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Journal Articles

Elucidating the Role of IL6 in Stress Erythropoiesis and in the Development of Anemia Under Inflammatory Conditions

Sayantani Sinha, PhD, Ritama Gupta, PhD, Jianbing Zhang, PhD, Amaliris Guerra, PhD, Ping La, Sara Gardenghi, PhD, Stefano Rivella, PhD

Blood (2019) 134 (Supplement_1): 940.

https://doi.org/10.1182/blood-2019-128826

Published: 2019

Journal Articles

Inflammasome Activation Promotes Deep Vein Thrombosis through Pyroptosis

Yan Zhang, Guoying Zhang, Cui Jian, Congqing Wu, PhD, Nigel Mackman, PhD, Susan Smyth, MD PhD, Yinan Wei, Zhenyu Li, PhD

Blood (2019) 134 (Supplement_1): 3644.

https://doi.org/10.1182/blood-2019-130439

Published: 2019

Journal Articles

β 2 -m - a Trigger for NLRP3 Inflammasome Activation within Macrophages Promoting Multiple Myeloma Cell Proliferation

Daniel Hofbauer, Dimitrios Mougiakakos, MD, Maike Büttner-Herold, Frank Neumann, PhD, Jens Nolting, Savita Bisht, Robert Zeiser, MD, Shaima'A Hamarsheh, MSc,BSc, Stefano Ricagno, PhD, Mario Zaiss, Martin Eberhardt, Martin Boettcher, PhD, Katrin Bitterer, Andreas Mackensen, MD, Heiko Bruns, PhD

Blood (2019) 134 (Supplement_1): 2314.

https://doi.org/10.1182/blood-2019-123958

Published: 2019

Journal Articles

Transcriptomic Profile of Bone Marrow-Derived Mesenchymal Stromal Cells of Pediatric Pre-B Acute Lymphoblastic Leukemia Patients and Healthy Donors after Interaction with Leukemic Cells

Tuba Özdemi̇r Sanci, MSc, Hilal Özdağ, PhD, Yasin Köksal, MSc, Seda Tasır Yılmaz, MSc, Husniye Nese Yarali, MD, Namik Yasar Özbek, MD, Habibe Meltem Özgüner, MD

Blood (2019) 134 (Supplement_1): 3957.

https://doi.org/10.1182/blood-2019-128282

Published: 2019

Journal Articles

Novel Evidence That the Nlrp3 Inflammasome Plays a Role in Bone Marrow As a "Cogwheel" Connecting Purinergic Signaling with Activation of the Complement Cascade to Induce "Sterile Inflammation", Which Is Required for Optimal Mobilization of Hematopoietic Stem/Progenitor Cells

Mateusz Adamiak, PhD, Anna Lenkiewicz, PhD, Kamila Bujko, MS, Arjun Thapa, PhD, Magdalena Kucia, PhD DSci, Ahmed Abdel-Latif, MD PhD, Janina Ratajczak, MD PhD DSci, Mariusz Z Ratajczak, MD PhD DSc

Blood (2019) 134 (Supplement_1): 4468.

https://doi.org/10.1182/blood-2019-125838

Published: 2019

Journal Articles

The Prolonged Inhibition of Chk1/Chk2 Kinases Enhances Genetic Instability and Compromises the Efficacy of Chemotherapy Against Acute Lymphoblastic Leukemia Cells

Andrea Ghelli Luserna Di Rorà, PhD, Antonella Padella, PhD, Maria Chiara Fontana, PhD, Eugenio Fonzi, PhD, Anna Ferrari, PhD, Enrica Imbrogno, PhD, Martina Ghetti, PhD, Roberta Napolitano, PhD, Maria Teresa Bochicchio, Giovanni Martinelli, MD, Giorgia Simonetti, PhD

Blood (2019) 134 (Supplement_1): 5047.

https://doi.org/10.1182/blood-2019-129964

Published: 2019

Journal Articles

Human and Pathogen Derived Ndpks Act As Novel Damps and PAMPs to Drive Leukemia Cell Survival and Progression through Signaling Via the TLR4-Mediated Alternative NLRP3 Inflammasome Pathway

Sandro Trova, PhD, Matthew Fenton, MBChB, Bhavini Chauhan, BSc, Avani Puri, Santosh Lomada, BSc, PhD, Alexandra Adams, Thomas Wieland, BSc, PhD, Mark T Drayson, MB ChB, PhD FRCPath, Farhat Latif Khanim, PhD, Chistopher M Bunce, BSc, Fei Lin, MBChB

Blood (2019) 134 (Supplement_1): 2684.

https://doi.org/10.1182/blood-2019-131236

Published: 2019

Journal Articles

Oxidized Mitochondrial DNA Engages TLR9 to Activate the NLRP3 Inflammasome in Myelodysplastic Syndromes

Grace A Ward, BS, Kathy McGraw, PhD, Amy F McLemore, M.S., Nghi B Lam, M.S., Hsin-An Hou, Benjamin S. Meyer, Alan F. List, MD

Blood (2019) 134 (Supplement_1): 774.

https://doi.org/10.1182/blood-2019-122358

Published: 2019

Journal Articles

The central role of inflammatory signaling in the pathogenesis of myelodysplastic syndromes

David A. Sallman, Alan List

Blood (2019) 133 (10): 1039–1048.

https://doi.org/10.1182/blood-2018-10-844654

Published: 2019

Journal Articles

Genomic-DNA Exposed By Somatic Gene Mutations Engages the cGAS/STING Axis to License the NLRP3 Inflammasome in Myelodysplastic Syndromes

Amy F McLemore, M.S., Kathy L McGraw, PhD, Hsin-An Hou, MD PhD, Grace A Ward, BS, Alexis H Onimus, BS, Nicole D. Vincelette, PhD, Matthew A. Rodrigues, PhD, Neelkamal Chaudhary, PhD, Ling Zhang, MD, Benjamin S. Meyer, Erika A Eksioglu, PhD MS, Sheng Wei, MD, Alan F. List, MD

Blood (2018) 132 (Supplement 1): 3075.

https://doi.org/10.1182/blood-2018-99-116929

Published: 2018

Journal Articles

Oxidized Mitochondrial DNA Is a Catalyst and Biomarker of Pyroptotic Cell Death in Myelodysplastic Syndromes

Grace A Ward, BS, Kathy L McGraw, PhD, Amy F McLemore, M.S., Farnoosh Abbas-Aghababazadeh, PhD, Hsin-An Hou, MD PhD, Thu Le Trinh, PhD, Nicole D. Vincelette, PhD, Benjamin S. Meyer, Alexis H Onimus, BS, Alexandra Calescibetta, Erika A Eksioglu, PhD MS, Sheng Wei, MD, Alan F. List, MD

Blood (2018) 132 (Supplement 1): 3076.

https://doi.org/10.1182/blood-2018-99-118493

Published: 2018

Journal Articles

Oncogenic KRAS G12D in the Hematopoietic System Causes NLRP3 Inflammasome Activation Leading to Myeloproliferative Syndrome

Shaima'A Hamarsheh, MSc, BSc, Miriam Erlacher, MD PhD, Lena Osswald, Oliver Gorka, PhD, Justus Duyster, Prof., Olaf Groß, PhD, Claudia Lengerke, MD, Melanie Börries, PhD, Tilman Brummer, PhD, Robert Zeiser, MD

Blood (2018) 132 (Supplement 1): 2618.

https://doi.org/10.1182/blood-2018-99-114161

Published: 2018

Journal Articles

Comprehensive Transcriptome Profiling of Cryptic CBFA2T3-GLIS2 Fusion-Positive AML Defines Novel Therapeutic Options — a COG and Target Pediatric AML Study

Jenny L. Smith, MSc, MD, Rhonda E. Ries, MA, Marianne T. Santaguida, BSc, PhD, Christos Gekas, PhD, Todd A Alonzo, PhD, Robert B Gerbing, MA, Alan S Gamis, MD MPH, Richard Aplenc, MD PhD, E. Anders Kolb, MD, Tiffany Hylkema, BS, Lisa Eidenschink Brodersen, PhD, Michael R. Loken, PhD, Hamid Bolouri, PhD, Soheil Meshinchi, MD PhD

Blood (2018) 132 (Supplement 1): 881.

https://doi.org/10.1182/blood-2018-99-115544

Published: 2018

Journal Articles

SNP-Array Genome Wide Association Study Meta-Analysis Identifies Innate Immune Susceptibility Loci Associated with Non-Del(5q) Myelodysplastic Syndromes Predisposition

Blood (2018) 132 (Supplement 1): 107.

https://doi.org/10.1182/blood-2018-99-118747

Published: 2018

Journal Articles

Cytoprotective activated protein C averts Nlrp3 inflammasome–induced ischemia-reperfusion injury via mTORC1 inhibition

Sumra Nazir, Ihsan Gadi, Moh’d Mohanad Al-Dabet, Ahmed Elwakiel, Shrey Kohli, Sanchita Ghosh, Jayakumar Manoharan, Satish Ranjan, Fabian Bock, Ruediger C. Braun-Dullaeus, Charles T. Esmon, Tobias B. Huber, Eric Camerer, Chris Dockendorff, John H. Griffin, Berend Isermann, Khurrum Shahzad

Blood (2017) 130 (24): 2664–2677.

https://doi.org/10.1182/blood-2017-05-782102

Published: 2017

Includes: Supplemental data

Journal Articles

Intrinsic Activation of the NLRP3 Inflammasome in Primary Human ALL Cells Is Regulated By Endogenous HMGB1 and Bone Marrow Macrophages

Liana M Toia, BS, John L Mariano, MD, Michael Weinstein Winter, MD, Jessica C Shand, MD

Blood (2017) 130 (Supplement 1): 2559.

https://doi.org/10.1182/blood.V130.Suppl_1.2559.2559

Published: 2017

Journal Articles

Canonical Inflammasome Formation in Monocytes of Sickle Cell Anemia Patients

Rafaela Mendonça, BS, Karla P.V Ferro, PhD, Flávia Costa Leonardo, PhD, Juliete A.F. Silva, PhD, Fernando Vieira Pericole, MD PhD, Sara T Olalla Saad, MD PhD, Fernando F. Costa, MD, PhD, Nicola Conran, PhD

Blood (2017) 130 (Supplement 1): 2233.

https://doi.org/10.1182/blood.V130.Suppl_1.2233.2233

Published: 2017

Journal Articles

The NLRP3 Inflammasome in Platelets Is Upregulated in Sickle Cell Disease and Promotes Platelet Aggregation and In Vitro Thrombosis

Sebastian Vogel, MD PhD, Taruna Arora, MD, Xunde Wang, PhD, Luis E. Almeida, MD PhD, Zenaide Quezado, MD, Swee Lay Thein, DSc,FRCP,FRCPath,MBBS,MRCPath,MRCP

Blood (2017) 130 (Supplement 1): 2234.

https://doi.org/10.1182/blood.V130.Suppl_1.2234.2234

Published: 2017

Journal Articles

Aging of Hematopoietic Stem Cells Is Driven By Regional Specialization of Marrow Macrophages

Corey M Hoffman, MS, Sarah E Latchney, PhD, Mark LaMere, BA, Jason R Myers, MS, John M Ashton, PhD, Allison J. Li, MS, Frank Akwaa, MD, Rakhil Rubinova, D.O., Amanda McCabe, PhD, Julianne N. Smith, PhD, Jane L. Liesveld, MD, Benjamin J. Frisch, PhD, Michael Rusty Elliott, PhD, Katherine C MacNamara, PhD, Michael W. Becker, MD, James Palis, MD, Archibald S. Perkins, MD PhD, Laura M. Calvi, MD

Blood (2017) 130 (Supplement 1): 95.

https://doi.org/10.1182/blood.V130.Suppl_1.95.95

Published: 2017

Journal Articles

Hairy Platelet-Derived Extracellular Vesicles Promote Lung Vaso-Occlusion in Sickle Cell Disease

Prithu Sundd, PhD, Maritza Ann Jimenez, BS, Margaret F. Bennewitz, PhD, Tomasz Brzoska, PhD, Egemen Tutuncuoglu, MSc, Gregory J. Kato, MD, Mark T Gladwin, MD

Blood (2017) 130 (Supplement 1): 958.

https://doi.org/10.1182/blood.V130.Suppl_1.958.958

Published: 2017

NARROW

Elucidating the Role of IL6 in Stress Erythropoiesis and in the Development of Anemia Under Inflammatory Conditions

Inflammasome Activation Promotes Deep Vein Thrombosis through Pyroptosis

β 2 -m - a Trigger for NLRP3 Inflammasome Activation within Macrophages Promoting Multiple Myeloma Cell Proliferation

Transcriptomic Profile of Bone Marrow-Derived Mesenchymal Stromal Cells of Pediatric Pre-B Acute Lymphoblastic Leukemia Patients and Healthy Donors after Interaction with Leukemic Cells

Novel Evidence That the Nlrp3 Inflammasome Plays a Role in Bone Marrow As a "Cogwheel" Connecting Purinergic Signaling with Activation of the Complement Cascade to Induce "Sterile Inflammation", Which Is Required for Optimal Mobilization of Hematopoietic Stem/Progenitor Cells

The Prolonged Inhibition of Chk1/Chk2 Kinases Enhances Genetic Instability and Compromises the Efficacy of Chemotherapy Against Acute Lymphoblastic Leukemia Cells

Human and Pathogen Derived Ndpks Act As Novel Damps and PAMPs to Drive Leukemia Cell Survival and Progression through Signaling Via the TLR4-Mediated Alternative NLRP3 Inflammasome Pathway

Oxidized Mitochondrial DNA Engages TLR9 to Activate the NLRP3 Inflammasome in Myelodysplastic Syndromes

The central role of inflammatory signaling in the pathogenesis of myelodysplastic syndromes

Genomic-DNA Exposed By Somatic Gene Mutations Engages the cGAS/STING Axis to License the NLRP3 Inflammasome in Myelodysplastic Syndromes

Oxidized Mitochondrial DNA Is a Catalyst and Biomarker of Pyroptotic Cell Death in Myelodysplastic Syndromes

Oncogenic KRAS G12D in the Hematopoietic System Causes NLRP3 Inflammasome Activation Leading to Myeloproliferative Syndrome

Comprehensive Transcriptome Profiling of Cryptic CBFA2T3-GLIS2 Fusion-Positive AML Defines Novel Therapeutic Options — a COG and Target Pediatric AML Study

SNP-Array Genome Wide Association Study Meta-Analysis Identifies Innate Immune Susceptibility Loci Associated with Non-Del(5q) Myelodysplastic Syndromes Predisposition

Cytoprotective activated protein C averts Nlrp3 inflammasome–induced ischemia-reperfusion injury via mTORC1 inhibition

Intrinsic Activation of the NLRP3 Inflammasome in Primary Human ALL Cells Is Regulated By Endogenous HMGB1 and Bone Marrow Macrophages

Canonical Inflammasome Formation in Monocytes of Sickle Cell Anemia Patients

The NLRP3 Inflammasome in Platelets Is Upregulated in Sickle Cell Disease and Promotes Platelet Aggregation and In Vitro Thrombosis

Aging of Hematopoietic Stem Cells Is Driven By Regional Specialization of Marrow Macrophages

Hairy Platelet-Derived Extracellular Vesicles Promote Lung Vaso-Occlusion in Sickle Cell Disease

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American Society of Hematology

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