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Rafael Martínez, MD
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Journal Articles

Biomarkers for Predicting Long-Term Disease Control in Transplant-Ineligible Multiple Myeloma Patients: The Presence of an MGUS- like Signature Is the Most Relevant Predictor

Paula Rodriguez Otero, MD, Maria-Victoria Mateos, MD PhD, Joaquin Martinez Lopez, MD PhD, Miguel-Teodoro Hernández, Enrique M. Ocio, MD, Laura Rosiñol, Rafael Martínez, MD, Ana Isabel Teruel, MDcal Doctor, Norma C. Gutierrez, MD PhD, Joan Bargay, MD PhD, Enrique Bengoechea, Yolanda Gonzalez-Montes, Jaime Perez De Oteyza, MD PhD, Mercedes Gironella, MD, Cristina Encinas, Jesús Martín, Carmen Cabrera, Luis Palomera, MD PhD, Felipe De Arriba, PhD, Maria Teresa Cedena Romero, MD PhD, Noemi Puig, MD PhD, Albert Oriol, MD, Bruno Paiva, MD PhD, Joan Bladé, MD, Juan Jose Lahuerta, MD PhD, Jesus F San-Miguel, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4503.
https://doi.org/10.1182/blood-2018-99-117431
Published: 2018
Journal Articles

The Presence of MDS-like Phenotypic Abnormalities (MDS-PA) Identifies Newly Diagnosed Multiple Myeloma (MM) Patients with MDS/AML-Related Somatic Mutations and Inferior Survival

Bruno Paiva, PhD, Noemi Puig, MD PhD, Maria Teresa Cedena, Iria Vazquez, PhD, Carmen Chillon, Yanira Ruiz, Joaquin Martinez-Lopez, Ramon Garcia-Sanz, Marcos González, MD PhD, Xabier Agirre, PhD, Maria-Jose Calasanz, Leire Burgos, Diego Alignani, Felipe Prosper, MD, Sergio Matarraz, Alberto Orfao, MD PhD, Albert Oriol, MD, Ana Isabel Teruel, MD, M Asuncion Echeveste, Raquel De Paz, PhD, Felipe De Arriba, Miguel-T Hernandez, Gemma Azaceta, MD PhD, Rafael Martinez, MD, Maria-Victoria Mateos, MD PhD, Joan Bladé, Juan José Lahuerta, MD PhD, Jesus San Miguel, MDPhD
Journal: Blood
Blood (2016) 128 (22): 375.
https://doi.org/10.1182/blood.V128.22.375.375
Published: 2016
Journal Articles

Ultra-Deep Targeted Sequencing Does Not Identify MM Patients with Different Prognosis: Results from a Randomized Phase II Clinical Trial

Yanira Ruiz-Heredia, Joaquín Martínez-López, MD PhD, Jose Carlos Martínez-Ávila, Beatriz Sanchez-Vega, PhD, Inmaculada Rapado, PhD, Cristina Jimenez, BSc, Esteban Braggio, PhD, Rafael Martinez, MD PhD, Laura Rosiñol, Enrique M. Ocio, MD PhD, M Asuncion Echeveste, Jaime Perez de Oteyza, Albert Oriol, Joan Bargay, MD, Mercedes Gironella, Jesus Martin, Rosa M. Ayala, MD PhD, Joan Bladé, Keith Stewart, M.B., Ch.B., Maria-Victoria Mateos, MD PhD, Jesus San Miguel, MD PhD, Ramon Garcia-Sanz, Juan José Lahuerta, MD PhD, Xabier Aguirre
Journal: Blood
Blood (2016) 128 (22): 2078.
https://doi.org/10.1182/blood.V128.22.2078.2078
Published: 2016
Journal Articles

The Poor Prognosis of High Cytogenetics Abnormalities in Elderly Patients Might be Overcome with an Optimized Total Therapy Approach Including Proteasome Inhibitors, Imid's Compounds and Alkylators

Maria-Victoria Mateos, MD PhD, Norma C Gutierrez, MD PhD, María-Luisa Martín, Joaquín Martínez-López, MD PhD, Miguel-T Hernandez, Enrique M. Ocio, MD PhD, Laura Rosiñol, Rafael Martinez, MD, Ana Isabel Teruel, MD, Albert Oriol, Joan Bargay, MD, Enrique Bengoechea, Yolanda Gonzalez, Jaime Perez de Oteyza, Mercedes Gironella, Cristina Encinas, Jesus Martin, Carmen Cabrera, Bruno Paiva, PhD, Noemi Puig, MD PhD, Joan Bladé, Juan José Lahuerta, MD PhD, Jesus San Miguel, MD PhD
Journal: Blood
Blood (2016) 128 (22): 5688.
https://doi.org/10.1182/blood.V128.22.5688.5688
Published: 2016
Journal Articles

Prognostic Value of Antigen Expression in Multiple Myeloma (MM): A Large GEM/Pethema Study Based in Four Consecutive Clinical Trials

Bruno Paiva, PhD, Noemi Puig, MD PhD, Paula Arana, Teresa Cedena, Lourdes Cordon, Maria Belen Vidriales, MD PhD, Norma C Gutierrez, Joaquin Martinez-López, MDPhD, Miguel T Hernandez, Ana Isabel Teruel, MD, Mercedes Gironella, M Asuncion Echeveste, Laura Rosiñol, MDPhD, Rafael Martinez, MD, Albert Oriol, MDPhD, Javier De La Rubia, Joan Blade, MDPhD, Juan Jose Lahuerta, Maria-Victoria Mateos, Jesus San Miguel, MDPhD
Journal: Blood
Blood (2015) 126 (23): 19.
https://doi.org/10.1182/blood.V126.23.19.19
Published: 2015
Journal Articles

The Relevance of Minimal Residual Disease (MRD) Monitoring in Elderly Multiple Myeloma (MM) Patients

Bruno Paiva, PhD, Teresa Cedena, Noemi Puig, MD PhD, Lourdes Cordon, Joaquin Martinez-López, MDPhD, Enrique M. Ocio, MD PhD, Miguel T Hernandez, Ana Isabel Teruel, MD, Mercedes Gironella, M Asuncion Echeveste, Laura Rosiñol, MDPhD, Rafael Martinez, MD, Albert Oriol, MDPhD, Jesus Martin, Norma C Gutiérrez, Maria Belen Vidriales, MD PhD, Joan Blade, MDPhD, Juan Jose Lahuerta, Maria-Victoria Mateos, Jesus San Miguel, MDPhD
Journal: Blood
Blood (2015) 126 (23): 4181.
https://doi.org/10.1182/blood.V126.23.4181.4181
Published: 2015
Journal Articles

Bortezomib, Melphalan, Prednisone (VMP) and Lenalidomide Plus Dexamethasone (Rd) Is the Optimal Combination for Patients with Newly Diagnosed Multiple Myeloma (MM) Patients Between 65 and 80 Years

Maria-Victoria Mateos, MD PhD, Joaquín Martínez-López, Miguel T Hernandez, Enrique M Ocio, Laura Rosiñol, MDPhD, Rafael Martinez, MD, Ana Isabel Teruel, MD, Norma C Gutierrez, María-Luisa Martín, Albert Oriol, MD, Joan Bargay, MD, Enrique Bengoechea, Yolanda Gonzalez, MD, Jaime Perez de Oteyza, Mercedes Gironella, Cristina Encinas, Carmen Cabrera, Bruno Paiva, PhD, Maria Teresa Cedena, Noemi Puig, MD PhD, Joan Blade, MDPhD, Juan José Lahuerta, Jesus San Miguel, MDPhD
Journal: Blood
Blood (2015) 126 (23): 1848.
https://doi.org/10.1182/blood.V126.23.1848.1848
Published: 2015
Journal Articles

Simplified in-House Deep Sequencing Method of Inmunoglobulin Genes for Minimal Residual Dissease Quantification and Risk Stratification in Multiple Myeloma

Beatriz Sanchez-Vega, Santiago Barrio, Yanira Ruiz, Ramon Garcia-Sanz, MD PhD, Bruno Paiva, PhD, Carlos Marin, Roberto Maldonado, Inmaculada Rapado, Jose Cervera, MD, Rosa M. Ayala, MD PhD, Teresa Cedena, Cristina Jimenez, BsC, Miguel T Hernandez, Rafael Martinez, MD, Enrique M Ocio, M Asuncion Echeveste, Laura Rosinol, Joan Blade, Maria-Victoria Mateos, Jesus San Miguel, MDPhD, Juan Jose Lahuerta, MD PhD, Joaquin Martinez Lopez, MDPhD
Journal: Blood
Blood (2015) 126 (23): 2972.
https://doi.org/10.1182/blood.V126.23.2972.2972
Published: 2015
Journal Articles

Clinical Significance of Sensitive Flow-MRD Monitoring in Elderly Multiple Myeloma Patients on the Pethema/GEM2010MAS65 Trial

Bruno Paiva, PhD, Maria Angeles Montalbán, Noemi Puig, MD PhD, Lourdes Cordon, Joaquin Martinez-Lopez, Enrique M Ocio, MD PhD, Miguel Hernandez, MD, Ana Isabel Teruel, Mercedes Gironella, MD, Maria Asunción Echeveste, Laura Rosiñol, MD PhD, Rafael Martinez, MD, Albert Oriol, MD, Jesus Martin, MD, Cristina Encinas, Norma Carmen Gutierrez, PhD MD, María-Belén Vidriales, MD PhD, Joan Blade, Juan José Lahuerta, MD PhD, Maria-Victoria Mateos, Jesus F. San Miguel
Journal: Blood
Blood (2014) 124 (21): 3390.
https://doi.org/10.1182/blood.V124.21.3390.3390
Published: 2014
Journal Articles

Phase 2 Study Of Bendamustine, Bortezomib (Velcade) and Prednisone (BVP) For Newly Diagnosed Multiple Myeloma (MM)

Maria-Victoria Mateos, MD, Ph.D, Albert Oriol, MD, Laura Rosiñol, MD, Felipe de Arriba, Jesús Martín, Joaquín Martínez-López, MD, PhD, Maria Asuncion Echeveste, Josep Sarrá, MD, Gemma Ramirez, Enrique M. Ocio, Rafael Martinez, MD, Luis Palomera, MD, Angel Payer, Rebeca Iglesias, Javier De La Rubia, MD, PhD, Adrian Alegre, MD, Anabelle Chinea, Joan Bladé, MD, PhD, Juan José Lahuerta, Jesús F San Miguel, MD
Journal: Blood
Blood (2013) 122 (21): 2155.
https://doi.org/10.1182/blood.V122.21.2155.2155
Published: 2013
Journal Articles

Phase III Trial Of Bortezomib, Melphalan, and Prednisone (VMP) Versus Bortezomib, Thalidomide, and Prednisone (VTP) In Elderly Multiple Myeloma (MM) Patients: Update Follow-Up, Patterns Management Of First Relapse/Progression

Aurelio Lopez, MD, Marta Valero, Ph, Jose Ignacio Lorenzo, MD, PhD, Maria-Victoria Mateos, MD, PhD, Albert Oriol, MD, Martínez Joaquin, Montserrat Perez, MD, Rafael Martinez, MD, Raquel de Paz, MD, Miguel Granell, MD, Felipe De Arriba, M. Jesús Blanchard, MD, Francisco Javier Peñalver, Jose Luis Bello, MD, Maria Luisa Martin, MD, Joan Bargay, MD, Joan Blade, MD, Juan Jose Lahuerta, MD, Jesús F. San Miguel, MD, PhD, Javier De La Rubia, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 1973.
https://doi.org/10.1182/blood.V122.21.1973.1973
Published: 2013
Journal Articles

Prognostic Value Of Deep Sequencing Approach For Minimal Residual Disease (MRD) Detection In Multiple Myeloma Patients

Joaquin Martinez-Lopez, MD, PhD, Juan José Laheurta, Francois Pepin, Marcos González, MD, Santiago Barrio, PhD, Rosa M. Ayala, MD, PhD, Noemí Puig, Maria Angeles Montalban, Bruno Paiva, Li Weng, PhD, Cristina Jimenez, Maria Sopena, Teresa Cedena, Inmaculada Rapado, Maria Victoria Mateo, Laura Rosiñol, MD, Albert Oriol, MD, María Jesús Blanchard, Rafael Martinez, MD, Joan Blade, MD, Jesus F San Miguel, Malek Faham, MD, PhD, Ramon Garcia-Sanz
Journal: Blood
Blood (2013) 122 (21): 1848.
https://doi.org/10.1182/blood.V122.21.1848.1848
Published: 2013
Journal Articles

Comparison Of Sequential Vs Alternating Administration Of Bortezomib, Melphalan and Prednisone (VMP) and Lenalidomide Plus Dexamethasone (Rd) In Elderly Patients With Newly Diagnosed Multiple Myeloma (MM) Patients: GEM2010MAS65 Trial

Maria-Victoria Mateos, MD, Ph.D, Joaquín Martínez-López, MD, PhD, Miguel T. Hernandez, Rafael Martinez, MD, Laura Rosiñol, MD, Enrique M. Ocio, Maria Asunción Echeveste, Jaime Pérez de Oteyza, Albert Oriol, Bargay Joan, Gironella Mercedes, Jesús Martín, Carmen Cabrera, Norma Gutierrez, PhD, MD, Martín María Luisa, Javier de la Rubia, Joan Blade, MD, Juan José Lahuerta, Jesús F San Miguel, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 403.
https://doi.org/10.1182/blood.V122.21.403.403
Published: 2013
Journal Articles

Assessment of Minimal Residual Disease Levels in B-CLL After Front-Line Treatment with FC-R and Rituximab Maintenance

Jose A. Garcia-Vela, MD, Javier Lopez, Secundino Ferrer, Pilar Giraldo, Eva González-Barca, Eulogio Conde, Marcos González, Jose-Luis Guzman, Javier De la Serna, MD, PhD, Mar Osma, MD, Guillermo Deben, MD, Encarna Monzo, MD, Raquel De Paz, MD, Francisco-Javier Penalver, Isidro Jarque, MD, Rafael Martinez, MD, Carmen Burgaleta, Jaime Perez de Oteiza, MD, M.Angeles Andreu, MD, Felix Carbonell, MD, Jose A Garcia-Marco
Journal: Blood
Blood (2012) 120 (21): 4599.
https://doi.org/10.1182/blood.V120.21.4599.4599
Published: 2012
Journal Articles

Under Scope of the Current Redefinition Process of Optimal Response in Multiple Myeloma: Assesment of Molecular Response by Fluorescent PCR of Ig Genes Has Similar Applicability and Prognosis Impact to Immunophenotypic Response. (A GEM/PETHEMA study),

Elena Fernandez Redondo, Joaquin Martinez-Lopez, Ramón García-Sanz, María-Angeles Montalbán, Pilar Martinez-Sanchez, Bruno Paiva, Maria-Victoria Mateos, MD, PhD, Laura Rosiñol, MD, Maria Luisa Martin, Rosa M. Ayala, MD, PhD, Rafael Martinez, MD, Javier Lopez, Adrian Alegre, Joan Besalduch, Joan Bargay, MT Hernandez, Maria Eugenia Sarasquete, P. sanchez-Godoy, Manuel Callis, MD, Manuela Fernandez, Joan Blade, Jesus F. San Miguel, MD, PhD, Juan José Lahuerta
Journal: Blood
Blood (2011) 118 (21): 3951.
https://doi.org/10.1182/blood.V118.21.3951.3951
Published: 2011
Journal Articles

Rituximab Maintenance Treatment After Combined Fludarabine, Cyclophosphamide and Rituximab In Previously Untreated Patients with Progressive B-Cell Chronic Lymphocytic Leukemia (CLL): Interim Analysis of An Ongoing Phase II Multicenter Trial On Behalf of the Spanish CLL Study Group (GELLC)

Jose A Garcia-Marco, MD, PhD, Javier Lopez-Jimenez, MD, Secundino Ferrer, MD, Pilar Giraldo, MD, PhD, Eva González-Barca, MD, Belen Navarro, MD, Eulogio Conde, MD, PhD, Marcos González, Jose L. Guzman, MD, Ernesto Perez, MD, Javier De la Serna, MD, PhD, Mar Osma, MD, Guillermo Deben, MD, Encarna Monzo, MD, Raquel de Paz, MD, M. Angeles Ruiz, MD, Francisco-Javier Penalver, Isidro Jarque, MD, Helena Bañas, MD, M. Carmen Fernandez, MD, Rafael Martinez, MD, Carmen Burgaleta, MD, Jaime Perez de Oteiza, MD, M.Angeles Andreu, MD, Ana Carral, MD, Inmaculada Fuentes, MD, Eva Donato, MD, Paola Leon, MD, Felix Carbonell, MD, Jose A. Garcia-Vela, MD
Journal: Blood
Blood (2010) 116 (21): 2448.
https://doi.org/10.1182/blood.V116.21.2448.2448
Published: 2010
Journal Articles

Apoptotic and Multi-Drug Resistance Profile in Elderly AML Patients.

Maria-Belen Vidriales, MD, PhD, Lilia Suarez, José García-Laraña, MD, PhD, Antonio López, María José Moreno, MD, PhD, Rafael Martinez, MD, PhD, Mar Tormo, MD, Esperanza Lavilla, MD, Consuelo López-Berges, MD, PhD, María de Santiago, Jesús F. San Miguel, MD, PhD, Alberto Orfao, MD, PhD, for the Pethema Cooperative Group
Journal: Blood
Blood (2004) 104 (11): 4472.
https://doi.org/10.1182/blood.V104.11.4472.4472
Published: 2004