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Journal Articles

Analysis of disease model iPSCs derived from patients with a novel Fanconi anemia–like IBMFS ADH5/ALDH2 deficiency

Anfeng Mu, Asuka Hira, Akira Niwa, Mitsujiro Osawa, Kenichi Yoshida, Minako Mori, Yusuke Okamoto, Kazuko Inoue, Keita Kondo, Masato T. Kanemaki, Tomonari Matsuda, Etsuro Ito, Seiji Kojima, Tatsutoshi Nakahata, Seishi Ogawa, Keigo Tanaka, Keitaro Matsuo, Megumu K. Saito, Minoru Takata
Journal: Blood
Blood (2021) 137 (15): 2021–2032.
https://doi.org/10.1182/blood.2020009111
Published: 2021
Includes: Supplemental data
Journal Articles

Hematopoietic Stem Cell Function in β-Thalassemia Is Impaired and Is Rescued By Targeting the Bone Marrow Niche

Annamaria Aprile, PhD, Alessandro Gulino, PhD, Isabella Villa, PhD, Stefano Beretta, PhD, Ivan Merelli, PhD, Alessandro Rubinacci, MD, Maurilio Ponzoni, MD, Sarah Marktel, MD, Claudio Tripodo, MD, Maria Rosa Lidonnici, PhD, Giuliana Ferrari, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 967.
https://doi.org/10.1182/blood-2019-126829
Published: 2019
Journal Articles

Disease Model of Atherosclerosis Using Werner Syndrome Patient-Derived Induced Pluripotent Stem Cells Reveals Excessive Inflammatory Response Against Ox-LDL

Sudip Kumar Paul, MSc, Masamitsu Sone, PhD, Hisaya Kato, MD PhD, Yoshiro Maezawa, MD PhD, Yasuo Ouchi, PhD, Koutaro Yokote, MD PhD, Koji Eto, MD, Naoya Takayama, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3615.
https://doi.org/10.1182/blood-2019-123919
Published: 2019
Journal Articles

Talazoparib Treatment Preferentially Depletes Cohesin-Mutant Clones in New In Vivo M odels of Cohesin-Mutant Myeloid Diseases

Mounica Vallurupalli, MD, Rebecca Gorelov, BS, Jacqueline S Garcia, MD, Elizabeth A Morgan, MD, Benjamin Ebert, MD, Zuzana Tothova, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 560.
https://doi.org/10.1182/blood-2019-130308
Published: 2019
Journal Articles

Mutation-Specific Dominant Negative Effects Determine the Phenotype in SRP54 D eficiency

Christoph Schuerch, MSc, Thorsten Schaefer, PhD, Joelle S. Müller, MSc, Pauline Hanns, MSc, Jonas Schärer, BSc, Julia Skokowa, MD PhD, Karl Welte, Raphael Carapito, PhD, Seiamak Bahram, MD, Martina Konantz, PhD, Claudia Lengerke, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 437.
https://doi.org/10.1182/blood-2019-127007
Published: 2019
Journal Articles

Autophagy in Endothelial Cells Regulates Their Hematopoiesis Supporting Ability

Yuan Kong, MD PhD, Xie-Na Cao, Zhong-Shi Lyu, PhD, Xiao-Dong Mo, Qi Wen, MD, Hong-Yan Zhao, MD, Yu-Hong Chen, Yu Wang, Ying-Jun Chang, Lan-Ping Xu, Xiao-Hui Zhang, Xiao-Jun Huang
Journal: Blood
Blood (2019) 134 (Supplement_1): 4425.
https://doi.org/10.1182/blood-2019-122227
Published: 2019
Journal Articles

Induction of a Leukemic Bone Marrow Niche Mediated By TGFB1 of Leukemic Blasts in Pediatric Acute Mekaryoblastic Leukemia: Results of an in Vitro and In Vivo Analysis

Theresa Hack, MSc, Stefanie Bertram, MD, Guntram Büsche, MD, Helmut Hanenberg, MD, Ludger Klein-Hitpass, PhD, Nils Von Neuhoff, PhD, Dirk Reinhardt, MD, Markus Schneider, PhD, Mareike Rasche, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3734.
https://doi.org/10.1182/blood-2019-126536
Published: 2019
Journal Articles

Purification Platelets from Mouse Blood with Sickle Cell Disease Using Iohexol Gradient Medium

Md Nasimuzzaman, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4888.
https://doi.org/10.1182/blood-2019-128459
Published: 2019
Journal Articles

The α-emitter astatine-211 targeted to CD38 can eradicate multiple myeloma in a disseminated disease model

Shyril O’Steen, Melissa L. Comstock, Johnnie J. Orozco, Donald K. Hamlin, D. Scott Wilbur, Jon C. Jones, Aimee Kenoyer, Margaret E. Nartea, Yukang Lin, Brian W. Miller, Theodore A. Gooley, Sherilyn A. Tuazon, Brian G. Till, Ajay K. Gopal, Brenda M. Sandmaier, Oliver W. Press, Damian J. Green
Journal: Blood
Blood (2019) 134 (15): 1247–1256.
https://doi.org/10.1182/blood.2019001250
Published: 2019
Includes: Supplemental data
Journal Articles

Calcium/Calmodulin Dependent Protein Kinase 2 Gamma Is Identified As a Potential Therapeutic Target of Myelofibrosis Using Disease-Specific Induced Pluripotent Stem Cells

Masashi Miyauchi, MD PhD, Ken Sasaki, MD, Kazuki Taoka, MD PhD, Yosuke Masamoto, MD PhD, Sho Yamazaki, MD PhD, Shunya Arai, MD PhD, Mineo Kurokawa, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3054.
https://doi.org/10.1182/blood-2018-99-113285
Published: 2018
Journal Articles

Environmental Cell-Matrix Adhesion Modulates Pluripotent Stem Cell Fate Toward Definitive Hemogenic Endothelium and Hematopoietic Progenitor Cells

Akinori Yuzuriha, Sou Nakamura, PhD, Toshie Kusunoki, Takuya Matsumoto, PhD, Naoshi Sugimoto, MD PhD, Kiyotoshi Sekiguchi, PhD, Koji Eto, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3845.
https://doi.org/10.1182/blood-2018-99-114505
Published: 2018
Journal Articles

5-Azacytidine Is Effective for Targeting Leukemia-Initiating Cells in Juvenile Myelomonocytic Leukemia

Christopher Felix Krombholz, PhD, Lorena Gallego Villar, PhD, Pritam Kumar Panda, MSc, MS, BSc, Sushree Sangita Sahoo, MSc, Marcin W. Wlodarski, MD PhD, Daniel B. Lipka, Christoph Plass, Charlotte Niemeyer, MD, Miriam Erlacher, MD PhD, Christian Flotho
Journal: Blood
Blood (2018) 132 (Supplement 1): 4342.
https://doi.org/10.1182/blood-2018-99-116594
Published: 2018
Journal Articles

An Engineered Cell-Traceable Model of Reticular Dysgenesis in Human Hematopoietic Stem Cells Linking Metabolism and Differentiation

Wenqing Wang, PhD, Avni Awani, PhD, Lauren Reich, Yusuke Nakauchi, MD PhD, Daniel Thomas, MD PhD, Daniel P. Dever, PhD, Matthew Porteus, MD PhD, Katja G. Weinacht, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2558.
https://doi.org/10.1182/blood-2018-99-117926
Published: 2018
Journal Articles

Integrin Alphav-beta3 on Podocytes Orchestrates Coagulation Protease Signaling through Protease-Activated Receptors

Madhusudhan Thati, PhD, Sanchita Ghosh, MS, Hongjie Wang, MD PhD, Wolfram Ruf, MD, Berend H. Isermann, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 137.
https://doi.org/10.1182/blood-2018-99-114566
Published: 2018
Journal Articles

Mechanisms of Azacitidine Chemotherapy Resistance in AML and MDS and New Therapy Options

Lubomir Minarik, MD, Leylah M. Drusbosky, PhD, Taher Abbasi, MS, MBA, Karina Vargova, MBBS, MSc, Vojtech Kulvait, PhD, Anna Jonasova, MD, Neeraj Kumar Singh, B.Tech, Chandan Kumar, M.Tech, Rakhi Purushothaman Suseela, B.Tech, Mamatha Patil, B.E, Patil Nilesh Dattatraya, M.Sc., Krishna Kumar Tiwari, B.Tech, Shireen Vali, PhD, Christopher R. Cogle, MD, Tomas Stopka, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 5506.
https://doi.org/10.1182/blood-2018-99-114466
Published: 2018
Journal Articles

Predicting Carfilzomib Resistance Mechanisms and Therapeutics Using Computational Modelling of Genomics and Proteomics

Andrej Besse, M.Sc, Christopher R. Cogle, MD, Leylah M. Drusbosky, PhD, Shireen Vali, PhD, Taher Abbasi, MS, MBA, Neeraj Kumar Singh, B.Tech, Neha G Gupta, M.Sc., Abha Kushwaha, M.Sc., Pallavi Kumari, M.Sc., Karthik Sundara Raju, M.Sc., Ganesh Naga, B.Tech, Sayani Basu, M.Tech, Christoph Driessen, MD, Lenka Besse, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3193.
https://doi.org/10.1182/blood-2018-99-116939
Published: 2018
Journal Articles

The Age of the Hematopoietic Microenvironment Specifies Lineage Commitment in MLL-Rearranged Leukemia

Grant Rowe, MD PhD, Edroaldo Lummertz da Rocha, Patricia Sousa, Pavlos Missios, Michael Morse, Jessica Barragan, Ronald Mathieu, George Q Daley, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 135.
https://doi.org/10.1182/blood.V130.Suppl_1.135.135
Published: 2017
Journal Articles

Splicing Modulation Perturbs Key Survival Pathways and Sensitizes Chronic Lymphocytic Leukemia to Venetoclax Treatment

Elisa Ten Hacken, PhD, Rebecca Valentin, MD, Jing Sun, PhD, Jing Deng, PhD, Angela Brooks, PhD, Lillian Werner, MS, Fara Faye Regis, BS, Michaela Gruber, MD PhD, Jessica Wong, BS, Zachary Cartun, BS, Michael Seiler, PhD, Peter Smith, PhD, Michael Thomas, PhD, Silvia Buonamici, PhD, Emanuela M. Ghia, PhD, Ekaterina Kim, PhD, Laura Z. Rassenti, PhD, Jan A. Burger, MD PhD, Thomas J. Kipps, MD, Matthew Meyerson, MDPhD, Donna S. Neuberg, ScD, Ruben D. Carrasco, MD PhD, Lili Wang, MD PhD, Matthew S. Davids, MD, Anthony Letai, MD PhD, Catherine J. Wu, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 264.
https://doi.org/10.1182/blood.V130.Suppl_1.264.264
Published: 2017
Journal Articles

Preclinical and Early Phase 1 Clinical Data of AZD2811 Nanoparticle in AML, an Aurora B Kinase Inhibitor

Wolfram Brugger, MDPhD, Susan Ashton, Carrie A. Adelman, Nicolas Floc'h, Paula Taylor, Maureen Hattersley, PhD, Shenghua Wen, Kimberly Maratea, Philip Overend, Steven Fox, Julie Charlton, Simon T Barry, Donald Strickland, MD, Suzanne Jones, PharmD, Howard A. Burris, MD, Carol Greenlees, Alexander MacDonald, J. Elizabeth Pease, PhD, William Donnellan
Journal: Blood
Blood (2017) 130 (Supplement 1): 1368.
https://doi.org/10.1182/blood.V130.Suppl_1.1368.1368
Published: 2017
Journal Articles

PRMT5 Initiates an Epigenetic Program That Promotes Progression of Chronic Lymphocytic Leukemia

Zachary A Hing, BS, Jordan N. Skinner, B.S., Larry P. Beaver, Tzung-Huei Lai, PhD, Casey B. Cempre, B.S., Bonnie K. Harrington, DVM, Deepa Sampath, PhD, Amy M. Lehman, PhD, Lianbo Yu, PhD, Lapo Alinari, MD PhD, John C. Byrd, MD, Robert A Baiocchi, MD PhD, Rosa Lapalombella, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2487.
https://doi.org/10.1182/blood.V130.Suppl_1.2487.2487
Published: 2017