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Journal Articles

Vorinostat inhibits STAT6-mediated T H 2 cytokine and TARC production and induces cell death in Hodgkin lymphoma cell lines

Daniela Buglio, Georgios V. Georgakis, Shino Hanabuchi, Kazuhiko Arima, Noor M. Khaskhely, Yong-Jun Liu, Anas Younes

Blood (2008) 112 (4): 1424–1433.

https://doi.org/10.1182/blood-2008-01-133769

Published: 2008

Includes: Supplemental data

Journal Articles

The antileukemia activity of a human anti-CD40 antagonist antibody, HCD122, on human chronic lymphocytic leukemia cells

Mohammad Luqman, Sha Klabunde, Karen Lin, Georgios V. Georgakis, Anu Cherukuri, Jocelyn Holash, Cheryl Goldbeck, Xiaomei Xu, Edward E. Kadel, III, Sang Hoon Lee, Sharon Lea Aukerman, Bahija Jallal, Natasha Aziz, Wen-Kai Weng, William Wierda, Susan O'Brien, Anas Younes

Blood (2008) 112 (3): 711–720.

https://doi.org/10.1182/blood-2007-04-084756

Published: 2008

Journal Articles

Inhibition of the Pan-Bcl-2 Family by the Small Molecule GX15-070 Induces Apoptosis in Mantle Cell Lymphoma (MCL) Cells and Enhances the Activity of Two Proteasome Inhibitors (NPI-0052 and Bortezomib), and Doxorubicin Chemotherapy.

Victor Y. Yazbeck, MD, Georgios V. Georgakis, M.D., Yang Li, David McConkey, Michael Andreeff, Anas Younes

Blood (2006) 108 (11): 2532.

https://doi.org/10.1182/blood.V108.11.2532.2532

Published: 2006

Journal Articles

Molecular Mechanisms of the mTOR Inhibitor Temsirolimus (CCI-779) Antiproliferative Effects in Mantle Cell Lymphoma: Induction of Cell Cycle Arrest, Autophagy, and Synergy with Vorinostat (SAHA).

Victor Y. Yazbeck, MD, Georgios V. Georgakis, M.D., Yang Li, M.S., Eiji Iwado, M.D., Seiji Kondo, M.D./PhD, Anas Younes, M.D.

Blood (2006) 108 (11): 2493.

https://doi.org/10.1182/blood.V108.11.2493.2493

Published: 2006

Journal Articles

The mTOR Inhibitor Temsirolimus (CCI-779) Induces Cell Cycle Arrest and Autophagy in Hodgkin Lymphoma (HL) Cell Lines and Enhances the Effect of the PI3-Kinase Inhibitor LY294002.

Georgios V. Georgakis, Victor Y. Yazbeck, Yang Li, Anas Younes, M.D.

Blood (2006) 108 (11): 2259.

https://doi.org/10.1182/blood.V108.11.2259.2259

Published: 2006

Journal Articles

The Histone Deacetylase Inhibitor Vorinostat (SAHA) Induces Apoptosis and Cell Cycle Arrest in Hodgkin Lymphoma (HL) Cell Lines by Altering Several Survival Signaling Pathways and Synergizes with Doxorubicin, Gemcitabine and Bortezomib.

Georgios V. Georgakis, MD, Victor Y. Yazbeck, M.D., Yang Li, M.D., Anas Younes, M.D.

Blood (2006) 108 (11): 2260.

https://doi.org/10.1182/blood.V108.11.2260.2260

Published: 2006

Journal Articles

Serum BLyS Level as a Prognostic Marker in Patients with Lymphoma.

Yasuhiro Oki, MD, Georgios V. Georgakis, MD, Thi-Sau Migone, PhD, Larry W. Kwak, M.D, PhD, Anas Younes, MD

Blood (2005) 106 (11): 1926.

https://doi.org/10.1182/blood.V106.11.1926.1926

Published: 2005

Journal Articles

A Non-Internalizing Anti-CD40 Antibody, CHIR-12.12, Blocks CD40L-Induced Cytokine Production and Mediates Greater ADCC Than Rituximab in Primary CLL Cells.

Xia Tong, MSc, Sharon Lea Aukerman, PhD, Karen Lin, BS, Natasha Aziz, PhD, Cheryl Goldbeck, BS, Georgios V. Georgakis, MD, Anas Younes, MD, Wen-Kai Weng, MD, PhD, Susan O’Brien, MD, William Wierda, MD, PhD, Bahija Jallal, PhD, Mohammad Luqman, PhD

Blood (2005) 106 (11): 2964.

https://doi.org/10.1182/blood.V106.11.2964.2964

Published: 2005

Journal Articles

Heat Shock Protein 90 (HSP90) Inhibition by the Small Molecule 17-AAG Induces Cell Cycle Arrest and Apoptosis in Anaplastic Large Cell Lymphoma (ALCL) Irrespective of ALK Expression: Role of Akt, ERK and ALK Kinases in the Molecular Mechanisms of 17-AAG Anti-Tumor Activity.

Georgios V. Georgakis, MD, Yang Li, MS, George Z. Rassidakis, MD, PhD, Felipe Samaniego, MD, L. Jeffrey Medeiros, MD, Anas Younes, MD

Blood (2005) 106 (11): 2811.

https://doi.org/10.1182/blood.V106.11.2811.2811

Published: 2005

Journal Articles

Heat Shock Protein 90 (HSP90) Is Overexpressed in Primary and Cultured Hodgkin Lymphoma (HL) Cells: Role of Therapeutic Targeting Using the Small Molecule Inhibitor 17-AAG.

Georgios V. Georgakis, MD, Yang Li, MS, George Z. Rassidakis, MD, PhD, L. Jeffrey Medeiros, MD, Anas Younes, MD

Blood (2005) 106 (11): 2422.

https://doi.org/10.1182/blood.V106.11.2422.2422

Published: 2005

Journal Articles

In Vitro Activity of a Novel Fully Human Anti-CD40 Antibody CHIR-12.12 in Chronic Lymphocytic Leukemia: Blockade of CD40 Activation and Induction of ADCC.

Xia Tong, Georgios V. Georgakis, Long Li, O’Brien Susan, Younes Anas, Luqman Mohammad

Blood (2004) 104 (11): 2504.

https://doi.org/10.1182/blood.V104.11.2504.2504

Published: 2004

Journal Articles

Differential Effects of Three Small Molecules Blocking Phosphatidylinositol-3 Kinase or AKT in Hodgkin Disease Cell Lines: Induction of Apoptosis and Cell Cycle Arrest.

Georgios V. Georgakis, MD, Yang Li, MSc, Georgios Z. Rassidakis, MD, Jeffrey L. Medeiros, MD, Gordon B. Mills, MD, PhD, Anas Younes, MD

Blood (2004) 104 (11): 428.

https://doi.org/10.1182/blood.V104.11.428.428

Published: 2004

Journal Articles

The Geldanamycin Analogue Heat Shock Protein 90 (HSP90) Inhibitor 17-AAG in Lymphomas: Molecular Mechanisms of 17-AAG-Induced Cell Death in Hodgkin Disease and Non- Hodgkin Lymphoma Cell Lines.

Georgios V. Georgakis, MD, Yang Li, MSc, Anas Younes, MD

Blood (2004) 104 (11): 3291.

https://doi.org/10.1182/blood.V104.11.3291.3291

Published: 2004

Journal Articles

c-kit is not expressed in Hodgkin disease and anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma

George Z. Rassidakis, Georgios V. Georgakis, Anas Younes, L. Jeffrey Medeiros

Blood (2003) 102 (13): 4619–4620.

https://doi.org/10.1182/blood-2003-09-3200

Published: 2003

NARROW

Vorinostat inhibits STAT6-mediated T H 2 cytokine and TARC production and induces cell death in Hodgkin lymphoma cell lines

The antileukemia activity of a human anti-CD40 antagonist antibody, HCD122, on human chronic lymphocytic leukemia cells

Inhibition of the Pan-Bcl-2 Family by the Small Molecule GX15-070 Induces Apoptosis in Mantle Cell Lymphoma (MCL) Cells and Enhances the Activity of Two Proteasome Inhibitors (NPI-0052 and Bortezomib), and Doxorubicin Chemotherapy.

Molecular Mechanisms of the mTOR Inhibitor Temsirolimus (CCI-779) Antiproliferative Effects in Mantle Cell Lymphoma: Induction of Cell Cycle Arrest, Autophagy, and Synergy with Vorinostat (SAHA).

The mTOR Inhibitor Temsirolimus (CCI-779) Induces Cell Cycle Arrest and Autophagy in Hodgkin Lymphoma (HL) Cell Lines and Enhances the Effect of the PI3-Kinase Inhibitor LY294002.

The Histone Deacetylase Inhibitor Vorinostat (SAHA) Induces Apoptosis and Cell Cycle Arrest in Hodgkin Lymphoma (HL) Cell Lines by Altering Several Survival Signaling Pathways and Synergizes with Doxorubicin, Gemcitabine and Bortezomib.

Serum BLyS Level as a Prognostic Marker in Patients with Lymphoma.

A Non-Internalizing Anti-CD40 Antibody, CHIR-12.12, Blocks CD40L-Induced Cytokine Production and Mediates Greater ADCC Than Rituximab in Primary CLL Cells.

Heat Shock Protein 90 (HSP90) Inhibition by the Small Molecule 17-AAG Induces Cell Cycle Arrest and Apoptosis in Anaplastic Large Cell Lymphoma (ALCL) Irrespective of ALK Expression: Role of Akt, ERK and ALK Kinases in the Molecular Mechanisms of 17-AAG Anti-Tumor Activity.

Heat Shock Protein 90 (HSP90) Is Overexpressed in Primary and Cultured Hodgkin Lymphoma (HL) Cells: Role of Therapeutic Targeting Using the Small Molecule Inhibitor 17-AAG.

In Vitro Activity of a Novel Fully Human Anti-CD40 Antibody CHIR-12.12 in Chronic Lymphocytic Leukemia: Blockade of CD40 Activation and Induction of ADCC.

Differential Effects of Three Small Molecules Blocking Phosphatidylinositol-3 Kinase or AKT in Hodgkin Disease Cell Lines: Induction of Apoptosis and Cell Cycle Arrest.

The Geldanamycin Analogue Heat Shock Protein 90 (HSP90) Inhibitor 17-AAG in Lymphomas: Molecular Mechanisms of 17-AAG-Induced Cell Death in Hodgkin Disease and Non- Hodgkin Lymphoma Cell Lines.

c-kit is not expressed in Hodgkin disease and anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma

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American Society of Hematology

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