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Stefan Radtke, PhD
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Journal Articles

Multiplex CRISPR/Cas9 Genome Editing Targeting the BCL11A/HBG Axis Maximizes Fetal Hemoglobin Reinduction but Generates Chromosomal Translocations Which Persist In Vivo

Clare Samuelson, Olivier Humbert, PhD, Stefan Radtke, PhD, Haiying Zhu, Mallory J Llewellyn, BS, Emily Fields, BS, Savannah Cook, BS, Meei-Li W Huang, Olivier Negre, PhD, Keith Jerome, MDPhD, Hans-Peter Kiem, MDPhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 47–48.
https://doi.org/10.1182/blood-2020-138539
Published: 2020
Journal Articles

In Vivo HSC Gene Therapy for Hemoglobinopathies: A Proof of Concept Evaluation in Rhesus Macaques

Chang Li, Hongjie Wang, PhD, Sucheol Gil, Afrodite Georgakopoulou, PhDstudent, Stefan Radtke, PhD, Evangelia Yannaki, MD, Thalia Papayannopoulou, MD DrSci, Hans-Peter Kiem, MDPhD, Andre Lieber, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 46–47.
https://doi.org/10.1182/blood-2020-141468
Published: 2020
Journal Articles

Fully Closed, Large-Scale, and Clinical Grade Cell Sorting of Hematopoietic Stem Cell (HSC)-Enriched CD90 + Cells for Transplantation and Gene Therapy

Stefan Radtke, PhD, Margaret Cui, Anai M Perez, Yan-Yi Chan, Stefanie Schmuck, BS, Andrew J Berger, PhD, Thomas Eunson, BSc, Hans-Peter Kiem, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3246.
https://doi.org/10.1182/blood-2019-125969
Published: 2019
Journal Articles

Persistence of CRISPR/Cas9-Edited Hematopoietic Stem and Progenitor Cells and Reactivation of Fetal Hemoglobin in Nonhuman Primates

Olivier Humbert, PhD, Stefan Radtke, PhD, Ray R Carillo, Anai M Perez, Sowmya Somashekar Reddy, Lauren E Schefter, Christopher Lux, MDPhD, Sowmya Pattabhi, PhD, Olivier Negre, PhD, Ciaran M Lee, PhD, Jennifer Adair, PhD, Christopher Peterson, PhD, Gang Bao, PhD, David J. Rawlings, MD, Andrew M. Scharenberg, MD, Hans-Peter Kiem, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 806.
https://doi.org/10.1182/blood-2018-99-112996
Published: 2018
Journal Articles

A Novel Highly Conserved Hematopoietic Stem/Progenitor Cell Population for Stem Cell Transplantation and Gene Therapy

Stefan Radtke, PhD, Yan-Yi Chan, Morgan A. Giese, Anthony Rongvaux, PhD, Jennifer Adair, PhD, Hans-Peter Kiem, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3339.
https://doi.org/10.1182/blood.V130.Suppl_1.3339.3339
Published: 2017
Journal Articles

Pharmacological Inhibition of Luteinizing Hormone Signaling Promotes HSC Quiescence and Hematopoietic Regeneration

Enrico Velardi, PhD BS, Jennifer Tsai, MD PhD, Stefan Radtke, PhD, Kirsten Cooper, Kimon Argyropoulos, MD, Shieh Jae-Hung, PhD, Yusuke Shono, MD PhD, Robert R. Jenq, MD, Alan M. Hanash, Malcolm A.S. Moore, DPhil, Hans-Peter Kiem, MD PhD, Marcel R.M. van den Brink, MD PhD, Jarrod A Dudakov, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1139.
https://doi.org/10.1182/blood.V130.Suppl_1.1139.1139
Published: 2017
Journal Articles

Identification and Characterization of a Distinct, Evolutionarily Conserved HSC Phenotype Associated with and Predicting Multi-Lineage Engraftment

Stefan Radtke, PhD, Morgan A. Giese, BA, Yan-Yi Chan, BA, Zachary K. Norgaard, MSc, Jennifer E Adair, PhD, Hans-Peter Kiem, MD FACP
Journal: Blood
Blood (2016) 128 (22): 1153.
https://doi.org/10.1182/blood.V128.22.1153.1153
Published: 2016
Journal Articles

Conserved Lineage Development in Human and Nonhuman Primate Hematopoiesis

Stefan Radtke, PhD, Yan-Yi Chan, BA, Morgan A. Giese, BA, Zachary K. Norgaard, MSc, Lauren E Schefter, BA, Jennifer E Adair, PhD, Hans-Peter Kiem, MD FACP
Journal: Blood
Blood (2016) 128 (22): 2646.
https://doi.org/10.1182/blood.V128.22.2646.2646
Published: 2016
Journal Articles

CD133 + CD34 + HSPCs Are Not Significantly Increased in Fetal Liver Compared to Adult or Umbilical Cord HSPCs

Stefan Radtke, PhD, Kevin G Haworth, PhD, Hans-Peter Kiem, MD
Journal: Blood
Blood (2015) 126 (23): 2369.
https://doi.org/10.1182/blood.V126.23.2369.2369
Published: 2015