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Pierre Fenaux, MD PhD
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Journal Articles

Mutation Profiles Identify Distinct Clusters of Lower Risk Myelodysplastic Syndromes with Unique Clinical and Biological Features and Clinical Endpoints

Luca Malcovati, MD, Simon Crouch, PhD BA, MA, MSc, Aniek O. De Graaf, PhD, Sarah Sandmann, Magnus Tobiasson, MD, Olivier Kosmider, PharmD, PhD, Bert A. van der Reijden, PhD, Daniel Painter, BSc, Arjan A. Van de Loosdrecht, MD PhD, Argiris Symeonidis, MD PhD, Jaroslav Cermak, MD PhD, Emmanuelle Clappier, PharmD,PhD, Claude Preudhomme, MD PhD, Reinhard Stauder, MD MSc, Moshe Mittelman, MD, Ulrich Germing, David Bowen, MD, Pierre Fenaux, MD PhD, Corine Van Marrewijk, PhD, Alexandra Smith, PhD, Martin Dugas, Eva Hellstrom Lindberg, MD PhD, Theo M de Witte, MD, Michaela Fontenay, Joop Jansen, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 29.
https://doi.org/10.1182/blood-2020-138549
Published: 2020
Journal Articles

Effect of Luspatercept on Biomarkers of Erythropoiesis in Patients (Pts) with Lower-Risk Myelodysplastic Syndromes (LR-MDS) in the Medalist Trial

Uwe Platzbecker, Yiming Zhu, Xianwei Ha, Alberto Risueño, Esther Chan, George Zhang, Diana R. Dunshee, Melih Acar, Jeevan K. Shetty, Rodrigo Ito, Kyle MacBeth, Valeria Santini, Maciej W. Garbowski, Pierre Fenaux, MD PhD, Martin Schwickart
Journal: Blood
Blood (2020) 136 (Supplement 1): 38–39.
https://doi.org/10.1182/blood-2020-136705
Published: 2020
Journal Articles

Red Blood Cell Transfusion Burden in Myelodysplastic Syndromes (MDS) with Ring Sideroblasts (RS): A Retrospective Multicenter Study By the Groupe Francophone Des Myélodysplasies (GFM)

Claire Jouzier, Amina Cherait, Pascale Cony-Makhoul, MD, Sylvain Thepot, MD, Thomas Cluzeau, MD PhD, Aspasia Stamatoulas Bastard, MD, Pierre Peterlin, MD, Agnes Guerci Bresler, MD, Sophie Dimicoli-Salazar, MD, Gian-Matteo Pica, MD, Stephane Cheze, MD, Clémence Santana, MD, Fatiha Chermat, Pierre Fenaux, MD PhD, Sophie Park, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 42–43.
https://doi.org/10.1182/blood-2020-138722
Published: 2020
Journal Articles

A Molecular-Based Response Prediction Model to Romiplostim in Patients with Lower-Risk Myelodysplastic Syndrome and Severe Thrombocytopenia

Anne Sophie Kubasch, Aristoteles Giagounidis, Georgia Metzgeroth, Anna Jonasova, MD PhD, Regina Herbst, MD, Jose Miguel Torregrosa Diaz, Benoit De Renzis, MD, Katharina S. Götze, Marie-Luise Huetter-Kroenke, MD, Marie-Pierre Gourin, Bohrane Slama, MD, Sophie Dimicoli-Salazar, MD, Pascale Cony-Makhoul, MD, Kamel Laribi, MD, Sophie Park, MD PhD, Katja Jersemann, Dorothea Schipp, Klaus H. Metzeler, MD, Oliver Tiebel, MD, Katja Sockel, MD, Silke Gloaguen, Msc, Anna Mies, Fatiha Chermat, Christian Thiede, MD, Rosa Sapena, Richard F. Schlenk, Pierre Fenaux, MD PhD, Uwe Platzbecker, Lionel Ades, MDPhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 44–45.
https://doi.org/10.1182/blood-2020-139291
Published: 2020
Journal Articles

The Commands Trial: A Phase 3 Study of the Efficacy and Safety of Luspatercept Versus Epoetin Alfa for the Treatment of Anemia Due to IPSS-R Very Low-, Low-, or Intermediate-Risk MDS in Erythropoiesis Stimulating Agent-Naive Patients Who Require RBC Transfusions

Matteo Della Porta, Uwe Platzbecker, Valeria Santini, Guillermo Garcia-Manero, MD, Rami S. Komrokji, MD, Rodrigo Ito, Pierre Fenaux, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 1–2.
https://doi.org/10.1182/blood-2020-140284
Published: 2020
Journal Articles

Imerge: A Phase 3 Study to Evaluate Imetelstat in Transfusion-Dependent Subjects with IPSS Low or Intermediate-1 Risk Myelodysplastic Syndromes (MDS) That Is Relapsed/Refractory to Erythropoiesis-Stimulating Agent (ESA) Treatment

Uwe Platzbecker, Pierre Fenaux, MD PhD, David P. Steensma, MD, Koen Van Eygen, MD, Azra Raza, MD, Ulrich Germing, Patricia Font, MD, Maria Diez-Campelo, PhDMD, Sylvain Thepot, MD, Edo Vellenga, MD PhD, Mrinal M. Patnaik, MDMBBS, Jun Ho Jang, MD PhD, Laurie Sherman, BSN, Souria Dougherty, BS, MBA, Libo Sun, PhD, Fei Huang, PhD, Ying Wan, PhD, Aleksandra Rizo, MD PhD, Tymara Berry, MD, Faye Feller, MD, Valeria Santini
Journal: Blood
Blood (2020) 136 (Supplement 1): 17.
https://doi.org/10.1182/blood-2020-138810
Published: 2020
Journal Articles

Very Long Term Follow up a Phase II Study of Post-Remission Subcutaneous (SC) Azacitidine (AZA) in Patients with AML Post-MDS or Higher-Risk (HR) MDS

Amina Cherait, Thorsten Braun, MD PhD, Krimo Bouabdallah, MD, Denis Caillot, Agnès Guerci, MD PhD, Emmanuel Raffoux, MD, Jean Pierre Marolleau, Cecile Pautas, MD, Anne Banos, MD, Chantal Himberlin, MD, Anne Laure Taksin, Arnaud Pigneux, MD PhD, Xavier Thomas, MD PhD, Norbert Vey, MD, Sylvie Chevret, MDPhD, Herve Dombret, MD PhD, Fatiha Chermat, Lionel Ades, MDPhD, Claude Gardin, Pierre Fenaux, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 1–2.
https://doi.org/10.1182/blood-2020-137012
Published: 2020
Journal Articles

Health-Related Quality of Life Outcomes in Patients with Myelodysplastic Syndromes with Ring Sideroblasts Treated with Luspatercept in the Medalist Study

Esther Natalie Oliva, MD, Uwe Platzbecker, Guillermo Garcia-Manero, MD, Ghulam J. Mufti, Professor, Valeria Santini, Mikkael A. Sekeres, Rami S. Komrokji, MD, Jeevan K. Shetty, Derek Tang, Shien Guo, Weiqin Liao, George Zhang, Xianwei Ha, Rodrigo Ito, Jennifer Lord-Bessen, Jay T. Backstrom, Pierre Fenaux, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 10–12.
https://doi.org/10.1182/blood-2020-136276
Published: 2020
Journal Articles

SY-1425, a Potent and Selective RARα Agonist, in Combination with Azacitidine Demonstrates a High Complete Response Rate and a Rapid Onset of Response in RARA-Positive Newly Diagnosed Unfit Acute Myeloid Leukemia

Stephane De Botton, Thomas Cluzeau, MDPhD, Carlos Enrique Vigil, MD, Rachel J. Cook, MD, Philippe Rousselot, MDPhD, David A Rizzieri, MD, Jane L. Liesveld, MD, Pierre Fenaux, MD PhD, Thorsten Braun, MD PhD, Anne Banos, MD, Michael R. Savona, MD, Don Park, MD, Michael J. Kelly, MD MPH, MS, Angela Volkert, Li Zhou, PhD, Qing Kang-Fortner, PhD, David A. Roth, MD, Eytan M. Stein, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 4–5.
https://doi.org/10.1182/blood-2020-134600
Published: 2020
Journal Articles

Preliminary Data on a Phase 1/2A First in Human Study of the Menin-KMT2A (MLL) Inhibitor KO-539 in Patients with Relapsed or Refractory Acute Myeloid Leukemia

Eunice S. Wang, MD, Jessica K. Altman, MD, Kristen Pettit, Stephane De Botton, Roland P Walter, MDPhD, Pierre Fenaux, MD PhD, Francis Burrows, PhD, Blake E. Tomkinson, PhDMBA, Bridget Martell, MA, MD, Amir T. Fathi, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 7–8.
https://doi.org/10.1182/blood-2020-134942
Published: 2020
Journal Articles

Efficacy and Safety of Luspatercept Treatment in Patients with Myelodysplastic Syndrome/Myeloproliferative Neoplasm with Ring Sideroblasts and Thrombocytosis (MDS/MPN-RS-T): A Retrospective Analysis from the Medalist Study

Rami S. Komrokji, MD, Uwe Platzbecker, Pierre Fenaux, MD PhD, Guillermo Garcia-Manero, MD, Ghulam J. Mufti, Professor, Valeria Santini, Maria Diez-Campelo, PhDMD, Carlo Finelli, Joseph G. Jurcic, MD, Peter L. Greenberg, Mikkael A. Sekeres, Amer M. Zeidan, MBBS, MHS, Amy E. DeZern, MD, Michael R. Savona, MD, Jeevan K. Shetty, Rodrigo Ito, George Zhang, Xianwei Ha, Daniel Sinsimer, Jay T. Backstrom, Amit Verma, MBBS
Journal: Blood
Blood (2020) 136 (Supplement 1): 13–15.
https://doi.org/10.1182/blood-2020-137232
Published: 2020
Journal Articles

Sequential Study By RNA-Seq Shows a Reduction in Inflammation and a Cell Cycle Activation in T-Lymphocytes from Myelodysplastic Syndrome with Del(5q) after Lenalidomide Treatment in Patients Included in the "Sintra-REV" Clinical Trial

Mónica Del Rey, Luis A Corchete, PhD, Teresa González, PhD, Félix López Cadenas, MD, Eva Lumbreras, Marta Martín Izquierdo, MSc, Sandra Santos-Mínguez, Sofía M Toribio, Blanca Xicoy, MD, Joaquín Sánchez-García, MD PhD, Teresa Bernal, MD PhD, Guillermo F Sanz, MD PhD, Benet Nomdedeu, MD, Pierre Fenaux, MD PhD, Jesús M Hernández Rivas, MD PhD, Maria Diez-Campelo, PhDMD
Journal: Blood
Blood (2020) 136 (Supplement 1): 26–27.
https://doi.org/10.1182/blood-2020-140703
Published: 2020
Journal Articles

Efficacy and Safety of Bemcentinib in Patients with Myelodysplastic Syndromes or Acute Myeloid Leukemia Failing Hypomethylating Agents

Anne Sophie Kubasch, Pierre Peterlin, MD, Thomas Cluzeau, MD PhD, Katharina S. Götze, Katja Sockel, MD, Raphael Teipel, MD, Madlen Jentzsch, MD, Sabine Kayser, MD, Habiba Attalah, Fatiha Chermat, Silke Gloaguen, Msc, Katja Jersemann, Dorothea Schipp, Aristoteles Giagounidis, Stuart McPherson, BSc, Irene Tirado-González, Arjan van de Loosdrecht, MD PhD, Pierre Fenaux, MD PhD, Uwe Platzbecker, Hind Medyouf, Lionel Ades, MDPhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 37–38.
https://doi.org/10.1182/blood-2020-140240
Published: 2020
Journal Articles

The STIMULUS Program: Clinical Trials Evaluating Sabatolimab (MBG453) Combination Therapy in Patients (Pts) with Higher-Risk Myelodysplastic Syndromes (HR-MDS) or Acute Myeloid Leukemia (AML)

Amer M. Zeidan, MBBS, MHS, Jordi Esteve, Aristoteles Giagounidis, Hee-Je Kim, MD, PhD, Yasushi Miyazaki, MD PhD, Uwe Platzbecker, Andre C. Schuh, Mikkael A. Sekeres, Jörg Westermann, Zhijian Xiao, Kamel Malek, Jeffrey Scott, Julie Niolat, Severine Peyrard, Fei Ma, Flavia Kiertsman, Mario Stegert, Sabine Hertle, Pierre Fenaux, MD PhD, Valeria Santini
Journal: Blood
Blood (2020) 136 (Supplement 1): 45–46.
https://doi.org/10.1182/blood-2020-134718
Published: 2020
Journal Articles

Phase 3 Study of Lenalidomide (LEN) Vs Placebo in Non-Transfusion Dependent (TD) Low Risk Del(5q) MDS Patients - Interim Analysis of the European Sintra-REV Trial

Félix López Cadenas, MD, Eva Lumbreras, Blanca Xicoy, MD, Joaquín Sánchez, MD, Rosa Coll, MD, Bohrane Slama, MD, Jose Angel Hernandez-Rivas, MD PhD, Sylvain Thepot, MD, Teresa Bernal, MD PhD, Beatriz Arrizabalaga, MD PhD, Agnès Guerci-Bresler, MD PhD, Guillermo F Sanz, MD PhD, Joan Bargay, MD, Maria Luz Amigo, MD, Raquel de Paz, MD, Benet Nomdedeu, MD, Aristoteles Giagounidis, Uwe Platzbecker, Stefan Wickenhauser, Katharina S. Götze, Ali Arar, Jesus María Hernández Rivas, MD PhD, Pierre Fenaux, MD PhD, Consuelo Del Cañizo, MDPhD, Maria Diez-Campelo, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 28–29.
https://doi.org/10.1182/blood-2020-140339
Published: 2020
Journal Articles

MDS/CMML with TET2 or IDH mutation Are Associated with Systemic Inflammatory and Autoimmune Diseases (SIAD) and T Cell Dysregulation

Lin-Pierre Zhao, MD, Maxime Boy, Celia Azoulay, Emmanuelle Clappier, PhD PharmD, Marie Sébert, MD PhD, Ludivine Amable, Jihene Klibi, Kamel Benlagha, Marion Espeli, Karl Balabanian, Claude Preudhomme, MD PhD, Alice Marceau, Raphael Itzykson, MD PhD, Arsène Mékinian, Olivier Fain, MD, Antoine Toubert, Pierre Fenaux, MD PhD, Nicolas Dulphy, Lionel Ades, MDPhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 31–32.
https://doi.org/10.1182/blood-2020-141228
Published: 2020
Journal Articles

Decitabine Versus Hydroxyurea for Advanced Proliferative CMML: Results of the Emsco Randomized Phase 3 Dacota Trial

Raphael Itzykson, MD PhD, Valeria Santini, Cendrine Chaffaut, Ades Lionel, Sylvain Thepot, MD, Aristoteles Giagounidis, Margot Morabito, Nathalie Droin, Michael Luebbert, Rosa Sapena, Stanislas Nimubona, MD, Jean E. Goasguen, MD PhD, Eric Wattel, MD PhD, Gina Zini, MDPhD, Jose Miguel Torregrosa Diaz, Ulrich Germing, Anna Maria Pelizzari, Sophie Park, MD PhD, Nadja Jaekel, Georgia Metzgeroth, Francesco Onida, MD, Robert Navarro, Andrea Patriarca, MD, Aspasia Stamatoulas Bastard, MD, Martin Puttrich, Sandra Mossuto, Eric Solary, MD PhD, Silke Gloaguen, Msc, Sylvie Chevret, MD PhD, Fatiha Chermat, Uwe Platzbecker, Pierre Fenaux, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 53–54.
https://doi.org/10.1182/blood-2020-138680
Published: 2020
Journal Articles

Prognostic Impact of Clonal Diversity in Acute Myeloid Leukemia (AML) Treated with Intensive Chemotherapy (IC)

Marco Cerrano, MD, Marie Passet, PharmD, Loic Vasseur, MD, Pierre Hirsch, MD PhD, Xavier Thomas, MD PhD, Samuel Quentin, Justine Pasanisi, Florence Rabian, MD, Ramy Rahmé, MD, Etienne Lengline, MD, Emmanuel Raffoux, MD, Nathalie Dhedin, MD, Marie Sebert, MD, Odile Maarek, Anna Raimbault, PhD, Karine Celli-Lebras, CRA, Lionel Ades, MD PhD, Pierre Fenaux, MD PhD, Nicolas Boissel, MD PhD, Francois Delhommeau, MD PhD, Jean Soulier, MD PhD, Herve Dombret, MD PhD, Emmanuelle Clappier, PhD PharmD, Pierre Sujobert, MD PhD, Raphael Itzykson, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2700.
https://doi.org/10.1182/blood-2019-127475
Published: 2019
Journal Articles

I-Care for MDS: Development of Guidelines-Based Indicators for Appropriate Care in Adult Patients with Myelodysplastic Syndromes

Kristina Stojkov, BSc, MSc Pharm, Tobias Silzle, MD, Georg Stussi, MD, David Schwappach, PhD MPH, Juerg Bernhard, PhD, David Bowen, MD, Jaroslav Cermak, Avinash G. Dinmohamed, BSc, MSc, Corien Eeltink, Sabrina Eggmann, PT, MSc, Pierre Fenaux, MD PhD, Ulrich Germing, MD, Manuel Haschke, MD, Eva Hellstrom Lindberg, MD PhD, Monika Heger, Arjan A. Van de Loosdrecht, MD PhD, Jakob R. Passweg, MDMS, Michael Pfeilstocker, MD, Uwe Platzbecker, MD, Luca Malcovati, MD, Antonio Medina De Almeida, MD PhD, Moshe Mittelman, MD, Christine Morgenthaler, David P. Steensma, MD, Valeria Santini, MD, Reinhard Stauder, MD MSc, Argiris Symeonidis, MD PhD, Saemi Schaer, PhD, Charlotte Maddox, DVM, PhD, Theo M de Witte, MD, Julia Bohlius, MD, Nicolas Bonadies, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4752.
https://doi.org/10.1182/blood-2019-122285
Published: 2019
Journal Articles

Long Term Effects of Eltrombopag Treatment Versus Placebo for Low-Risk Myelodysplastic Syndromes with Thrombocytopenia (EQoL-MDS): Interim Results of a Single-Blind, Randomised, Controlled, Phase 2 Superiority Trial

Esther Natalie Oliva, MD, Caterina Alati, MD, Valeria Santini, MD, Antonella Poloni, PhD MD, Marta Riva, MD, Pasquale Niscola, MD PhD, Valentina Giai, MD, Grazia Sanpaolo, MD, Enrico Balleari, Elena Crisà, MD, Dario Ferrero, MD, Ulrich Germing, MD, Pierre Fenaux, MD PhD, Giuseppe A. Palumbo, MD PhD, Prassede Salutari, MD, Stefana Impera, MD, Isabella Capodanno, MD, Gianluigi Reda, MD, Anna Marina Liberati, Alfredo Molteni, MD, Giorgina Specchia, MD, Francesco Buccisano, MD, Maria Teresa Voso, MD, Stefano Mancini, MD, Monica Bocchia, Anna Candoni, MD, Bruno Martino, MD, Patrizia Cufari, Maria Grazia D'Errigo, Gina Zini, MD PhD, Roberto Latagliata
Journal: Blood
Blood (2019) 134 (Supplement_1): 3000.
https://doi.org/10.1182/blood-2019-126744
Published: 2019