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Thomas Mercher, Ph.D.
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Journal Articles

Identification of Inducers of Megakaryocyte Polyploidization and Their Use as Targeted Differentiation Therapy for Acute Megakaryocytic Leukemia.

Qiang Wen, PhD, MD, Zan Huang, PhD, Sara Small, Niket Bubna, Frank An, PhD, Meghan Bliss-Moreau, Lynn Verplank, PhD, Tim Lewis, PhD, Monica Schenone, PhD, Nicola Tolliday, PhD, Chris Moore, Ann Carpenter, PhD, Thomas Mercher, Ph.D, Ross L. Levine, MD, Shai Izraeli, MD, Andrew Stern, PhD, Robert Gould, PhD, James E. Bradner, MD, John Crispino, PhD
Journal: Blood
Blood (2009) 114 (22): 792.
https://doi.org/10.1182/blood.V114.22.792.792
Published: 2009
Journal Articles

A Regulatory Network Between Notch and AKT Signaling Pathways Differentially Controls Megakaryocyte Development From Hematopoietic Stem or Committed Progenitor Cells.

Melanie G Cornejo, Stephen M Sykes, Cristina Lo Celso, Zuzana Tothova, Jon Aster, MD, PhD, Ronald A DePinho, MD, David T Scadden, MD, D. Gary Gilliland, MD, PhD, Thomas Mercher, Ph.D
Journal: Blood
Blood (2009) 114 (22): 384.
https://doi.org/10.1182/blood.V114.22.384.384
Published: 2009
Journal Articles

Inhibition of AKT Signaling Potently Inhibits Growth of MPL-Mutant Cells in the Myeloproliferative Neoplasms.

Zan Huang, PhD, Priya Koppikar, PhD, Thomas Mercher, Ph.D, Ross L. Levine, MD, John Crispino, PhD
Journal: Blood
Blood (2009) 114 (22): 1896.
https://doi.org/10.1182/blood.V114.22.1896.1896
Published: 2009
Journal Articles

Runx1 Is Required for Notch-Induced Specification of Megakaryocyte Development from Early Hematopoietic Stem and Progenitor Cells

Melanie G Cornejo, Thomas Mercher, Ph.D, Joseph D. Growney, PhD, Jonathan Jesneck, Ivan Maillard, MD, PhD, Warren S. Pear, MD, PhD, Jon Aster, MD, PhD, D. Gary Gilliland, MD, PhD
Journal: Blood
Blood (2008) 112 (11): 1370.
https://doi.org/10.1182/blood.V112.11.1370.1370
Published: 2008
Journal Articles

Cdx4 Is Dispensable for Murine Hematopoiesis and MLL-AF9 Mediated Leukemogenesis.

Sumin Koo, Thomas Mercher, Ph.D, Shannon Mckinney- Freeman, Ph.D, Yuan Wang, Ph.D, Brian Ball, Brian JP Huntly, MD, PhD, Dimple Bansal, Ph.D, George Q. Daley, MD, PhD, D. Gary Gilliland
Journal: Blood
Blood (2008) 112 (11): 1404.
https://doi.org/10.1182/blood.V112.11.1404.1404
Published: 2008
Journal Articles

OTT-MAL Activates the Notch Signaling Transcription Factor RBPJ and Cooperates with Mutant MPL to Induce Acute Megakaryoblastic Leukemia

Thomas Mercher, Ph.D, Glen D. Raffel, MD, PhD, Sandra A Moore, Melanie G Cornejo, Dominique Baudry-Bluteau, Ph.D, Nicolas Cagnard, Jonathan Jesneck, Yana Pikman, Dana E. Cullen, Ifor Williams, Koichi Akashi, MD, PhD, Hirokazu Shigematsu, Jean-Pierre Bourquin, MD, PhD, Marco Giovannini, MD, PhD, William Vainchenker, Ross L Levine, MD, Benjamin H. Lee, MD, PhD, Olivier Bernard, D. Gary Gilliland
Journal: Blood
Blood (2008) 112 (11): 508.
https://doi.org/10.1182/blood.V112.11.508.508
Published: 2008
Journal Articles

Constitutive JAK3 Activation as a Mouse Model for Human Peripheral T-Cell Lymphoma.

Melanie G. Cornejo, BS, Michael G. Kharas, Ph.D, Benjamin Lee, M.D, Sandra A. Moore, B.S, Gary Gilliland, M.D, Ph.D, Thomas Mercher, Ph.D
Journal: Blood
Blood (2007) 110 (11): 1612.
https://doi.org/10.1182/blood.V110.11.1612.1612
Published: 2007
Journal Articles

Ott1(Rbm15) Is Essential for Pre-B Differentiation and Has an Inhibitory Role in Myeloid and Megakaryocytic Lineages.

Glen D. Raffel, MD, PhD, Thomas Mercher, Ph.D., Hirokazu Shigematsu, M.D., Ifor R. Williams, M.D., Ph.D., Dana E. Cullen, Koichi Akashi, M.D., Ph.D., Olivier A. Bernard, Ph.D., D. Gary Gilliland, M.D., Ph.D.
Journal: Blood
Blood (2006) 108 (11): 784.
https://doi.org/10.1182/blood.V108.11.784.784
Published: 2006