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Journal Articles

A Proteogenomic Approach to Identify Potential Drivers of Hyperdiploid Multiple Myeloma

J Erin Wiedmeier-Nutor, Surendra Dasari, Richard Kumaran Kandasamy, Kiran Manalaparthi, Laura Ann Bruins, Gregory Ahmann, Mariano Arribas, P. Leif Bergsagel, Akhilesh Pandey, Esteban Braggio, Rafael Fonseca

Blood (2024) 144 (Supplement 1): 3269.

https://doi.org/10.1182/blood-2024-206239

Published: 2024

Journal Articles

Unraveling Antioxidative Metabolic Pathways in Multiple Myeloma: Augmenting IMiD Sensitivity through Intracellular Cysteine Biosynthesis Inhibition

Sinto Sebastian Chirackal, Taro Hitosugi, Gregory Ahmann, Esteban Braggio, Marta Chesi, P. Leif Bergsagel, Rafael Fonseca

Blood (2023) 142 (Supplement 1): 3291.

https://doi.org/10.1182/blood-2023-189785

Published: 2023

Journal Articles

Beyond the Primary: Unveiling the Prognostic Value of Secondary Cytogenetic Abnormalities in Multiple Myeloma

Rodrigo Fonseca, Mariano Arribas, Gregory Ahmann, Janna C Castro, Erin E Wiedmeier-Nutor, Linda Banovic Baughn, P. Leif Bergsagel, Rafael Fonseca

Blood (2023) 142 (Supplement 1): 2000.

https://doi.org/10.1182/blood-2023-190701

Published: 2023

Journal Articles

Evaluation of Revised International Staging System for Transplant-Eligible Multiple Myeloma Patients

Veronica Gonzalez-Calle, MD, Abigail Slack, Susan Luft, M.S., R.N., Kathryn Pearce, Rhett P. Ketterling, MD, Tania Jain, M.B., B.S, Sinto Sebastian Chirackal, PhD, Craig B. Reeder, MD, Joseph Mikhael, MD, Leif Bergsagel, MD, Pierre Noel, MD, Angela Mayo, P.A.-C., M.S., James L. Slack, MD, Roberta H. Adams, MD, Gregory Ahmann, Esteban Braggio, PhD, Keith Stewart, M.B., Ch.B., Scott Van Wier, Rafael Fonseca, MD

Blood (2016) 128 (22): 3452.

https://doi.org/10.1182/blood.V128.22.3452.3452

Published: 2016

Journal Articles

Selinexor and Low Dose Dexamethasone (Sd) in Patients with Lenalidomide, Pomalidomide, Bortezomib, Carfilzomib and Anti-CD38 Ab Refractory Multiple Myeloma (MM): STORM Study

Blood (2016) 128 (22): 491.

https://doi.org/10.1182/blood.V128.22.491.491

Published: 2016

Journal Articles

Complementary Activation of Ccnd, MYC, RAS and NFkB By Mutations in Multiple Myeloma

Kristine Misund, PhD, Niamh Keane, MD, Yan W Asmann, PhD, Scott Van Wier, Daniel Riggs, PhD, Gregory Ahmann, Marta Chesi, PhD, K. Martin Körtum, MD, Rafael Fonseca, MD, A. Keith Stewart, MD, Esteban Braggio, PhD, P. Leif Bergsagel, MD

Blood (2016) 128 (22): 355.

https://doi.org/10.1182/blood.V128.22.355.355

Published: 2016

Journal Articles

Lenalidomide Inhibits Thioredoxin Reductase (TrxR) in Multiple Myeloma (MM) Cells but Direct Inhibition of Trxr and Thioredoxin (Trx) Can Bypass Requirement of Cereblon (CRBN)

Sinto Sebastian Chirackal, PhD, Esteban Braggio, PhD, Yuan Xiao Zhu, PhD, Chang-Xin Shi, PhD, Scott Van Wier, Gregory Ahmann, Veronica Gonzalez-Calle, MD, Marta Chesi, PhD, Leif Bergsagel, MD, Keith Stewart, M.B., Ch.B., Rafael Fonseca, MD

Blood (2016) 128 (22): 4482.

https://doi.org/10.1182/blood.V128.22.4482.4482

Published: 2016

Journal Articles

A Second Generation, Multiple Myeloma-Specific, Targeted Sequencing Platform for Detecting Translocations, Copy Number Alterations, and Single Nucleotide Variants

Brian S White, PhD, Irena Lanc, PhD, Daniel Auclair, PhD, Robert Fulton, PhD, Mark A Fiala, BS, CCRP, Justin King, Gregory Ahmann, BS, Mary Derome, MS, Elaine R Mardis, PhD, Joan Levy, PhD, Ravi Vij, MD MBA, John F. DiPersio, MD PhD, Michael Tomasson, MD

Blood (2015) 126 (23): 4207.

https://doi.org/10.1182/blood.V126.23.4207.4207

Published: 2015

Journal Articles

Immunomodulatory Drugs Inhibit H 2 O 2 Decomposition in Multiple Myeloma Cells and Its Mediated Cytotoxicity Is Determined By Cellular Antioxidative Capacity

Sinto Sebastian Chirackal, PhD, Yuan Xiao Zhu, PhD, Esteban Braggio, PhD, Chang-Xin Shi, PhD, Sonali Panchabhai, MBBS, Gregory Ahmann, BS, Scott A. Van Wier, BS, Marta Chesi, PhD, Leif Bergsagel, MD PhD, Keith Stewart, MD, Rafael Fonseca, MD

Blood (2015) 126 (23): 2475.

https://doi.org/10.1182/blood.V126.23.2475.2475

Published: 2015

Journal Articles

Development and Results of a Multiple Myeloma Specific Custom 77-Gene Mutation Panel for Clinical Targeted Sequencing

K. Martin Kortuem, MD, A. Keith Stewart, MD, Laura Ann Bruins, Gregory Ahmann, BS, George Vasmatzis, PhD, S. Vincent Rajkumar, MD, Shaji Kumar, MD, Angela Dispenzieri, MD, Martha Q Lacy, MD, Morie A Gertz, MD, Rafael Fonseca, MD, Mia Champion, PhD, P. Leif Bergsagel, MD, Esteban Braggio, PhD

Blood (2014) 124 (21): 169.

https://doi.org/10.1182/blood.V124.21.169.169

Published: 2014

Journal Articles

Intracellular Accumulation Of Light Chains Caused By Lenalidomide, and Mediated Via CRBN, Causes Major ER Stress and Is Implicated In The Synergistic Combination Of Imids and Proteasome Inhibitors

Sinto Sebastian, Ph.D., Yuan Xiao Zhu, PhD, Esteban Braggio, Ph.D., Sonali Panchabhai, MBBS, Chang-Xin Shi, Ph.D., Gregory Ahmann, BS, Leif Bergsagel, M.D., Rafael Fonseca, M.D.

Blood (2013) 122 (21): 4434.

https://doi.org/10.1182/blood.V122.21.4434.4434

Published: 2013

Journal Articles

Uncovering the biology of multiple myeloma among African Americans: a comprehensive genomics approach

Angela Baker, Esteban Braggio, Susanna Jacobus, Sungwon Jung, Dirk Larson, Terry Therneau, Angela Dispenzieri, Scott A. Van Wier, Gregory Ahmann, Joan Levy, Louise Perkins, Seungchan Kim, Kimberly Henderson, David Vesole, S. Vincent Rajkumar, Diane F. Jelinek, John Carpten, Rafael Fonseca

Blood (2013) 121 (16): 3147–3152.

https://doi.org/10.1182/blood-2012-07-443606

Published: 2013

Includes: Supplemental data

Journal Articles

PARP Inhibition (OLAPARIB) Enhance Melphalan and Nutlin-3a Sensitivity in TP53 Positive Multiple Myeloma

Sinto Sebastian, Ph.D., Marta Chesi, PhD, Esteban Braggio, Ph.D., Leif Bergsagel, MD, Keith Stewart, MBA, MB, CHB, Gregory Ahmann, BS, Rafael Fonseca, MD

Blood (2012) 120 (21): 1846.

https://doi.org/10.1182/blood.V120.21.1846.1846

Published: 2012

Journal Articles

Cereblon Expression Predicts Response, Progression Free and Overall Survival After Pomalidomide and Dexamethasone Therapy in Multiple Myeloma

Blood (2012) 120 (21): 194.

https://doi.org/10.1182/blood.V120.21.194.194

Published: 2012

Journal Articles

Generation of An Automated Tool for the Identification of Genetics Markers and Signatures in Multiple Myeloma Risk-Stratification

Esteban Braggio, PhD, Jonathan J Keats, PhD, Shaji Kumar, MD, Gregory Ahmann, BS, Jeremy Mantei, Keith Stewart, MBA, MB, CHB, P.Leif Bergsagel, MD, Rafael Fonseca, MD

Blood (2011) 118 (21): 2881.

https://doi.org/10.1182/blood.V118.21.2881.2881

Published: 2011

Journal Articles

HOXA9 Is a Novel Therapeutic Target in Multiple Myeloma.

Michael A Chapman, Jean-Philippe Brunet, Jonathan J Keats, PhD, Angela Baker, Mazhar Adli, Anna C. Schinzel, Gregory Ahmann, BS, Harview Christina, Anna Moore, Vijayalakshmi Shanmugam, Louise M. Perkins, PhD, Daniel Auclair, PhD, William C. Hahn, MD, PhD, Bradley E. Bernstein, MD, Leif Bergsagel, Rafael Fonseca, John Carpten, Jeffrey Trent, Todd R. Golub, MD

Blood (2009) 114 (22): 832.

https://doi.org/10.1182/blood.V114.22.832.832

Published: 2009

Journal Articles

CpG Methylation Profiling in Multiple Myeloma.

Bodour Salhia, PhD, Angela Baker, PhD, Jonathan J Keats, PhD, Gregory Ahmann, BS, Daniel Auclair, PhD, Bunmi Mfuko, Louise M. Perkins, PhD, Joan Levy, PhD, Leif Bergsagel, MD, Rafael Fonseca, MD, John Carpten, PhD

Blood (2009) 114 (22): 604.

https://doi.org/10.1182/blood.V114.22.604.604

Published: 2009

Journal Articles

Interim Analyses of the MMRC Reference Collection Identifies Recurrent Genomic-Level Events in Multiple Myeloma and Demonstrates That CDKN2C/p18 Deletion Is the Pre-Eminent Copy Number Alteration in Poor Prognosis Disease

Michael A Chapman, Jean-Philippe Brunet, Angela Baker, Jonathan Keats, Gregory Ahmann, BS, Anna C Schinzel, PhD, Anna Moore, Vijayalakshmi Shanmugam, Louise M. Perkins, PhD, Daniel Auclair, PhD, William C. Hahn, M.D., Ph.D, P. Leif Bergsagel, MD, Rafael Fonseca, MD, John Carpten, Jeffrey Trent, Todd R. Golub, MD

Blood (2008) 112 (11): 497.

https://doi.org/10.1182/blood.V112.11.497.497

Published: 2008

Journal Articles

Genomc-Wide Profiling of Gene Expression and DNA Copy Number Alterations in Multiple Myeloma.

Jonathan Keats, PhD, Mike Chapman, PhD, John Carpten, PhD, Wee-Joo Chng, MD, Angela Baker, PhD, Gregory Ahmann, Suzanne Trudel, MD, David Siegel, MD, PhD, S. Vincent Rajkumar, MD, Melissa Alsina, MD, Paul Richardson, MD, Kenneth Anderson, MD, Daniel Auclair, PhD, Louise M. Perkins, PhD, Jeffrey Trent, PhD, Todd R. Golub, MD, Rafael Fonseca, MD

Blood (2007) 110 (11): 396.

https://doi.org/10.1182/blood.V110.11.396.396

Published: 2007

Journal Articles

Combined High Resolution Array Comparative Genomic Hybridization and Gene Expression Profiling Reveal Rb1 Haploinsufficiency as a Possibile Tumorigenic Mechanism in Myeloma.

Wee-Joo Chng, MD, Angela Baker, PhD, Travis Henry, PhD, Tammy Price-Troska, Scott Van Wier, Tae-Hoon Chung, PhD, Kim Henderson, Gregory Ahmann, Martha Lacy, MD, Angela Dispenzieri, MD, Morie Abraham Gertz, MD, Philip Greipp, MD, Peter Leif Bergsagel, MD, John Carpten, PhD, Rafael Fonseca, MD

Blood (2006) 108 (11): 113.

https://doi.org/10.1182/blood.V108.11.113.113

Published: 2006

NARROW

A Proteogenomic Approach to Identify Potential Drivers of Hyperdiploid Multiple Myeloma

Unraveling Antioxidative Metabolic Pathways in Multiple Myeloma: Augmenting IMiD Sensitivity through Intracellular Cysteine Biosynthesis Inhibition

Beyond the Primary: Unveiling the Prognostic Value of Secondary Cytogenetic Abnormalities in Multiple Myeloma

Evaluation of Revised International Staging System for Transplant-Eligible Multiple Myeloma Patients

Selinexor and Low Dose Dexamethasone (Sd) in Patients with Lenalidomide, Pomalidomide, Bortezomib, Carfilzomib and Anti-CD38 Ab Refractory Multiple Myeloma (MM): STORM Study

Complementary Activation of Ccnd, MYC, RAS and NFkB By Mutations in Multiple Myeloma

Lenalidomide Inhibits Thioredoxin Reductase (TrxR) in Multiple Myeloma (MM) Cells but Direct Inhibition of Trxr and Thioredoxin (Trx) Can Bypass Requirement of Cereblon (CRBN)

A Second Generation, Multiple Myeloma-Specific, Targeted Sequencing Platform for Detecting Translocations, Copy Number Alterations, and Single Nucleotide Variants

Immunomodulatory Drugs Inhibit H 2 O 2 Decomposition in Multiple Myeloma Cells and Its Mediated Cytotoxicity Is Determined By Cellular Antioxidative Capacity

Development and Results of a Multiple Myeloma Specific Custom 77-Gene Mutation Panel for Clinical Targeted Sequencing

Intracellular Accumulation Of Light Chains Caused By Lenalidomide, and Mediated Via CRBN, Causes Major ER Stress and Is Implicated In The Synergistic Combination Of Imids and Proteasome Inhibitors

Uncovering the biology of multiple myeloma among African Americans: a comprehensive genomics approach

PARP Inhibition (OLAPARIB) Enhance Melphalan and Nutlin-3a Sensitivity in TP53 Positive Multiple Myeloma

Cereblon Expression Predicts Response, Progression Free and Overall Survival After Pomalidomide and Dexamethasone Therapy in Multiple Myeloma

Generation of An Automated Tool for the Identification of Genetics Markers and Signatures in Multiple Myeloma Risk-Stratification

HOXA9 Is a Novel Therapeutic Target in Multiple Myeloma.

CpG Methylation Profiling in Multiple Myeloma.

Interim Analyses of the MMRC Reference Collection Identifies Recurrent Genomic-Level Events in Multiple Myeloma and Demonstrates That CDKN2C/p18 Deletion Is the Pre-Eminent Copy Number Alteration in Poor Prognosis Disease

Genomc-Wide Profiling of Gene Expression and DNA Copy Number Alterations in Multiple Myeloma.

Combined High Resolution Array Comparative Genomic Hybridization and Gene Expression Profiling Reveal Rb1 Haploinsufficiency as a Possibile Tumorigenic Mechanism in Myeloma.

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American Society of Hematology

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American Society of Hematology

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