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Peng Huang, PhD
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Journal Articles

A β-Globin Locus-Intrinsic Epigenetic Mechanism Underlies Fetal Globin Production in F-Cells

Eugene Khandros, MD PhD, Peng Huang, PhD, Scott A. Peslak, MD PhD, Malini Sharma, BS, Osheiza Abdulmalik, DVM, Belinda Giardine, Zhe Zhang, PhD, Cheryl A. Keller, PhD, Ross C. Hardison, PhD, Gerd A. Blobel, MDPhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 16–17.
https://doi.org/10.1182/blood-2020-137646
Published: 2020
Journal Articles

Control of Fetal Hemoglobin Levels By NFI Transcription Factors

Kunhua Qin, Peng Huang, PhD, Anran Huang, BS, Ruopeng Feng, PhD, Thiyagaraj Mayuranathan, Cheryl A. Keller, PhD, Belinda Giardine, Ross C. Hardison, PhD, Mitchell J. Weiss, MD PhD, Junwei Shi, PhD, Gerd A. Blobel, MDPhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 54.
https://doi.org/10.1182/blood-2020-136167
Published: 2020
Journal Articles

Heme-Regulated Inhibitor (HRI) Depletion Cooperates with Pharmacologic Inducers to Strongly Elevate Fetal Hemoglobin and Reduce Sickle Cell Formation

Scott A. Peslak, MD PhD, Xianjiang Lan, PhD, Eugene Khandros, MD PhD, Peng Huang, PhD, Jennifer A. Yano, BA, Jeremy D. Grevet, PhD, Osheiza Abdulmalik, DVM, Cheryl A Keller, PhD, Ross C. Hardison, PhD, Junwei Shi, PhD, Gerd A. Blobel, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3557.
https://doi.org/10.1182/blood-2019-125664
Published: 2019
Journal Articles

Heme-Regulated Inhibitor (HRI) Activates Transcription Factor ATF4 to Promote BCL11A Transcription and Fetal Hemoglobin Silencing

Peng Huang, PhD, Scott A. Peslak, MD PhD, Xianjiang Lan, PhD, Eugene Khandros, MD PhD, Malini Sharma, BS, Kunhua Qin, PhD, Cheryl A Keller, PhD, Belinda Giardine, Junwei Shi, PhD, Ross C. Hardison, PhD, Gerd A. Blobel, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 814.
https://doi.org/10.1182/blood-2019-123837
Published: 2019
Journal Articles

Understanding Heterogeneity of Fetal Hemoglobin Induction through Comparative Analysis of Stage-Matched F- and a-Cells

Eugene Khandros, MD PhD, Peng Huang, PhD, Scott A. Peslak, MD PhD, Belinda Giardine, Zhe Zhang, PhD, Cheryl A Keller, PhD, Ross C. Hardison, PhD, Gerd A. Blobel, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 981.
https://doi.org/10.1182/blood-2019-124099
Published: 2019
Journal Articles

Comparison of Fetal and Adult Erythroid Chromosomal Architectures Identifies a Novel Fetal Hemoglobin Regulatory Region

Peng Huang, PhD, Cheryl A. Keller, PhD, Belinda Giardine, James O.J. Davies, Jim R. Hughes, Ross C Hardison, PhD, Gerd Blobel, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 774.
https://doi.org/10.1182/blood.V130.Suppl_1.774.774
Published: 2017
Journal Articles

Development of a Human Therapeutic L-Cyst(e)Ine-Degrading Enzyme for the Treatment of Hematological Malignancies

Giulia Agnello, PhD, Susan Alters, PhD, Joseph Tyler, MS, Jinyun Liu, PhD, Peng Huang, PhD, Everett Stone, PhD, George Georgiou, PhD, David Lowe, PhD, Scott Rowlinson, PhD
Journal: Blood
Blood (2016) 128 (22): 1587.
https://doi.org/10.1182/blood.V128.22.1587.1587
Published: 2016
Journal Articles

The BET Protein BRD2 Cooperates with CTCF to Enforce a Transcriptional Boundary in Erythroid Cells

Sarah C. Hsu, Caroline Bartman, Aaron J Stonestrom, MD PhD, Christopher R Edwards, PhD, Thomas Gilgenast, Daniel Emerson, Peng Huang, PhD, Michael T. Werner, Kristen Jahn, Cheryl A. Keller, PhD, Belinda Giardine, Ross C. Hardison, PhD, Arjun Raj, PhD, Jennifer E. Phillips-Cremins, PhD, Gerd A. Blobel, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1034.
https://doi.org/10.1182/blood.V128.22.1034.1034
Published: 2016
Journal Articles

Genome Editing Recreates Hereditary Persistence of Fetal Hemoglobin in Primary Human Erythroblasts

Elizabeth Traxler, Yu Yao, MD, Chunliang Li, Jeremy Grevet, Peng Huang, PhD, Shaela Wright, Gerd A. Blobel, MD PhD, Mitchell J. Weiss, MD PhD
Journal: Blood
Blood (2015) 126 (23): 640.
https://doi.org/10.1182/blood.V126.23.640.640
Published: 2015
Journal Articles

A Hyperactive Transcriptional State Marks Genome Reactivation during Mitotic Exit

Gerd A. Blobel, MD PhD, Chris C.S. Hsiung, B.A., Peng Huang, PhD, Cheryl Keller, PhD, Paul Ginart, Kristen Jahn, Caroline Bartman, Aaron James Stonestrom, BS, Perry Evans, Belinda Giardine, Ross C. Hardison, PhD, Arjun Raj, PhD
Journal: Blood
Blood (2015) 126 (23): 48.
https://doi.org/10.1182/blood.V126.23.48.48
Published: 2015
Journal Articles

Dissection of BET Protein Function in a Hematopoietic Differentiation Model

Aaron J Stonestrom, Sarah C Hsu, Kristen S Jahn, Chris CS Hsuing, Peng Huang, PhD, Ross C Hardison, PhD, Gerd A. Blobel, MD PhD
Journal: Blood
Blood (2014) 124 (21): 1574.
https://doi.org/10.1182/blood.V124.21.1574.1574
Published: 2014
Journal Articles

The Combination of PEITC (Phenehyl Isothiocyanate) with a Histone Deacetylase Inhibitor (HDACi) Has Synergistic Antileukemia Activity by Overcoming a Redox-Mediated Resistance Pathway.

Yumin Hu, MD, PhD, Gang Chen, Yu Jia, Hui Zhang, Peng Huang, PhD, Kapil N. Bhalla, MD, Michael Keating, MD, Guillermo Garcia-Manero, MD
Journal: Blood
Blood (2009) 114 (22): 1739.
https://doi.org/10.1182/blood.V114.22.1739.1739
Published: 2009
Journal Articles

A Therapeutic Approach for Acute Leukemias: Glycolysis Inhibition Revisited

Lauren J. Akers, DO, Alejandro G. Levy, MD, Anna R. Franklin, MD, Wendy Fang, MD, Peng Huang, PhD, Patrick Zweidler-McKay, MD, PhD
Journal: Blood
Blood (2008) 112 (11): 5020.
https://doi.org/10.1182/blood.V112.11.5020.5020
Published: 2008