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Journal Articles

Analysis of Genomic Landscape of Large Granular Lymphocyte Leukemia Reveals Etiologic Insights

HeeJin Cheon, BSc, Jeffrey C Xing, BS, David S Chung, BS, Mariella F Toro, BA, Cait E Hamele, BS, Thomas L. Olson, PhD, David J Feith, PhD, Aakrosh Ratan, PhD, Thomas P. Loughran, Jr., MD

Blood (2020) 136 (Supplement 1): 27–28.

https://doi.org/10.1182/blood-2020-137269

Published: 2020

Journal Articles

Recurrent Mutations of the C-C Motif Chemokine Ligand 22 ( CCL22 ) Define a Distinct Subgroup of Chronic Lymphoproliferative Disorder of NK Cells (CLPD-NK)

Constance Baer, PhD, Shunsuke Kimura, Ilaria Iacobucci, David J Feith, BS, PhD, Wencke Walter, PhD, Manja Meggendorfer, PhD, Thomas L. Olson, PhD, Aakrosh Ratan, PhD, Martha-Lena Müller, PhD, Mitra Rana, Chunxu Qu, PhD, Ravi Kalathur, Claudia Haferlach, MD, Wolfgang Kern, MD, Thomas P. Loughran, Jr., MD, Charles G Mullighan, MBBS, MD, Torsten Haferlach, MD

Blood (2020) 136 (Supplement 1): 19.

https://doi.org/10.1182/blood-2020-140695

Published: 2020

Journal Articles

Blockade of IL-15 Utilizing Bnz-1, a Selective γ-Chain Inhibiting Peptide, Is Safe and Has Clinical Activity in Patients with T-Cell Large Granular Lymphocytic Leukemia (T-LGLL): Results of a Phase I/II Multi-Center Clinical Trial

Jonathan E. Brammer, MD, Lubomir Sokol, MD PhD, Yutaka Tagaya, MD PhD, Kerry Rogers, Anjali Mishra, PhD, Thomas A. Waldmann, MD, Nazli Azimi, PhD PharmD, Paul Frohna, MD PhD PharmD, Anoshie Ratnayake, MD, Thomas P Loughran, Jr., MD, Karen Ballen, MD

Blood (2019) 134 (Supplement_1): 2835.

https://doi.org/10.1182/blood-2019-129291

Published: 2019

Journal Articles

GDF1 Regulation of Ceramide Metabolism Restores Effective Hematopoiesis in Myelodysplastic Syndrome

Brian Barth, PhD MS, BS, Weiyuan Wang, Emily Sullivan, Vasiliki Papakotsi, Andrea Cote, Paul Toran, PhD, Sarah Walker, PhD, Thomas P Loughran, Jr., MD

Blood (2019) 134 (Supplement_1): 1700.

https://doi.org/10.1182/blood-2019-131623

Published: 2019

Journal Articles

GDF1 Is a Regulator of Sphingolipid Metabolism in Acute Myeloid Leukemia

Weiyuan Wang, Emily Sullivan, Vasiliki Papakotsi, Andrea Cote, Paul Toran, PhD, Thomas P Loughran, Jr., MD, Brian Barth, PhD MS, BS

Blood (2019) 134 (Supplement_1): 1245.

https://doi.org/10.1182/blood-2019-130964

Published: 2019

Journal Articles

Therapeutic Efficacy of Mcl-1 Antagonism in Large Granular Lymphocyte Leukemia

Francis R LeBlanc, PhD, Jun Yang, MD, John H Heller, B.S., Shubha Dighe, M.S., Alejandro A. Gru, MD, Marya Dunlap-Brown, M.S., Hong-Gang Wang, PhD, David J Feith, PhD, Thomas P Loughran, Jr., MD

Blood (2017) 130 (Supplement 1): 1217.

https://doi.org/10.1182/blood.V130.Suppl_1.1217.1217

Published: 2017

Journal Articles

Blockade of IL-2 and IL-15 Gamma Chain Receptor Signaling Decreases Leukemic Cell Viability in T-Cell Large Granular Lymphocyte Leukemia and Adult T-Cell Leukemia

Tracy Tiffany Wang, BS, Jun Yang, MD, Yong Zhang, PhD, Meili Zhang, PhD, Kevin C Conlon, MD, Yutaka Tagaya, B.M., PhD, Thomas L Olson, PhD, David J Feith, PhD, Nazli Azimi, Pharm.D., PhD, Thomas A. Waldmann, MD, Thomas P Loughran, Jr., MD

Blood (2017) 130 (Supplement 1): 3585.

https://doi.org/10.1182/blood.V130.Suppl_1.3585.3585

Published: 2017

Journal Articles

Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) Mediates and Sustains NF-κb Constitutive Activation in LGL Leukemia Cells

Jun Yang, MD, Francis R Leblanc, PhD, Shubha Dighe, MS, Susan B. Nyland, PhD, David J. Feith, PhD, Thomas P. Loughran, Jr., MD

Blood (2016) 128 (22): 2762.

https://doi.org/10.1182/blood.V128.22.2762.2762

Published: 2016

Journal Articles

Mutational Landscape of Aggressive Natural Killer Cell Leukemia and Drug Sensitivity Profiling Reveal Therapeutic Options in Natural Killer Cell Malignancies

Blood (2016) 128 (22): 2921.

https://doi.org/10.1182/blood.V128.22.2921.2921

Published: 2016

Journal Articles

Acid Ceramidase Inhibition Impairs Tumor Progression in a Rat Model of LGL Leukemia

Su-Fern Tan, PhD, Xin Liu, MD PhD, Kathleen Broeg, B.S., Todd E. Fox, PhD, David J. Feith, PhD, Thomas P. Loughran, Jr., MD

Blood (2015) 126 (23): 1246.

https://doi.org/10.1182/blood.V126.23.1246.1246

Published: 2015

Journal Articles

FTY720 (Fingolimod) Targets the Sphingolipid Pathway and Induces Autophagy-Related Apoptosis in Human Natural Killer Large Granular Lymphocyte Leukemia

Francis Roland LeBlanc, B.S., Hong-Gang Wang, MD PhD, David J. Feith, PhD, Thomas P. Loughran, Jr., MD

Blood (2015) 126 (23): 1288.

https://doi.org/10.1182/blood.V126.23.1288.1288

Published: 2015

Journal Articles

Exome Sequencing of Aggressive Natural Killer Cell Leukemia and Drug Profiling Highlight Candidate Driver Pathways in Malignant Natural Killer Cells

Blood (2015) 126 (23): 700.

https://doi.org/10.1182/blood.V126.23.700.700

Published: 2015

Journal Articles

Overcoming Ibrutinib Resitance In Relapsed Chronic Lymphocytic Leukemia

Kamal Sharma, DO, August Stuart, MS, Elliot M Epner, MD, PhD, Thomas P. Loughran, Jr., MD

Blood (2013) 122 (21): 4891.

https://doi.org/10.1182/blood.V122.21.4891.4891

Published: 2013

Journal Articles

Combinatorial Anti-Leukemic Activity Of Liposomal Ceramide and Inhibitors Of Autophagy

Brian Barth, Ph.D., Nicole Keasey, PhD, Lindsey Fisher, Bsc, Megan Young, Bsc, Stephan Stern, PhD, Thomas P. Loughran, Jr., MD, Mark Kester, PhD, Hong-Gang Wang, PhD, David F. Claxton, MD

Blood (2013) 122 (21): 2694.

https://doi.org/10.1182/blood.V122.21.2694.2694

Published: 2013

Journal Articles

Targeting Sphingosine Kinase 1 in NK-LGL Leukemia

Francis LeBlanc, Xin Liu, MD, PhD, Todd Fox, PhD, Mithun Shah, MD, PhD, Andrew Rogers, Lindsay Ryland, PhD, Mark Kester, PhD, Jong Yun, PhD, Thomas P. Loughran, Jr., MD

Blood (2012) 120 (21): 1313.

https://doi.org/10.1182/blood.V120.21.1313.1313

Published: 2012

Journal Articles

Human Telomerase Reverse Transcriptase (hTERT) Deficiency in Myelodysplastic Syndrome (MDS) Demonstrates Mechanistic Linkage to Aplastic Anemia Pathophysiology

Lili Yang, PhD, Adam W Mailloux, PhD, Dana E Rollison, PhD, Jong Park, PhD, Jeffrey S. Painter, B.S., Rami S. Komrokji, MD, Jaroslaw P Maciejewski, MD, PhD, Ronald Paquette, MD, PhD, Thomas P. Loughran, Jr., MD, Sheng Wei, MD, Alan F. List, MD, Pearlie K Epling-Burnette, Pharm D, PhD

Blood (2011) 118 (21): 791.

https://doi.org/10.1182/blood.V118.21.791.791

Published: 2011

Journal Articles

Cytopenias in Large Granular Lymphocyte Leukemia Are Mediated by Pro-Fibrotic Mesenchymal Stem Cells in the Bone Marrow Niche with Functional Restoration by FGFb

Adam W Mailloux, PhD, Ling Zhang, MD, Lili Yang, PhD, Cody Wei, Lubomir Sokol, MD, PhD, Lynn Moscinski, MD, John M. Bennett, MD, Thomas P. Loughran, Jr., MD, P.K. Epling-Burnette, PharmD, PhD

Blood (2011) 118 (21): 932.

https://doi.org/10.1182/blood.V118.21.932.932

Published: 2011

Journal Articles

A Switch in Regulatory T-Cell Memory Phenotype Is Associated with Poor Survival in Lower Risk Myleodysplastic Syndrome Patients

Adam W Mailloux, PhD, Chiharu Sugimori, Rami S. Komrokji, MD, Jaroslaw P. Maciejewski, MD, PhD, Ronald Paquette, MD, PhD, Thomas P. Loughran, Jr., MD, Alan F. List, MD, P.K. Epling-Burnette, PharmD, PhD

Blood (2011) 118 (21): 1703.

https://doi.org/10.1182/blood.V118.21.1703.1703

Published: 2011

Journal Articles

Results of a Prospective Multicenter Phase II Study of Initial Treatment with Methotrexate In LGL Leukemia (ECOG Protocol E5998)

Thomas P. Loughran, Jr., MD, Xiaopan Yao, PhD, MS, John M. Bennett, MD, Mark R. Litzow, MD, Andrew M Evens, DO, MSc, Martin S. Tallman, MD

Blood (2010) 116 (21): 702.

https://doi.org/10.1182/blood.V116.21.702.702

Published: 2010

Journal Articles

Therapeutic Efficacy of FTY720 In a Rat Model of LGL Leukemia

Xin Liu, Aijun Liao, Hong-Gang Wang, Dhimant Desai, Shantu Amin, Thomas P. Loughran, Jr., MD

Blood (2010) 116 (21): 776.

https://doi.org/10.1182/blood.V116.21.776.776

Published: 2010

NARROW

Analysis of Genomic Landscape of Large Granular Lymphocyte Leukemia Reveals Etiologic Insights

Recurrent Mutations of the C-C Motif Chemokine Ligand 22 ( CCL22 ) Define a Distinct Subgroup of Chronic Lymphoproliferative Disorder of NK Cells (CLPD-NK)

Blockade of IL-15 Utilizing Bnz-1, a Selective γ-Chain Inhibiting Peptide, Is Safe and Has Clinical Activity in Patients with T-Cell Large Granular Lymphocytic Leukemia (T-LGLL): Results of a Phase I/II Multi-Center Clinical Trial

GDF1 Regulation of Ceramide Metabolism Restores Effective Hematopoiesis in Myelodysplastic Syndrome

GDF1 Is a Regulator of Sphingolipid Metabolism in Acute Myeloid Leukemia

Therapeutic Efficacy of Mcl-1 Antagonism in Large Granular Lymphocyte Leukemia

Blockade of IL-2 and IL-15 Gamma Chain Receptor Signaling Decreases Leukemic Cell Viability in T-Cell Large Granular Lymphocyte Leukemia and Adult T-Cell Leukemia

Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) Mediates and Sustains NF-κb Constitutive Activation in LGL Leukemia Cells

Mutational Landscape of Aggressive Natural Killer Cell Leukemia and Drug Sensitivity Profiling Reveal Therapeutic Options in Natural Killer Cell Malignancies

Acid Ceramidase Inhibition Impairs Tumor Progression in a Rat Model of LGL Leukemia

FTY720 (Fingolimod) Targets the Sphingolipid Pathway and Induces Autophagy-Related Apoptosis in Human Natural Killer Large Granular Lymphocyte Leukemia

Exome Sequencing of Aggressive Natural Killer Cell Leukemia and Drug Profiling Highlight Candidate Driver Pathways in Malignant Natural Killer Cells

Overcoming Ibrutinib Resitance In Relapsed Chronic Lymphocytic Leukemia

Combinatorial Anti-Leukemic Activity Of Liposomal Ceramide and Inhibitors Of Autophagy

Targeting Sphingosine Kinase 1 in NK-LGL Leukemia

Human Telomerase Reverse Transcriptase (hTERT) Deficiency in Myelodysplastic Syndrome (MDS) Demonstrates Mechanistic Linkage to Aplastic Anemia Pathophysiology

Cytopenias in Large Granular Lymphocyte Leukemia Are Mediated by Pro-Fibrotic Mesenchymal Stem Cells in the Bone Marrow Niche with Functional Restoration by FGFb

A Switch in Regulatory T-Cell Memory Phenotype Is Associated with Poor Survival in Lower Risk Myleodysplastic Syndrome Patients

Results of a Prospective Multicenter Phase II Study of Initial Treatment with Methotrexate In LGL Leukemia (ECOG Protocol E5998)

Therapeutic Efficacy of FTY720 In a Rat Model of LGL Leukemia

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American Society of Hematology

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American Society of Hematology

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