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Journal Articles

Efficacy of an Antagonistic Anti-CD40 Monoclonal Antibody, HCD122 (CHIR-12.12), in Preclinical Models of Human Non-Hodgkin’s Lymphoma and Hodgkin’s Disease.

Li Long, PhD, Montesa Patawaran, B.Sc., Xia Tong, M.Sc., Seema Kantak, Ph.D., Sharon L. Aukerman, Ph.D., Nancy Pryer, Ph.D., Mohammad Luqman, Ph.D.
Journal: Blood
Blood (2006) 108 (11): 230.
https://doi.org/10.1182/blood.V108.11.230.230
Published: 2006
Journal Articles

Antagonist Anti-CD40 Antibody, CHIR-12.12, Induces ADCC, Inhibits Tumor Growth, and Prolongs Survival in a Human Multiple Myeloma Xenograft Model.

Li Long, PhD, Xia Tong, M.Sc, Montesa Patawaran, B.Sc, Sharon L. Aukerman, PhD, Bahija Jallal, PhD, Mohammad Luqman, PhD
Journal: Blood
Blood (2005) 106 (11): 3470.
https://doi.org/10.1182/blood.V106.11.3470.3470
Published: 2005
Journal Articles

A Non-Internalizing Anti-CD40 Antibody, CHIR-12.12, Blocks CD40L-Induced Cytokine Production and Mediates Greater ADCC Than Rituximab in Primary CLL Cells.

Xia Tong, MSc, Sharon Lea Aukerman, PhD, Karen Lin, BS, Natasha Aziz, PhD, Cheryl Goldbeck, BS, Georgios V. Georgakis, MD, Anas Younes, MD, Wen-Kai Weng, MD, PhD, Susan O’Brien, MD, William Wierda, MD, PhD, Bahija Jallal, PhD, Mohammad Luqman, PhD
Journal: Blood
Blood (2005) 106 (11): 2964.
https://doi.org/10.1182/blood.V106.11.2964.2964
Published: 2005
Journal Articles

CHIR-12.12, an Antagonist Anti-CD40 Antibody, Exhibits Greater ADCC Than Rituximab Against a Variety of Malignant B Cells: Evaluation of FcγRIIIa Polymorphism and ADCC Response.

Mohammad Luqman, PhD, Xia Tong, MSc, Xiaohong Niu, BS, Pablo Garcia, PhD, Michel Faure, PhD, Asha Yabannavar, PhD, Bahija Jallal, PhD
Journal: Blood
Blood (2005) 106 (11): 1472.
https://doi.org/10.1182/blood.V106.11.1472.1472
Published: 2005
Journal Articles

Modulation of in vitro proliferation kinetics and primitive hematopoietic potential of individual human CD34 + CD38 – /lo cells in G 0

Edward F. Srour, Xia Tong, Ki Woong Sung, P. Artur Plett, Susan Rice, Joanne Daggy, Constantin T. Yiannoutsos, Rafat Abonour, Christie M. Orschell
Journal: Blood
Blood (2005) 105 (8): 3109–3116.
https://doi.org/10.1182/blood-2004-05-1773
Published: 2005
Journal Articles

A Fully Human Anti-CD40 Antagonistic Antibody, CHIR-12.12, Inhibit the Proliferation of Human B Cell Non-Hodgkin’s Lymphoma.

Wen-Kai Weng, MD, PhD, Xia Tong, Mohammad Luqman, PhD, Ronald Levy, MD
Journal: Blood
Blood (2004) 104 (11): 3279.
https://doi.org/10.1182/blood.V104.11.3279.3279
Published: 2004
Journal Articles

Antagonist Anti-CD40 Monoclonal Antibody, CHIR-12.12, Inhibits Growth of a Rituximab-Resistant NHL Xenograft Model and Achieves Synergistic Activity When Combined with Ineffective Rituximab.

Li Long, Ph.D., Xia Tong, M.Sc., Montesa Patawaran, B.Sc., Lea Aukerman, Ph.D., Julie Klinger, Ph.D., Bahija Jallal, Ph.D., Mohammad Luqman, Ph.D.
Journal: Blood
Blood (2004) 104 (11): 3281.
https://doi.org/10.1182/blood.V104.11.3281.3281
Published: 2004
Journal Articles

Safety Evaluation of an Fully Human Antagonist Anti-CD40 Antibody, CHIR-12.12, in a Dose Range-Finding Study in Cynomolgus Monkeys.

Ursula B. Jeffry, Kay Huh, Xia Tong, Julie Klinger, Werner Frings, Antje Fuchs, Nancy Turner, Mohammad Luqman
Journal: Blood
Blood (2004) 104 (11): 3282.
https://doi.org/10.1182/blood.V104.11.3282.3282
Published: 2004
Journal Articles

In Vitro Activity of a Novel Fully Human Anti-CD40 Antibody CHIR-12.12 in Chronic Lymphocytic Leukemia: Blockade of CD40 Activation and Induction of ADCC.

Xia Tong, Georgios V. Georgakis, Long Li, O’Brien Susan, Younes Anas, Luqman Mohammad
Journal: Blood
Blood (2004) 104 (11): 2504.
https://doi.org/10.1182/blood.V104.11.2504.2504
Published: 2004
Journal Articles

Antagonist Anti-CD40 Antibody CHIR-12.12 Causes Tumor Regression and Prolongs Survival in Multiple Myeloma Xenograft Models.

Li Long, Ph.D., Xia Tong, M.Sc., Montesa Patawaran, B.Sc., Lea Aukerman, Ph.D., Bahija Jallal, Ph.D., Mohammad Luqman, Ph.D.
Journal: Blood
Blood (2004) 104 (11): 4888.
https://doi.org/10.1182/blood.V104.11.4888.4888
Published: 2004
Journal Articles

Homing efficiency, cell cycle kinetics, and survival of quiescent and cycling human CD34 + cells transplanted into conditioned NOD/SCID recipients

Anna Jetmore, P. Artur Plett, Xia Tong, Frances M. Wolber, Robert Breese, Rafat Abonour, Christie M. Orschell-Traycoff, Edward F. Srour
Journal: Blood
Blood (2002) 99 (5): 1585–1593.
https://doi.org/10.1182/blood.V99.5.1585
Published: 2002
Journal Articles

Similar repopulating capacity of mitotically active and resting umbilical cord blood CD34 + cells in NOD/SCID mice

Jannine Wilpshaar, J. H. Frederik Falkenburg, Xia Tong, Willy A. Noort, Robert Breese, Doug Heilman, Humphrey Kanhai, Christie M. Orschell-Traycoff, Edward F. Srour
Journal: Blood
Blood (2000) 96 (6): 2100–2107.
https://doi.org/10.1182/blood.V96.6.2100
Published: 2000