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Rahul Palchaudhuri, PhD
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Journal Articles

Single Agent CD45-Targeted Antibody Drug Conjugate Enables Full Mismatch Allogeneic Hematopoietic Stem Cell Transplantation in a Murine HSCT Model

Sharon L. Hyzy, MS, Jennifer L Proctor, BS, Geoff O Gillard, PhD, Katelyn J. Hammond, BS, Ganapathy N. Sarma, PhD, Asim Saha, PhD, Nicholas Clark, PhD, Anjali Bhat, MS, Tahirih L Lamothe, BS, Rahul Palchaudhuri, PhD, Bradley R Pearse, PhD, Charlotte F McDonagh, PhD, Hans-Peter Kiem, MDPhD, John E Wagner, MD, Bruce R. Blazar, MD, Anthony E Boitano, PhD, Michael P Cooke, PhD, John C. Davis, Jr., MD MPH, MS
Journal: Blood
Blood (2020) 136 (Supplement 1): 31.
https://doi.org/10.1182/blood-2020-140489
Published: 2020
Journal Articles

Reversing Clonal Hematopoiesis and Associated Atherosclerotic Disease By Targeted Antibody-Drug-Conjugate (ADC) Conditioning and Transplant

Karin Gustafsson, PhD, Catherine S Rhee, PhD, Elizabeth W Scadden, Vanessa Frodermann, Rahul Palchaudhuri, PhD, Sharon L. Hyzy, MS, Jennifer L Proctor, BS, Geoff O Gillard, PhD, Anthony E Boitano, PhD, Michael P. Cooke, PhD, Matthias Nahrendorf, PhD, David T. Scadden, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 34–35.
https://doi.org/10.1182/blood-2020-143176
Published: 2020
Journal Articles

A Single Dose of a Novel Anti-Human CD117-Amanitin Antibody Drug Conjugate (ADC) Engineered for a Short Half-Life Provides Dual Conditioning and Anti-Leukemic Activity and Extends Survival Compared to Standard of Care in Multiple Preclinical Models of Acute Myeloid Leukemia (AML)

Leanne Lanieri, Tahirih L Lamothe, BS, Oliver Miske, Sean M McDonough, Ganapathy N Sarma, Prashant Bhattarai, Kellie Latimer, Junia Dushime, Nidhi Jain, Rahul Palchaudhuri, PhD, Ryan Knihtila, Bradley R Pearse, PhD, Jennifer L Proctor, BS, Anthony E Boitano, PhD, Michael P Cooke, PhD, John C. Davis, Jr., MD MPH, MS
Journal: Blood
Blood (2020) 136 (Supplement 1): 47–48.
https://doi.org/10.1182/blood-2020-140422
Published: 2020
Journal Articles

A Single Dose of CD117 Antibody Drug Conjugate Enables Autologous Gene-Modified Hematopoietic Stem Cell Transplant (Gene Therapy) in Nonhuman Primates

John F. Tisdale, MD, Robert E. Donahue, VMD, Naoya Uchida, MD, Bradley R Pearse, PhD, Sean M McDonough, MS, Jennifer L Proctor, BS, Allen Krouse, Nathaniel S. Linde, Aylin C. Bonifacino, Rajiv Panwar, PhD, Ganapathy N. Sarma, PhD, Lena Kien, BS, Kellie Latimer, Junia Dushime, BS, Sharon L. Hyzy, MS, Melissa L. Brooks, BS, Rahul Palchaudhuri, PhD, Qing Li, PhD, Pranoti Sawant, MS, Charlotte F McDonagh, PhD, Anthony E. Boitano, PhD, Michael P. Cooke, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 610.
https://doi.org/10.1182/blood-2019-125968
Published: 2019
Journal Articles

A Novel Targeted Approach to Achieve Immune System Reset: CD45-Targeted Antibody Drug Conjugates Enable Autologous HSCT, Ameliorate Disease in Autoimmune Models, Potently Kill Human Immune Cells from Normal Donors and MS Patients, and Achieve Immune Depletion in Non-Human Primates (NHP)

Geoff O Gillard, Jennifer L Proctor, BS, Melissa L. Brooks, BS, Tahirih L Lamothe, BS, Sharon L. Hyzy, MS, Oliver Mikse, Sean McDonough, Rahul Palchaudhuri, PhD, Anjali Bhat, MS, Ganapathy N. Sarma, PhD, Prashant Bhattarai, Pranoti Sawant, MS, Bradley R Pearse, PhD, Charlotte F. Mcdonough, PhD, Anthony E. Boitano, PhD, Michael P. Cooke, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3208.
https://doi.org/10.1182/blood-2019-130752
Published: 2019
Journal Articles

CD117-Amanitin Antibody Drug Conjugates Effectively Deplete Human and Non-Human Primate HSCs: Proof of Concept As a Targeted Strategy for Conditioning Patients for Bone Marrow Transplant

Bradley R Pearse, PhD, Sean M McDonough, MS, Jennifer L Proctor, BS, Rajiv Panwar, PhD, Ganapathy Sarma, PhD, Molly A McShea, MS, Lena Kien, BS, Junia Dushime, BS, Hillary L Adams, MS, Sharon L. Hyzy, MS, Melissa L. Brooks, BS, Rahul Palchaudhuri, PhD, Qing Li, PhD, Nathan M Kallen, BA, Pranoti Sawant, MS, Charlotte F McDonagh, PhD, Anthony E. Boitano, PhD, Michael P. Cooke, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3314.
https://doi.org/10.1182/blood-2018-99-114881
Published: 2018
Journal Articles

Single Doses of Antibody Drug Conjugates (ADCs) Targeted to CD117 or CD45 Have Potent In Vivo Anti-Leukemia Activity and Survival Benefit in Patient Derived AML Models

Jennifer L Proctor, BS, Sharon L. Hyzy, MS, Hillary L Adams, MS, Melissa L. Brooks, BS, Andrew D Gabros, Sean M McDonough, MS, Lena Kien, BS, Sharon Aslanian, MS, Bradley R Pearse, PhD, Rahul Palchaudhuri, PhD, Qing Li, PhD, Nathan M Kallen, BA, Ganapathy Sarma, PhD, Molly A McShea, MS, Danielle Ladwig, MS, Junia Dushime, BS, Rajiv Panwar, PhD, Charlotte F McDonagh, PhD, Anthony E. Boitano, PhD, Michael P. Cooke, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3316.
https://doi.org/10.1182/blood-2018-99-112726
Published: 2018
Journal Articles

Targeting CD45 with an Amanitin Antibody-Drug Conjugate Effectively Depletes Human HSCs and Immune Cells for Transplant Conditioning

Rahul Palchaudhuri, PhD, Bradley R Pearse, PhD, Jennifer L Proctor, BS, Sharon L. Hyzy, MS, Sharon Aslanian, MS, Sean M McDonough, MS, Ganapathy Sarma, PhD, Melissa L. Brooks, BS, Anjali Bhat, MS, Danielle Ladwig, MS, Molly A McShea, MS, Nathan M Kallen, BA, Qing Li, PhD, Rajiv Panwar, PhD, Junia Dushime, BS, Pranoti Sawant, MS, Hillary L Adams, MS, Patrick C. Falahee, PhD, Tahirih L Lamothe, Andrew D Gabros, Lena Kien, BS, Geoff Gillard, PhD, Charlotte F McDonagh, PhD, Anthony E. Boitano, PhD, Michael P. Cooke, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4526.
https://doi.org/10.1182/blood-2018-99-117167
Published: 2018
Journal Articles

Non-Genotoxic Conditioning Efficiently Depletes Host Hematopoietic Stem Cells and Facilitates Robust Multi-Lineage Engraftment in a Mouse Model of Fanconi Anemia

Meera Srikanthan, MD, Kevin G. Haworth, PhD, Christina M. Ironside, BS, Jerry Chen, Adam J. Hartigan, PhD, Rahul Palchaudhuri, PhD, Anthony E. Boitano, PhD, Michael P. Cooke, PhD, Hans-Peter Kiem, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2041.
https://doi.org/10.1182/blood-2018-99-116851
Published: 2018
Journal Articles

Antibody Drug Conjugates Targeted to CD45 or CD117 Enable Allogeneic Hematopoietic Stem Cell Transplantation in Animal Models

Rahul Palchaudhuri, PhD, Sharon L. Hyzy, MS, Jennifer L Proctor, BS, Hillary L Adams, MS, Bradley R Pearse, PhD, Ganapathy Sarma, PhD, Sharon Aslanian, MS, Geoff Gillard, PhD, Tahirih L Lamothe, Olga Burenkova, BS, Melissa L. Brooks, BS, Andrew D Gabros, Charlotte F McDonagh, PhD, Anthony E. Boitano, PhD, Michael P. Cooke, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3324.
https://doi.org/10.1182/blood-2018-99-119432
Published: 2018
Journal Articles

Non-Genotoxic Conditioning for Hematopoietic Stem Cell Transplant Using a Human Antibody Drug Conjugate Targeting C-KIT

Adam J. Hartigan, PhD, Bradley R. Pearse, PhD, Sean M. McDonough, Jennifer L. Proctor, BS, Hillary L. Adams, MS, Molly A. McShea, Megan D. Hoban, Rajiv Panwar, PhD, Sharon L. Hyzy, MS, Kevin A. Goncalves, PhD, Rahul Palchaudhuri, PhD BA, Anthony E. Boitano, PhD, Michael P. Cooke, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1894.
https://doi.org/10.1182/blood.V130.Suppl_1.1894.1894
Published: 2017
Journal Articles

Completely Non-Myeloablative/Non-Lymphoablative Conditioning for BMT/HSCT Using Anti-Ckit Immunotoxins

Agnieszka Czechowicz, MD PhD, Rahul Palchaudhuri, PhD, Amelia Scheck, BS, Jonathan Hoggatt, PhD, Borja Saez, PhD, David T. Scadden, MD, Derrick J. Rossi, PhD
Journal: Blood
Blood (2016) 128 (22): 493.
https://doi.org/10.1182/blood.V128.22.493.493
Published: 2016
Journal Articles

Immunotoxin Enables Non-Genotoxic Conditioning for Hematopoietic Stem Cell Transplantation

Rahul Palchaudhuri, PhD, Borja Saez, PhD, Jonathan Hoggatt, PhD, Amir Schajnovitz, David B. Sykes, MD PhD, Michael K Mansour, MD PhD, David T. Scadden, MD
Journal: Blood
Blood (2015) 126 (23): 32.
https://doi.org/10.1182/blood.V126.23.32.32
Published: 2015
Journal Articles

Differentiation Induction In Acute Myeloid Leukemia Using Site-Specific DNA-Targeting

Rahul Palchaudhuri, PhD, Kwan-Keat Ang, Borja Saez, PhD, David B. Sykes, MD, PhD, Gregory L. Verdine, PhD, David T. Scadden, MD
Journal: Blood
Blood (2013) 122 (21): 3940.
https://doi.org/10.1182/blood.V122.21.3940.3940
Published: 2013
Journal Articles

Aldehyde Dehydrogenase 3a2 (Aldh3a2) Represents a Distinct Metabolic Vulnerability in MLL-AF9 AML Leukemia Initiating Cells

Rushdia Z. Yusuf, MBBS, MPH, Sanket S. Acharya, BA, MBS, Vionnie W.C. Yu, PhD, Borja Saez, PhD, Julien M Cobert, BA, John Doench, PhD, Lars Bullinger, MD, PhD, Dana S'aulis, BA, Dongjun Lee, PhD, Rahul Palchaudhuri, PhD, Akachimere C. Uzosike, Mildred Duvet, BA, David J. Logan, PhD, Sudeshna Das, PhD, Colleen M Cook, BA, Michael Churchill, BS, Elizabeth Scadden, BA, Gohar Warraich, Hao Liu, BA, Shrikanta Chattopadhyay, MD, Adam Brown, PhD, Stephen M. Sykes, PhD, David B. Sykes, MD, PhD, Francois Mercier, MD, Anne E. Carpenter, PhD, Scott A. Armstrong, MD, PhD, Matthew Vander Heiden, MD, PhD, Benjamin L. Ebert, Andrew L. Kung, MD, PhD, William B. Rizzo, MD, Siddhartha Mukherjee, MD, PhD, David T. Scadden, MD
Journal: Blood
Blood (2012) 120 (21): 208.
https://doi.org/10.1182/blood.V120.21.208.208
Published: 2012
Journal Articles

Hematopoietic Stem/Progenitor Cell Retention in the Bone Marrow Depends On Tissue Specific Heparan Sulfate Proteoglycans

Borja Saez, PhD, Francesca Ferraro, MD, Rushdia Z. Yusuf, MBBS, MPH, Colleen M Cook, BA, Stephen M. Sykes, PhD, Ana Pardo, PhD, Vionnie W.C. Yu, PhD, Sutada Lotinun, Rahul Palchaudhuri, PhD, Dongjun Lee, PhD, Stefania Lymperi, BSc, MSc, PhD, Robyn Day, Radovan Vasic, Sanket S. Acharya, BA, MBS, Roland Baron, Amy J. Wagers, PhD, David T. Scadden, MD
Journal: Blood
Blood (2012) 120 (21): 637.
https://doi.org/10.1182/blood.V120.21.637.637
Published: 2012