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Journal Articles

Preclinical Activity of Allogeneic CS1-Specific CAR T-Cells (UCARTCS1) in Multiple Myeloma

Charlotte L.B.M. Korst, Wassilis S.C. Bruins, Meliha Cosovic, Christie P.M. Verkleij, Inoka Twickler, Diane Le Clerre, Isabelle Chion-Sotinel, Sonja Zweegman, Roman Galetto, Tuna Mutis, Niels WCJ Van De Donk

Blood (2022) 140 (Supplement 1): 4215–4216.

https://doi.org/10.1182/blood-2022-157950

Published: 2022

Journal Articles

Ameli-01: Phase I, Open Label Dose-Escalation and Dose-Expansion Study to Evaluate the Safety, Expansion, Persistence and Clinical Activity of UCART123 (allogeneic engineered T-cells expressing anti-CD123 chimeric antigen receptor), Administered in Patients with Relapsed/Refractory Acute Myeloid Leukemia

Gail J. Roboz, MD, Daniel J. DeAngelo, MD PhD, David A. Sallman, MD, Monica L. Guzman, PhD, Pinkal Desai, MDMPH, Hagop M. Kantarjian, MD, Marina Konopleva, MD PhD, Nelli Bejanyan, MD, Hany Elmariah, MD MS, Francisco Javier Esteva, MD PhD, Andrew Garton, Kate Backhouse, Roman Galetto, PhD, Carrie Brownstein, MD, Naveen Pemmaraju, MD

Blood (2020) 136 (Supplement 1): 41–42.

https://doi.org/10.1182/blood-2020-138984

Published: 2020

Journal Articles

Investigation of Allocar T TM Targeting CD70 As a Potential Therapy for an Array of Hematological Malignancies

Siler Panowski, PhD, Surabhi Srinivasan, MS, Thomas Van Blarcom, PhD, Cesar Sommer, PhD, Hsin-Yuan Cheng, PhD, Thomas Pertel, PhD, Marianne A Santaguida, PhD, Roman Galetto, PhD, Alan Dunlop, BSc, MSc, Reuben Benjamin, MD, Barbra Sasu, PhD

Blood (2019) 134 (Supplement_1): 5157.

https://doi.org/10.1182/blood-2019-128808

Published: 2019

Journal Articles

Efficacy Proof of Concept for Allogeneic CD123 Targeting CAR T-Cells Against Primary Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN): Efficient Control of Tumor Progression in PDX Model and Potential Loss of CD123 Expression in Relapsed Disease

Blood (2019) 134 (Supplement_1): 2659.

https://doi.org/10.1182/blood-2019-126869

Published: 2019

Journal Articles

ALLO-715, an Allogeneic BCMA CAR T Therapy Possessing an Off-Switch for the Treatment of Multiple Myeloma

Cesar Sommer, PhD, Bijan Boldajipour, PhD, Julien Valton, PhD, Roman Galetto, PhD, Trevor Bentley, Janette Sutton, Yajin Ni, PhD, Mark Leonard, PhD, Thomas Van Blarcom, PhD, Julianne Smith, PhD, Javier Chaparro-Riggers, PhD, Barbra Sasu, PhD

Blood (2018) 132 (Supplement 1): 591.

https://doi.org/10.1182/blood-2018-99-119227

Published: 2018

Journal Articles

Pre-Clinical Activity of Allogeneic Anti-CD22 CAR-T Cells for the Treatment of B-Cell Acute Lymphoblastic Leukemia

Julia Wells, PhD, Tianyu Cai, PhD, Cécile Schiffer-Manniou, PhD, Stéphanie Filipe, PhD, Agnès Gouble, PhD, Roman Galetto, PhD, Nitin Jain, MD, Elias J. Jabbour, MD, Julianne Smith, PhD, Marina Konopleva, MD PhD

Blood (2017) 130 (Supplement 1): 808.

https://doi.org/10.1182/blood.V130.Suppl_1.808.808

Published: 2017

Journal Articles

Pre-Clinical Studies of Allogeneic Anti-CD123 CAR T-Cells for the Therapy of Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)

Tianyu Cai, PhD, Roman Galetto, PhD, Agnès Gouble, PhD, Julianne Smith, PhD, Antonio Cavazos, MSc, Lina Han, PhD, Qi Zhang, PhD MD, Vinitha Mary Kuruvilla, Sergej Naumovich Konoplev, MD PhD, Sattva S. Neelapu, MD, Andrew A. Lane, MD PhD, Monica L. Guzman, PhD, Hagop M. Kantarjian, MD, Naveen Pemmaraju, MD, Marina Konopleva, MD PhD

Blood (2017) 130 (Supplement 1): 2625.

https://doi.org/10.1182/blood.V130.Suppl_1.2625.2625

Published: 2017

Journal Articles

Universal SLAMF7-Specific CAR T-Cells As Treatment for Multiple Myeloma

Rohit Mathur, PhD, Zheng Zhang, Jin He, Roman Galetto, PhD, Agnès Gouble, PhD, Isabelle Chion-Sotinel, Stéphanie Filipe, PhD, Annabelle Gariboldi, Tanooha Veeramachaneni, Elisabet E. Manasanch, MD, Sheeba K. Thomas, MD, Hans C. Lee, MD, Krina K. Patel, MDMSc, Donna M. Weber, MD, R. Eric Davis, MD, Robert J. Orlowski, MD PhD, Julianne Smith, PhD, Jing Yang, PhD, Sattva S. Neelapu, MD

Blood (2017) 130 (Supplement 1): 502.

https://doi.org/10.1182/blood.V130.Suppl_1.502.502

Published: 2017

Journal Articles

Pre-Clinical Studies of Anti-CD123 CAR-T Cells for the Treatment of Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)

Tianyu Cai, PhD, Roman Galetto, PhD, Agnès Gouble, PhD, Julianne Smith, PhD, Antonio Cavazos, MS, Sergej Konoplev, MD PhD, Andrew A. Lane, MD PhD, Monica L. Guzman, PhD, Hagop M. Kantarjian, MD, Naveen Pemmaraju, MD, Marina Konopleva, MD PhD

Blood (2016) 128 (22): 4039.

https://doi.org/10.1182/blood.V128.22.4039.4039

Published: 2016

Journal Articles

Selection and Characterization of Antibody Clones Are Critical for Accurate Flow Cytometry-Based Monitoring of CD123 in Acute Myeloid Leukemia

Nicole M. Cruz, MD, Linda Lam, Mayumi Sugita, MD, Roman Galetto, PhD, Agnès Gouble, PhD, Julianne Smith, PhD, Gail J. Roboz, Monica L. Guzman, PhD

Blood (2016) 128 (22): 1693.

https://doi.org/10.1182/blood.V128.22.1693.1693

Published: 2016

Journal Articles

Preclinical Evaluation of Allogeneic Anti-Bcma Chimeric Antigen Receptor T Cells with Safety Switch Domains and Lymphodepletion Resistance for the Treatment of Multiple Myeloma

Bijan Boldajipour, PhD, Roman Galetto, PhD, Cesar Sommer, PhD, Thomas Pertel, PhD, Julien Valton, PhD, Yoon Park, PhD, Annabelle Gariboldi, Amy Chen, Tao Geng, Hong H Dong, Gregory R Boucher, Thomas J Van Blarcom, PhD, Javier Chaparro-Riggers, PhD, Arvind Rajpal, PhD, Julianne Smith, PhD, Tracy Kuo, PhD, Barbra Sasu, PhD

Blood (2016) 128 (22): 381.

https://doi.org/10.1182/blood.V128.22.381.381

Published: 2016

Journal Articles

Gene Editing of the Human Pklr Gene in Human Hematopoietic Progenitors to Correct Pyruvate Kinase Deficiency

Oscar Quintana-Bustamante, Sara Fañanas, Israel Orman, Agnès Gouble, PhD, Roman Galetto, PhD, Laurent Poirot, PhD, Juan A. Bueren, PhD, Jose C. Segovia, PhD

Blood (2016) 128 (22): 3513.

https://doi.org/10.1182/blood.V128.22.3513.3513

Published: 2016

Journal Articles

Allogeneic Tcrα/β Deficient CAR T-Cells Targeting CD123 Prolong Overall Survival of AML Patient-Derived Xenografts

Monica L. Guzman, PhD, Mayumi Sugita, MD, Hongliang Zong, MD PhD, Nathan Ewing-Crystal, Vicenta Trujillo-Alonso, Nuria Mencia-Trinchant, PhD, Linda Lam, Nicole M. Cruz, MD, Roman Galetto, PhD, Agnès Gouble, PhD, Duane C Hassane, PhD, Julianne Smith, PhD, Gail J. Roboz

Blood (2016) 128 (22): 765.

https://doi.org/10.1182/blood.V128.22.765.765

Published: 2016

Journal Articles

TCRab Deficient CAR T-Cells Targeting CD123: An Allogeneic Approach of Adoptive Immunotherapy for the Treatment of Acute Myeloid Leukemia (AML)

Roman Galetto, PhD, Céline Lebuhotel, Agnès Gouble, PhD, Nuria Mencia-Trinchant, PhD, Cruz M Nicole, MD, Gail J. Roboz, MD, Monica L. Guzman, PhD, Julianne Smith, PhD

Blood (2015) 126 (23): 2555.

https://doi.org/10.1182/blood.V126.23.2555.2555

Published: 2015

Journal Articles

Bypassing the Constraint for Chimeric Antigen Receptor (CAR) Development in T-Cells Expressing the Targeted Antigen: Improvement of Anti-CS1 CAR Activity in Allogenic TCRa/CS1 Double Knockout T-Cells for the Treatment of Multiple Myeloma (MM)

Roman Galetto, PhD, Isabelle Chion-Sotinel, Agnès Gouble, PhD, Julianne Smith, PhD

Blood (2015) 126 (23): 116.

https://doi.org/10.1182/blood.V126.23.116.116

Published: 2015

Journal Articles

In Vivo Proof of Concept of Activity and Safety of UCART19, an Allogeneic “Off-the-Shelf” Adoptive T-Cell Immunotherapy Against CD19 + B-Cell Leukemias

Agnes Gouble, Brian Philip, Laurent Poirot, Cecile Schiffer-Mannioui, Roman Galetto, Sophie Derniame, Gordon Weng-Kit Cheung, Sylvain Arnould, Carole Desseaux, Martin Pule, Julianne Smith

Blood (2014) 124 (21): 4689.

https://doi.org/10.1182/blood.V124.21.4689.4689

Published: 2014

Journal Articles

Multiplex Genome Editing As a Platform for “Off-the-Shelf” Adoptive CAR T-Cell Immunotherapies

Sophie Derniame, Hong Zhan, Laurent Poirot, Cecile Schiffer-Mannioui, Roman Galetto, Marine Beurdeley, Stephan Reynier, Sylvain Arnould, Waseem Qasim, Julianne Smith

Blood (2014) 124 (21): 1111.

https://doi.org/10.1182/blood.V124.21.1111.1111

Published: 2014

Journal Articles

Allogenic T-Cells Targeting CD123 for Adoptive Immunotherapy of Acute Myeloid Leukemia (AML)

Roman Galetto, Celine Lebuhotel, Agnes Gouble, Cecile Schiffer-Mannioui, Julianne Smith

Blood (2014) 124 (21): 1116.

https://doi.org/10.1182/blood.V124.21.1116.1116

Published: 2014

NARROW

Preclinical Activity of Allogeneic CS1-Specific CAR T-Cells (UCARTCS1) in Multiple Myeloma

Investigation of Allocar T TM Targeting CD70 As a Potential Therapy for an Array of Hematological Malignancies

Efficacy Proof of Concept for Allogeneic CD123 Targeting CAR T-Cells Against Primary Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN): Efficient Control of Tumor Progression in PDX Model and Potential Loss of CD123 Expression in Relapsed Disease

ALLO-715, an Allogeneic BCMA CAR T Therapy Possessing an Off-Switch for the Treatment of Multiple Myeloma

Pre-Clinical Activity of Allogeneic Anti-CD22 CAR-T Cells for the Treatment of B-Cell Acute Lymphoblastic Leukemia

Pre-Clinical Studies of Allogeneic Anti-CD123 CAR T-Cells for the Therapy of Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)

Universal SLAMF7-Specific CAR T-Cells As Treatment for Multiple Myeloma

Pre-Clinical Studies of Anti-CD123 CAR-T Cells for the Treatment of Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)

Selection and Characterization of Antibody Clones Are Critical for Accurate Flow Cytometry-Based Monitoring of CD123 in Acute Myeloid Leukemia

Preclinical Evaluation of Allogeneic Anti-Bcma Chimeric Antigen Receptor T Cells with Safety Switch Domains and Lymphodepletion Resistance for the Treatment of Multiple Myeloma

Gene Editing of the Human Pklr Gene in Human Hematopoietic Progenitors to Correct Pyruvate Kinase Deficiency

Allogeneic Tcrα/β Deficient CAR T-Cells Targeting CD123 Prolong Overall Survival of AML Patient-Derived Xenografts

TCRab Deficient CAR T-Cells Targeting CD123: An Allogeneic Approach of Adoptive Immunotherapy for the Treatment of Acute Myeloid Leukemia (AML)

Bypassing the Constraint for Chimeric Antigen Receptor (CAR) Development in T-Cells Expressing the Targeted Antigen: Improvement of Anti-CS1 CAR Activity in Allogenic TCRa/CS1 Double Knockout T-Cells for the Treatment of Multiple Myeloma (MM)

In Vivo Proof of Concept of Activity and Safety of UCART19, an Allogeneic “Off-the-Shelf” Adoptive T-Cell Immunotherapy Against CD19 + B-Cell Leukemias

Multiplex Genome Editing As a Platform for “Off-the-Shelf” Adoptive CAR T-Cell Immunotherapies

Allogenic T-Cells Targeting CD123 for Adoptive Immunotherapy of Acute Myeloid Leukemia (AML)

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American Society of Hematology

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ASH Publications

American Society of Hematology

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