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Journal Articles

Tax-Targeting Dendritic Cell Therapy for ATL: A Phase Ia/Ib Clinical Study

Motoaki Shiratsuchi, MDPhD, Tetsuya Fukuda, MD PhD, Tadafumi Iino, MD PhD, Atsuhiko Hasegawa, PhD, Jun-ichirou Yasunaga, MD PhD, Ken Watanabe, MD PhD, Akie Hirata, MD PhD, Hayato Utsunomiya, MD, Hirofumi Ohno, MD, Takashi Ishida, MD PhD, Koichi Akashi, MD PhD, Masao Matsuoka, MDPhD, Mari Kannagi, MD PhD, Youko Suehiro, MDPhD

Blood (2018) 132 (Supplement 1): 1649.

https://doi.org/10.1182/blood-2018-99-113315

Published: 2018

Journal Articles

Identification of unipotent megakaryocyte progenitors in human hematopoiesis

Blood (2017) 129 (25): 3332–3343.

https://doi.org/10.1182/blood-2016-09-741611

Published: 2017

Includes: Supplemental data

Journal Articles

The Methylcytosine Dioxygenase TET3 Is Aberrantly Expressed in Acute Myeloid Leukemia and Promotes AML Growth

Alex Pulikkottil Jose, M.Sc, Fabian Mohr, PhD, Shiva Bamezai, PhD, Holzmann Karlheinz, Dr., Ursula Kohlhofer, Dr. MD vet., Leticia Quintanilla-Martinez Fend, Prof. Dr., Tadafumi Iino, Dr., Koichi Akashi, MD PhD, Konstanze Döhner, Hartmut Döhner, MD, Michaela Feuring-Buske, PD Dr., Christian Buske, Vijay P.S. Rawat, PhD

Blood (2016) 128 (22): 771.

https://doi.org/10.1182/blood.V128.22.771.771

Published: 2016

Journal Articles

The Expansion Of CML Clones Initiates At The CMP Stage, and Is Associated With The Down-Regulation Of IRF8 and GFI1

Kohta Miyawaki, MD, Hirotake Kusumoto, MD, Tadafumi Iino, MD, Kentaro Kohno, MD, Hirofumi Tsuzuki, Takahiro Shima, MD, Yoshikane Kikushige, MD, PhD, Yojiro Arinobu, MD, PhD, Katsuto Takenaka, MD, PhD, Toshihiro Miyamoto, MD, Hiromi Iwasaki, MD, PhD, Koichi Akashi, MD, PhD

Blood (2013) 122 (21): 1477.

https://doi.org/10.1182/blood.V122.21.1477.1477

Published: 2013

Journal Articles

A Therapeutic Vaccine In Adult T-Cell Leukemia Patients With Autologous Dendritic Cells Pulsed With Peptides Corresponding To Tax-Specific Cytotoxic T Lymphocyte Epitopes

Tadafumi Iino, MD, Youko Suehiro, MD, PhD, Atsuhiko Hasegawa, PhD, Nobukazu Watanabe, MD, PhD, Ryuji Tanosaki, MD, PhD, Atae Utsunomiya, M.D., PhD, Masao Matsuoka, MD, PhD, Takanori Teshima, MD, PhD, Koichi Akashi, MD, PhD, Naokuni Uike, MD, PhD, Jun Okamura, MD, PhD, Mari Kannagi, MD, PhD

Blood (2013) 122 (21): 5130.

https://doi.org/10.1182/blood.V122.21.5130.5130

Published: 2013

Journal Articles

C/EBPα is required for development of dendritic cell progenitors

Robert S. Welner, Deepak Bararia, Giovanni Amabile, Akos Czibere, Touati Benoukraf, Christian Bach, K. Disnika Senali Abayratna Wansa, Min Ye, Hong Zhang, Tadafumi Iino, Christopher J. Hetherington, Koichi Akashi, Daniel G. Tenen

Blood (2013) 121 (20): 4073–4081.

https://doi.org/10.1182/blood-2012-10-463448

Published: 2013

Includes: Supplemental data

Journal Articles

PU.1 is a potent tumor suppressor in classical Hodgkin lymphoma cells

Hiromichi Yuki, Shikiko Ueno, Hiro Tatetsu, Hiroaki Niiro, Tadafumi Iino, Shinya Endo, Yawara Kawano, Yoshihiro Komohara, Motohiro Takeya, Hiroyuki Hata, Seiji Okada, Toshiki Watanabe, Koichi Akashi, Hiroaki Mitsuya, Yutaka Okuno

Blood (2013) 121 (6): 962–970.

https://doi.org/10.1182/blood-2012-05-431429

Published: 2013

Includes: Supplemental data

Journal Articles

Prospective Isolation of the Earliest Common Myeloid Progenitor in Adult Hematopoiesis

Kohta Miyawaki, MD, Yojiro Arinobu, MD, PhD, Kentaro Kohno, MD, Hirofumi Tsuzuki, Tadafumi Iino, MD, Takahiro Shima, MD, Hiromi Iwasaki, MD, PhD, Koichi Akashi, MD, PhD.

Blood (2012) 120 (21): 768.

https://doi.org/10.1182/blood.V120.21.768.768

Published: 2012

Journal Articles

Selective Disruption of PU.1 in Mature Dendritic Cells Affects Their Tissue Distribution and T Cell Homeostasis

Tadafumi Iino, MD, Hiromi Iwasaki, MD, PhD, Kentaro Kohno, MD, Shin-ichi Mizuno, MD.PhD, Yojiro Arinobu, MD, PhD, Daniel G. Tenen, Boris Reizis, PhD, Koichi Akashi, MD, PhD.

Blood (2011) 118 (21): 518.

https://doi.org/10.1182/blood.V118.21.518.518

Published: 2011

Journal Articles

Cyclin A2 Plays a Critical Role in Proliferation of Lymphoid Progenitors

Kentaro Kohno, MD, Hiromi Iwasaki, MD, PhD, Tadafumi Iino, MD, Shin-ichi Mizuno, MD.PhD, Peter Sicinski, MD, PhD, Koichi Akashi, MD, PhD.

Blood (2011) 118 (21): 914.

https://doi.org/10.1182/blood.V118.21.914.914

Published: 2011

Journal Articles

FLT3-ITD up-regulates MCL-1 to promote survival of stem cells in acute myeloid leukemia via FLT3-ITD–specific STAT5 activation

Goichi Yoshimoto, Toshihiro Miyamoto, Siamak Jabbarzadeh-Tabrizi, Tadafumi Iino, Jennifer L. Rocnik, Yoshikane Kikushige, Yasuo Mori, Takahiro Shima, Hiromi Iwasaki, Katsuto Takenaka, Koji Nagafuji, Shin-ichi Mizuno, Hiroaki Niiro, Gary D. Gilliland, Koichi Akashi

Blood (2009) 114 (24): 5034–5043.

https://doi.org/10.1182/blood-2008-12-196055

Published: 2009

Includes: Supplemental data

Journal Articles

Cyclin A2 Plays a Critical Role Not Only in Self-Renewal of Hematopoietic Stem Cells, but Also in Non-Self-Renewing Proliferation of Lymphoid Progenitors.

Kentaro Kohno, hMD, Tadafumi Iino, MD, Kyoko Ito, Shin-ichi Mizuno, MD, PhD, Piotr Sicinski, MD, PhD, Koichi Akashi, MD, PhD

Blood (2009) 114 (22): 381.

https://doi.org/10.1182/blood.V114.22.381.381

Published: 2009

Journal Articles

PU.1 Is Indispensable for Development of Mature Dendritic Cells and Their Function That Plays a Critical Role in Maintenance of Normal T Cell Pool.

Tadafumi Iino, MD, Yong Jeong, MD, PhD, Shin-ichi Mizuno, MD, PhD, Kentaro Kohno, MD, Kyoko Ito, Daniel G. Tenen, MD, PhD, Boris Reizis, PhD, Koichi Akashi, MD, PhD

Blood (2009) 114 (22): 1471.

https://doi.org/10.1182/blood.V114.22.1471.1471

Published: 2009

Journal Articles

Hematopoietic Stem Cells Are Primarily Involved in Pathogenesis of Chronic Lymphocytic Leukemia

YoshiKane KiKushige, MD, Toshihiro Miyamoto, MD, PhD, Tadafumi Iino, MD, Fumihiko Ishikawa, MD, PhD, Koichi Akashi, MD, PhD

Blood (2008) 112 (11): 29.

https://doi.org/10.1182/blood.V112.11.29.29

Published: 2008

Journal Articles

Conditionally Expressed PU.1 Transactivates TRAIL Gene and Induces Apoptosis in Myeloma Cell Lines.

Shikiko Ueno, Hiro Tatetsu, Hiroyuki Hata, MD, PhD, Tadafumi IIno, Hiroaki Niiro, Koichi Akashi, MD, PhD, Daniel G. Tenen, MD, Hiroaki Mitsuya, Yutaka Okuno

Blood (2008) 112 (11): 1676.

https://doi.org/10.1182/blood.V112.11.1676.1676

Published: 2008

Journal Articles

PU.1 Plays a Critical Role in Maintenance of Mature Dendritic Cell Pool

Tadafumi Iino, MD, Yong Chong, MD, PhD, Shin-ichi Mizuno, MD, PhD, Kyoko Ito, PhD, Daniel G. Tenen, MD, Boris Reizis, PhD, Koichi Akashi, MD, PhD

Blood (2008) 112 (11): 3554.

https://doi.org/10.1182/blood.V112.11.3554.3554

Published: 2008

Journal Articles

Notch1 Expression Is Regulated at Post-Transcriptional Level by 3′UTR Region in Hematopoietic Stem Cell Development

Shin-ichi Mizuno, MD, PhD, Hidetoshi Ozawa, PhD, Tadafumi Iino, MD, Yojiro Arinobu, MD, PhD, Chong Yong, MD, PhD, Hirokazu Shigematsu, MD, PhD, Koichi Akashi, MD, PhD

Blood (2008) 112 (11): 2457.

https://doi.org/10.1182/blood.V112.11.2457.2457

Published: 2008

Journal Articles

Microarray Analysis of PU.1-Induced Growth Arrest and Apoptosis of Myeloma Cell Lines.

Shikiko Ueno, Hiro Tatetsu, Naoko Harada, Hiroyuki Hata, Tadafumi Iino, Hiroaki Niiro, Koichi Akashi, Daniel G. Tenen, Hiroaki Mitsuya, Yutaka Okuno

Blood (2007) 110 (11): 2499.

https://doi.org/10.1182/blood.V110.11.2499.2499

Published: 2007

Journal Articles

Reciprocal Activation of GATA-1 and PU.1 Marks Initial Specification of Hematopoietic Stem Cells into Myelo-Erythroid and Myelo-Lymphoid Lineages.

Yojiro Arinobu, MD, PhD, Shin-ichi Mizuno, M.D., Ph.D., Yong Chong, M.D., Ph.D., Hirokazu Shigematsu, M.D., Ph.D., Tadafumi Iino, M.D., Hiromi Iwasaki, M.D., Ph.D., Thomas Graf, Ph.D., Robin Mayfield, Ph.D., Susan Chan, Ph.D., Philippe Kastner, Ph.D., Koichi Akashi, M.D., Ph.D.

Blood (2007) 110 (11): 1228.

https://doi.org/10.1182/blood.V110.11.1228.1228

Published: 2007

Journal Articles

In Vivo Permanent Marking of Cells with RAG1 Activation History Demonstrates That Lymphoid and Myeloid Derived Dendritic Cells Operate an Identical Developmental Program after Their Lineage Commitment.

Yong Chong, MD, PhD, Tadafumi Iino, MD., Ph.D, Shin-ichi Mizuno, MD., Ph.D, Hirokazu Shigematsu, MD., Ph.D, Yojiro Arinobu, MD., Ph.D, Hiromi Iwasaki, MD., Ph.D, Koichi Akashi, MD., Ph.D

Blood (2007) 110 (11): 1328.

https://doi.org/10.1182/blood.V110.11.1328.1328

Published: 2007

NARROW

Tax-Targeting Dendritic Cell Therapy for ATL: A Phase Ia/Ib Clinical Study

Identification of unipotent megakaryocyte progenitors in human hematopoiesis

The Methylcytosine Dioxygenase TET3 Is Aberrantly Expressed in Acute Myeloid Leukemia and Promotes AML Growth

The Expansion Of CML Clones Initiates At The CMP Stage, and Is Associated With The Down-Regulation Of IRF8 and GFI1

A Therapeutic Vaccine In Adult T-Cell Leukemia Patients With Autologous Dendritic Cells Pulsed With Peptides Corresponding To Tax-Specific Cytotoxic T Lymphocyte Epitopes

C/EBPα is required for development of dendritic cell progenitors

PU.1 is a potent tumor suppressor in classical Hodgkin lymphoma cells

Prospective Isolation of the Earliest Common Myeloid Progenitor in Adult Hematopoiesis

Selective Disruption of PU.1 in Mature Dendritic Cells Affects Their Tissue Distribution and T Cell Homeostasis

Cyclin A2 Plays a Critical Role in Proliferation of Lymphoid Progenitors

FLT3-ITD up-regulates MCL-1 to promote survival of stem cells in acute myeloid leukemia via FLT3-ITD–specific STAT5 activation

Cyclin A2 Plays a Critical Role Not Only in Self-Renewal of Hematopoietic Stem Cells, but Also in Non-Self-Renewing Proliferation of Lymphoid Progenitors.

PU.1 Is Indispensable for Development of Mature Dendritic Cells and Their Function That Plays a Critical Role in Maintenance of Normal T Cell Pool.

Hematopoietic Stem Cells Are Primarily Involved in Pathogenesis of Chronic Lymphocytic Leukemia

Conditionally Expressed PU.1 Transactivates TRAIL Gene and Induces Apoptosis in Myeloma Cell Lines.

PU.1 Plays a Critical Role in Maintenance of Mature Dendritic Cell Pool

Notch1 Expression Is Regulated at Post-Transcriptional Level by 3′UTR Region in Hematopoietic Stem Cell Development

Microarray Analysis of PU.1-Induced Growth Arrest and Apoptosis of Myeloma Cell Lines.

Reciprocal Activation of GATA-1 and PU.1 Marks Initial Specification of Hematopoietic Stem Cells into Myelo-Erythroid and Myelo-Lymphoid Lineages.

In Vivo Permanent Marking of Cells with RAG1 Activation History Demonstrates That Lymphoid and Myeloid Derived Dendritic Cells Operate an Identical Developmental Program after Their Lineage Commitment.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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