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Journal Articles

Impaired Osteoblastic Differentiation of MSCs Suppresses Normal Hematopoiesis in MDS

Blood (2020) 136 (Supplement 1): 17–18.

https://doi.org/10.1182/blood-2020-142284

Published: 2020

Journal Articles

Mutant ASXL1 Disrupts Paraspeckle Formation through Aberrant Interaction with Nono in Hematopoietic Cells

Yamamoto Keita, MD, Susumu Goyama, MD PhD, Shuhei Asada, MD PhD, Takeshi Fujino, MD, Tomofusa Fukuyama, MD PhD, Yosuke Tanaka, MD, Ayana Kon, MD PhD, Yasuhito Nannya, MD PhD, Seishi Ogawa, MD PhD, Reina Onoguchi, PhD, Nobuyoshi Akimitsu, PhD, Toshio Kitamura, MD PhD

Blood (2019) 134 (Supplement_1): 2514.

https://doi.org/10.1182/blood-2019-125472

Published: 2019

Journal Articles

The Ubiquitin Ligase DTX2 Promotes Nuclear Export of RUNX1 and Inhibits RUNX1-Dependent Leukemogenesis

Taishi Yonezawa, MSc, Hirotaka Takahasi, PhD, Tatsuya Sawasaki, PhD, Toshio Kitamura, MD PhD, Susumu Goyama, MD PhD

Blood (2019) 134 (Supplement_1): 1252.

https://doi.org/10.1182/blood-2019-126264

Published: 2019

Journal Articles

Homeobox Transcription Factor Hhex Promotes Myeloid Leukemia in Cooperation with Mutant ASXL1

Blood (2019) 134 (Supplement_1): 2525.

https://doi.org/10.1182/blood-2019-126663

Published: 2019

Journal Articles

Leukemogenic Functions of Mutant ASXL1 Are Regulated By CDK-Mediated Phosphorylation

Shuhei Asada, MD PhD, Susumu Goyama, MD PhD, Reina Takeda, MD, Keita Yamamoto, MD, Hiroko Kozuka-Hata, PhD, Masaaki Oyama, PhD, Daichi Inoue, MD PhD, Hiroaki Honda, MD PhD, Toshio Kitamura, MD PhD

Blood (2019) 134 (Supplement_1): 731.

https://doi.org/10.1182/blood-2019-125959

Published: 2019

Journal Articles

Mutant ASXL1 Promotes Expansion of the Phenotypic Hematopoietic Stem Cell Compartment

Takeshi Fujino, MD, Susumu Goyama, MD PhD, Yuki Sugiura, PhD, Daichi Inoue, MD PhD, Satoshi Yamasaki, PhD, Akiko Matsumoto, Naru Sato, MD, Hironobu Morinaga, PhD, Shiori Shikata, Tomofusa Fukuyama, MD PhD, Yosuke Tanaka, PhD, Shuhei Asada, MD PhD, Tsuyoshi Fukushima, MD PhD, Hiroaki Honda, MD PhD, Emi K Nishimura, MD PhD, Tatsuhiro Shibata, MD PhD, Makoto Suematsu, MD PhD, Toshio Kitamura, MD PhD

Blood (2019) 134 (Supplement_1): 821.

https://doi.org/10.1182/blood-2019-127904

Published: 2019

Journal Articles

Chromatin Architecture Modulation in B-Cell Acute Lymphoblastic Leukemia Carrying DUX4 Fusions

Yosuke Tanaka, MD, Masahito Kawazu, MD PhD, Satoshi Inoue, PhD, Shinya Kojima, Ueno Toshihide, PhD, Toshiaki Uno, Moe Tamura, Susumu Goyama, MD PhD, Toshio Kitamura, MD PhD, Shinichi Morishita, PhD, Hiroyuki Mano, MD PhD

Blood (2019) 134 (Supplement_1): 1240.

https://doi.org/10.1182/blood-2019-125207

Published: 2019

Journal Articles

Mutant ASXL1 Cooperates with BAP1 to Promote Myeloid Leukemogenesis

Shuhei Asada, MD, Susumu Goyama, MD PhD, Daichi Inoue, MD PhD, Reina Takeda, MD, Masahito Kawazu, Hiroyuki Mano, MDPhD, Toshio Kitamura, MD PhD

Blood (2017) 130 (Supplement 1): 562.

https://doi.org/10.1182/blood.V130.Suppl_1.562.562

Published: 2017

Journal Articles

A p53-MDM2 Interaction Inhibitor, DS-5272, Inhibits the Development of MLL-Fusion Leukemia with the Assistance of Tumor Immunity

Susumu Goyama, MD PhD, Yasutaka Hayashi, XiaoXiao Liu, Shiori Shikata, Yosuke Tanaka, Tomofusa Fukuyama, MD PhD, Akiko Matsumoto, Satoshi Yamasaki, Tatsuhiro Shibata, Toshio Kitamura, MD PhD

Blood (2017) 130 (Supplement 1): 796.

https://doi.org/10.1182/blood.V130.Suppl_1.796.796

Published: 2017

Journal Articles

RARB Translocations in Acute Promyelocytic Leukemia without Rara translocation

Blood (2017) 130 (Supplement 1): 104.

https://doi.org/10.1182/blood.V130.Suppl_1.104.104

Published: 2017

Journal Articles

Inhibition of Impdh As an Effective Treatment for MLL-Fusion Leukemia

Susumu Goyama, MD PhD, Shiori Shikata, Yasutaka Hayashi, Yuto Izawa, Janet Schibler, Hiroyuki Iwamura, Dphil, Motoki Saito, PhD, Satoshi Kofuji, Kazutaka Sumita, Atsuo T Sasaki, James C. Mulloy, PhD, Toshio Kitamura, MD PhD

Blood (2016) 128 (22): 750.

https://doi.org/10.1182/blood.V128.22.750.750

Published: 2016

Journal Articles

Protease-Activated Receptor 1 (PAR-1) Inhibits Proliferation but Enhances Leukemia Stem Cell Activity in Acute Myeloid Leukemia

Susumu Goyama, MD PhD, Mahesh Shrestha, Janet Schibler, Leah Rosenfeldt, Whitney Miller, Eric O'Brien, Benjamin Mizukawa, MD, Toshio Kitamura, MD PhD, Joseph S. Palumbo, MD, James C. Mulloy, PhD

Blood (2016) 128 (22): 2730.

https://doi.org/10.1182/blood.V128.22.2730.2730

Published: 2016

Journal Articles

Growth Suppressing Activity of Lhx2 in Human T Cell Acute Lymphoblastic Leukemia (T-ALL)-Derived Cells and Large-Scale Screening of a Lead Compounds Targeting T-ALL

Kazuya Miyashita, Noritaka Kagaya, PhD, Miho Izumikawa, PhD, Kenji Kitajima, PhD, Kyoko Watakabe-Inamoto, MD, Yuho Najima, Noriko Doki, Takeshi Kobayashi, MD, Kazuhiko Kakihana, MD PhD, Susumu Goyama, MD PhD, Toshio Kitamura, MD PhD, Kazuteru Ohashi, Kazuo Shin-ya, PhD, Takahiko Hara, PhD

Blood (2016) 128 (22): 2813.

https://doi.org/10.1182/blood.V128.22.2813.2813

Published: 2016

Journal Articles

Dysregulation of RUNX1 Plays a Critical Role in the Progression of Myelodysplastic Syndromes

Hiroko Sakurai, MD, Yuka Harada, MD PhD, Hirotaka Matsui, MD PhD, Hideaki Nakajima, MD PhD, Toshio Kitamura, MD PhD, Norio Komatsu, MD PhD, Hironori Harada, MD PhD

Blood (2015) 126 (23): 4108.

https://doi.org/10.1182/blood.V126.23.4108.4108

Published: 2015

Journal Articles

A Patient-Derived EZH2 Mutant Induces MDS-like Diseases with Derepressed ABCG2 Expression in Mice

Kimihito Cojin Kawabata, MD PhD, Daichi Inoue, MD PhD, Jiro Kitaura, MD PhD, Yuka Harada, MD PhD, Susumu Goyama, MD PhD, Hironori Harada, MD PhD, Hiroyuki Aburatani, MD PhD, Toshio Kitamura, MD PhD

Blood (2015) 126 (23): 4116.

https://doi.org/10.1182/blood.V126.23.4116.4116

Published: 2015

Journal Articles

SETBP1 Mutations Drive Leukemic Transformation in ASXL1 -Mutated MDS

Daichi Inoue, MD PhD, Hirotaka Matsui, MD PhD, Hsin-An Hou, MD PhD, Wen-Chien Chou, MD PhD, Akiko Nagamachi, PhD, Jiro Kitaura, MD PhD, Kimihito Cojin Kawabata, MD PhD, Katsuhiro Togami, MD PhD, Reina Nagase, Sayuri Horikawa, Makoto Saika, MD, Jean-Baptiste Micol, MD, Yasutaka Hayashi, MD, Yuka Harada, MD PhD, Hironori Harada, MD PhD, Hwei-Fang Tien, MD PhD, Omar Abdel-Wahab, MD, Toshio Kitamura, MD PhD

Blood (2014) 124 (21): 525.

https://doi.org/10.1182/blood.V124.21.525.525

Published: 2014

Journal Articles

C-Terminal-Truncating ASXL1 Mutations Induce MDS Via Inhibition Of PRC2

Daichi Inoue, MD, Jiro Kitaura, Katsuhiro Togami, Koutarou Nishimura, Yutaka Enomoto, Tomoyuki Uchida, Yuki Kagiyama, PhD, Kimihito Cojin Kawabata, Fumio Nakahara, Toshihiko Oki, Hironori Harada, Takahiro Ochiya, PhD, Hiroyuki Aburatani, M.D., Ph.D., Hiroshi Kimura, Felicitas Thol, MD, Michael Heuser, MD, Ross L. Levine, MD, Omar Abdel-Wahab, MD, Toshio Kitamura, MD, PhD

Blood (2013) 122 (21): 471.

https://doi.org/10.1182/blood.V122.21.471.471

Published: 2013

Journal Articles

RUNX1/AML1 Mutants Collaborate with BMI1 in the Development of Myelodysplastic Syndromes (MDS) / Acute Myeloid Leukemia (AML) in a Mouse BMT Model.

Hironori Harada, MD, PhD, Daichi Inoue, MD, Noriko Doki, MD, Ye Ding, MD, PhD, Yuka Harada, MD, PhD, Toshio Kitamura, MD, PhD

Blood (2012) 120 (21): 2820.

https://doi.org/10.1182/blood.V120.21.2820.2820

Published: 2012

Journal Articles

Nov/CCN3 Enhances Long-Term Repopulating Activity of Mouse Hematopoietic Stem Cells Via Intergin β3 Signaling Collaborating with Thrombopoietin

Jun Ishihara, Terumasa Umemoto, Ph.D, Masayuki Yamato, Ph.D, Yoshiko Shiratsuchi, Ph.D, Brian G. Petrich, PhD, Hiromitsu Nakauchi, MD, PhD, Koji Eto, M.D., Ph.D., Toshio Kitamura, MD, PhD, Teruo Okano, Ph.D

Blood (2011) 118 (21): 862.

https://doi.org/10.1182/blood.V118.21.862.862

Published: 2011

Journal Articles

Dual Inhibition of the STAT3 and Src Pathways by NS-018, a JAK2 and Src-Family Kinase Inhibitor, Reduces Myeloma Cell Proliferation and Adhesion and Suppresses Osteoclast Formation

Kazuya Kuramoto, PhD, Ayumi Kodama, Junko Homan, Yohei Nakaya, Toshio Kitamura, MD, PhD, Haruna Naito, PhD

Blood (2011) 118 (21): 2900.

https://doi.org/10.1182/blood.V118.21.2900.2900

Published: 2011

NARROW

Impaired Osteoblastic Differentiation of MSCs Suppresses Normal Hematopoiesis in MDS

Mutant ASXL1 Disrupts Paraspeckle Formation through Aberrant Interaction with Nono in Hematopoietic Cells

The Ubiquitin Ligase DTX2 Promotes Nuclear Export of RUNX1 and Inhibits RUNX1-Dependent Leukemogenesis

Homeobox Transcription Factor Hhex Promotes Myeloid Leukemia in Cooperation with Mutant ASXL1

Leukemogenic Functions of Mutant ASXL1 Are Regulated By CDK-Mediated Phosphorylation

Mutant ASXL1 Promotes Expansion of the Phenotypic Hematopoietic Stem Cell Compartment

Chromatin Architecture Modulation in B-Cell Acute Lymphoblastic Leukemia Carrying DUX4 Fusions

Mutant ASXL1 Cooperates with BAP1 to Promote Myeloid Leukemogenesis

A p53-MDM2 Interaction Inhibitor, DS-5272, Inhibits the Development of MLL-Fusion Leukemia with the Assistance of Tumor Immunity

RARB Translocations in Acute Promyelocytic Leukemia without Rara translocation

Inhibition of Impdh As an Effective Treatment for MLL-Fusion Leukemia

Protease-Activated Receptor 1 (PAR-1) Inhibits Proliferation but Enhances Leukemia Stem Cell Activity in Acute Myeloid Leukemia

Growth Suppressing Activity of Lhx2 in Human T Cell Acute Lymphoblastic Leukemia (T-ALL)-Derived Cells and Large-Scale Screening of a Lead Compounds Targeting T-ALL

Dysregulation of RUNX1 Plays a Critical Role in the Progression of Myelodysplastic Syndromes

A Patient-Derived EZH2 Mutant Induces MDS-like Diseases with Derepressed ABCG2 Expression in Mice

SETBP1 Mutations Drive Leukemic Transformation in ASXL1 -Mutated MDS

C-Terminal-Truncating ASXL1 Mutations Induce MDS Via Inhibition Of PRC2

RUNX1/AML1 Mutants Collaborate with BMI1 in the Development of Myelodysplastic Syndromes (MDS) / Acute Myeloid Leukemia (AML) in a Mouse BMT Model.

Nov/CCN3 Enhances Long-Term Repopulating Activity of Mouse Hematopoietic Stem Cells Via Intergin β3 Signaling Collaborating with Thrombopoietin

Dual Inhibition of the STAT3 and Src Pathways by NS-018, a JAK2 and Src-Family Kinase Inhibitor, Reduces Myeloma Cell Proliferation and Adhesion and Suppresses Osteoclast Formation

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American Society of Hematology

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ASH Publications

American Society of Hematology

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