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Journal Articles

Gene Therapy of Chronic Myelogenous Leukemia Using Pseudotyped Recombinant Adeno-Associated Viral Vectors.

Leopold Sellner, MD, Marlon R Veldwijk, PhD, Jürgen A. Kleinschmidt, PhD, Stephanie Laufs, PhD, Julian Topaly, MD, W. Jens Zeller, MD, Frederik Wenz, MD, Stefan Fruehauf, MD

Blood (2009) 114 (22): 4506.

https://doi.org/10.1182/blood.V114.22.4506.4506

Published: 2009

Journal Articles

Impact of Chemoselective Pressure on Integration Site Patterns of Lentivirally Transduced Human Hematopoietic Stem Cells

Nadja Grund, Patrick Maier, Uwe Appelt, Heike Allgayer, Frederik Wenz, W. Jens Zeller, Stefan Fruehauf, MD, Stefanie Laufs

Blood (2008) 112 (11): 4622.

https://doi.org/10.1182/blood.V112.11.4622.4622

Published: 2008

Journal Articles

Efficient Gene Transfer into Human CD34 + Peripheral Blood Progenitor Cells Using Pseudotyped Recombinant Adeno-Associated Viral Vectors

Leopold Sellner, Marlon Veldwijk, PhD, Marius Stiefelhagen, Jurgen A. Kleinschmidt, PhD, Stephanie Laufs, PhD, Julian Topaly, MD, W. Jens Zeller, MD, Frederik Wenz, MD, Stefan Fruehauf, MD

Blood (2008) 112 (11): 4627.

https://doi.org/10.1182/blood.V112.11.4627.4627

Published: 2008

Journal Articles

Genes Involved in Acute Leukemias Are Favored Targets of HIV Vector Integration

Jens U. Appelt, Frank A. Giordano, Marcel Zimmermann, Stephan Weinhard, Ph.D., Nadja Grund, Agnes Hotz-Wagenblatt, Ph.D., W. Jens Zeller, M.D., Heike Allgayer, M.D., Ph.D., Stefan Fruehauf, MD, Stephanie Laufs, Ph.D.

Blood (2007) 110 (11): 3738.

https://doi.org/10.1182/blood.V110.11.3738.3738

Published: 2007

Journal Articles

Novel Efficient Primary Human Peripheral Blood Progenitor Cell-Targeted Recombinant Adeno-Associated Viral Vectors.

Marlon R. Veldwijk, Ph.D., Leopold Sellner, Marius Stiefelhagen, Jürgen A. Kleinschmidt, Ph.D., Stephanie Laufs, Ph.D., Julian Topaly, M.D., Frederik Wenz, M.D., W. Jens Zeller, M.D., Stefan Fruehauf, MD

Blood (2007) 110 (11): 5144.

https://doi.org/10.1182/blood.V110.11.5144.5144

Published: 2007

Journal Articles

Drug Resistance Gene Therapy by Simultaneous Lentiviral Overexpression of MDR1 in Combination with the MGMT P140K Mutant in Human Hematopoietic Stem Cells.

Isabel Spier, Patrick Maier, Ph.D., Stephanie Laufs, Ph.D., Marlon R. Veldwijk, Ph.D., Frederik Wenz, M.D., W. Jens Zeller, M.D., Stefan Fruehauf, MD

Blood (2007) 110 (11): 5146.

https://doi.org/10.1182/blood.V110.11.5146.5146

Published: 2007

Journal Articles

Multiple Displacement Amplification Enables Large Scale Clonal Analysis after Retroviral Gene Therapy.

Stephanie Bleier, Patrick Maier, Frederik Wenz, W. Jens Zeller, Stephanie Laufs, Stefan Fruehauf

Blood (2006) 108 (11): 5469.

https://doi.org/10.1182/blood.V108.11.5469.5469

Published: 2006

Journal Articles

Generation of Highly Efficient Recombinant Adeno-Associated Virus (rAAV) Vectors Targeted to Chronic Myelogenous Leukemia (CML) - and CD34+ Progenitor Cells Obtained by the „AAV Random Peptide Library“ Method.

Leopold Sellner, Marlon Veldwijk, Marius Stiefelhagen, Juergen A. Kleinschmidt, Frederik Wenz, W. Jens Zeller, Stefan Fruehauf

Blood (2006) 108 (11): 2203.

https://doi.org/10.1182/blood.V108.11.2203.2203

Published: 2006

Journal Articles

Treatment of Imatinib-Sensitive and -Resistant Chronic Myelogenous Leukemia Cells with a Combination of Imatinib and Farnesyltransferase Inhibitors.

Aleksandar Radujkovic, Julian Topaly, MD, W. Jens Zeller, MD, Anthony D. Ho, MD, Stefan Fruehauf, MD

Blood (2005) 106 (11): 4881.

https://doi.org/10.1182/blood.V106.11.4881.4881

Published: 2005

Journal Articles

A ComParison of Retroviral Integration Sites in Donor T-Lymphocytes In Vivo and In Vitro.

Frank A. Giordano, Stephanie Laufs, Boris Fehse, K. Zsuzsanna Nagy, Agnes Hotz-Wagenblatt, Daniel Lauterborn, Kurt Fellenberg, Klaus Kuehlcke, Sonja Naundorf, Axel R. Zander, W. Jens Zeller, Stefan Fruehauf

Blood (2005) 106 (11): 1403.

https://doi.org/10.1182/blood.V106.11.1403.1403

Published: 2005

Journal Articles

Automated Retroviral Insertion Site Sequence Analysis and Mapping Tool Followed by Database Analysis.

Stephanie Laufs, Frank A. Giordano, Agnes Hotz-Wagenblatt, Uwe Appelt, Daniel Lauterborn, Kurt Fellenberg, W. Jens Zeller, Stefan Fruehauf

Blood (2005) 106 (11): 5528.

https://doi.org/10.1182/blood.V106.11.5528.5528

Published: 2005

Journal Articles

Quantitative Real Time PCR Analysis of MDR1 Transduced Rhesus Macaque Hematopoietic Stem Cells Shows No Indication for Proliferative Advantage after Long-Term Follow-Up.

Farastuk Bozorgmehr, Stephanie Laufs, PhD, Eike C. Buss, MD, Katalina Z. Nagy, Stephanie E. Sellers, PhD, W. Jens Zeller, MD, Cynthia E. Dunbar, MD, Stefan Fruehauf, MD

Blood (2005) 106 (11): 2198.

https://doi.org/10.1182/blood.V106.11.2198.2198

Published: 2005

Journal Articles

An Novel Approach in Protective Gene Therapy: Recombinant Adeno-Associated Virus 2-Mediated Transfer of the Human Superoxide-Dismutase Gene.

Marlon R. Veldwijk, Carsten Herskind, Stephanie Laufs, Marius Stiefelhagen, W. Jens Zeller, Stefan Fruehauf, Frederik Wenz

Blood (2004) 104 (11): 5265.

https://doi.org/10.1182/blood.V104.11.5265.5265

Published: 2004

Journal Articles

Clonal Analysis of Hematopoietic Stem Cells after Serial Transplantation of Animals Receiving MGMT P140K Gene Transduced Cells Following Chemotherapy.

Stephanie Laufs, Phd, Ursula Sorg, Phd, Veronika Kleff, Laila Gao, Michael Flasshove, MD, W. Jens Zeller, MD, Thomas Moritz, MD, Stefan Fruehauf, MD

Blood (2004) 104 (11): 1182.

https://doi.org/10.1182/blood.V104.11.1182.1182

Published: 2004

Journal Articles

Synergism between 17-AAG and Imatinib in Imatinib-Resistant CML Cells: Inhibition of P-Glycoprotein by 17-AAG as a New Mechanism of Increasing Imatinib Activity.

Aleksandar Radujkovic, Moritz Schad, Julian Topaly, MD, Stephanie Laufs, PhD, Anna Jauch, MD, Beate Schultheis, MD, Junia V. Melo, MD, Anthony D. Ho, MD, Stefan Fruehauf, MD, W. Jens Zeller, MD

Blood (2004) 104 (11): 2094.

https://doi.org/10.1182/blood.V104.11.2094.2094

Published: 2004

Journal Articles

New Aspects on the Safety of Multidrug-Resistance 1 Gene Transfers: No Indication for Clonal Dominance after Long-Term Follow-Up in a Primate Transplantation Model.

Farastuk Bozorgmehr, Eike C. Buss, Stephanie Laufs, K. Zsuzsanna Nagy, Stephanie Sellers, W. Jens Zeller, Cynthia E. Dunbar, Stefan Fruehauf

Blood (2004) 104 (11): 2108.

https://doi.org/10.1182/blood.V104.11.2108.2108

Published: 2004

Journal Articles

Collaborative RISC-Score Database: Creation of an International Database for Retroviral Integration Analysis.

Stephanie Laufs, Phd, Frank Giordano, Daniel Lauterborn, K. Zsuzsanna Nagy, Kurt Fellernberg, Phd, Agnes Hotz-Wagenblatt, Phd, Guillermo Guenechea, Phd, Boris Fehse, Phd, Juan B. Bueren, Phd, Axel Zander, MD, Cynthia E. Dunbar, MD, W. Jens Zeller, MD, Stefan Fruehauf, MD

Blood (2004) 104 (11): 2110.

https://doi.org/10.1182/blood.V104.11.2110.2110

Published: 2004

Journal Articles

Functional Activity of In Vivo Primed Granulocytes: A Comparative Study.

Daniel Ribeiro, Stephanie Laufs, Phd, Eike B. Buss, MD, W. Jens Zeller, MD, Anthony D. Ho, MD, Stefan Fruehauf, MD

Blood (2004) 104 (11): 3818.

https://doi.org/10.1182/blood.V104.11.3818.3818

Published: 2004

Journal Articles

Retroviral vector integration occurs in preferred genomic targets of human bone marrow–repopulating cells

Stephanie Laufs, Bernhard Gentner, K. Zsuzsanna Nagy, Anna Jauch, Axel Benner, Sonja Naundorf, Klaus Kuehlcke, Bernhard Schiedlmeier, Anthony D. Ho, W. Jens Zeller, Stefan Fruehauf

Blood (2003) 101 (6): 2191–2198.

https://doi.org/10.1182/blood-2002-02-0627

Published: 2003

NARROW

Gene Therapy of Chronic Myelogenous Leukemia Using Pseudotyped Recombinant Adeno-Associated Viral Vectors.

Impact of Chemoselective Pressure on Integration Site Patterns of Lentivirally Transduced Human Hematopoietic Stem Cells

Efficient Gene Transfer into Human CD34 + Peripheral Blood Progenitor Cells Using Pseudotyped Recombinant Adeno-Associated Viral Vectors

Genes Involved in Acute Leukemias Are Favored Targets of HIV Vector Integration

Novel Efficient Primary Human Peripheral Blood Progenitor Cell-Targeted Recombinant Adeno-Associated Viral Vectors.

Drug Resistance Gene Therapy by Simultaneous Lentiviral Overexpression of MDR1 in Combination with the MGMT P140K Mutant in Human Hematopoietic Stem Cells.

Multiple Displacement Amplification Enables Large Scale Clonal Analysis after Retroviral Gene Therapy.

Generation of Highly Efficient Recombinant Adeno-Associated Virus (rAAV) Vectors Targeted to Chronic Myelogenous Leukemia (CML) - and CD34+ Progenitor Cells Obtained by the „AAV Random Peptide Library“ Method.

Treatment of Imatinib-Sensitive and -Resistant Chronic Myelogenous Leukemia Cells with a Combination of Imatinib and Farnesyltransferase Inhibitors.

A ComParison of Retroviral Integration Sites in Donor T-Lymphocytes In Vivo and In Vitro.

Automated Retroviral Insertion Site Sequence Analysis and Mapping Tool Followed by Database Analysis.

Quantitative Real Time PCR Analysis of MDR1 Transduced Rhesus Macaque Hematopoietic Stem Cells Shows No Indication for Proliferative Advantage after Long-Term Follow-Up.

An Novel Approach in Protective Gene Therapy: Recombinant Adeno-Associated Virus 2-Mediated Transfer of the Human Superoxide-Dismutase Gene.

Clonal Analysis of Hematopoietic Stem Cells after Serial Transplantation of Animals Receiving MGMT P140K Gene Transduced Cells Following Chemotherapy.

Synergism between 17-AAG and Imatinib in Imatinib-Resistant CML Cells: Inhibition of P-Glycoprotein by 17-AAG as a New Mechanism of Increasing Imatinib Activity.

New Aspects on the Safety of Multidrug-Resistance 1 Gene Transfers: No Indication for Clonal Dominance after Long-Term Follow-Up in a Primate Transplantation Model.

Collaborative RISC-Score Database: Creation of an International Database for Retroviral Integration Analysis.

Functional Activity of In Vivo Primed Granulocytes: A Comparative Study.

Retroviral vector integration occurs in preferred genomic targets of human bone marrow–repopulating cells

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American Society of Hematology

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American Society of Hematology

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