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Journal Articles

Droplet Digital PCR for the Quantification of Alu Methylation Status in Hematological Malignancies

Paola Orsini, Luciana Impera, Elisa Parciante, Cosimo Cumbo, Crescenzio Francesco Minervini, Angela Minervini, Luisa Anelli, Antonella Zagaria, Nicoletta Coccaro, Paola Casieri, Giuseppina Tota, Claudia Brunetti, Alessandra Ricco, MD, Paola Carluccio, Giorgina Specchia, MD, Francesco Albano, MD

Blood (2018) 132 (Supplement 1): 2612.

https://doi.org/10.1182/blood-2018-99-115966

Published: 2018

Journal Articles

Epigenetic Silencing of Catalase Induces Accumulation of Reactive Oxygen Species in Chronic Lymphocytic Leukemia B Cells Leading to Activation of Axl: An Escape Strategy?

Guru P Maiti, PhD MSc, Sutapa Sinha, PhD, Justin C Boysen, Neil E. Kay, MD, Asish K Ghosh, PhD

Blood (2016) 128 (22): 4363.

https://doi.org/10.1182/blood.V128.22.4363.4363

Published: 2016

Journal Articles

Myelodysplastic Syndrome Marrow Stroma Shows Widespread Aberrant Hypermethylation That Is Abrogated By Treatment with Dnmt Inhibitors

Tushar D Bhagat, PhD, Matthias Bartenstein, MD, Yiting Yu, PhD, A. Mario Q. Marcondes, MD PhD, Britta Will, PhD, Orsolya Giricz, PhD, Davendra P. Sohal, MD MPH, Ioannis Mantzaris, MD, Amittha Wickrema, PhD, Christine Mcmahon, MD, Yeung Cecilia, MD, John Greally, MB, PhD, Siddhartha Mukherjee, MD PhD, Ulrich Steidl, MD PhD, H. Joachim Deeg, MD, Amit Verma, MD

Blood (2014) 124 (21): 4379.

https://doi.org/10.1182/blood.V124.21.4379.4379

Published: 2014

Journal Articles

The Tet Dioxygenase Co-Factor Ascorbic Acid Reduces DNA Methylation and Increases Expression of the γ-Globin Gene and Acts in a Combinatorial Manner with HbF-Inducing Drugs Targeting Repressive Epigenetic Modifications

Maria Armila Ruiz, B.S., Angela Rivers, MD PhD, Kestis Vaitkus, Vinzon Ibanez, Robert E. Molokie, MD, Joseph DeSimone, PhD, Donald Lavelle, PhD

Blood (2014) 124 (21): 334.

https://doi.org/10.1182/blood.V124.21.334.334

Published: 2014

Journal Articles

Genome-Wide DNA Methylation Analysis Reveals Biological and Clinical Insights In Relapsed Childhood Acute Lymphoblastic Leukemia: A Report From The COG ALL Target Project

Huimin Geng, PhD, Mignon L. Loh, MD, Richard C. Harvey, PhD, I-Ming Chen, DVM, Meenakshi Devidas, PhD, Tanja M. Davidsen, PhD, Jaime M. Guidry Auvil, PhD, Daniela S. Gerhard, Ph.D., Malcolm A. Smith, MD PhD, Andrew J. Carroll, PhD, Nyla A. Heerema, PhD, Julie M. Gastier-Foster, PhD, Cheryl L. Willman, MD, Charles G. Mullighan, MBBS MSc MD, Stephen P. Hunger, MD, Ari Melnick, MD

Blood (2013) 122 (21): 3736.

https://doi.org/10.1182/blood.V122.21.3736.3736

Published: 2013

Journal Articles

Elevated Levels Of γ-Globin Gene Promoter 5-Hydroxymethylcytosine are Associated With Increased DNA Hypomethylation and HbF Expression

Maria Armila Ruiz, BS, Angela Rivers, MD, PhD, Kestis Vaitkus, Tatiana Kouznetsova, M.S., Nadim Mahmud, MD, PhD, Joseph DeSimone, PhD, Donald Lavelle, PH.D.

Blood (2013) 122 (21): 438.

https://doi.org/10.1182/blood.V122.21.438.438

Published: 2013

Journal Articles

Lineage, Fusion Partner and Age Differences in the Methylome of MLL-r Leukemias

Eric S Schafer, MD, Rumen Kostadinov, PhD, Peter Murakami, MSc, Sandeep S. Negi, PhD, Maria E Figueroa, MD, Ari Melnick, MD, Patrick Brown, MD

Blood (2012) 120 (21): 3506.

https://doi.org/10.1182/blood.V120.21.3506.3506

Published: 2012

Journal Articles

A Phase I/II Study of Vorinostat (SAHA), Cladribine (2-CdA), and Rituximab Shows Significant Activity in Previously Untreated Mantle Cell Lymphoma

Stephen Spurgeon, MD, Andy I Chen, MD, PhD, Craig Okada, MD, PhD, Samir Parekh, MD, Violetta V. Leshchenko, PhD, Gundula Palmbach, Bashi Ratterree, RN, Nan Subbiah, Christine Capper, RN, Elliot M Epner, MD, PhD

Blood (2011) 118 (21): 441.

https://doi.org/10.1182/blood.V118.21.441.441

Published: 2011

Journal Articles

Genome Wide DNA Methylation Analysis Reveals Significant Differences Between Blasts of Patients with Acute Promyelocytic Leukemia and CD34 + -Hematopoietic Stem Cells of Healthy Individuals

Mark Reinwald, MD, Anjulie Haag, Eva Lengfelder, MD, Verena Nowak, Maximilian Mossner, Marion Klaumuenzer, Florian Nolte, MD, Thomas Büchner, MD, Karsten Spiekermann, MD, Wolf-Karsten Hofmann, MD, Daniel Nowak, MD

Blood (2011) 118 (21): 1452.

https://doi.org/10.1182/blood.V118.21.1452.1452

Published: 2011

Journal Articles

Epigenomic Profiling of Myeloproliferative Diseases Reveal Idiopathic Myelofibrosis as An Epigenetically Distinct Subgroup and Highlights the Epigenetic Effects of Jak2V617F Mutation

Sangeeta Nischal, Li Zhou, Yiting Yu, Tushar Bhagat, Yongkai Mo, Christoph Heuck, Masako Suzuki, Shahina Maqbool, Animesh Pardanani, John Greally, Alison Moliterno, Amit Verma

Blood (2010) 116 (21): 627.

https://doi.org/10.1182/blood.V116.21.627.627

Published: 2010

Journal Articles

Global DNA Demethylation During Physiological Erythropoiesis In Vivo

Jeffrey R Shearstone, Ramona Pop, Merav Socolovsky

Blood (2010) 116 (21): 2083.

https://doi.org/10.1182/blood.V116.21.2083.2083

Published: 2010

Journal Articles

Epigenomic Profiling of Multiple Myeloma Shows Widespread Stage Specific Alterations In DNA Methylation That Occur Early During Myelomagenesis

Christoph Heuck, MD, Jayesh Mehta, MD, Joseph Tariman, Natalie Pulliam, Yiting Yu, Tushar Bhagat, Sangeeta Nischal, Richard Meagher, Caroline Y. Hu, MD, Amit Verma, Seema B. Singhal, MD

Blood (2010) 116 (21): 784.

https://doi.org/10.1182/blood.V116.21.784.784

Published: 2010

Journal Articles

MDS Marrow Stroma Is Characterized by Distinct Epigenetic Alterations

Tushar D Bhagat, Emily Spaulding, Davendra Sohal, Yongkai Mo, Mario Marcondes, Li Zhou, Reid Thompson, John Greally, H. Joachim Deeg, Amit Verma

Blood (2008) 112 (11): 3635.

https://doi.org/10.1182/blood.V112.11.3635.3635

Published: 2008

Journal Articles

Integrative Genomic Analysis Reveals Aberrant Epigenetic Marks in MDS That Can Be Seen in Peripheral Blood Leucocytes

Li Zhou, Joanna B. Opalinska, Davendra P. Sohal, Yongkai Mo, Suman Kambhampati, Simrit Parmar, Christina Alencar, Christoph Heuck, Ivette Vigoda, Chun Ng, Perry Pahanish, Swati Goel, Carolina Schinke, Lawrence Cytryn, Ellen Friedman, Maria E Figueroa, Amittha Wickrema, PhD, John Greally, Amit Verma

Blood (2008) 112 (11): 595.

https://doi.org/10.1182/blood.V112.11.595.595

Published: 2008

Journal Articles

Downregulation of Ribosomal Proteins Is Seen in Non 5q- MDS

Davendra P. Sohal, Andrea Pellagati, Li Zhou, Yongkai Mo, Joanna B. Opalinska, Christina Alencar, Christoph Heuck, Amittha Wickrema, Ellen Friedman, John Greally, Benjamin L. Ebert, Jonathan Warner, Jacqueline Boultwood, Amit Verma

Blood (2008) 112 (11): 854.

https://doi.org/10.1182/blood.V112.11.854.854

Published: 2008

Journal Articles

Two Different EVI1 Expressing Poor-Risk AML Subgroups with Distinct Epigenetic Signatures Uncovered by Genome Wide DNA Methylation Profiling

Sanne Lugthart, MD, Maria E Figueroa, MD, Peter JM Valk, PhD, Yushan Li, Claudia Erpelinck-Verschueren, John Greally, MB, PhD, Bob Löwenberg, MD, PhD, Ari Melnick, MD, Ruud Delwel, PhD

Blood (2008) 112 (11): 757.

https://doi.org/10.1182/blood.V112.11.757.757

Published: 2008

Journal Articles

Genetic vs. Epigenetic Disruption of the CEBPA Locus Yields Epigenomically and Biologically Distinct Leukemia Phenotypes.

Maria E. Figueroa, MD, Bas J. Wouters, MD, Yushan Li, Peter Valk, PhD, Bob Lowenberg, MD, PhD, Ari M. Melnick, MD, Ruud Delwel, PhD

Blood (2007) 110 (11): 2117.

https://doi.org/10.1182/blood.V110.11.2117.2117

Published: 2007

Journal Articles

High Resolution Epigenomic Profiling of Loss of Heterozygosity in MDS Reveals an Important Role of DNA Methylation in Regulating Expression of Genes in the Deleted Regions of Chromosomes 5q, 7q and 20q.

D. Sohal, J. Opalinska, L. Zhou, P. Pahanish, E. Friedman, R. Thompson, K. Ye, M. Figueroa, A. Melnick, J. Greally, A. List, A. Verma

Blood (2007) 110 (11): 2120.

https://doi.org/10.1182/blood.V110.11.2120.2120

Published: 2007

Journal Articles

Increased Global Gene Promoter Methylation after Relapse (Rel) of Acute Promyelocytic Leukemia (APL) from All- trans Retinoic Acid (ATRA)-Containing Treatment Is Dissociated from Concurrent Gene Expression Changes.

Da-Cheng Zhou, MD, PhD, Qingping Cui, PhD, Haesook Kim, PhD, Reid Thompson, BS, John Greally, MD, PhD, Eric E. Bouhassira, PhD, Robert E. Gallagher, MD

Blood (2007) 110 (11): 2121.

https://doi.org/10.1182/blood.V110.11.2121.2121

Published: 2007

Journal Articles

Integrated Epigenomic Profiling Reveals Aberrant DNA Hypomethylation in LGL and Demonstrates That a Combination of Genetic and Epigenetic Events Results in Leukemic Evolution in Model of Large Granular Lymphocytic Leukemia.

J. Opalinska, M. Daibata, D. Sohal, L. Zhou, R. Thompson, P. Pahanish, M. Affer, M. Figueroa, K. Ye, J. Greally, F. Bai, A. List, A. Melnick, P. Epling-Burnette, A. Verma

Blood (2007) 110 (11): 2129.

https://doi.org/10.1182/blood.V110.11.2129.2129

Published: 2007

NARROW

Droplet Digital PCR for the Quantification of Alu Methylation Status in Hematological Malignancies

Epigenetic Silencing of Catalase Induces Accumulation of Reactive Oxygen Species in Chronic Lymphocytic Leukemia B Cells Leading to Activation of Axl: An Escape Strategy?

Myelodysplastic Syndrome Marrow Stroma Shows Widespread Aberrant Hypermethylation That Is Abrogated By Treatment with Dnmt Inhibitors

The Tet Dioxygenase Co-Factor Ascorbic Acid Reduces DNA Methylation and Increases Expression of the γ-Globin Gene and Acts in a Combinatorial Manner with HbF-Inducing Drugs Targeting Repressive Epigenetic Modifications

Genome-Wide DNA Methylation Analysis Reveals Biological and Clinical Insights In Relapsed Childhood Acute Lymphoblastic Leukemia: A Report From The COG ALL Target Project

Elevated Levels Of γ-Globin Gene Promoter 5-Hydroxymethylcytosine are Associated With Increased DNA Hypomethylation and HbF Expression

Lineage, Fusion Partner and Age Differences in the Methylome of MLL-r Leukemias

A Phase I/II Study of Vorinostat (SAHA), Cladribine (2-CdA), and Rituximab Shows Significant Activity in Previously Untreated Mantle Cell Lymphoma

Genome Wide DNA Methylation Analysis Reveals Significant Differences Between Blasts of Patients with Acute Promyelocytic Leukemia and CD34 + -Hematopoietic Stem Cells of Healthy Individuals

Epigenomic Profiling of Myeloproliferative Diseases Reveal Idiopathic Myelofibrosis as An Epigenetically Distinct Subgroup and Highlights the Epigenetic Effects of Jak2V617F Mutation

Global DNA Demethylation During Physiological Erythropoiesis In Vivo

Epigenomic Profiling of Multiple Myeloma Shows Widespread Stage Specific Alterations In DNA Methylation That Occur Early During Myelomagenesis

MDS Marrow Stroma Is Characterized by Distinct Epigenetic Alterations

Integrative Genomic Analysis Reveals Aberrant Epigenetic Marks in MDS That Can Be Seen in Peripheral Blood Leucocytes

Downregulation of Ribosomal Proteins Is Seen in Non 5q- MDS

Two Different EVI1 Expressing Poor-Risk AML Subgroups with Distinct Epigenetic Signatures Uncovered by Genome Wide DNA Methylation Profiling

Genetic vs. Epigenetic Disruption of the CEBPA Locus Yields Epigenomically and Biologically Distinct Leukemia Phenotypes.

High Resolution Epigenomic Profiling of Loss of Heterozygosity in MDS Reveals an Important Role of DNA Methylation in Regulating Expression of Genes in the Deleted Regions of Chromosomes 5q, 7q and 20q.

Increased Global Gene Promoter Methylation after Relapse (Rel) of Acute Promyelocytic Leukemia (APL) from All- trans Retinoic Acid (ATRA)-Containing Treatment Is Dissociated from Concurrent Gene Expression Changes.

Integrated Epigenomic Profiling Reveals Aberrant DNA Hypomethylation in LGL and Demonstrates That a Combination of Genetic and Epigenetic Events Results in Leukemic Evolution in Model of Large Granular Lymphocytic Leukemia.

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American Society of Hematology

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American Society of Hematology

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