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Journal Articles

Unraveling Antioxidative Metabolic Pathways in Multiple Myeloma: Augmenting IMiD Sensitivity through Intracellular Cysteine Biosynthesis Inhibition

Sinto Sebastian Chirackal, Taro Hitosugi, Gregory Ahmann, Esteban Braggio, Marta Chesi, P. Leif Bergsagel, Rafael Fonseca
Journal: Blood
Blood (2023) 142 (Supplement 1): 3291.
https://doi.org/10.1182/blood-2023-189785
Published: 2023
Journal Articles

Multiple myeloma cells’ capacity to decompose H 2 O 2 determines lenalidomide sensitivity

Sinto Sebastian, Yuan X. Zhu, Esteban Braggio, Chang-Xin Shi, Sonali C. Panchabhai, Scott A. Van Wier, Greg J. Ahmann, Marta Chesi, P. Leif Bergsagel, A. Keith Stewart, Rafael Fonseca
Journal: Blood
Blood (2017) 129 (8): 991–1007.
https://doi.org/10.1182/blood-2016-09-738872
Published: 2017
Includes: Supplemental data
Journal Articles

Lenalidomide Inhibits Thioredoxin Reductase (TrxR) in Multiple Myeloma (MM) Cells but Direct Inhibition of Trxr and Thioredoxin (Trx) Can Bypass Requirement of Cereblon (CRBN)

Sinto Sebastian Chirackal, PhD, Esteban Braggio, PhD, Yuan Xiao Zhu, PhD, Chang-Xin Shi, PhD, Scott Van Wier, Gregory Ahmann, Veronica Gonzalez-Calle, MD, Marta Chesi, PhD, Leif Bergsagel, MD, Keith Stewart, M.B., Ch.B., Rafael Fonseca, MD
Journal: Blood
Blood (2016) 128 (22): 4482.
https://doi.org/10.1182/blood.V128.22.4482.4482
Published: 2016
Journal Articles

Evaluation of Revised International Staging System for Transplant-Eligible Multiple Myeloma Patients

Veronica Gonzalez-Calle, MD, Abigail Slack, Susan Luft, M.S., R.N., Kathryn Pearce, Rhett P. Ketterling, MD, Tania Jain, M.B., B.S, Sinto Sebastian Chirackal, PhD, Craig B. Reeder, MD, Joseph Mikhael, MD, Leif Bergsagel, MD, Pierre Noel, MD, Angela Mayo, P.A.-C., M.S., James L. Slack, MD, Roberta H. Adams, MD, Gregory Ahmann, Esteban Braggio, PhD, Keith Stewart, M.B., Ch.B., Scott Van Wier, Rafael Fonseca, MD
Journal: Blood
Blood (2016) 128 (22): 3452.
https://doi.org/10.1182/blood.V128.22.3452.3452
Published: 2016
Journal Articles

Immunomodulatory Drugs Inhibit H 2 O 2 Decomposition in Multiple Myeloma Cells and Its Mediated Cytotoxicity Is Determined By Cellular Antioxidative Capacity

Sinto Sebastian Chirackal, PhD, Yuan Xiao Zhu, PhD, Esteban Braggio, PhD, Chang-Xin Shi, PhD, Sonali Panchabhai, MBBS, Gregory Ahmann, BS, Scott A. Van Wier, BS, Marta Chesi, PhD, Leif Bergsagel, MD PhD, Keith Stewart, MD, Rafael Fonseca, MD
Journal: Blood
Blood (2015) 126 (23): 2475.
https://doi.org/10.1182/blood.V126.23.2475.2475
Published: 2015
Journal Articles

Ornithine Decarboxylase: Novel Prognostic Marker and Target for Multiple Myeloma Therapy

Sonali Panchabhai, MBBS, Ilana Miriam Schlam, MD, Sinto Sebastian Chirackal, PhD, Rafael Fonseca, MD
Journal: Blood
Blood (2015) 126 (23): 1824.
https://doi.org/10.1182/blood.V126.23.1824.1824
Published: 2015
Journal Articles

PRIMA-1 (p53 Reactivation and Induction of Massive Apoptosis) Mediates Anti-Myeloma Effect through the ER Stress Pathway

Phaik Ju Teoh, Chonglei Bi, Sinto Sebastian, PhD, Rafael Fonseca, MD, Wee Joo Chng, MD PhD
Journal: Blood
Blood (2014) 124 (21): 2093.
https://doi.org/10.1182/blood.V124.21.2093.2093
Published: 2014
Journal Articles

Intracellular Accumulation Of Light Chains Caused By Lenalidomide, and Mediated Via CRBN, Causes Major ER Stress and Is Implicated In The Synergistic Combination Of Imids and Proteasome Inhibitors

Sinto Sebastian, Ph.D., Yuan Xiao Zhu, PhD, Esteban Braggio, Ph.D., Sonali Panchabhai, MBBS, Chang-Xin Shi, Ph.D., Gregory Ahmann, BS, Leif Bergsagel, M.D., Rafael Fonseca, M.D.
Journal: Blood
Blood (2013) 122 (21): 4434.
https://doi.org/10.1182/blood.V122.21.4434.4434
Published: 2013
Journal Articles

Role Of Folate Receptor Targeted Therapy In Multiple Myeloma

Sonali Panchabhai, MBBS, Katalin Kelemen, MD, PhD, Sinto Sebastian Chirackal, PhD, BSc, MSc, Rafael Fonseca, M.D.
Journal: Blood
Blood (2013) 122 (21): 4436.
https://doi.org/10.1182/blood.V122.21.4436.4436
Published: 2013
Journal Articles

PARP Inhibition (OLAPARIB) Enhance Melphalan and Nutlin-3a Sensitivity in TP53 Positive Multiple Myeloma

Sinto Sebastian, Ph.D., Marta Chesi, PhD, Esteban Braggio, Ph.D., Leif Bergsagel, MD, Keith Stewart, MBA, MB, CHB, Gregory Ahmann, BS, Rafael Fonseca, MD
Journal: Blood
Blood (2012) 120 (21): 1846.
https://doi.org/10.1182/blood.V120.21.1846.1846
Published: 2012