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Stephen D. Nimer, MD
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Journal Articles

CARM1 Inhibition: Evaluation of Response and Efficacy in Acute Myeloid Leukemia

Adnan K Mookhtiar, BS, Sarah Greenblatt, PhD, Na Man, PhD, Daniel Karl, PhD, Vasileios Stathias, PhD, Stephan Schurer, PhD, Stephen D. Nimer, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2719.
https://doi.org/10.1182/blood-2018-99-114981
Published: 2018
Journal Articles

Cooperative Epigenetic Regulation By ASXL1 and NF1 Loss on Leukemogenesis

Peng Zhang, PhD, Fuhong He, PhD, Jie Bai, MD, Shi Chen, Stephen D. Nimer, MD, Yuan Zhou, PhD, Mingjiang Xu, MD PhD, Qianfei Wang, PhD, Feng-Chun Yang, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 652.
https://doi.org/10.1182/blood-2018-99-110964
Published: 2018
Journal Articles

Hoxblinc Is Aberrantly Expressed in Acute Myeloid Leukemia and Functions As a Potent Oncogenic Long Non-Coding RNA in Leukemogenesis

Ganqian Zhu, PhD, Huacheng Luo, Shi Chen, Qian Lai, Ying Guo, Olga A Guryanova, MDPhD, Yi Qiu, Feng-Chun Yang, MD PhD, Wei Li, Stephen D. Nimer, MD, Suming Huang, Mingjiang Xu, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 886.
https://doi.org/10.1182/blood-2018-99-112232
Published: 2018
Journal Articles

The Three E Proteins Define a Heterogeneity of the AML1-ETO-Containing Transcription Factor Complex (AETFC) and Differentially Regulate t(8;21) Leukemogenesis

Na Liu, Junhong Song, Yangyang Xie, Xiao-Lin Wang, Bowen Rong, Na Man, PhD, Meng-Meng Zhang, Qunling Zhang, MD PhD, Fei-Fei Gao, Mei-Rong Du, Ying Zhang, Jian Shen, Chun-Hui Xu, Cheng-Long Hu, Ji-Chuan Wu, Ping Liu, Yuan-Liang Zhang, Yin-Yin Xie, Ping Liu, Jinyan Huang, PhD, Qiu-Hua Huang, Fei Lan, Shuhong Shen, MD PhD, Stephen D. Nimer, MD, Zhu Chen, Sai-Juan Chen, Robert G. Roeder, Lan Wang, MD, Xiao-Jian Sun, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 5247.
https://doi.org/10.1182/blood-2018-99-112372
Published: 2018
Journal Articles

PRMT5 Regulates DNA Repair By Controlling the Alternative Splicing of Epigenetic Factors

Pierre-Jacques Hamard, PhD, Gabriel Emmanuel Santiago, Fan Liu, PhD, Sarah Greenblatt, PhD, Daniel Karl, PhD, Concepcion Martinez, B.S., Ramiro E Verdun, PhD, Stephen D. Nimer, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1148.
https://doi.org/10.1182/blood.V130.Suppl_1.1148.1148
Published: 2017
Journal Articles

CARM1/PRMT4 As a Novel Therapeutic Target for AML

Sarah Greenblatt, PhD, Na Man, Pierre-Jacques Hamard, PhD, Concepcion Martinez, B.S., Ye Xu, PhD, Fan Liu, PhD, Justin M Watts, MD, Daniel G. Tenen, MD, Stephen D. Nimer, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 241.
https://doi.org/10.1182/blood.V130.Suppl_1.241.241
Published: 2017
Journal Articles

Caspase-3 Can Promote Acute Myeloid Leukemia Development By Regulation of Autophagy

Na Man, PhD, Yurong Tan, PhD, Fan Liu, PhD, Guoyan Cheng, PhD, Sarah Merin Greenblatt, PhD, Camilo Martinez, Xiao-Jian Sun, PhD, Stephen D. Nimer, MD, Lan Wang, PhD
Journal: Blood
Blood (2016) 128 (22): 2714.
https://doi.org/10.1182/blood.V128.22.2714.2714
Published: 2016
Journal Articles

The AML-Associated FLT3-ITD Kinase Regulates Histone Modifications and Cytokine Signaling, Via Effects on PRMT5

Koji Ando, MD PhD, Pierre-Jacques Hamard, PhD, Fan Liu, PhD, Concepcion Martinez, Yuguang Ban, PhD, Xi Chen, PhD, Stephen D. Nimer, MD
Journal: Blood
Blood (2016) 128 (22): 2696.
https://doi.org/10.1182/blood.V128.22.2696.2696
Published: 2016
Journal Articles

ASXL2 Is Required for Normal Hematopoiesis and Loss of a sxl2 Leads to Myeloid Malignancies in Mice

Jianping Li, Fuhong He, PhD, Peng Zhang, PhD, Shi Chen, MD PhD, Hui Shi, Yanling Sun, Guo Ying, Hui Yang, Stephen D. Nimer, MD, Qian-Fei Wang, Mingjiang Xu, MD PhD, Feng-Chun Yang, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1509.
https://doi.org/10.1182/blood.V128.22.1509.1509
Published: 2016
Journal Articles

TAFII250 Is Critical in AML1-ETO Mediated Leukemogenesis

Ye Xu, PhD, Na Man, PhD, Concepcion Martinez, Camilo Martinez, Felipe Beckedorf, Guoyan Cheng, PhD, Sarah Merin Greenblatt, PhD, Lan Wang, PhD, Ramin Shiekhattar, Stephen D. Nimer, MD
Journal: Blood
Blood (2016) 128 (22): 1520.
https://doi.org/10.1182/blood.V128.22.1520.1520
Published: 2016
Journal Articles

Prmt5 Negatively Regulates Erythropoiesis By Multiple Mechanisms, Including Controlling DNA Methyltransferase 3A Protein Levels

Pierre-Jacques Hamard, PhD, Luisa Luciani, PhD, Fan Liu, PhD, Guoyan Cheng, PhD, Megan A. Hatlen, PhD, Olga A Guryanova, MD, PhD, Xinyang Zhao, PhD, Ross L. Levine, MD, Stephen D. Nimer, MD
Journal: Blood
Blood (2015) 126 (23): 1181.
https://doi.org/10.1182/blood.V126.23.1181.1181
Published: 2015
Journal Articles

Integrative Analysis of the Mutational Landscape of Mouse and Human AML Identifies Functionally Relevant Leukemia Disease Alleles

Megan A. Hatlen, PhD, Kanika Arora, MS, Vladimir Vacic, PhD, Ewa A. Grabowska, BS, Willey Liao, BS, Bridget Riley-Gillis, PhD, Dayna M. Oschwald, BS, Lan Wang, PhD, Jacob E. Joergens, Alan H. Shih, MD PhD, Franck Rapaport, PhD, Shengqing Gu, PhD, Francesca Voza, BS, Takashi Asai, MD PhD, Benjamin Neel, MD PhD, Michael G. Kharas, PhD, Mithat Gonen, PhD, Ross L. Levine, MD, Stephen D. Nimer, MD
Journal: Blood
Blood (2015) 126 (23): 1247.
https://doi.org/10.1182/blood.V126.23.1247.1247
Published: 2015
Journal Articles

MSI2 Is Required for Maintaining the Activated Myelodysplastic Syndrome Stem Cell

Tzu-Chieh Ho, PhD, James Taggart, BS, Elianna Amin, PhD, Haiming Xu, PhD, Trevor Barlowe, BA, Alexander R Perez, BS, Patrick Tivnan, BS, Rachel Okabe, BS, Christopher Lengner, PhD, Amit Verma, MD, Gail J Roboz, MD, Monica L. Guzman, PhD, Christina S Leslie, PhD, Stephen D. Nimer, MD, Michael G. Kharas, PhD
Journal: Blood
Blood (2015) 126 (23): 714.
https://doi.org/10.1182/blood.V126.23.714.714
Published: 2015
Journal Articles

HIF-1a Pathway, As a Signal Funnel for Genetic, Epigenetic, and Metabolic Aberrations, Is Sufficient and Essential for MDS Development

Yoshihiro Hayashi, MD PhD, Yue Zhang, MD, Xiaomei Yan, MD PhD, Kwangmin Choi, PhD, Goro Sashida, MD PhD, Yunzhu Dong, Zefeng Xu, MD, Lingyun Wu, MD PhD, Aili Chen, PhD, Xiujuan Sun, MD, Andre Olsson, PhD, Hironori Harada, MD PhD, Lee-Yung Shih, MD, William Tse, MD FACP, James Bridges, PhD, David P Witte, MD, Qianfei Wang, Michael A. Caligiuri, MD, H. Leighton Grimes, PhD, Stephen D. Nimer, MD, Zhijian Xiao, MD, Gang Huang, PhD
Journal: Blood
Blood (2015) 126 (23): 303.
https://doi.org/10.1182/blood.V126.23.303.303
Published: 2015
Journal Articles

RUNX1/CBFβ Dosage Is Critical for MLL Leukemias Development

Xiaomei Yan, MD PhD, Yoshihiro Hayashi, MD PhD, Xinghui Zhao, PhD, Aili Chen, PhD, Yue Zhang, MD, Fuhong He, Yunzhu Dong, Yalan Rao, PhD, Bo Li, Rajeana Conway, Alba Maiques-Díaz, Nuomin Huang, Shannon E Elf, Johannes Zuber, MD, Zhijian Xiao, MD, William Tse, Daniel G. Tenen, MD, Qianfei Wang, Wei Chen, James C. Mulloy, PhD, Stephen D Nimer, MD, Gang Huang, PhD
Journal: Blood
Blood (2014) 124 (21): 2187.
https://doi.org/10.1182/blood.V124.21.2187.2187
Published: 2014
Journal Articles

IPS Cells From Del(7q)-MDS Patients Display Impaired Proliferation and Hematopoietic Commitment

Ibrahim Boussaad, PhD, Emily K Dolezal, Fabiana Perna, MD, Stephen D Nimer, MD, Eirini P Papapetrou, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 174.
https://doi.org/10.1182/blood.V120.21.174.174
Published: 2012
Journal Articles

Generation of a Novel, Multi-Stage, Progressive, and Transplantable Model of Multiple Myeloma

Takashi Asai, MD, PhD, Silvia Menendez, Delphine Ndiaye-Lobry, Anthony R Deblasio, Kazunori Murata, PhD, Martin Fleisher, PhD, John Petrini, PhD, Stephen D Nimer, MD
Journal: Blood
Blood (2012) 120 (21): 327.
https://doi.org/10.1182/blood.V120.21.327.327
Published: 2012
Journal Articles

PRMT1 Interacts with AML1-ETO to Promote Its Transcriptional Activation and Progenitor Cell Proliferative Potential

Wei-Jong Shia, PhD, Akiko J. Okumura, PhD, Ming Yan, PhD, Ali Sarkeshik, Miao-Chia Lo, PhD, Shinobu Matsuura, DVM, PhD, Yukiko Komeno, MD, PhD, Xinyang Zhao, PhD, Stephen D. Nimer, MD, John R. Yates, III, PhD, Dong-Er Zhang, PhD
Journal: Blood
Blood (2011) 118 (21): 4621.
https://doi.org/10.1182/blood.V118.21.4621.4621
Published: 2011
Journal Articles

Transcriptome Sequence Analysis of Pediatric Acute Megakaryoblastic Leukemia Identifies An Inv(16)(p13.3;q24.3)-Encoded CBFA2T3-GLIS2 Fusion Protein As a Recurrent Lesion in 39% of Non-Infant Cases: A Report From the St. Jude Children's Research Hospital – Washington University Pediatric Cancer Genome Project

Tanja A Gruber, MD, PhD, Amanda Larson Gedman, PhD, Huy Q. Ta, PhD, Jinghui Zhang, PhD, Cary Koss, BS, Shann-Ching Chen, PhD, Xiaoping Su, PhD, Vedant Gupta, BS, Stacey Ogden, PhD, Anna K. Andersson, PhD, John Easton, PhD, Jianmin Wang, PhD, Michael Rusch, BA, Li Ding, PhD, Giovanni Cazzaniga, Andrea Biondi, MD, Steven M. Kornblau, MD, Farhad Ravandi, MD, Hagop M. Kantarjian, Stephen D. Nimer, MD, Konstanze Doehner, Prof., Hartmut Doehner, MD, Timothy J Ley, MD, Sheila Shurtleff, PhD, Jeffrey Rubnitz, MD, PhD, Ching-Hon Pui, MD, Elaine R. Mardis, PhD, Richard K. Wilson, PhD, James R. Downing, MD
Journal: Blood
Blood (2011) 118 (21): 757.
https://doi.org/10.1182/blood.V118.21.757.757
Published: 2011
Journal Articles

ASXL1 Mutations Promote Myeloid Transformation Through Inhibition of PRC2-Mediated Gene Repression

Omar Abdel-Wahab, MD, Mazhar Adli, PhD, Lindsay Saunders, B.Sc., Jie Gao, PhD, Alan H. Shih, MD, PhD, Suveg Pandey, B.Sc., Jake Jaffe, PhD, Xinyang Zhao, PhD, Fabiana Perna, MD, Martin Carroll, MD, Ari Melnick, MD, Stephen D. Nimer, MD, Iannis Aifantis, PhD, Bradley Bernstein, Ross L Levine, MD
Journal: Blood
Blood (2011) 118 (21): 405.
https://doi.org/10.1182/blood.V118.21.405.405
Published: 2011