://doi.org/10.1182/blood.V130.Suppl_1.2073.2073

Published: 2017

Journal Articles

Utilization of a-Ketoglutarate for Synthesis of 2-Hydroxyglutarate Oncometabolite Promotes Catabolic Flexibility, Redox Perturbation and Mitochondrial Activity That Supports Chemoresistance in IDH1 Mutant Acute Myeloid Leukemia

Lucille Stuani, PhD, Christian Recher, MD PhD, Jean-Charles Portais, PhD, Jean-Emmanuel Sarry, PhD

Blood (2017) 130 (Supplement 1): 5080.

https://doi.org/10.1182/blood.V130.Suppl_1.5080.5080

Published: 2017

Journal Articles

NADPH Oxidases Inhibitors Induce Oxidative Stress and Apoptosis in Acute Myeloid Leukemia Cells

Hassan Dakik, Jerome Bourgeais, PhD, Ali Nehme, PhD, Frederic Picou, PhD, Noemie Ravalet, Farah Kouzi, Georges Khamis, Elfi Ducrocq, Sophie Hamard, Fabrice Gouilleux, PhD, Kazem Zibara, PhD, Olivier Herault, MDPhD, Frederic Mazurier, PhD

Blood (2017) 130 (Supplement 1): 5107.

https://doi.org/10.1182/blood.V130.Suppl_1.5107.5107

Published: 2017

Journal Articles

Mechanisms of NT5C2 mutations Driving Thiopurine Resistance in Acute Lymphoblastic Leukemia

Chelsea Dieck, Gannie Tzoneva, PhD, Farhad Forouhar, Zachary Carpenter, PhD, Alberto Ambesi-Impiombato, Marta Sanchez-Martin, PhD, Liang Tong, Adolfo A. Ferrando, MD PhD

Blood (2017) 130 (Supplement 1): 715.

https://doi.org/10.1182/blood.V130.Suppl_1.715.715

Published: 2017

Journal Articles

CD38 Deregulation As Strategy to Make Multiple Myeloma Cells More Sensitive to NAD+ Depleting Agents

Michele Cea, MD, Antonia Cagnetta, MD, Debora Soncini, PhD, Paola Minetto, MD, Micaela Bergamaschi, MD, Giulia Rivoli, MD, Letizia Canepa, MD, Marco Gobbi, MD, Roberto M Lemoli, MD

Blood (2016) 128 (22): 5671.

https://doi.org/10.1182/blood.V128.22.5671.5671

Published: 2016

Journal Articles

Synergistic Inhibition of Geranylgeranyl Diphosphate Synthase By a Mixture of Olefin Stereoisomers

Cheryl Allen, BS, Joseph I. Metzger, BA, Veronica S. Wills, PhD, Huaxiang Tong, PhD, Sandhya Kortagere, PhD, David F. Wiemer, PhD, Sarah A. Holstein, MD PhD

Blood (2016) 128 (22): 2320.

https://doi.org/10.1182/blood.V128.22.2320.2320

Published: 2016

NARROW

Pharmacological Inhibition of the RNA m 6 a Writer METTL3 As a Novel Therapeutic Strategy for Acute Myeloid Leukemia

Selective Targeting of Histone Deacetylase 11 Disables Metabolism of Myeloproliferative Neoplasms

Molecular Mechanisms Mediating Relapse Following Ivosidenib Monotherapy in Patients with IDH1 -Mutant Relapsed or Refractory Acute Myeloid Leukemia

Phenotypic Corrections of Ex Vivo Erythrocytes Derived from Chronic Hemolytic Anemia Patients Due to Krϋppel-like Factor 1 ( KLF-1 ) Mutations By AG-348: A Novel Synthetic Pyruvate Kinase Activator

Identification of FASN-Dependent Onco-Metabolic Regulation of the Pentose Phosphate Pathway (PPP) and Nucleotide Metabolism in Non-Hodgkin Lymphoma (NHL)

Spectrum of Genetic Defects and Phenotype-Genotype Correlation in Dyserythropoietic Anemias: Bench to Bedside Approach in the Indian Scenario

Management Algorithms for Gaucher Disease Type 1 in Saudi Arabia: A Consensus Result from a National Meeting

Preclinical Evaluation of MAX-40279, a FLT3/FGFR Dual Kinase Inhibitor for Treatment of Acute Myeloid Leukemia

Monitoring Asparaginase Activity in 21 Patients with Extranodal NK/T-Cell Lymphoma Shows a Very High Proportion of Asparaginase Inactivation

Isoprenoid Amide Bisphosphonates As a Novel Class of Geranylgeranyl Diphosphate Synthase Inhibitors

Structure-Function Relationships of Novel Benzimidazole-Based Inhibitors of the Isoprenoid Biosynthetic Pathway in Myeloma Cells

The Role of TCA Cycle Compounds in Erythroid Heme Synthesis and Its Regulation During an Inflammatory Response

β1,4-Galactosyltransferase 1 Is a Key Regulator of Thrombopoiesis

Glucose-6-Phosphate Dehydrogenase Deficiency in Blood Donors Is Associated with Decreased Post-Transfusion Red Cell Recovery

Development and Characterization of the Novel Orally Bioavailable EZH1/2 Dual Inhibitor DS-3201

Utilization of a-Ketoglutarate for Synthesis of 2-Hydroxyglutarate Oncometabolite Promotes Catabolic Flexibility, Redox Perturbation and Mitochondrial Activity That Supports Chemoresistance in IDH1 Mutant Acute Myeloid Leukemia

NADPH Oxidases Inhibitors Induce Oxidative Stress and Apoptosis in Acute Myeloid Leukemia Cells

Mechanisms of NT5C2 mutations Driving Thiopurine Resistance in Acute Lymphoblastic Leukemia

CD38 Deregulation As Strategy to Make Multiple Myeloma Cells More Sensitive to NAD+ Depleting Agents

Synergistic Inhibition of Geranylgeranyl Diphosphate Synthase By a Mixture of Olefin Stereoisomers

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American Society of Hematology

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American Society of Hematology

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