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Journal Articles

Topoisomerase 2β mutation impairs early B-cell development

Clinical Trials & Observations
Olivier Papapietro, Anita Chandra, Davide Eletto, Sarah Inglott, Vincent Plagnol, James Curtis, Mailis Maes, Ali Alisaac, Adriana S. Albuquerque, Eugenie Basseres, Olivier Hermine, Capucine Picard, Alain Fischer, Anne Durandy, Sven Kracker, Siobhan O. Burns, Delphine Cuchet-Lourenco, Klaus Okkenhaug, Sergey Nejentsev
Journal: Blood
Blood (2020) 135 (17): 1497–1501.
https://doi.org/10.1182/blood.2019003299
Published: 2020
Includes: Supplemental data
Journal Articles

Nonpermissive bone marrow environment impairs early B-cell development in common variable immunodeficiency

Brief Report
Arianna Troilo, Claudia Wehr, Iga Janowska, Nils Venhoff, Jens Thiel, Justyna Rawluk, Natalie Frede, Julian Staniek, Raquel Lorenzetti, Marei-Theresa Schleyer, Georg W. Herget, Lukas Konstantinidis, Miriam Erlacher, Michele Proietti, Nadezhda Camacho-Ordonez, Reinhard Edmund Voll, Bodo Grimbacher, Klaus Warnatz, Ulrich Salzer, Marta Rizzi
Journal: Blood
Blood (2020) 135 (17): 1452–1457.
https://doi.org/10.1182/blood.2019003855
Published: 2020
Includes: Supplemental data
Journal Articles

A Distinct Oncofetal B-Cell Transcriptional Program Is Activated in Infant Acute Myeloid Leukemia and Reveals Novel Therapeutic Strategies

Hamid Bolouri, PhD, Benjamin K. Johnson, PhD, Rhonda E. Ries, MA, Laura Pardo, Tiffany A. Hylkema, BS, Wanding Zhou, PhD, Jenny L. Smith, MSc, MD, Amanda R. Leonti, MS, Allison Kaeding, MD, Michael R. Loken, PhD, Jason E. Farrar, MD, Soheil Meshinchi, MD PhD, Timothy Junius Triche, Jr., PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3768.
https://doi.org/10.1182/blood-2019-123487
Published: 2019
Journal Articles

Single Cell Sequencing Reveals Heterogeneity of Gene Expression in KMT2A Rearranged Infant ALL at Relapse Compared to Diagnosis

Erin Guest, MD, Byunggil Yoo, MS, Rumen Kostadinov, PhD, Midhat S. Farooqi, MD PhD, Emily Farrow, PhD CGC, Margaret Gibson, Neil Miller, Karina Shah, Tomi Pastinen, MD PhD, Patrick A. Brown, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2756.
https://doi.org/10.1182/blood-2019-131999
Published: 2019
Journal Articles

Role of Ubiquitin E3 Ligase UBR5 in B-Cell Development and Lymphoma

Tyler Gilbreath, B.S., Samantha Swenson, PhD, Shannon M. Buckley, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2794.
https://doi.org/10.1182/blood-2019-128747
Published: 2019
Journal Articles

The Tetraspanin CD53 Regulates Early B Cell Development By Promoting IL-7R Signaling

Zev J. Greenberg, BS, Darlene A. Monlish, PhD, Rachel L. Bartnett, Jeffrey J. Bednarski, MD PhD, Laura G. Schuettpelz, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 79.
https://doi.org/10.1182/blood-2019-131641
Published: 2019
Journal Articles

Signaling Input from Divergent Pathways Subverts Malignant B-Cell Transformation

Lai N Chan, PhD, Mark A. Murakami, MDMA,MMSc, Rebecca Caesar, Christian Hurtz, PhD, Kohei Kume, PhD, Teresa Sadras, PhD, Seyedmehdi Shojaee, PhD, Petri Pölönen, MSc, Amol Ugale, PhD, Jaewoong Lee, PhD, Kadriye Nehir Cosgun, PhD, Huimin Geng, PhD, Merja Heinäniemi, PhD, Olli Lohi, MD PhD, Arun P. Wiita, MD PhD, Shai Izraeli, MD, David M Weinstock, Markus Müschen, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3944.
https://doi.org/10.1182/blood-2019-130774
Published: 2019
Journal Articles

Deciphering the Role of Locally Disordered DNA Methylation on CLL Development In Vivo

Anat Biran, PhD, Helene Kretzmer, PhD, Shanye Yin, PhD, Leah Billington, BA, Fara Faye Regis, BS, Arman W. Mohammad, BA, Andreas Gnirke, Donna S Neuberg, ScD, Ruben D. Carrasco, MD PhD, Alexander Meissner, PhD, Catherine J. Wu, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1737.
https://doi.org/10.1182/blood-2019-130744
Published: 2019
Journal Articles

B Cell Restricted Expression of Mutated IKZF3 modulates BCR Signaling and Homing Pathways in a Mouse Model of CLL

Gregory Lazarian, PharmD, Shanye Yin, PhD, Elisa Ten Hacken, PhD, Tomasz Sewastianik, MSc,PhD, Alba Font-tello, PhD, Heather Joyal, Elizabeth Witten, Mei Zheng, Christopher J. Ott, PhD, Donna S Neuberg, ScD, Lili Wang, MD PhD, Ruben D. Carrasco, MD PhD, Catherine J. Wu, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 848.
https://doi.org/10.1182/blood-2019-123963
Published: 2019
Journal Articles

Lgr5 Functions As a Critical Negative Regulator of Wnt/β-Catenin Signaling and Is Essential for B-Lymphopoiesis and Malignant B-Cell Transformation

Kadriye Nehir Cosgun, PhD, Gauri Deb, MS, PhD, Xin Yang, MD, Gang Xiao, PhD, Teresa Sadras, PhD, Jaewoong Lee, PhD, Lai N Chan, PhD, Kohei Kume, PhD, Lu Yang, PhD, Huimin Geng, PhD, John Chan, MD, Joo Y. Song, MD, Hassan Jumaa, PhD, Andrew G. Polson, PhD, Hans Clevers, MD PhD, Markus Müschen, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 748.
https://doi.org/10.1182/blood-2019-127263
Published: 2019
Journal Articles

Highly Potent BTK Degradation Induced By NRX0492 As a Therapeutic Strategy for CLL

Deyi Zhang, PhD, Hailey Harris, Aileen Kelly, PhD, Daniel W Robbins, May Tan, Timothy Ingallinera, Neil Bence, Arthur T Sands, Sivasubramanian Baskar, Sarah E. M. Herman, Adrian Wiestner, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 174.
https://doi.org/10.1182/blood-2019-126921
Published: 2019
Journal Articles

Dynamic Assembly of a Feedback Complex to Regulate Oncogenic B-Cell Receptor-Signaling

Jaewoong Lee, PhD, Kohei Kume, PhD, Zhengshan Chen, MD PhD, Gang Xiao, PhD, Kadriye Nehir Nehir Cosgun, PhD, Liting Chen, PhD, Lai N Chan, PhD, Lars Klemm, MS, Chun-Wei David Chen, PhD, Ning Ma, PhD, Wing C. Chan, MD, Stephen J Forman, MD, Francesca Zammarchi, PhD, Patrick Van Berkel, PhD, Ari Melnick, MD, Vu N Ngo, PhD, Huimin Geng, PhD, Selina M. Luger, MD FRCPC, Mark Litzow, MD, Michael T McManus, PhD, Nagarajan Vaidehi, PhD, Elisabeth M. Paietta, PhD, Eric Meffre, PhD, David M. Weinstock, MD, Markus Müschen, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 393.
https://doi.org/10.1182/blood-2019-131270
Published: 2019
Journal Articles

Interrogation of Individual CLL Loss-of-Function Lesions By CRISPR In Vivo Editing Reveals Common and Unique Pathway Alterations

Elisa Ten Hacken, PhD, Shanye Yin, PhD, Kendell Clement, PhD, Robert A. Redd, MS, Maria Hernandez-Sanchez, PhD, Shuqiang Li, PhD, Michaela Gruber, MD PhD, Heather Joyal, Geoffrey Fell, MS, Shu Wang, Jose Jacob, James Flynn, David Ruff, Keith W. Jones, Lili Wang, MD PhD, Donna S Neuberg, ScD, Luca Pinello, PhD, Kenneth J. Livak, PhD, Ruben D. Carrasco, MD PhD, Catherine J. Wu, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 684.
https://doi.org/10.1182/blood-2019-127673
Published: 2019
Journal Articles

MHC class II cell-autonomously regulates self-renewal and differentiation of normal and malignant B cells

Julia Merkenschlager, Urszula Eksmond, Luca Danelli, Jan Attig, George R. Young, Carla Nowosad, Pavel Tolar, George Kassiotis
Journal: Blood
Blood (2019) 133 (10): 1108–1118.
https://doi.org/10.1182/blood-2018-11-885467
Published: 2019
Includes: Supplemental data
Journal Articles

The Complex Role of KDM6A in B-Cell Development and Function

Ling Tian, PhD, Monique Chavez, B.S., Lukas D Wartman, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 513.
https://doi.org/10.1182/blood-2018-99-119538
Published: 2018
Journal Articles

Regulation of Homeostatic and Malignant B Cell Development By the Tetraspanin CD53

Zev J. Greenberg, BS, Darlene A. Monlish, PhD, Rachel L. Bartnett, Laura G. Schuettpelz, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3699.
https://doi.org/10.1182/blood-2018-99-111957
Published: 2018
Journal Articles

Leukemia Risk Gene ARID5B is a Crucial Regulator of B-Cell Development

Charnise Goodings-Harris, PhD, Hui Zhang, PhD, Xuijie Zhao, Heng Xu, PhD, Omar I Abdel-Wahab, MD, Shannon McKinney-Freeman, PhD, Jun J. Yang, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 385.
https://doi.org/10.1182/blood-2018-99-113686
Published: 2018
Journal Articles

Normal and Aberrant NKL-Code in B-Cell Development and Lymphoma

Stefan Nagel, PhD, MacLeod A.F. Roderick, PhD, Corinna Meyer, Maren Kaufmann, Hans G. Drexler, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3901.
https://doi.org/10.1182/blood-2018-99-110286
Published: 2018
Journal Articles

KZF-L162R Mutation Affects Splenic Mature B Cell Development and Alters Expression of Aiolos Target Genes

Gregory Lazarian, Shanye Yin, PhD, Alba Font-tello, PhD, Elisa Ten Hacken, PhD, Tomasz Sevastianik, PhD, Daniel Tom, Fara Faye Regis, BS, Amy Gill, Mei Zheng, Katia Georgopoulos, PhD, Donna S Neuberg, ScD, Lili Wang, MDPhD, Ruben D. Carrasco, MD PhD, Catherine J. Wu, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 668.
https://doi.org/10.1182/blood-2018-99-115483
Published: 2018
Journal Articles

Integrated Genomic and Proteomic Analysis of Murine CLL-like Cells Reveals SF3B1 Mutation to Impact DNA Damage Response and BCR Signaling

Lili Wang, MDPhD, Shanye Yin, PhD, Aina zurita Martinez, Fara Faye Regis, BS, Angela Brooks, PhD, Sarah E. M. Herman, PhD, Elisa Ten Hacken, PhD, Esther Obeng, MD PhD, Dean Campagna, BS, Mark D. Fleming, MD DPhil, Benjamin L. Ebert, MDPhD, Adrian Wiestner, MD, Ignaty Leshchiner, PhD, Gad Getz, PhD, Ruben D. Carrasco, MD PhD, Catherine J. Wu, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 947.
https://doi.org/10.1182/blood-2018-99-117691
Published: 2018